Homo-catiomer integration into PEGylated polyplex micelle from block-catiomer for systemic anti-angiogenic gene therapy for fibrotic pancreatic tumors

Biomaterials

Volumn 33, Issue 18, 2012, Pages 4722-4730

  Chen, Qixian ^a   Osada, Kensuke ^a   Ishii, Takehiko ^a   Oba, Makoto ^b   Uchida, Satoshi ^b   Tockary, Theofilus A ^a   Endo, Taisuke ^a   Ge, Zhishen ^a   Kinoh, Hiroaki ^a   Kano, Mitsunobu R ^b   Itaka, Keiji ^b   Kataoka, Kazunori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

DNA; Gene transfer; In vitro test; In vivo test; Micelle; Nanoparticle

Indexed keywords

CELL TRANSFECTION; CELLULAR UPTAKE; ENDOSOMES; GENE CARRIER; GENE TRANSFECTION; IN-VITRO EVALUATION; IN-VITRO TESTS; IN-VIVO; IN-VIVO TESTS; INHIBITORY EFFECT; NONVIRAL; PANCREATIC TUMORS; POLYPLEXES; SYSTEMIC ADMINISTRATION; TRANSFECTION ACTIVITY; TUMOR GROWTH; TUMOR SITE; TUMOR SUPPRESSION; VASCULAR ENDOTHELIAL CELLS;

DNA; ENDOTHELIAL CELLS; GENE TRANSFER; GENES; INTEGRATION; MICELLES; NANOPARTICLES; POLYETHYLENE GLYCOLS; TUMORS;

MOLECULAR BIOLOGY;

DRUG CARRIER; HOMO POLY[N' [N' (2 AMINOETHYL) 2 AMINOEHTYL]ASPARTAMIDE]; MACROGOL; RECOMBINANT ENZYME; RECOMBINANT GROWTH FACTOR; RECOMBINANT LUCIFERASE; RECOMBINANT VASCULOTROPIN RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC GENE THERAPY; ARTICLE; CANCER INHIBITION; CELL STIMULATION; CONTROLLED STUDY; ENDOSOME; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MICELLE; MOUSE; NONHUMAN; PANCREAS TUMOR; PRIORITY JOURNAL;

ANIMALS; CELL LINE; CELL SURVIVAL; FLOW CYTOMETRY; GENE THERAPY; HUMANS; MICE; MICE, NUDE; MICELLES; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; PANCREATIC NEOPLASMS; POLYETHYLENE GLYCOLS;

EID: 84859835238     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.03.017     Document Type: Article

References (34)

