Synthesis of novel 1,2,3-triazole substituted-N-alkyl/aryl nitrone derivatives, their anti-inflammatory and anticancer activity

European Journal of Medicinal Chemistry

Volumn 80, Issue , 2014, Pages 184-191

  Sambasiva Rao, P ^a   Kurumurthy, C ^a   Veeraswamy, B ^a   Santhosh Kumar, G ^a   Poornachandra, Y ^a   Ganesh Kumar, C ^a   Vasamsetti, Sathish Babu ^a   Kotamraju, Srigiridhar ^a   Narsaiah, B ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Anticancer activity; Antiinflammatory; Nitrone; Schiff's base; Triazole

Indexed keywords

1 PHENYL N [(1 PHENYL 1H 1,2,3 TRIAZOL 4 YL)METHYLENE]METHANAMINE OXIDE; 1 PHENYL N [[1 [4 (TRIFLUOROMETHYL)PHENYL] 1H 1,2,3 TRIAZOL 4 YL]METHYLENE]METHANAMINE OXIDE; 1,2,3 TRIAZOLE DERIVATIVE; 2 METHYL N [(1 DECYL 1H 1,2,3 TRIAZOL 4 YL)METHYLENE]PROPAN 2 AMINE OXIDE; 2 METHYL N [(1 OCTYL 1H 1,2,3 TRIAZOL 4 YL)METHYLENE]PROPAN 2 AMINE OXIDE; 2 METHYL N [(1 PHENYL 1H 1,2,3 TRIAZOL 4 YL)METHYLENE]PROPAN 2 AMINE OXIDE; 2 METHYL N [[1 (3,3,4,4,5,5,6,6,7,7,8,8,8 TRIDECAFLUOROOCTYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLENE]PROPAN 2 AMINE OXIDE; 2 METHYL N [[1 [4 (TRIFLUOROMETHYL)PHENYL] 1H 1,2,3 TRIAZOL 4 YL]METHYLENE]PROPAN 2 AMINE OXIDE; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; CASPASE 3; DOXORUBICIN; INTERLEUKIN 1BETA; N [(1 DECYL 1H 1,2,3 TRIAZOL 4 YL)METHYLENE] 1 PHENYLMETHANAMINE OXIDE; N [(1 DECYL 1H 1,2,3 TRIAZOL 4 YL)METHYLENE]ANILINE OXIDE; N [(1 OCTYL 1H 1,2,3 TRIAZOL 4 YL)METHYLENE] 1 PHENYLMETHANAMINE OXIDE; N [(1 PHENYL 1H 1,2,3 TRIAZOL 4 YL)METHYLENE]ANILINE OXIDE; N [[1 (3,3,4,4,5,5,6,6,7,7,8,8,8 TRIDECAFLUOROOCTYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLENE] 1 PHENYLMETHANAMINE OXIDE; N [[1 (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10 HEPTADECAFLUORODECYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLENE] 1 PHENYLMETHANAMINE OXIDE; N [[1 (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10 HEPTADECAFLUORODECYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLENE] 2 METHYLPROPAN 2 AMINE OXIDE; N [[1 (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10 HEPTADECAFLUORODECYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLENE]ANILINE OXIDE; N [[1 (4 CHLOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLENE]ANILINE OXIDE; N [[1 (4 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLENE] 1 PHENYLMETHANAMINE OXIDE; N [[1 (4 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLENE] 2 METHYLPROPAN 2 AMINE OXIDE; N [[1 (4 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLENE]ANILINE OXIDE; N [[1 (4 METHOXYPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLENE] 1 PHENYLMETHANAMINE OXIDE; N [[1 (4 METHOXYPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYLENE] 2 METHYLPROPAN 2 AMINE OXIDE; NITRONE DERIVATIVE; SCHIFF BASE; UNCLASSIFIED DRUG; NITROGEN OXIDE; NITRONES; TRIAZOLE DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; IN VITRO STUDY; OXIDATION; REDUCTION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; IC50; SYNTHESIS; TUMOR CELL LINE;

ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CHEMISTRY TECHNIQUES, SYNTHETIC; HUMANS; INHIBITORY CONCENTRATION 50; NITROGEN OXIDES; TRIAZOLES;

EID: 84899550870     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.04.052     Document Type: Article

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