메뉴 건너뛰기




Volumn 5, Issue JUN, 2015, Pages

Pathology, molecular genetics, and epigenetics of diffuse intrinsic pontine glioma

Author keywords

ACVR1; DIPG; Glioblastoma; Glioma; H3F3A; Histone; K27M; Pediatric

Indexed keywords


EID: 84934291386     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2015.00147     Document Type: Review
Times cited : (95)

References (85)
  • 2
    • 84919480160 scopus 로고    scopus 로고
    • Histopathological spectrum of paediatric diffuse intrinsic pontine glioma: diagnostic and therapeutic implications
    • Buczkowicz P, Bartels U, Bouffet E, Becher O, Hawkins C. Histopathological spectrum of paediatric diffuse intrinsic pontine glioma: diagnostic and therapeutic implications. Acta Neuropathol (2014) 128(4):573-81. doi:10.1007/s00401-014-1319-6.
    • (2014) Acta Neuropathol , vol.128 , Issue.4 , pp. 573-581
    • Buczkowicz, P.1    Bartels, U.2    Bouffet, E.3    Becher, O.4    Hawkins, C.5
  • 3
    • 84865863019 scopus 로고    scopus 로고
    • K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
    • Khuong-Quang DA, Buczkowicz P, Rakopoulos P, Liu XY, Fontebasso AM, Bouffet E, et al. K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathol (2012) 124(3):439-47. doi:10.1007/s00401-012-0998-0.
    • (2012) Acta Neuropathol , vol.124 , Issue.3 , pp. 439-447
    • Khuong-Quang, D.A.1    Buczkowicz, P.2    Rakopoulos, P.3    Liu, X.Y.4    Fontebasso, A.M.5    Bouffet, E.6
  • 4
    • 84906934474 scopus 로고    scopus 로고
    • Diffuse intrinsic pontine glioma: a reassessment
    • Robison NJ, Kieran MW. Diffuse intrinsic pontine glioma: a reassessment. J Neurooncol (2014) 119(1):7-15. doi:10.1007/s11060-014-1448-8.
    • (2014) J Neurooncol , vol.119 , Issue.1 , pp. 7-15
    • Robison, N.J.1    Kieran, M.W.2
  • 5
    • 84888016199 scopus 로고    scopus 로고
    • Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy - results of a United Kingdom phase II trial (CNS 2007 04)
    • Bailey S, Howman A, Wheatley K, Wherton D, Boota N, Pizer B, et al. Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy - results of a United Kingdom phase II trial (CNS 2007 04). Eur J Cancer (2013) 49(18):3856-62. doi:10.1016/j.ejca.2013.08.006.
    • (2013) Eur J Cancer , vol.49 , Issue.18 , pp. 3856-3862
    • Bailey, S.1    Howman, A.2    Wheatley, K.3    Wherton, D.4    Boota, N.5    Pizer, B.6
  • 6
    • 84930980137 scopus 로고    scopus 로고
    • Phase 2 study of safety and efficacy of nimotuzumab in pediatric patients with progressive diffuse intrinsic pontine glioma
    • Bartels U, Wolff J, Gore L, Dunkel I, Gilheeney S, Allen J, et al. Phase 2 study of safety and efficacy of nimotuzumab in pediatric patients with progressive diffuse intrinsic pontine glioma. Neuro Oncol (2014) 16(11):1554-9. doi:10.1093/neuonc/nou091.
    • (2014) Neuro Oncol , vol.16 , Issue.11 , pp. 1554-1559
    • Bartels, U.1    Wolff, J.2    Gore, L.3    Dunkel, I.4    Gilheeney, S.5    Allen, J.6
  • 7
    • 84878991908 scopus 로고    scopus 로고
    • Phase I trial, pharmacokinetics, and pharmacodynamics of vandetanib and dasatinib in children with newly diagnosed diffuse intrinsic pontine glioma
    • Broniscer A, Baker SD, Wetmore C, Pai Panandiker AS, Huang J, Davidoff AM, et al. Phase I trial, pharmacokinetics, and pharmacodynamics of vandetanib and dasatinib in children with newly diagnosed diffuse intrinsic pontine glioma. Clin Cancer Res (2013) 19(11):3050-8. doi:10.1158/1078-0432.CCR-13-0306.
    • (2013) Clin Cancer Res , vol.19 , Issue.11 , pp. 3050-3058
    • Broniscer, A.1    Baker, S.D.2    Wetmore, C.3    Pai Panandiker, A.S.4    Huang, J.5    Davidoff, A.M.6
  • 8
    • 84878269566 scopus 로고    scopus 로고
    • A phase I trial of arsenic trioxide chemoradiotherapy for infiltrating astrocytomas of childhood
    • Cohen KJ, Gibbs IC, Fisher PG, Hayashi RJ, Macy ME, Gore L. A phase I trial of arsenic trioxide chemoradiotherapy for infiltrating astrocytomas of childhood. Neuro Oncol (2013) 15(6):783-7. doi:10.1093/neuonc/not021.
    • (2013) Neuro Oncol , vol.15 , Issue.6 , pp. 783-787
    • Cohen, K.J.1    Gibbs, I.C.2    Fisher, P.G.3    Hayashi, R.J.4    Macy, M.E.5    Gore, L.6
  • 9
    • 84855913314 scopus 로고    scopus 로고
    • Diffuse intrinsic pontine gliomas: a systematic update on clinical trials and biology
    • Jansen MH, van Vuurden DG, Vandertop WP, Kaspers GJ. Diffuse intrinsic pontine gliomas: a systematic update on clinical trials and biology. Cancer Treat Rev (2012) 38(1):27-35. doi:10.1016/j.ctrv.2011.06.007.
