Induction of mitochondrial dysfunction and oxidative stress in leishmania donovani by orally active clerodane diterpene

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 10, 2014, Pages 5916-5928

  Kathuria, Manoj ^a   Bhattacharjee, Arindam ^a   Sashidhara, Koneni V ^a,b   Singh, Suriya Pratap ^a   Mitra, Kalyan ^a,b  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

Author keywords

[No Author keywords available]

Indexed keywords

16 ALPHA HYDROXYCLERODA 3,13(14) DIEN 15,16 OLIDE; ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ANTILEISHMANIAL AGENT; CASPASE 3; CASPASE 7; CLERODANE DERIVATIVE; CYTOCHROME C; FAT DROPLET; GENOMIC DNA; GLUTATHIONE; MILTEFOSINE; PHOSPHATIDYLSERINE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BIOLUMINESCENCE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL DEATH; CELL SURFACE; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; DEPOLARIZATION; DNA FRAGMENTATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME RELEASE; FLOW CYTOMETRY; IC50; KINETOPLAST; LEISHMANIA DONOVANI; LIPID METABOLISM; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MULTIVESICULAR BODY; NONHUMAN; OXIDATIVE STRESS; PROMASTIGOTE; SCANNING ELECTRON MICROSCOPY; SPECTROFLUOROMETRY; TRANSMISSION ELECTRON MICROSCOPY; VISCERAL LEISHMANIASIS; CONFOCAL MICROSCOPY; DRUG EFFECTS; METABOLISM; ULTRASTRUCTURE;

ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 7; CYTOCHROMES C; DITERPENES, CLERODANE; GLUTATHIONE; LEISHMANIA DONOVANI; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIA; OXIDATIVE STRESS;

EID: 84907279954     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02459-14     Document Type: Article

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