-
1
-
-
33644600485
-
Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab
-
Adams CW, Allison DE, Flagella K, Presta L, Clarke J, Dybdal N, McKeever K, Sliwkowski MX (2006) Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab. Cancer Immunol Immunother 55: 717-727
-
(2006)
Cancer Immunol Immunother
, vol.55
, pp. 717-727
-
-
Adams, C.W.1
Allison, D.E.2
Flagella, K.3
Presta, L.4
Clarke, J.5
Dybdal, N.6
McKeever, K.7
Sliwkowski, M.X.8
-
2
-
-
19044380618
-
Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
-
Agus DB, Akita RW, Fox WD, Lewis GD, Higgins B, Pisacane PI, Lofgren JA, Tindell C, Evans DP, Maiese K, Scher HI, Sliwkowski MX (2002) Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth. Cancer Cell 2: 127-137
-
(2002)
Cancer Cell
, vol.2
, pp. 127-137
-
-
Agus, D.B.1
Akita, R.W.2
Fox, W.D.3
Lewis, G.D.4
Higgins, B.5
Pisacane, P.I.6
Lofgren, J.A.7
Tindell, C.8
Evans, D.P.9
Maiese, K.10
Scher, H.I.11
Sliwkowski, M.X.12
-
3
-
-
20244378677
-
Phase i clinical study of pertuzumab, a novel HER dimerization inhibitor in patients with advanced cancer
-
Agus DB, Gordon MS, Taylor C, Natale RB, Karlan B, Mendelson DS, Press MF, Allison DE, Sliwkowski MX, Lieberman G, Kelsey SM, Fyfe G (2005) Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor in patients with advanced cancer. J Clin Oncol 23: 2534-2543
-
(2005)
J Clin Oncol
, vol.23
, pp. 2534-2543
-
-
Agus, D.B.1
Gordon, M.S.2
Taylor, C.3
Natale, R.B.4
Karlan, B.5
Mendelson, D.S.6
Press, M.F.7
Allison, D.E.8
Sliwkowski, M.X.9
Lieberman, G.10
Kelsey, S.M.11
Fyfe, G.12
-
4
-
-
31444451572
-
Trastuzumab-based treatment of HER2-positive breast cancer: An antibody-dependent cellular cytotoxicity mechanism?
-
Arnould L, Gelly M, Penault-Llorca F, Benoit L, Bonnetain F, Migeon C, Cabaret V, Fermeaux V., Bertheau P, Garnier J, Jeannin JF, Coudert B (2006) Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism? Br J Cancer 94: 259-267
-
(2006)
Br J Cancer
, vol.94
, pp. 259-267
-
-
Arnould, L.1
Gelly, M.2
Penault-Llorca, F.3
Benoit, L.4
Bonnetain, F.5
Migeon, C.6
Cabaret, V.7
Fermeaux, V.8
Bertheau, P.9
Garnier, J.10
Jeannin, J.F.11
Coudert, B.12
-
5
-
-
0025281906
-
Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer
-
Berchuck A, Kamel A, Whitaker R, Kerns B, Olt G, Kinney R, Soper JT, Dodge R, Clarke-Pearson DL, Marks P, McKenzie S, Yin S, Bast Jr RC (1990) Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer. Cancer Res 50: 4087-4091
-
(1990)
Cancer Res
, vol.50
, pp. 4087-4091
-
-
Berchuck, A.1
Kamel, A.2
Whitaker, R.3
Kerns, B.4
Olt, G.5
Kinney, R.6
Soper, J.T.7
Dodge, R.8
Clarke-Pearson, D.L.9
Marks, P.10
McKenzie, S.11
Yin, S.12
Bast Jr, R.C.13
-
6
-
-
0026098279
-
Overexpression of HER-2/neu in endometrial cancer is associated with advanced stage disease
-
Berchuck A, Rodriguez G, Kinney RB, Soper JT, Dodge RK, Clarke-Pearson DL, Bast Jr RC (1991) Overexpression of HER-2/neu in endometrial cancer is associated with advanced stage disease. Am J Obstet Gynecol 164: 15-21
-
(1991)
Am J Obstet Gynecol
, vol.164
, pp. 15-21
-
-
Berchuck, A.1
Rodriguez, G.2
Kinney, R.B.3
Soper, J.T.4
Dodge, R.K.5
Clarke-Pearson, D.L.6
Bast Jr, R.C.7
-
7
-
-
0034772498
-
Interleukin-2 enhances the natural killer cell response to Herceptin-coated Her2/neu-positive breast cancer cells
-