    • (2012) Cancer Treat Rev , vol.38 , Issue.1 , pp. 27-35
    • Jansen, M.H.1    van Vuurden, D.G.2    Vandertop, W.P.3    Kaspers, G.J.4
  • 10
    • 84872184811 scopus 로고    scopus 로고
    • Hypofractionation vs conventional radiation therapy for newly diagnosed diffuse intrinsic pontine glioma: a matched-cohort analysis
    • Janssens GO, Jansen MH, Lauwers SJ, Nowak PJ, Oldenburger FR, Bouffet E, et al. Hypofractionation vs conventional radiation therapy for newly diagnosed diffuse intrinsic pontine glioma: a matched-cohort analysis. Int J Radiat Oncol Biol Phys (2013) 85(2):315-20. doi:10.1016/j.ijrobp.2012.04.006.
    • (2013) Int J Radiat Oncol Biol Phys , vol.85 , Issue.2 , pp. 315-320
    • Janssens, G.O.1    Jansen, M.H.2    Lauwers, S.J.3    Nowak, P.J.4    Oldenburger, F.R.5    Bouffet, E.6
  • 11
    • 84897012467 scopus 로고    scopus 로고
    • Craniospinal irradiation with concurrent temozolomide for primary metastatic pediatric high-grade or diffuse intrinsic pontine gliomas. A first report from the GPOH-HIT-HGG Study Group
    • Muller K, Schlamann A, Guckenberger M, Warmuth-Metz M, Gluck A, Pietschmann S, et al. Craniospinal irradiation with concurrent temozolomide for primary metastatic pediatric high-grade or diffuse intrinsic pontine gliomas. A first report from the GPOH-HIT-HGG Study Group. Strahlenther Onkol (2014) 190(4):377-81. doi:10.1007/s00066-013-0513-0.
    • (2014) Strahlenther Onkol , vol.190 , Issue.4 , pp. 377-381
    • Muller, K.1    Schlamann, A.2    Guckenberger, M.3    Warmuth-Metz, M.4    Gluck, A.5    Pietschmann, S.6
  • 12
    • 84887120094 scopus 로고    scopus 로고
    • Phase I study of bevacizumab plus irinotecan in pediatric patients with recurrent/refractory solid tumors
    • Okada K, Yamasaki K, Tanaka C, Fujisaki H, Osugi Y, Hara J. Phase I study of bevacizumab plus irinotecan in pediatric patients with recurrent/refractory solid tumors. Jpn J Clin Oncol (2013) 43(11):1073-9. doi:10.1093/jjco/hyt124.
    • (2013) Jpn J Clin Oncol , vol.43 , Issue.11 , pp. 1073-1079
    • Okada, K.1    Yamasaki, K.2    Tanaka, C.3    Fujisaki, H.4    Osugi, Y.5    Hara, J.6
  • 13
    • 84904440506 scopus 로고    scopus 로고
    • Radiation therapy and concurrent topotecan followed by maintenance triple anti-angiogenic therapy with thalidomide, etoposide, and celecoxib for pediatric diffuse intrinsic pontine glioma
    • Porkholm M, Valanne L, Lonnqvist T, Holm S, Lannering B, Riikonen P, et al. Radiation therapy and concurrent topotecan followed by maintenance triple anti-angiogenic therapy with thalidomide, etoposide, and celecoxib for pediatric diffuse intrinsic pontine glioma. Pediatr Blood Cancer (2014) 61(9):1603-9. doi:10.1002/pbc.25045.
    • (2014) Pediatr Blood Cancer , vol.61 , Issue.9 , pp. 1603-1609
    • Porkholm, M.1    Valanne, L.2    Lonnqvist, T.3    Holm, S.4    Lannering, B.5    Riikonen, P.6
  • 14
    • 84923501738 scopus 로고    scopus 로고
    • Temozolomide in the treatment of newly diagnosed diffuse brainstem glioma in children: a broken promise?
    • Rizzo D, Scalzone M, Ruggiero A, Maurizi P, Attina G, Mastrangelo S, et al. Temozolomide in the treatment of newly diagnosed diffuse brainstem glioma in children: a broken promise? J Chemother (2015) 27(2):106-10. doi:10.1179/1973947814Y.0000000228.
    • (2015) J Chemother , vol.27 , Issue.2 , pp. 106-110
    • Rizzo, D.1    Scalzone, M.2    Ruggiero, A.3    Maurizi, P.4    Attina, G.5    Mastrangelo, S.6
  • 15
    • 0032999663 scopus 로고    scopus 로고
    • Randomized trials on radioactive iodine ablation of thyroid remnants for thyroid carcinoma - a critique
    • Roos DE, Smith JG. Randomized trials on radioactive iodine ablation of thyroid remnants for thyroid carcinoma - a critique. Int J Radiat Oncol Biol Phys (1999) 44(3):493-5. doi:10.1016/S0360-3016(98)00553-7.
    • (1999) Int J Radiat Oncol Biol Phys , vol.44 , Issue.3 , pp. 493-495
    • Roos, D.E.1    Smith, J.G.2
  • 17
    • 84902156586 scopus 로고    scopus 로고
    • Hypofractionated conformal radiotherapy for pediatric diffuse intrinsic pontine glioma (DIPG): a randomized controlled trial
    • Zaghloul MS, Eldebawy E, Ahmed S, Mousa AG, Amin A, Refaat A, et al. Hypofractionated conformal radiotherapy for pediatric diffuse intrinsic pontine glioma (DIPG): a randomized controlled trial. Radiother Oncol (2014) 111(1):35-40. doi:10.1016/j.radonc.2014.01.013.
