Hypofractionated conformal radiotherapy for pediatric diffuse intrinsic pontine glioma (DIPG): A randomized controlled trial

Radiotherapy and Oncology

Volumn 111, Issue 1, 2014, Pages 35-40

  Zaghloul, Mohamed S ^a   Eldebawy, Eman ^a   Ahmed, Soha ^a   Mousa, Amr G ^a   Amin, Amr ^a   Refaat, Amal ^b   Zaky, Iman ^b   Elkhateeb, Nada ^c   Sabry, Mohamed ^c  

^a CAIRO UNIVERSITY   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c CHILDREN S CANCER HOSPITAL   (Egypt)

Author keywords

Diffuse intrinsic pontine glioma; DIPG; Hypofractionation; Overall and progression free survival

Indexed keywords

ARTICLE; CANCER RADIOTHERAPY; CANCER SURVIVAL; CHILD; CHILDHOOD CANCER; COMPUTER ASSISTED RADIOTHERAPY; CONTROLLED STUDY; DEPRESSION; DESQUAMATION; DYSPHAGIA; ERYTHEMA; EXTERNAL EAR DISEASE; FEMALE; HUMAN; HYPOFRACTIONATED CONFORMAL RADIOTHERAPY; INSOMNIA; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; NERVOUSNESS; NIGHTMARE; OVERALL SURVIVAL; PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMA; PONTINE GLIOMA; POST TREATMENT SURVIVAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; RADIATION DERMATITIS; RADIATION DOSE FRACTIONATION; RADIATION INJURY; RANDOMIZED CONTROLLED TRIAL; SOMNOLENCE; SURVIVAL RATE; SURVIVAL TIME; TREATMENT OUTCOME; ADOLESCENT; ADVERSE EFFECTS; BRAIN STEM NEOPLASMS; DISEASE FREE SURVIVAL; GLIOMA; PRESCHOOL CHILD; PROCEDURES; APPETITE DISORDER; CANCER CENTER; COMPARATIVE EFFECTIVENESS; CONE BEAM COMPUTED TOMOGRAPHY; EAR DISEASE; EGYPT; FOLLOW UP; NEURORADIOLOGIST; NUCLEAR MAGNETIC RESONANCE IMAGING; PREDICTOR VARIABLE; PROSPECTIVE STUDY;

ADOLESCENT; BRAIN STEM NEOPLASMS; CHILD; CHILD, PRESCHOOL; DISEASE-FREE SURVIVAL; DOSE FRACTIONATION; FEMALE; GLIOMA; HUMANS; MALE; RADIOTHERAPY, CONFORMAL; SURVIVAL RATE;

EID: 84902156586     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2014.01.013     Document Type: Article

References (26)

