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Volumn 12, Issue 7, 2015, Pages 1121-1133

Self-nano-emulsifying drug delivery systems: An update of the biopharmaceutical aspects

Author keywords

Intra enterocyte metabolism; Lymphatic delivery; Oral bioavailability; P gp efflux; Poorly water soluble drugs; Self emulsifying drug delivery systems; Solubilization

Indexed keywords

EXCIPIENT; LIPID; DRUG; EMULSION; WATER;

EID: 84931824661     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2015.999038     Document Type: Review
Times cited : (135)

References (100)
  • 1
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski CA, Lombardo F, Dominy BW, et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 2001; 46(1-3): 3-26
    • (2001) Adv Drug Deliv Rev , vol.46 , Issue.1-3 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3
  • 3
    • 0028948839 scopus 로고
    • A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability
    • Amidon GL, Lennernas H, Shah VP, et al. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 1995; 12(3): 413-20
    • (1995) Pharm Res , vol.12 , Issue.3 , pp. 413-420
    • Amidon, G.L.1    Lennernas, H.2    Shah, V.P.3
  • 4
    • 0035946615 scopus 로고    scopus 로고
    • Solid lipid nanoparticles: Production, characterization and applications
    • Mehnert W, Mader K. Solid lipid nanoparticles: production, characterization and applications. Adv Drug Deliv Rev 2001; 47(2-3): 165-96
    • (2001) Adv Drug Deliv Rev , vol.47 , Issue.2-3 , pp. 165-196
    • Mehnert, W.1    Mader, K.2
  • 5
    • 1842684453 scopus 로고    scopus 로고
    • Self-emulsifying drug delivery systems (sedds) for improved oral delivery of lipophilic drugs
    • Gursoy RN, Benita S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother 2004; 58(3): 173-82
    • (2004) Biomed Pharmacother , vol.58 , Issue.3 , pp. 173-182
    • Gursoy, R.N.1    Benita, S.2
  • 6
    • 39149092022 scopus 로고    scopus 로고
    • Enhancing intestinal drug solubilisation using lipid-based delivery systems
    • Porter CJ, Pouton CW, Cuine JF, et al. Enhancing intestinal drug solubilisation using lipid-based delivery systems. Adv Drug Deliv Rev 2008; 60(6): 673-91
    • (2008) Adv Drug Deliv Rev , vol.60 , Issue.6 , pp. 673-691
    • Porter, C.J.1    Pouton, C.W.2    Cuine, J.F.3
  • 7
    • 0029562489 scopus 로고
    • Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects
    • Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm Res 1995; 12(11): 1561-72
    • (1995) Pharm Res , vol.12 , Issue.11 , pp. 1561-1572
    • Constantinides, P.P.1
  • 8
    • 0024565173 scopus 로고
    • Enhanced intestinal absorption of cyclosporine in rats through the reduction of emulsion droplet size
    • Tarr BD, Yalkowsky SH. Enhanced intestinal absorption of cyclosporine in rats through the reduction of emulsion droplet size. Pharm Res 1989; 6(1): 40-3
    • (1989) Pharm Res , vol.6 , Issue.1 , pp. 40-43
    • Tarr, B.D.1    Yalkowsky, S.H.2
  • 9
    • 0030471901 scopus 로고    scopus 로고
    • Gastrointestinal uptake of biodegradable microparticles: Effect of particle size
    • Desai MP, Labhasetwar V, Amidon GL, et al. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm Res 1996; 13(12): 1838-45
    • (1996) Pharm Res , vol.13 , Issue.12 , pp. 1838-1845
    • Desai, M.P.1    Labhasetwar, V.2    Amidon, G.L.3
  • 10
    • 1942498889 scopus 로고    scopus 로고
    • Cyclosporin nanoparticulate lipospheres for oral administration