    • (2014) Radiother Oncol , vol.111 , Issue.1 , pp. 35-40
    • Zaghloul, M.S.1    Eldebawy, E.2    Ahmed, S.3    Mousa, A.G.4    Amin, A.5    Refaat, A.6
  • 18
    • 84884508614 scopus 로고    scopus 로고
    • Treatment of children with diffuse intrinsic pontine gliomas with chemoradiotherapy followed by a combination of temozolomide, irinotecan, and bevacizumab
    • Zaky W, Wellner M, Brown RJ, Bluml S, Finlay JL, Dhall G. Treatment of children with diffuse intrinsic pontine gliomas with chemoradiotherapy followed by a combination of temozolomide, irinotecan, and bevacizumab. Pediatr Hematol Oncol (2013) 30(7):623-32. doi:10.3109/08880018.2013.829895.
    • (2013) Pediatr Hematol Oncol , vol.30 , Issue.7 , pp. 623-632
    • Zaky, W.1    Wellner, M.2    Brown, R.J.3    Bluml, S.4    Finlay, J.L.5    Dhall, G.6
  • 19
    • 0032694190 scopus 로고    scopus 로고
    • Chemotherapy for brain stem gliomas
    • Freeman CR, Perilongo G. Chemotherapy for brain stem gliomas. Childs Nerv Syst (1999) 15(10):545-53. doi:10.1007/s003810050542.
    • (1999) Childs Nerv Syst , vol.15 , Issue.10 , pp. 545-553
    • Freeman, C.R.1    Perilongo, G.2
  • 21
    • 33644850759 scopus 로고    scopus 로고
    • Advances toward an understanding of brainstem gliomas
    • Donaldson SS, Laningham F, Fisher PG. Advances toward an understanding of brainstem gliomas. J Clin Oncol (2006) 24(8):1266-72. doi:10.1200/JCO.2005.04.6599.
    • (2006) J Clin Oncol , vol.24 , Issue.8 , pp. 1266-1272
    • Donaldson, S.S.1    Laningham, F.2    Fisher, P.G.3
  • 22
    • 0021021848 scopus 로고
    • Brain stem gliomas of children. A clinicopathological study
    • Albright AL, Price RA, Guthkelch AN. Brain stem gliomas of children. A clinicopathological study. Cancer (1983) 52(12):2313-9. doi:10.1002/1097-0142(19831215)52:12<2313::AID-CNCR2820521226>3.0.CO;2-I.
    • (1983) Cancer , vol.52 , Issue.12 , pp. 2313-2319
    • Albright, A.L.1    Price, R.A.2    Guthkelch, A.N.3
  • 23
    • 0027519434 scopus 로고
    • Magnetic resonance scans should replace biopsies for the diagnosis of diffuse brain stem gliomas: a report from the children's cancer group
    • Albright AL, Packer RJ, Zimmerman R, Rorke LB, Boyett J, Hammond GD. Magnetic resonance scans should replace biopsies for the diagnosis of diffuse brain stem gliomas: a report from the children's cancer group. Neurosurgery (1993) 33(6):1026-9. doi:10.1227/00006123-199312000-00010.
    • (1993) Neurosurgery , vol.33 , Issue.6 , pp. 1026-1029
    • Albright, A.L.1    Packer, R.J.2    Zimmerman, R.3    Rorke, L.B.4    Boyett, J.5    Hammond, G.D.6
  • 24
    • 84862777348 scopus 로고    scopus 로고
    • Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
    • Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K, et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature (2012) 482(7384):226-31. doi:10.1038/nature10833.
    • (2012) Nature , vol.482 , Issue.7384 , pp. 226-231
    • Schwartzentruber, J.1    Korshunov, A.2    Liu, X.Y.3    Jones, D.T.4    Pfaff, E.5    Jacob, K.6
  • 25
    • 84862777410 scopus 로고    scopus 로고
    • Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
    • Wu G, Broniscer A, McEachron TA, Lu C, Paugh BS, Becksfort J, et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet (2012) 44(3):251-3. doi:10.1038/ng.1102.
    • (2012) Nat Genet , vol.44 , Issue.3 , pp. 251-253
    • Wu, G.1    Broniscer, A.2    McEachron, T.A.3    Lu, C.4    Paugh, B.S.5    Becksfort, J.6
  • 26
    • 84880765927 scopus 로고    scopus 로고
    • Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children
    • Cage TA, Samagh SP, Mueller S, Nicolaides T, Haas-Kogan D, Prados M, et al. Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children. Childs Nerv Syst (2013) 29(8):1313-9. doi:10.1007/s00381-013-2101-0.
    • (2013) Childs Nerv Syst , vol.29 , Issue.8 , pp. 1313-1319
    • Cage, T.A.1    Samagh, S.P.2    Mueller, S.3    Nicolaides, T.4    Haas-Kogan, D.5    Prados, M.6
  • 27
    • 84859374349 scopus 로고    scopus 로고
    • Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine glioma
    • Grill J, Puget S, Andreiuolo F, Philippe C, MacConaill L, Kieran MW. Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine glioma. Pediatr Blood Cancer (2012) 58(4):489-91. doi:10.1002/pbc.24060.
    • (2012) Pediatr Blood Cancer , vol.58 , Issue.4 , pp. 489-491
    • Grill, J.1    Puget, S.2    Andreiuolo, F.3    Philippe, C.4    MacConaill, L.5    Kieran, M.W.6
  • 28
    • 84922784152 scopus 로고    scopus 로고
    • Time to rethink the unthinkable: upfront biopsy of children with newly diagnosed diffuse intrinsic pontine glioma (DIPG)
    • Kieran MW. Time to rethink the unthinkable: upfront biopsy of children with newly diagnosed diffuse intrinsic pontine glioma (DIPG). Pediatr Blood Cancer (2015) 62(1):3-4. doi:10.1002/pbc.25266.
