Triazole analog 1-(1-benzyl-5-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)-2-(4-bromophenylamino)-1-(4-chlorophenyl)ethanol induces reactive oxygen species and autophagy-dependent apoptosis in both in vitro and in vivo breast cancer models

International Journal of Biochemistry and Cell Biology

Volumn 65, Issue , 2015, Pages 275-287

  Hamidullah, ^a   Saini, Karan Singh ^a   Ajay, Arya ^b   Devender, N ^b   Bhattacharjee, Arindam ^b   Das, Sharmistha ^a   Dwivedi, Sonam ^a   Gupt, Munna Prasad ^b   Bora, Himangsu Kousik ^a,b   Mitra, Kalyan ^a,b   Tripathi, Rama Pati ^a,b   Konwar, Rituraj ^a  

^a ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Apoptosis; Autophagy; Breast cancer; ROS; Triazole

Indexed keywords

1 [1 BENZYL 5 (4 CHLOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL] 2 (4 BROMOPHENYLAMINO) 1 (4 CHLOROPHENYL)ETHANOL; 1,2,3 TRIAZOLE DERIVATIVE; 3 METHYLADENINE; ACETYLCYSTEINE; BECLIN 1; CASPASE 3; CHLOROQUINE; CYCLIN E; CYTOTOXIC AGENT; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE B; PROTEIN P21; PROTEIN P62; REACTIVE OXYGEN METABOLITE; TAMOXIFEN; UNCLASSIFIED DRUG; ALCOHOL; TRIAZOLE DERIVATIVE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; BODY WEIGHT; BREAST CANCER; CANCER INHIBITION; CELL CYCLE ARREST; CELL DEATH; CELL MEMBRANE DEPOLARIZATION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; FEMALE; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; NONHUMAN; OXIDATIVE STRESS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TUMOR REGRESSION; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; BREAST NEOPLASMS; DISEASE MODEL; DRUG EFFECTS; HEK293 CELL LINE; MAMMARY NEOPLASMS, EXPERIMENTAL; MCF 7 CELL LINE; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; TUMOR CELL LINE;

RATTUS;

ANIMALS; APOPTOSIS; AUTOPHAGY; BREAST NEOPLASMS; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; ETHANOL; FEMALE; HEK293 CELLS; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MCF-7 CELLS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TRIAZOLES;

EID: 84933522412     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2015.06.016     Document Type: Article

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