SOCS3 drives proteasomal degradation of TBK1 and negatively regulates antiviral innate immunity

Molecular and Cellular Biology

Volumn 35, Issue 14, 2015, Pages 2400-2413

  Liu, Dong ^a   Sheng, Chunjie ^a   Gao, Shijuan ^a   Yao, Chen ^a   Li, Jiandong ^a   Jiang, Wei ^a   Chen, Huiming ^a   Wu, Jiaoxiang ^a   Pan, Changchuan ^c   Chen, Shuai ^a,b   Huang, Wenlin ^a,b,d  

^a INSTITUTE OF MICROBIOLOGY   (China)

^b SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^c SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^d Guangzhou Double Bioproduct Inc   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; INTERFERON REGULATORY FACTOR 3; PHOSPHOTRANSFERASE; PROTEASOME; SUPPRESSOR OF CYTOKINE SIGNALING 3; TANK BINDING KINASE 1; UNCLASSIFIED DRUG; IRF3 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; SOCS3 PROTEIN, HUMAN; SUPPRESSOR OF CYTOKINE SIGNALING; TBK1 PROTEIN, HUMAN;

ANTIVIRAL ACTIVITY; ARTICLE; CATALYST; CONTROLLED STUDY; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; INFLUENZA VIRUS A; INNATE IMMUNITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UBIQUITINATION; VESICULOVIRUS; VIRUS REPLICATION; VIRUS STRAIN; ANIMAL; CELL CULTURE; CELL LINE; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENETICS; HEK293 CELL LINE; IMMUNOBLOTTING; IMMUNOLOGY; INFLUENZA A VIRUS; METABOLISM; MOUSE; PHOSPHORYLATION; RNA INTERFERENCE; TUMOR CELL LINE; VESICULAR STOMATITIS INDIANA VIRUS;

INFLUENZA A VIRUS; VESICULAR STOMATITIS VIRUS;

ANIMALS; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; GENE EXPRESSION; HEK293 CELLS; HELA CELLS; HUMANS; IMMUNITY, INNATE; IMMUNOBLOTTING; INFLUENZA A VIRUS; INTERFERON REGULATORY FACTOR-3; INTERFERON-BETA; MICE; MICROSCOPY, FLUORESCENCE; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; SUPPRESSOR OF CYTOKINE SIGNALING 3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; UBIQUITINATION; VESICULAR STOMATITIS INDIANA VIRUS;

EID: 84932633445     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00090-15     Document Type: Article

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