    • (2015) Pediatr Blood Cancer , vol.62 , Issue.1 , pp. 3-4
    • Kieran, M.W.1
  • 29
    • 84859400830 scopus 로고    scopus 로고
    • Diffuse intrinsic pontine glioma (DIPG): time to biopsy again?
    • MacDonald TJ. Diffuse intrinsic pontine glioma (DIPG): time to biopsy again? Pediatr Blood Cancer (2012) 58(4):487-8. doi:10.1002/pbc.24090.
    • (2012) Pediatr Blood Cancer , vol.58 , Issue.4 , pp. 487-488
    • MacDonald, T.J.1
  • 30
    • 0032745828 scopus 로고    scopus 로고
    • Genetic alterations in pediatric high-grade astrocytomas
    • Cheng Y, Ng HK, Zhang SF, Ding M, Pang JC, Zheng J, et al. Genetic alterations in pediatric high-grade astrocytomas. Hum Pathol (1999) 30(11):1284-90. doi:10.1016/S0046-8177(99)90057-6.
    • (1999) Hum Pathol , vol.30 , Issue.11 , pp. 1284-1290
    • Cheng, Y.1    Ng, H.K.2    Zhang, S.F.3    Ding, M.4    Pang, J.C.5    Zheng, J.6
  • 31
    • 0027261003 scopus 로고
    • Molecular genetics of pediatric brain stem gliomas. Application of PCR techniques to small and archival brain tumor specimens
    • Louis DN, Rubio MP, Correa KM, Gusella JF, von Deimling A. Molecular genetics of pediatric brain stem gliomas. Application of PCR techniques to small and archival brain tumor specimens. J Neuropathol Exp Neurol (1993) 52(5):507-15. doi:10.1097/00005072-199309000-00009.
    • (1993) J Neuropathol Exp Neurol , vol.52 , Issue.5 , pp. 507-515
    • Louis, D.N.1    Rubio, M.P.2    Correa, K.M.3    Gusella, J.F.4    von Deimling, A.5
  • 32
    • 0031032368 scopus 로고    scopus 로고
    • The relationship between TP53 mutations and overexpression of p53 and prognosis in malignant gliomas of childhood
    • Pollack IF, Hamilton RL, Finkelstein SD, Campbell JW, Martinez AJ, Sherwin RN, et al. The relationship between TP53 mutations and overexpression of p53 and prognosis in malignant gliomas of childhood. Cancer Res (1997) 57(2):304-9.
    • (1997) Cancer Res , vol.57 , Issue.2 , pp. 304-309
    • Pollack, I.F.1    Hamilton, R.L.2    Finkelstein, S.D.3    Campbell, J.W.4    Martinez, A.J.5    Sherwin, R.N.6
  • 33
    • 1842409553 scopus 로고    scopus 로고
    • Determination of p53 mutations, EGFR overexpression, and loss of p16 expression in pediatric glioblastomas
    • Sure U, Ruedi D, Tachibana O, Yonekawa Y, Ohgaki H, Kleihues P, et al. Determination of p53 mutations, EGFR overexpression, and loss of p16 expression in pediatric glioblastomas. J Neuropathol Exp Neurol (1997) 56(7):782-9. doi:10.1097/00005072-199707000-00004.
    • (1997) J Neuropathol Exp Neurol , vol.56 , Issue.7 , pp. 782-789
    • Sure, U.1    Ruedi, D.2    Tachibana, O.3    Yonekawa, Y.4    Ohgaki, H.5    Kleihues, P.6
  • 35
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research N. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature (2008) 455(7216):1061-8. doi:10.1038/nature07385.
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1061-1068
    • Cancer Genome Atlas Research, N.1
  • 36
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell (2010) 17(1):98-110. doi:10.1016/j.ccr.2009.12.020.
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3    Wang, V.4    Qi, Y.5    Wilkerson, M.D.6
  • 37
    • 77950487385 scopus 로고    scopus 로고
    • Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets
    • Zarghooni M, Bartels U, Lee E, Buczkowicz P, Morrison A, Huang A, et al. Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets. J Clin Oncol (2010) 28(8):1337-44. doi:10.1200/JCO.2009.25.5463.
    • (2010) J Clin Oncol , vol.28 , Issue.8 , pp. 1337-1344
    • Zarghooni, M.1    Bartels, U.2    Lee, E.3    Buczkowicz, P.4    Morrison, A.5    Huang, A.6
  • 38
    • 80054771090 scopus 로고    scopus 로고
    • Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma
    • Paugh BS, Broniscer A, Qu C, Miller CP, Zhang J, Tatevossian RG, et al. Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma. J Clin Oncol (2011) 29(30):3999-4006. doi:10.1200/JCO.2011.35.5677.
    • (2011) J Clin Oncol , vol.29 , Issue.30 , pp. 3999-4006
    • Paugh, B.S.1    Broniscer, A.2    Qu, C.3    Miller, C.P.4    Zhang, J.5    Tatevossian, R.G.6
  • 39
    • 77954596239 scopus 로고    scopus 로고
    • Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease
    • Paugh BS, Qu C, Jones C, Liu Z, Adamowicz-Brice M, Zhang J, et al. Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease. J Clin Oncol (2010) 28(18):3061-8. doi:10.1200/JCO.2009.26.7252.