1. Mastrobattista E., van der Aa M.A.E.M., Hennink W.E., Crommelin D.J.A Artificial viruses: a nanotechnological approach to gene delivery Nat Rev Drug Discov 2006, 5:115-121.
2. Mintzer M., Simanek E.E Nonviral vectors for gene delivery Chem Rev 2009, 109:259-302.
3. Morille M., Passirani C., Vonarbourg A., Clavreul A., Benoit J.P Progress in developing cationic vectors for non-viral systemic gene therapy against cancer Biomaterials 2008, 29:3477-3496.
4. Osada K., Christie R.J., Kataoka K Polymeric micelles from poly(ethylene glycol)-poly(amino acid) block copolymer for drug and gene delivery J R Soc Interface 2009, 6:S325-S339.
5. Kanayama N., Fukushima S., Nishiyama N., Itaka K., Jang W.D., Miyata K., et al A PEG-based biocompatible block catiomer with high buffering capacity for the construction of polyplex micelles showing efficient gene transfer toward primary cells Chem Med Chem 2006, 1:439-444.
6. Miyata K., Oba M., Nakanishi M., Fukushima S., Yamasaki Y., Koyama H., et al Polyplexes from poly(aspartamide) bearing 1,2-diaminoethane side chains induce pH-selective, endosomal membrane destabilization with amplified transfection and negligible cytotoxicity J Am Chem Soc 2008, 130:16287-16294.
7. Itaka K., Ishii T., Hasegawa Y., Kataoka K Biodegradable polyamino acid-based polycations as safe and effective gene carrier minimizing cumulative toxicity Biomaterials 2010, 31(13):3707-3714.
8. Kim H.J., Ishii A., Miyata K., Lee Y., Wu S., Oba M., et al Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown J Control Release 2010, 145:141-148.
9. Uchida H., Miyata K., Oba M., Ishii T., Suma T., Itaka K., et al Odd-even effect of repeating aminoethylene units in the side chain of N-substituted polyaspartamides on gene transfection profiles J Am Chem Soc 2011, 133:15524-15532.
10. Miyata K., Nishiyama N., Kataoka K Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses Chem Soc Rev 2012, 41:2562-2574.
11. Nomoto T., Matsumoto Y., Miyata K., Oba M., Fukushima S., Nishiyama N., et al In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy J Control Release 2011, 151:104-109.
12. Takae S., Miyata K., Oba M., Ishii T., Nishiyama N., Itaka K., et al PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors J Am Chem Soc 2008, 130:6001-6009.
13. Uchida S., Itaka K., Chen Q., Osada K., Ishii T., Shibata M.A., et al PEGylated polyplex with optimized PEG shielding enhances gene introduction in lungs by minimizing inflammatory responses Mol Ther 2012, 10.1038/mt.2012.20.
14. Oba M., Miyata K., Osada K., Christie R.J., Sanjoh M., Li W.D., et al Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery Biomaterials 2011, 32:652-663.
15. Harada A., Kataoka K Formation of polyion complex micelles in an aqueous milieu from a pair of oppositely-charged block copolymers with poly(ethylene glycol) segments Macromolecules 1995, 28:5294-5299.
16. Jones M.C., Leroux J.C Polymeric micelles - a new generation of colloidal drug carriers Eur J Pharm Biopharm 1999, 48:101-111.
17. Otsuka H., Nagasaki Y., Kataoka K Self-assembly of poly(ethylene glycol)-based block copolymers for biomedical applications Curr Opin Colloid Interface Sci 2001, 6:3-10.
18. Osada K., Oshima H., Kobayashi D., Doi M., Enoki M., Yamasaki Y., et al Quantized folding of plasmid DNA condensed with block catiomer into characteristic rod structures promoting transgene efficacy J Am Chem Soc 2010, 132:12343-12348.
19. Mishra S., Webster P., Davis M.E PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles Eur J Cell Biol 2004, 83:97-111.
20. Kursa M., Walker G.F., Roessler V., Ogris M., Roedl W., Kircheis R., et al Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer Bioconjug Chem 2003, 14:222-231.
21. Varkouhi A.K., Scholte M., Storm G., Haisma H.J Endosomal escape pathways for delivery of biologicals J Control Release 2011, 151:220-228.
22. Mancuso A., Calabrò F., Sternberg C.N Current therapies and advances in the treatment of pancreatic cancer Crit Rev Oncol Hematol 2006, 58:231-241.
23. Freelove R., Walling A.D Pancreatic cancer: diagnosis and management Am Fam Physician 2006, 73:485-492.
24. Huguet F., Girard N., Guerche C.S Chemoradiotherapy in the management of locally advanced pancreatic carcinoma: a qualitative systematic review J Clin Oncol 2009, 27:2269-2277.
25. Klautke G., Brunner T.B Radiotherapy in pancreatic cancer Strahlenther Onkol 2008, 184:557-564.
26. Zuckerman D.S., Ryan D.P Adjuvant therapy for pancreatic cancer: a review Cancer 2008, 112:243-249.
27. Folkman J., Bach M., Rowe J.W., Davidoff F., Lambert P., Hirsch C., et al Tumor angiogenesis-therapeutic implications N Engl J Med 1971, 285:1182-1186.
28. Quesada A.R., Munoz-Chapuli R., Medina M.A Anti-angiogenic drugs: from bench to clinical trials Med Res Rev 2006, 26:483-530.
29. Pralhad T., Madhusudan S., Rajendrakumar K Concept mechanisms and therapeutics of angiogenesis in cancer and other diseases J Pharm Pharmaco 2003, 55:1045-1053.
30. Carmeliet P., Jain R.K Angiogenesis in cancer and other diseases Nature 2000, 407:249-257.
31. Kong H.L., Hecht D., Song W., Kovesdi I., Hackett N.R., Yayon A., et al Regional suppression of tumor growth by in vivo transfer of a cDNA encoding a secreted form of the extracellular domain of the Flt-1 vascular endothelial growth factor receptor Hum Gene Ther 1998, 9:823-833.
32. Oba M., Vachutinsky Y., Miyata K., Kano M.R., Ikeda S., Nishiyama N., et al Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-1 Mol Pharm 2010, 7:501-509.
33. Vachutinsky Y., Oba M., Miyata K., Hiki S., Kano M.R., Nishiyama N., et al Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles J Control Release 2011, 149:51-57.
34. Cabral H., Matsumoto Y., Mizuno K., Chen Q., Murakami M., Kimura M., et al Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size Nat Nanotech 2011, 12:815-823.