Carson WE, Parihar R, Lindemann MJ, Personeni N, Dierksheide J, Meropol NJ, Baselga J, Caligiuri MA (2001) Interleukin-2 enhances the natural killer cell response to Herceptin-coated Her2/neu-positive breast cancer cells. Eur J immunol 31: 3016-3025
-
(2001)
Eur J Immunol
, vol.31
, pp. 3016-3025
-
-
Carson, W.E.1
Parihar, R.2
Lindemann, M.J.3
Personeni, N.4
Dierksheide, J.5
Meropol, N.J.6
Baselga, J.7
Caligiuri, M.A.8
-
8
-
-
0034076307
-
Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
-
Clynes RA, Towers TL, Presta LG, Ravetch JV (2000) Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med 6: 443-446
-
(2000)
Nat Med
, vol.6
, pp. 443-446
-
-
Clynes, R.A.1
Towers, T.L.2
Presta, L.G.3
Ravetch, J.V.4
-
9
-
-
0035207182
-
Carcinoma of the corpus uteri
-
Creasman WT, Odicino F, Maisonneuve P, Beller U, Benedet JL, Heintz AP, Ngan HY, Sideri M, Pecorelli S (2001) Carcinoma of the corpus uteri. J Epidemiol Biostat 6: 47-86
-
(2001)
J Epidemiol Biostat
, vol.6
, pp. 47-86
-
-
Creasman, W.T.1
Odicino, F.2
Maisonneuve, P.3
Beller, U.4
Benedet, J.L.5
Heintz, A.P.6
Ngan, H.Y.7
Sideri, M.8
Pecorelli, S.9
-
10
-
-
29144457521
-
Clinical significance of Her-2/neu overexpression in uterine serous carcinoma
-
Diaz-Montes TP, Ji H, Sehdev AE, Zahurak ML, Kurman RJ, Armstrong DK, Bristow RE (2006) Clinical significance of Her-2/neu overexpression in uterine serous carcinoma. Gynecol Oncol 100: 139-144
-
(2006)
Gynecol Oncol
, vol.100
, pp. 139-144
-
-
Diaz-Montes, T.P.1
Ji, H.2
Sehdev, A.E.3
Zahurak, M.L.4
Kurman, R.J.5
Armstrong, D.K.6
Bristow, R.E.7
-
11
-
-
4444372733
-
Pilot study of the mechanism of action of preoperative trastuzumab in patients with primary operable breast tumors overexpressing HER2
-
Gennari R, Menard S, Fagnoni F, Ponchio L, Scelsi M, Tagliabue E, Castiglioni F, Villani L, Magalotti C, Gibelli N, Oliviero B, Ballardini B, Da Prada G, Zambelli A, Costa A (2004) Pilot study of the mechanism of action of preoperative trastuzumab in patients with primary operable breast tumors overexpressing HER2. Clin Cancer Res 10: 5650-5655
-
(2004)
Clin Cancer Res
, vol.10
, pp. 5650-5655
-
-
Gennari, R.1
Menard, S.2
Fagnoni, F.3
Ponchio, L.4
Scelsi, M.5
Tagliabue, E.6
Castiglioni, F.7
Villani, L.8
Magalotti, C.9
Gibelli, N.10
Oliviero, B.11
Ballardini, B.12
Da Prada, G.13
Zambelli, A.14
Costa, A.15
-
12
-
-
33749003463
-
Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: Potential predictive relationship with tumor HER2 activation status
-
Gordon MS, Matei D, Aghajanian C, Matulonis UA, Brewer M, Fleming GF, Hainsworth JD, Garcia AA, Pegram MD, Schilder RJ, Cohn DE, Roman L (2006) Clinical activity of pertuzumab (rhuMAb 2C4), a HER dimerization inhibitor, in advanced ovarian cancer: potential predictive relationship with tumor HER2 activation status. J Clin Oncol 24: 4324-4332
-
(2006)
J Clin Oncol
, vol.24
, pp. 4324-4332
-
-
Gordon, M.S.1
Matei, D.2
Aghajanian, C.3
Matulonis, U.A.4
Brewer, M.5
Fleming, G.F.6
Hainsworth, J.D.7
Garcia, A.A.8
Pegram, M.D.9
Schilder, R.J.10
Cohn, D.E.11
Roman, L.12
-
13
-
-
37349093010
-
An exploratory analysis of HER-2 amplification and overexpression in advanced endometrial carcinoma: A Gynecologic Oncology Group study
-
Gynecologic Oncology Group
-