    • (2010) J Clin Oncol , vol.28 , Issue.18 , pp. 3061-3068
    • Paugh, B.S.1    Qu, C.2    Jones, C.3    Liu, Z.4    Adamowicz-Brice, M.5    Zhang, J.6
  • 40
    • 84899570180 scopus 로고    scopus 로고
    • Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations
    • Buczkowicz P, Hoeman C, Rakopoulos P, Pajovic S, Letourneau L, Dzamba M, et al. Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations. Nat Genet (2014) 46(5):451-6. doi:10.1038/ng.2936.
    • (2014) Nat Genet , vol.46 , Issue.5 , pp. 451-456
    • Buczkowicz, P.1    Hoeman, C.2    Rakopoulos, P.3    Pajovic, S.4    Letourneau, L.5    Dzamba, M.6
  • 41
    • 84899559895 scopus 로고    scopus 로고
    • Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma
    • Taylor KR, Mackay A, Truffaux N, Butterfield YS, Morozova O, Philippe C, et al. Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma. Nat Genet (2014) 46(5):457-61. doi:10.1038/ng.2925.
    • (2014) Nat Genet , vol.46 , Issue.5 , pp. 457-461
    • Taylor, K.R.1    Mackay, A.2    Truffaux, N.3    Butterfield, Y.S.4    Morozova, O.5    Philippe, C.6
  • 42
    • 84899526966 scopus 로고    scopus 로고
    • The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
    • Wu G, Diaz AK, Paugh BS, Rankin SL, Ju B, Li Y, et al. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet (2014) 46(5):444-50. doi:10.1038/ng.2938.
    • (2014) Nat Genet , vol.46 , Issue.5 , pp. 444-450
    • Wu, G.1    Diaz, A.K.2    Paugh, B.S.3    Rankin, S.L.4    Ju, B.5    Li, Y.6
  • 44
    • 80053436907 scopus 로고    scopus 로고
    • The human histone H3 complement anno 2011
    • Ederveen TH, Mandemaker IK, Logie C. The human histone H3 complement anno 2011. Biochim Biophys Acta (2011) 1809(10):577-86. doi:10.1016/j.bbagrm.2011.07.002.
    • (2011) Biochim Biophys Acta , vol.1809 , Issue.10 , pp. 577-586
    • Ederveen, T.H.1    Mandemaker, I.K.2    Logie, C.3
  • 45
    • 48049097565 scopus 로고    scopus 로고
    • Tyrosine kinase expression in pediatric high grade astrocytoma
    • Liang ML, Ma J, Ho M, Solomon L, Bouffet E, Rutka JT, et al. Tyrosine kinase expression in pediatric high grade astrocytoma. J Neurooncol (2008) 87(3):247-53. doi:10.1007/s11060-007-9513-1.
    • (2008) J Neurooncol , vol.87 , Issue.3 , pp. 247-253
    • Liang, M.L.1    Ma, J.2    Ho, M.3    Solomon, L.4    Bouffet, E.5    Rutka, J.T.6
  • 46
    • 84903627855 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas
    • Zhang L, Chen LH, Wan H, Yang R, Wang Z, Feng J, et al. Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas. Nat Genet (2014) 46(7):726-30. doi:10.1038/ng.2995.
    • (2014) Nat Genet , vol.46 , Issue.7 , pp. 726-730
    • Zhang, L.1    Chen, L.H.2    Wan, H.3    Yang, R.4    Wang, Z.5    Feng, J.6
  • 47
    • 84886028950 scopus 로고    scopus 로고
    • Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas
    • Paugh BS, Zhu X, Qu C, Endersby R, Diaz AK, Zhang J, et al. Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas. Cancer Res (2013) 73(20):6219-29. doi:10.1158/0008-5472.CAN-13-1491.
    • (2013) Cancer Res , vol.73 , Issue.20 , pp. 6219-6229
    • Paugh, B.S.1    Zhu, X.2    Qu, C.3    Endersby, R.4    Diaz, A.K.5    Zhang, J.6
  • 48
    • 84857527038 scopus 로고    scopus 로고
    • Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas
    • Puget S, Philippe C, Bax DA, Job B, Varlet P, Junier MP, et al. Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas. PLoS One (2012) 7(2):e30313. doi:10.1371/journal.pone.0030313.
    • (2012) PLoS One , vol.7 , Issue.2
    • Puget, S.1    Philippe, C.2    Bax, D.A.3    Job, B.4    Varlet, P.5    Junier, M.P.6
  • 50
    • 84891546869 scopus 로고    scopus 로고
    • H3F3A K27M mutations in thalamic gliomas from young adult patients
    • Aihara K, Mukasa A, Gotoh K, Saito K, Nagae G, Tsuji S, et al. H3F3A K27M mutations in thalamic gliomas from young adult patients. Neuro Oncol (2014) 16(1):140-6. doi:10.1093/neuonc/not144.
    • (2014) Neuro Oncol , vol.16 , Issue.1 , pp. 140-146
    • Aihara, K.1    Mukasa, A.2    Gotoh, K.3    Saito, K.4    Nagae, G.5    Tsuji, S.6
  • 51
    • 33646070846 scopus 로고    scopus 로고
    • A bivalent chromatin structure marks key developmental genes in embryonic stem cells
    • Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 125(2):315-26. doi:10.1016/j.cell.2006.02.041.
    • (2006) Cell , vol.125 , Issue.2 , pp. 315-326
    • Bernstein, B.E.1    Mikkelsen, T.S.2    Xie, X.3    Kamal, M.4    Huebert, D.J.5    Cuff, J.6
  • 52
    • 49649125042 scopus 로고    scopus 로고
    • Genome-scale DNA methylation maps of pluripotent and differentiated cells
    • Meissner A, Mikkelsen TS, Gu H, Wernig M, Hanna J, Sivachenko A, et al. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 454(7205):766-70. doi:10.1038/nature07107.
