In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy

Journal of Controlled Release

Volumn 151, Issue 2, 2011, Pages 104-109

  Nomoto, Takahiro ^a   Matsumoto, Yu ^b,c   Miyata, Kanjiro ^b   Oba, Makoto ^d   Fukushima, Shigeto ^a   Nishiyama, Nobuhiro ^b   Yamasoba, Tatsuya ^b   Kataoka, Kazunori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c MITSUI MEMORIAL HOSPITAL   (Japan)

^d UNIVERSITY OF TOKYO HOSPITAL   (Japan)

Author keywords

Block copolymer; Intravital confocal microscopy; Polyethylene glycol; Polymer micelle; Polyplex

Indexed keywords

AGGREGATE FORMATION; BLOOD CIRCULATION; BLOOD FLOW; COEFFICIENT OF VARIATION; CONFOCAL LASER SCANNING MICROSCOPY; DYNAMIC STATE; EXPERIMENTAL ANIMALS; GENE DELIVERY; GENE VECTORS; IN-SITU; IN-SITU MONITORING; INTRAVENOUS INJECTIONS; INTRAVITAL CONFOCAL MICROSCOPY; NO FORMATION; NONVIRAL; NOVEL METHODS; PEARSON'S CORRELATION COEFFICIENTS; PEGYLATION; PLASMID DNA; POLYMER MICELLE; POLYPLEXES; SURFACE MODIFICATION;

AGGLOMERATION; ANIMALS; BIOCOMPATIBILITY; BLOCK COPOLYMERS; BLOOD VESSELS; CONFOCAL MICROSCOPY; CORRELATION METHODS; ENZYME INHIBITION; ETHYLENE; ETHYLENE GLYCOL; GENE THERAPY; GENE TRANSFER; LASER APPLICATIONS; MICELLES; PHYSIOLOGY; PLATELETS; POLYETHYLENE OXIDES;

POLYETHYLENE GLYCOLS;

MACROGOL; PLASMID DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL GENE; BLOOD ANALYSIS; BLOOD FLOW; CIRCULATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CORRELATION COEFFICIENT; EAR LOBE; FEMALE; GENE TARGETING; GENE VECTOR; MICELLE; MOUSE; NON INVASIVE PROCEDURE; NONHUMAN; POLYPLEX MICELLE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; QUANTITATIVE ANALYSIS;

ANIMALS; BLOOD CIRCULATION; BLOOD PLATELETS; COMPUTER SYSTEMS; EAR AURICLE; FEMALE; GENETIC VECTORS; INJECTIONS, INTRAVENOUS; MICE; MICE, INBRED BALB C; MICE, NUDE; MICELLES; MICROSCOPY, CONFOCAL; POLYETHYLENE GLYCOLS;

EID: 79956097876     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.02.011     Document Type: Article

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