Grushko TA, Filiaci VL, Mundt AJ, Ridderstrale K, Olopade OI, Fleming GF (2008) Gynecologic Oncology Group. An exploratory analysis of HER-2 amplification and overexpression in advanced endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 108: 3-9
-
(2008)
Gynecol Oncol
, vol.108
, pp. 3-9
-
-
Grushko, T.A.1
Filiaci, V.L.2
Mundt, A.J.3
Ridderstrale, K.4
Olopade, O.I.5
Fleming, G.F.6
-
14
-
-
0026677492
-
HER-2/neu expression: A major prognostic factor in endometrial cancer
-
Hetzel DJ, Wilson TO, Keeney GL, Roche PC, Cha SS, Podratz KC (1992) HER-2/neu expression: a major prognostic factor in endometrial cancer. Gynecol Oncol 47: 179-185
-
(1992)
Gynecol Oncol
, vol.47
, pp. 179-185
-
-
Hetzel, D.J.1
Wilson, T.O.2
Keeney, G.L.3
Roche, P.C.4
Cha, S.S.5
Podratz, K.C.6
-
15
-
-
1942441770
-
Blockade of epidermal growth factor-or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects
-
Jackson JG, St. Clair P, Sliwkowski MX, Brattain MG (2004) Blockade of epidermal growth factor-or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects. Cancer Res 64: 2601-2609
-
(2004)
Cancer Res
, vol.64
, pp. 2601-2609
-
-
Jackson, J.G.1
St. Clair, P.2
Sliwkowski, M.X.3
Brattain, M.G.4
-
16
-
-
41349099104
-
Cancer statistics 2008
-
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ (2008) Cancer Statistics 2008. CA Cancer J Clin 58: 71-96
-
(2008)
CA Cancer J Clin
, vol.58
, pp. 71-96
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
Murray, T.6
Thun, M.J.7
-
17
-
-
33846818624
-
Sensitivity to pertuzumab (2C4) in ovarian cancer models: Cross-talk with estrogen receptor signaling
-
Mullen P, Cameron DA, Hasmann M, Smyth JF, Langdon SP (2007) Sensitivity to pertuzumab (2C4) in ovarian cancer models: cross-talk with estrogen receptor signaling. Mol Cancer Ther 6: 93-100
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 93-100
-
-
Mullen, P.1
Cameron, D.A.2
Hasmann, M.3
Smyth, J.F.4
Langdon, S.P.5
-
18
-
-
1942474587
-
The HER-2 targeting antibody trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells
-
Nahta R, Hung M, Esteva FJ (2004) The HER-2 targeting antibody trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. Cancer Res 64: 2343-2346
-
(2004)
Cancer Res
, vol.64
, pp. 2343-2346
-
-
Nahta, R.1
Hung, M.2
Esteva, F.J.3
-
19
-
-
0037479973
-
Trastuzumab and interleukin-2 in HER2-positive metastatic breast cancer: A pilot study
-
Repka T, Chiorean EG, Gay J, Herwig KE, Kohl VK, Yee D, Miller JS (2003) Trastuzumab and interleukin-2 in HER2-positive metastatic breast cancer: a pilot study. Clin Cancer Res 9: 2440-2446
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2440-2446
-
-
Repka, T.1
Chiorean, E.G.2
Gay, J.3
Herwig, K.E.4
Kohl, V.K.5
Yee, D.6
Miller, J.S.7
-
20
-
-
0036094324
-
Over-expression of HER-2/Neu in uterine serous papillary cancer
-
Santin AD, Bellone S, Gokden M, Palmieri M, Dunn D, Agha J, Roman JJ, Hutchins L, Pecorelli S, O'Brien T, Cannon MJ, Parham GP (2002) Over-expression of HER-2/Neu in uterine serous papillary cancer. Clin Cancer Res 8: 1271-1279
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1271-1279
-
-
Santin, A.D.1
Bellone, S.2
Gokden, M.3
Palmieri, M.4
Dunn, D.5
Agha, J.6
Roman, J.J.7
Hutchins, L.8
Pecorelli, S.9
O'Brien, T.10
Cannon, M.J.11
Parham, G.P.12
-
21
-
-
46749152126
-
Tras-tuzumab treatment in patients with advanced or recurrent endometrial carcinoma overexpressing HER2/neu
-