    • (2008) Nature , vol.454 , Issue.7205 , pp. 766-770
    • Meissner, A.1    Mikkelsen, T.S.2    Gu, H.3    Wernig, M.4    Hanna, J.5    Sivachenko, A.6
  • 53
    • 84856431427 scopus 로고    scopus 로고
    • NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression
    • Reynolds N, Salmon-Divon M, Dvinge H, Hynes-Allen A, Balasooriya G, Leaford D, et al. NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression. EMBO J (2012) 31(3):593-605. doi:10.1038/emboj.2011.431.
    • (2012) EMBO J , vol.31 , Issue.3 , pp. 593-605
    • Reynolds, N.1    Salmon-Divon, M.2    Dvinge, H.3    Hynes-Allen, A.4    Balasooriya, G.5    Leaford, D.6
  • 54
    • 84894573670 scopus 로고    scopus 로고
    • Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge
    • Sturm D, Bender S, Jones DT, Lichter P, Grill J, Becher O, et al. Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge. Nat Rev Cancer (2014) 14(2):92-107. doi:10.1038/nrc3655.
    • (2014) Nat Rev Cancer , vol.14 , Issue.2 , pp. 92-107
    • Sturm, D.1    Bender, S.2    Jones, D.T.3    Lichter, P.4    Grill, J.5    Becher, O.6
  • 55
    • 84887617868 scopus 로고    scopus 로고
    • Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas
    • Bender S, Tang Y, Lindroth AM, Hovestadt V, Jones DT, Kool M, et al. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell (2013) 24(5):660-72. doi:10.1016/j.ccr.2013.10.006.
    • (2013) Cancer Cell , vol.24 , Issue.5 , pp. 660-672
    • Bender, S.1    Tang, Y.2    Lindroth, A.M.3    Hovestadt, V.4    Jones, D.T.5    Kool, M.6
  • 56
    • 84877299145 scopus 로고    scopus 로고
    • The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
    • Chan KM, Fang D, Gan H, Hashizume R, Yu C, Schroeder M, et al. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev (2013) 27(9):985-90. doi:10.1101/gad.217778.113.
    • (2013) Genes Dev , vol.27 , Issue.9 , pp. 985-990
    • Chan, K.M.1    Fang, D.2    Gan, H.3    Hashizume, R.4    Yu, C.5    Schroeder, M.6
  • 57
    • 84882273357 scopus 로고    scopus 로고
    • Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas
    • Venneti S, Garimella MT, Sullivan LM, Martinez D, Huse JT, Heguy A, et al. Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas. Brain Pathol (2013) 23(5):558-64. doi:10.1111/bpa.12042.
    • (2013) Brain Pathol , vol.23 , Issue.5 , pp. 558-564
    • Venneti, S.1    Garimella, M.T.2    Sullivan, L.M.3    Martinez, D.4    Huse, J.T.5    Heguy, A.6
  • 58
    • 84919928729 scopus 로고    scopus 로고
    • A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas
    • Venneti S, Santi M, Felicella MM, Yarilin D, Phillips JJ, Sullivan LM, et al. A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas. Acta Neuropathol (2014) 128(5):743-53. doi:10.1007/s00401-014-1338-3.
    • (2014) Acta Neuropathol , vol.128 , Issue.5 , pp. 743-753
    • Venneti, S.1    Santi, M.2    Felicella, M.M.3    Yarilin, D.4    Phillips, J.J.5    Sullivan, L.M.6
  • 59
    • 84877785024 scopus 로고    scopus 로고
    • Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma
    • Lewis PW, Muller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, et al. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science (2013) 340(6134):857-61. doi:10.1126/science.1232245.
    • (2013) Science , vol.340 , Issue.6134 , pp. 857-861
    • Lewis, P.W.1    Muller, M.M.2    Koletsky, M.S.3    Cordero, F.4    Lin, S.5    Banaszynski, L.A.6
  • 60
    • 84892631703 scopus 로고    scopus 로고
    • PPM1D mutations in circulating white blood cells and the risk for ovarian cancer
    • Akbari MR, Lepage P, Rosen B, McLaughlin J, Risch H, Minden M, et al. PPM1D mutations in circulating white blood cells and the risk for ovarian cancer. J Natl Cancer Inst (2014) 106(1):djt323. doi:10.1093/jnci/djt323.
    • (2014) J Natl Cancer Inst , vol.106 , Issue.1
    • Akbari, M.R.1    Lepage, P.2    Rosen, B.3    McLaughlin, J.4    Risch, H.5    Minden, M.6
  • 62
    • 84925303588 scopus 로고    scopus 로고
    • Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients
    • Zajkowicz A, Butkiewicz D, Drosik A, Giglok M, Suwinski R, Rusin M. Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients. Br J Cancer (2015) 112:1114-20. doi:10.1038/bjc.2015.79.
    • (2015) Br J Cancer , vol.112 , pp. 1114-1120
    • Zajkowicz, A.1    Butkiewicz, D.2    Drosik, A.3    Giglok, M.4    Suwinski, R.5    Rusin, M.6
  • 63
    • 84878548536 scopus 로고    scopus 로고
    • Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint
    • Kleiblova P, Shaltiel IA, Benada J, Sevcik J, Pechackova S, Pohlreich P, et al. Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint. J Cell Biol (2013) 201(4):511-21. doi:10.1083/jcb.201210031.
    • (2013) J Cell Biol , vol.201 , Issue.4 , pp. 511-521
    • Kleiblova, P.1    Shaltiel, I.A.2    Benada, J.3    Sevcik, J.4    Pechackova, S.5    Pohlreich, P.6
  • 64
    • 61649084689 scopus 로고    scopus 로고
    • Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1
    • Kaplan FS, Xu M, Seemann P, Connor JM, Glaser DL, Carroll L, et al. Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1. Hum Mutat (2009) 30(3):379-90. doi:10.1002/humu.20868.
