1,2,3-Triazole-containing derivatives of rupestonic acid: Click-chemical synthesis and antiviral activities against influenza viruses

European Journal of Medicinal Chemistry

Volumn 76, Issue , 2014, Pages 245-255

  He, Yao Wu ^a,b   Dong, Chang Zhi ^b,c   Zhao, Jiang Yu ^a   Ma, Lin Lin ^d   Li, Yu Huan ^d   Aisa, Haji Akber ^a  

^a XINJIANG TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY   (China)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c GUANGDONG UNIVERSITY OF TECHNOLOGY   (China)

^d INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

1,2,3 Triazole; Click chemistry; Influenza virus; Rupestonic acid

Indexed keywords

(1 BENZYL 1H 1,2,3 TRIAZOL 4 YL)METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLATE; (1 CYCLOHEXYL 1H 1,2,3 TRIAZOL 4 YL)METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYROAZULEN 5 YL)ACRYLATE; 1,2,3 TRIAZOLE DERIVATIVE; [1 (2 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLATE; [1 (2 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLATE; [1 (2 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 (3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLATE; [1 (2 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLATE; [1 (3 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLATE; [1 (3 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLATE; [1 (3 METHOXYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLATE; [1 (3 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLATE; [1 (3,4 DICHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLATE; [1 (4 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLATE; [1 (4 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLATE; [1 (4 METHOXYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLATE; [1 (4 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLATE; [1 (CYCLOHEX 2 ENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLATE; [1 (CYCLOHEX 2 ENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYROAZULEN 5 YL)ACRYLATE; ANTIVIRUS AGENT; N [1 (2 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLAMIDE; N [1 (2 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLAMIDE; N [1 (3 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLAMIDE; N [1 (3 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLAMIDE; N [1 (3 METHYLBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLAMIDE; N [1 (3,4 DICHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL)METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLAMIDE; N [1 (4 CHLOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLAMIDE; N [1 (4 FLUOROBENZYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL 2 ( 3,8 DIMETHYL 2 OXO 1,2,4,5,6,7,8,8A OCTAHYDROAZULEN 5 YL)ACRYLAMIDE; RIBAVIRIN; RUPESTONIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG; AZULENE DERIVATIVE; SESQUITERPENE; TRIAZOLE DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; INFLUENZA A (H3N2); INFLUENZA B; INFLUENZA VIRUS; INFLUENZA VIRUS A H1N1; MDCK CELL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; VIRUS CULTURE; VIRUS STRAIN; CHEMISTRY; CLASSIFICATION; CLICK CHEMISTRY; DRUG EFFECTS; ELECTROSPRAY MASS SPECTROMETRY; INFRARED SPECTROPHOTOMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORTHOMYXOVIRUS; SYNTHESIS;

ANTIVIRAL AGENTS; AZULENES; CLICK CHEMISTRY; MAGNETIC RESONANCE SPECTROSCOPY; ORTHOMYXOVIRIDAE; SESQUITERPENES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED; TRIAZOLES;

EID: 84896861606     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.02.029     Document Type: Article

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