Polyplex nanomicelle promotes hydrodynamic gene introduction to skeletal muscle

Journal of Controlled Release

Volumn 143, Issue 1, 2010, Pages 112-119

  Itaka, Keiji ^a,b   Osada, Kensuke ^b   Morii, Katsue ^a   Kim, Pilhan ^c   Yun, Seok Hyun ^c   Kataoka, Kazunori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Hydrodynamic delivery; Intravenous injection; Muscle gene delivery; Plasmid DNA; Polyplex nanomicelle

Indexed keywords

GENE DELIVERY; INTRAVENOUS INJECTION; INTRAVENOUS INJECTIONS; PLASMID DNA; POLYPLEXES;

DNA; FLUID DYNAMICS; GENE TRANSFER; HYDRODYNAMICS; MICROBIOLOGY; MUSCLE; OPTOELECTRONIC DEVICES; POLYETHYLENE GLYCOLS; TUMORS;

GENE THERAPY;

LUCIFERASE; MACROGOL; NAKED DNA; PLASMID DNA; POLYLYSINE; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG SAFETY; EXPRESSION VECTOR; FEASIBILITY STUDY; GENE EXPRESSION; HYDRODYNAMICS; MICELLE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; SKELETAL MUSCLE; TARGET ORGAN; TRANSGENE; VIDEORECORDING;

ADENOCARCINOMA; ANIMALS; DNA; FEASIBILITY STUDIES; GENE THERAPY; HUMANS; INJECTIONS, INTRAVENOUS; LUCIFERASES; LYSINE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICELLES; MICROSCOPY, CONFOCAL; MICROSCOPY, VIDEO; MUSCLE, SKELETAL; NANOPARTICLES; NANOTECHNOLOGY; NEOVASCULARIZATION, PATHOLOGIC; PANCREATIC NEOPLASMS; POLYETHYLENE GLYCOLS; TIME FACTORS; TRANSFECTION; TUMOR BURDEN; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 77950517035     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.12.014     Document Type: Article

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