    • (2009) Hum Mutat , vol.30 , Issue.3 , pp. 379-390
    • Kaplan, F.S.1    Xu, M.2    Seemann, P.3    Connor, J.M.4    Glaser, D.L.5    Carroll, L.6
  • 65
    • 63749106137 scopus 로고    scopus 로고
    • Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients
    • Petrie KA, Lee WH, Bullock AN, Pointon JJ, Smith R, Russell RG, et al. Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients. PLoS One (2009) 4(3):e5005. doi:10.1371/journal.pone.0005005.
    • (2009) PLoS One , vol.4 , Issue.3
    • Petrie, K.A.1    Lee, W.H.2    Bullock, A.N.3    Pointon, J.J.4    Smith, R.5    Russell, R.G.6
  • 66
    • 77954588190 scopus 로고    scopus 로고
    • Molecular consequences of the ACVR1(R206H) mutation of fibrodysplasia ossificans progressiva
    • Song GA, Kim HJ, Woo KM, Baek JH, Kim GS, Choi JY, et al. Molecular consequences of the ACVR1(R206H) mutation of fibrodysplasia ossificans progressiva. J Biol Chem (2010) 285(29):22542-53. doi:10.1074/jbc.M109.094557.
    • (2010) J Biol Chem , vol.285 , Issue.29 , pp. 22542-22553
    • Song, G.A.1    Kim, H.J.2    Woo, K.M.3    Baek, J.H.4    Kim, G.S.5    Choi, J.Y.6
  • 67
    • 0032601166 scopus 로고    scopus 로고
    • Primary and secondary glioblastomas: from concept to clinical diagnosis
    • Kleihues P, Ohgaki H. Primary and secondary glioblastomas: from concept to clinical diagnosis. Neuro Oncol (1999) 1(1):44-51. doi:10.1215/15228517-1-1-44.
    • (1999) Neuro Oncol , vol.1 , Issue.1 , pp. 44-51
    • Kleihues, P.1    Ohgaki, H.2
  • 68
    • 29644444900 scopus 로고    scopus 로고
    • Pediatric high-grade glioma: molecular genetic clues for innovative therapeutic approaches
    • Rood BR, MacDonald TJ. Pediatric high-grade glioma: molecular genetic clues for innovative therapeutic approaches. J Neurooncol (2005) 75(3):267-72. doi:10.1007/s11060-005-6749-5.
    • (2005) J Neurooncol , vol.75 , Issue.3 , pp. 267-272
    • Rood, B.R.1    MacDonald, T.J.2
  • 69
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • Hegi ME, Diserens AC, Gorlia T, Hamou MF, de Tribolet N, Weller M, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med (2005) 352(10):997-1003. doi:10.1056/NEJMoa043331.
    • (2005) N Engl J Med , vol.352 , Issue.10 , pp. 997-1003
    • Hegi, M.E.1    Diserens, A.C.2    Gorlia, T.3    Hamou, M.F.4    de Tribolet, N.5    Weller, M.6
  • 70
    • 84907549680 scopus 로고    scopus 로고
    • ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents
    • Agnihotri S, Burrell K, Buczkowicz P, Remke M, Golbourn B, Chornenkyy Y, et al. ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents. Cancer Discov (2014) 4(10):1198-213. doi:10.1158/2159-8290.CD-14-0157.
    • (2014) Cancer Discov , vol.4 , Issue.10 , pp. 1198-1213
    • Agnihotri, S.1    Burrell, K.2    Buczkowicz, P.3    Remke, M.4    Golbourn, B.5    Chornenkyy, Y.6
  • 72
    • 84871020024 scopus 로고    scopus 로고
    • Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations
    • Liu XY, Gerges N, Korshunov A, Sabha N, Khuong-Quang DA, Fontebasso AM, et al. Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations. Acta Neuropathol (2012) 124(5):615-25. doi:10.1007/s00401-012-1031-3.
    • (2012) Acta Neuropathol , vol.124 , Issue.5 , pp. 615-625
    • Liu, X.Y.1    Gerges, N.2    Korshunov, A.3    Sabha, N.4    Khuong-Quang, D.A.5    Fontebasso, A.M.6
  • 73
    • 84867606428 scopus 로고    scopus 로고
    • Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
    • Sturm D, Witt H, Hovestadt V, Khuong-Quang DA, Jones DT, Konermann C, et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell (2012) 22(4):425-37. doi:10.1016/j.ccr.2012.08.024.
    • (2012) Cancer Cell , vol.22 , Issue.4 , pp. 425-437
    • Sturm, D.1    Witt, H.2    Hovestadt, V.3    Khuong-Quang, D.A.4    Jones, D.T.5    Konermann, C.6
  • 74
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature (1990) 345(6274):458-60. doi:10.1038/345458a0.
    • (1990) Nature , vol.345 , Issue.6274 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 75
    • 0025472467 scopus 로고
    • Telomeres, telomerase and senescence
    • Greider CW. Telomeres, telomerase and senescence. Bioessays (1990) 12(8):363-9. doi:10.1002/bies.950120803.
    • (1990) Bioessays , vol.12 , Issue.8 , pp. 363-369
    • Greider, C.W.1
  • 76
    • 0028564951 scopus 로고
    • Specific association of human telomerase activity with immortal cells and cancer
    • Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, et al. Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 266(5193):2011-5. doi:10.1126/science.7605428.