1. D. Hargrave, U. Bartels, and E. Bouffet Diffuse brainstem glioma in children: critical review of clinical trials Lancet Oncol 7 2006 241 248
2. M.H.A. Hansen, D.G. Van Vuurden, W.P. Vandertop, and G.J.L. Kaspers Diffuse intrinsic pontine glioma: a systematic update on clinical trials and biology Cancer Treat Rev 38 2012 27 35
3. B.J. Slotman, T.H. Kralendonk, and H.A. Van Alphen Hypofractionated radiationtherapy in patients with glioblastoma multiforme: results of treatment and impact of prognostic factors Int J Radiat Oncol Biol Phys 34 1994 895 898
4. G.O. Janssens, C.E. Gidding, and E. Van Lindert et al. The role of hypofractionation radiotherapy for diffuse intrinsic brainstem glioma in children: a piolet study Int J Radiat Oncol Biol Phys 73 2009 722 726
5. L. Negretti, K. Bouchireb, and C. Levy-Piedbois et al. Hypofractionated radiotherapy in the treatment of diffuse intrinsic pontine glioma in children. A single institution experience J Neuroncol 104 2011 773 777
6. R.A. Olson, M.A. Bobinski, A. Ho, and K.J. Goddard Oncologists' view of informed consent and shared decision making in pediatric radiation oncology Radiother Oncol 102 2012 210 213
7. M.S. Zaghloul, A.G. Mousa, and E. Eldebawy et al. Comparison of electronic portal imaging and cone beam computed tomography for position verification in children Clin Oncol (R Coll Radiol) 22 2010 850 861
8. J.D. Cox, J. Stetz, and T.F. Pajak Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) Int J Radiat Oncol Biol Phys 31 1995 1341 1346
9. K.Y. Liang, and S.L. Zeger Longitudinal data analysis using generalized linear models Biometrika 73 1986 13 22
10. G. Freitag Methods for assessing noninferiority with censored data Biometrical J 47 2005 88 98
11. I.A. Langmoen, T. Laudar, and I. Storm-Mathisen et al. Management of pediatric pontine gliomas Child New Syst 7 1991 13 15
12. T. Sun, W. Wan, and Z. Wu et al. Clinical outcomes and natural history of pediatric brainstem tumors: with 33 cases follow up Neurosurg Rev 36 2013 311 319
13. L.R. Mandell, R. Kadota, and C. Freeman et al. There is no role for hyperfractionated radiotherapy in the management of children with newly diagnosed diffuse intrinsic brainstem tumors: results of a Pediatric Oncology Group phase III trial comparing conventional vs. hyperfractionated radiotherapy Int J Radiat Oncol Biol Phys 43 1999 959 964
14. S.S. Donaldson, F. Laningham, and P.G. Fisher Advances toward an understanding of brainstem gliomas J Clin Oncol 24 2006 1266 1272
15. D.N. Korones Treatment of newly diagnosed diffuse brainstem glioma in children: in search of the holey grail Expert Rev Anticancer Ther 7 2007 663 674
16. G.O. Janssens, M.H. Jansen, and S.J. Lauwers et al. Hypofractionation vs conventional radiation therapy for newly diagnosed diffuse intrinsic pontine glioma: a matched-cohort analysis Int J Radiat Oncol Biol Phys 85 2013 315 320
17. R. Jalali, N. Raut, and B. Arora et al. Prospective evaluation of radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma Int J Radiat Oncol Biol Phys 77 2010 113 118
18. J.R. Sharp, E. Bouffet, and D. Stempak et al. A multi-centre Canadian pilot study of metronomic temozolomide combined with radiotherapy for newly diagnosed paediatric brainstem glioma Eur J Cancer 46 2010 3271 3279
19. K.J. Cohen, and R.L. Heideman et al. Temozolomide in the treatment of children with newly diagnosed diffuse intrinsic pontine gliomas: a report from the Children's Oncology Group Neuro Oncol 13 2011 410 416
20. E. Bouffet, M. Raquin, and F. Doz et al. Radiotherapy followed by high dose busulfan and thiotepa: a prospective assessment of high-dose chemotherapy in children with diffuse pontine gliomas Cancer 88 2000 685 692
21. S. Bailey, A. Howman, and K. Wheatley et al. Diffuse intrinsic pontine glioma treated with prolonged temozolomide and radiotherapy - results of United Kingdom phase II trial (CNS 2007 04) Eur J Cancer 49 2013 3856 3862
22. D.A. Haas-Kogan, G. Yount, and M. Haas et al. P53-dependent G1 arrest and P53-independent apoptosis influence on the radiobiologic response of glioblastoma Int J Radiat Biol Phys 36 1996 95 103
23. D.A. Haas-Kogan, S.S. Kogan, and G. Yount et al. P53 function influences the effect of fractionated radiotherapy on glioblastoma tumors Int J Radiat Biol Phys 43 1999 399 403
24. M. Zarghooni, U. Bartels, and E. Lee et al. Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets J Clin Oncol 28 2010 1337 1344
25. J. Grill, S. Puget, and F. Andreiuolo et al. Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine glioma Pediatr Blood Cancer 58 2012 489 491
26. J.F. Fowler The linear quadratic-formula and progress in fractionated radiotherapy Br J Radiol 62 1989 679 694