Santin AD, Bellone S, Roman JJ, McKenney JK, Pecorelli S (2008) Tras-tuzumab treatment in patients with advanced or recurrent endometrial carcinoma overexpressing HER2/neu. Int J Gynecol Obstet 102: 128-131
-
(2008)
Int J Gynecol Obstet
, vol.102
, pp. 128-131
-
-
Santin, A.D.1
Bellone, S.2
Roman, J.J.3
McKenney, J.K.4
Pecorelli, S.5
-
22
-
-
20444451579
-
Determination of HER2/neu status in uterine serous papillary carcinoma: Comparative analysis of immunohistochemistry and fluorescence in situ hybridization
-
Santin AD, Bellone S, Van Stedum S, Bushen W, De Las Casas LE, Korourian S, Tian E, Roman JJ, Burnett A, Pecorelli S (2005a) Determination of HER2/neu status in uterine serous papillary carcinoma: comparative analysis of immunohistochemistry and fluorescence in situ hybridization. Gynecol Oncol 98: 24-30
-
(2005)
Gynecol Oncol
, vol.98
, pp. 24-30
-
-
Santin, A.D.1
Bellone, S.2
Van Stedum, S.3
Bushen, W.4
De Las Casas, L.E.5
Korourian, S.6
Tian, E.7
Roman, J.J.8
Burnett, A.9
Pecorelli, S.10
-
23
-
-
25144510392
-
A major prognostic indicator in uterine serous papillary carcinoma
-
Amplification of c-erbB-2 oncogene
-
Santin AD, Bellone S, Van Stedum S, Bushen W, Palmieri M, Siegel ER, De Las Casas LE, Roman JJ, Burnett A, Pecorelli S (2005b) Amplification of c-erbB-2 oncogene. A major prognostic indicator in uterine serous papillary carcinoma. Cancer 104: 1391-1397
-
(2005)
Cancer
, vol.104
, pp. 1391-1397
-
-
Santin, A.D.1
Bellone, S.2
Van Stedum, S.3
Bushen, W.4
Palmieri, M.5
Siegel, E.R.6
De Las Casas, L.E.7
Roman, J.J.8
Burnett, A.9
Pecorelli, S.10
-
24
-
-
0033056681
-
Induction of human papillo-mavirus-specific CD4+ and CD8+ lymphocytes by E7 pulsed autologous dendritic cells in patients with HPV16 and 18 positive cervical cancer
-
Santin AD, Hermonat PL, Ravaggi A, Chiriva-Internati M, Zhan D, Pecorelli S, Parham GP, Cannon MJ (1999) Induction of human papillo-mavirus-specific CD4+ and CD8+ lymphocytes by E7 pulsed autologous dendritic cells in patients with HPV16 and 18 positive cervical cancer. J Virol 73: 5402-5410
-
(1999)
J Virol
, vol.73
, pp. 5402-5410
-
-
Santin, A.D.1
Hermonat, P.L.2
Ravaggi, A.3
Chiriva-Internati, M.4
Zhan, D.5
Pecorelli, S.6
Parham, G.P.7
Cannon, M.J.8
-
25
-
-
13344279436
-
Effects of tumor necrosis factor-a plus interferon-g combined with high dose g irradiation on the expression of major histocompatibility complex molecules and intercellular adhesion molecule-1 in human ovarian cancers
-
Santin AD, Rose GS, Hiserodt JC, Fruehauf J, Eck LM, Garcia RI, Schranz V, Disaia PJ, Pecorelli S, Granger GA (1996) Effects of tumor necrosis factor-a plus interferon-g combined with high dose g irradiation on the expression of major histocompatibility complex molecules and intercellular adhesion molecule-1 in human ovarian cancers. Int J Cancer 65: 688-694
-
(1996)
Int J Cancer
, vol.65
, pp. 688-694
-
-
Santin, A.D.1
Rose, G.S.2
Hiserodt, J.C.3
Fruehauf, J.4
Eck, L.M.5
Garcia, R.I.6
Schranz, V.7
Disaia, P.J.8
Pecorelli, S.9
Granger, G.A.10
-
26
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of HER-2/neu oncogene
-
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL (1987) Human breast cancer: correlation of relapse and survival with amplification of HER-2/neu oncogene. Science 235: 177-182
-
(1987)
Science
, vol.235
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