    • (1994) Science , vol.266 , Issue.5193 , pp. 2011-2015
    • Kim, N.W.1    Piatyszek, M.A.2    Prowse, K.R.3    Harley, C.B.4    West, M.D.5    Ho, P.L.6
  • 77
    • 0029872174 scopus 로고    scopus 로고
    • Telomerase activity in human germline and embryonic tissues and cells
    • Wright WE, Piatyszek MA, Rainey WE, Byrd W, Shay JW. Telomerase activity in human germline and embryonic tissues and cells. Dev Genet (1996) 18(2):173-9. doi:10.1002/(SICI)1520-6408(1996)18:2<173::AID-DVG10>3.0.CO;2-3.
    • (1996) Dev Genet , vol.18 , Issue.2 , pp. 173-179
    • Wright, W.E.1    Piatyszek, M.A.2    Rainey, W.E.3    Byrd, W.4    Shay, J.W.5
  • 78
    • 84939890243 scopus 로고    scopus 로고
    • Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells
    • Barszczyk M, Buczkowicz P, Castelo-Branco P, Mack SC, Ramaswamy V, Mangerel J, et al. Telomerase inhibition abolishes the tumorigenicity of pediatric ependymoma tumor-initiating cells. Acta Neuropathol (2014) 128(6):863-77. doi:10.1007/s00401-014-1327-6.
    • (2014) Acta Neuropathol , vol.128 , Issue.6 , pp. 863-877
    • Barszczyk, M.1    Buczkowicz, P.2    Castelo-Branco, P.3    Mack, S.C.4    Ramaswamy, V.5    Mangerel, J.6
  • 79
    • 84919917043 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric malignant brain tumors
    • Mangerel J, Price A, Castelo-Branco P, Brzezinski J, Buczkowicz P, Rakopoulos P, et al. Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric malignant brain tumors. Acta Neuropathol (2014) 128(6):853-62. doi:10.1007/s00401-014-1348-1.
    • (2014) Acta Neuropathol , vol.128 , Issue.6 , pp. 853-862
    • Mangerel, J.1    Price, A.2    Castelo-Branco, P.3    Brzezinski, J.4    Buczkowicz, P.5    Rakopoulos, P.6
  • 80
    • 84892621211 scopus 로고    scopus 로고
    • TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma
    • Remke M, Ramaswamy V, Peacock J, Shih DJ, Koelsche C, Northcott PA, et al. TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma. Acta Neuropathol (2013) 126(6):917-29. doi:10.1007/s00401-013-1198-2.
    • (2013) Acta Neuropathol , vol.126 , Issue.6 , pp. 917-929
    • Remke, M.1    Ramaswamy, V.2    Peacock, J.3    Shih, D.J.4    Koelsche, C.5    Northcott, P.A.6
  • 82
    • 79952194421 scopus 로고    scopus 로고
    • Prospective neuraxis MRI surveillance reveals a high risk of leptomeningeal dissemination in diffuse intrinsic pontine glioma
    • Sethi R, Allen J, Donahue B, Karajannis M, Gardner S, Wisoff J, et al. Prospective neuraxis MRI surveillance reveals a high risk of leptomeningeal dissemination in diffuse intrinsic pontine glioma. J Neurooncol (2011) 102(1):121-7. doi:10.1007/s11060-010-0301-y.
    • (2011) J Neurooncol , vol.102 , Issue.1 , pp. 121-127
    • Sethi, R.1    Allen, J.2    Donahue, B.3    Karajannis, M.4    Gardner, S.5    Wisoff, J.6
  • 83
    • 0042320363 scopus 로고    scopus 로고
    • Clinicopathological study of diffuse type brainstem gliomas: analysis of 40 autopsy cases
    • Yoshimura J, Onda K, Tanaka R, Takahashi H. Clinicopathological study of diffuse type brainstem gliomas: analysis of 40 autopsy cases. Neurol Med Chir (2003) 43(8):375-82. doi:10.2176/nmc.43.375.
    • (2003) Neurol Med Chir , vol.43 , Issue.8 , pp. 375-382
    • Yoshimura, J.1    Onda, K.2    Tanaka, R.3    Takahashi, H.4
  • 84
    • 84864569215 scopus 로고    scopus 로고
    • Diffuse intrinsic pontine tumors: a study of primitive neuroectodermal tumors versus the more common diffuse intrinsic pontine gliomas
    • Sufit A, Donson AM, Birks DK, Knipstein JA, Fenton LZ, Jedlicka P, et al. Diffuse intrinsic pontine tumors: a study of primitive neuroectodermal tumors versus the more common diffuse intrinsic pontine gliomas. J Neurosurg Pediatr (2012) 10(2):81-8. doi:10.3171/2012.3.PEDS11316.
    • (2012) J Neurosurg Pediatr , vol.10 , Issue.2 , pp. 81-88
    • Sufit, A.1    Donson, A.M.2    Birks, D.K.3    Knipstein, J.A.4    Fenton, L.Z.5    Jedlicka, P.6
  • 85
    • 84901676138 scopus 로고    scopus 로고
    • Comparative multidimensional molecular analyses of pediatric diffuse intrinsic pontine glioma reveals distinct molecular subtypes
    • Saratsis AM, Kambhampati M, Snyder K, Yadavilli S, Devaney JM, Harmon B, et al. Comparative multidimensional molecular analyses of pediatric diffuse intrinsic pontine glioma reveals distinct molecular subtypes. Acta Neuropathol (2014) 127(6):881-95. doi:10.1007/s00401-013-1218-2.
    • (2014) Acta Neuropathol , vol.127 , Issue.6 , pp. 881-895
    • Saratsis, A.M.1    Kambhampati, M.2    Snyder, K.3    Yadavilli, S.4    Devaney, J.M.5    Harmon, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.