Gene therapy for nucleus pulposus regeneration by heme oxygenase-1 plasmid DNA carried by mixed polyplex micelles with thermo-responsive heterogeneous coronas

Biomaterials

Volumn 52, Issue 1, 2015, Pages 1-13

  Feng, Ganjun ^a   Chen, Hongying ^a   Li, Junjie ^b   Huang, Qiang ^a   Gupte, Melanie J ^c   Liu, Hao ^a   Song, Yueming ^a   Ge, Zhishen ^b  

^a SICHUAN UNIVERSITY   (China)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Gene therapy; Nonviral gene carrier; Nucleus pulposus regeneration; Polyplex micelles; Thermo responsive

Indexed keywords

ACRYLIC MONOMERS; AMIDES; BIOMOLECULES; BLOCK COPOLYMERS; DISEASE CONTROL; DNA; EFFICIENCY; GENE THERAPY; GENE TRANSFER; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; PORPHYRINS; SOLS;

GENE CARRIER; HYDROPHOBIC AND HYDROPHILIC; MATRIX METALLOPROTEINASES; N- ISOPROPYLACRYLAMIDE; NON-VIRAL GENE DELIVERY; NUCLEUS PULPOSUS; POLYPLEX MICELLES; THERMO-RESPONSIVE;

MICELLES;

AGGRECAN; COLLAGEN TYPE 2; CYCLOOXYGENASE 2; GLYCOSAMINOGLYCAN; HEME OXYGENASE 1; INTERLEUKIN 1BETA; PLASMID DNA; STROMELYSIN; TRANSCRIPTION FACTOR SOX9; ACRYLIC ACID RESIN; DNA; MICELLE; POLY-N-ISOPROPYLACRYLAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSFECTION; HEATING; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; INTERVERTEBRAL DISK DEGENERATION; MALE; MICELLE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUCLEUS PULPOSUS; NUCLEUS PULPOSUS REGENERATION; PHENOTYPE; PRIORITY JOURNAL; RAT; STAB WOUND; ADMINISTRATION AND DOSAGE; ANIMAL; CELL CULTURE; CERVICAL SPINE; CHEMISTRY; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; METABOLISM; PHYSIOLOGY; PLASMID; PROCEDURES; RABBIT; REGENERATION; SPRAGUE DAWLEY RAT; TEMPERATURE; THERAPEUTIC USE;

RATTUS;

ACRYLIC RESINS; ANIMALS; CELLS, CULTURED; CERVICAL VERTEBRAE; DNA; GENE EXPRESSION REGULATION; GENETIC THERAPY; GENETIC VECTORS; HEME OXYGENASE-1; MICELLES; PLASMIDS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; REGENERATION; TEMPERATURE; TRANSFECTION;

EID: 84932615132     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.02.024     Document Type: Article

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