Levin, W.J.4
Ullrich, A.5
McGuire, W.L.6
-
27
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A, Fleming T, Eiermann W, Wolter J, Pegram M, Baselga J, Norton L (2001) Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. New Engl J Med 344: 783-792
-
(2001)
New Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
Fuchs, H.4
Paton, V.5
Bajamonde, A.6
Fleming, T.7
Eiermann, W.8
Wolter, J.9
Pegram, M.10
Baselga, J.11
Norton, L.12
-
28
-
-
4143100453
-
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma
-
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH (2004) Her-2/neu overexpression and amplification in uterine papillary serous carcinoma. J Clin Oncol 22: 3126-3132
-
(2004)
J Clin Oncol
, vol.22
, pp. 3126-3132
-
-
Slomovitz, B.M.1
Broaddus, R.R.2
Burke, T.W.3
Sneige, N.4
Soliman, P.T.5
Wu, W.6
Sun, C.C.7
Munsell, M.F.8
Gershenson, D.M.9
Lu, K.H.10
-
29
-
-
40749126861
-
Endometrial cancer
-
Sorosky J (2008) Endometrial cancer. Obstet Gynecol 111: 436-447
-
(2008)
Obstet Gynecol
, vol.111
, pp. 436-447
-
-
Sorosky, J.1
-
30
-
-
29144434036
-
2C4, a monoclonal antibody against HER2, disrupts the HER kinase signaling pathway and inhibits ovarian carcinoma cell growth
-
Takai N, Jain A, Kawamata N, Popoviciu LM, Said JW, Whittaker S, Miyakawa I, Agus DB, Koeffler HP (2005) 2C4, a monoclonal antibody against HER2, disrupts the HER kinase signaling pathway and inhibits ovarian carcinoma cell growth. Cancer 104: 2701-2708
-
(2005)
Cancer
, vol.104
, pp. 2701-2708
-
-
Takai, N.1
Jain, A.2
Kawamata, N.3
Popoviciu, L.M.4
Said, J.W.5
Whittaker, S.6
Miyakawa, I.7
Agus, D.B.8
Koeffler, H.P.9
-
31
-
-
37549011436
-
Elements related to heterogeneity of antibody-dependent cell cytotoxicity in patients under trastuzumab therapy for primary operable breast cancer overexpressing Her2
-
Varchetta S, Gibelli N, Oliviero B, Nardini E, Gennari R, Gatti G, Silva LS, Villani L, Tagliabue E, Menard S, Costa A, Fagnoni FF (2007) Elements related to heterogeneity of antibody-dependent cell cytotoxicity in patients under trastuzumab therapy for primary operable breast cancer overexpressing Her2. Cancer Res 67: 11991-11999
-
(2007)
Cancer Res
, vol.67
, pp. 11991-11999
-
-
Varchetta, S.1
Gibelli, N.2
Oliviero, B.3
Nardini, E.4
Gennari, R.5
Gatti, G.6
Silva, L.S.7
Villani, L.8
Tagliabue, E.9
Menard, S.10
Costa, A.11
Fagnoni, F.F.12
-
32
-
-
33749144509
-
HER-2/Neu overexpression in uterine papillary serous cancers and its possible therapeutic implications
-
Villella JA, Cohen S, Smith DH, Hibshoosh H, Hershman D (2006) HER-2/Neu overexpression in uterine papillary serous cancers and its possible therapeutic implications. Int J Gynecol Cancer 16: 1897-1902
-
(2006)
Int J Gynecol Cancer
, vol.16
, pp. 1897-1902
-
-
Villella, J.A.1
Cohen, S.2
Smith, D.H.3
Hibshoosh, H.4
Hershman, D.5
-
33
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
Vogel CL, Cobleigh MA, Tripathy D, Gutheil JC, Harris LN, Fehrenbacher L, Slamon DJ, Murphy M, Novotny WF, Burchmore M, Shak S, Stewart SJ (2002) Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 20: 719-726
-
(2002)
J Clin Oncol
, vol.20
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
Gutheil, J.C.4
Harris, L.N.5
Fehrenbacher, L.6
Slamon, D.J.7
Murphy, M.8
Novotny, W.F.9
Burchmore, M.10
Shak, S.11
Stewart, S.J.12
|