    • Bekerman T, Golenser J, Domb A. Cyclosporin nanoparticulate lipospheres for oral administration. J Pharm Sci 2004; 93(5): 1264-70
    • (2004) J Pharm Sci , vol.93 , Issue.5 , pp. 1264-1270
    • Bekerman, T.1    Golenser, J.2    Domb, A.3
  • 11
    • 71049183092 scopus 로고    scopus 로고
    • Particle size reduction for improvement of oral absorption of the poorly soluble drug ug558 in rats during early development
    • Sigfridsson K, Lundqvist AJ, Strimfors M. Particle size reduction for improvement of oral absorption of the poorly soluble drug UG558 in rats during early development. Drug Dev Ind Pharm 2009; 35(12): 1479-86
    • (2009) Drug Dev Ind Pharm , vol.35 , Issue.12 , pp. 1479-1486
    • Sigfridsson, K.1    Lundqvist, A.J.2    Strimfors, M.3
  • 12
    • 24744435122 scopus 로고    scopus 로고
    • Three generations of cyclosporine a formulations: An in vitro comparison
    • Thomas K, Koelwel C, Machei U, et al. Three generations of cyclosporine a formulations: an in vitro comparison. Drug Dev Ind Pharm 2005; 31(4-5): 357-66
    • (2005) Drug Dev Ind Pharm , vol.31 , Issue.4-5 , pp. 357-366
    • Thomas, K.1    Koelwel, C.2    MacHei, U.3
  • 13
    • 84871441882 scopus 로고    scopus 로고
    • Oral bioavailability of cinnarizine in dogs: Relation to snedds droplet size, drug solubility and in vitro precipitation
    • Larsen AT, Ohlsson AG, Polentarutti B, et al. Oral bioavailability of cinnarizine in dogs: relation to SNEDDS droplet size, drug solubility and in vitro precipitation. Eur J Pharm Sci 2013; 48(1-2): 339-50
    • (2013) Eur J Pharm Sci , vol.48 , Issue.1-2 , pp. 339-350
    • Larsen, A.T.1    Ohlsson, A.G.2    Polentarutti, B.3
  • 14
    • 0035937599 scopus 로고    scopus 로고
    • Nanosuspensions as particulate drug formulations in therapy rationale for development and what we can expect for the future
    • Muller RH, Jacobs C, Kayser O. Nanosuspensions as particulate drug formulations in therapy. Rationale for development and what we can expect for the future. Adv Drug Deliv Rev 2001; 47(1): 3-19
    • (2001) Adv Drug Deliv Rev , vol.47 , Issue.1 , pp. 3-19
    • Muller, R.H.1    Jacobs, C.2    Kayser, O.3
  • 15
    • 0034671698 scopus 로고    scopus 로고
    • Charge-dependent interaction of selfemulsifying oil formulations with caco-2 cells monolayers: Binding, effects on barrier function and cytotoxicity
    • Gershanik T, Haltner E, Lehr CM, et al. Charge-dependent interaction of selfemulsifying oil formulations with Caco-2 cells monolayers: binding, effects on barrier function and cytotoxicity. Int J Pharm 2000; 211(1-2): 29-36
    • (2000) Int J Pharm , vol.211 , Issue.1-2 , pp. 29-36
    • Gershanik, T.1    Haltner, E.2    Lehr, C.M.3
  • 16
    • 0025253424 scopus 로고
    • Characterization of the barrier properties of mucosal membranes
    • Corbo DC, Liu JC, Chien YW. Characterization of the barrier properties of mucosal membranes. J Pharm Sci 1990; 79(3): 202-6
    • (1990) J Pharm Sci , vol.79 , Issue.3 , pp. 202-206
    • Corbo, D.C.1    Liu, J.C.2    Chien, Y.W.3
  • 17
    • 0030298897 scopus 로고    scopus 로고
    • Positively charged self-emulsifying oil formulation for improving oral bioavailability of progesterone
    • Gershanik T, Benita S. Positively charged self-emulsifying oil formulation for improving oral bioavailability of progesterone. Pharm Dev Technol 1996; 1(2): 147-57
    • (1996) Pharm Dev Technol , vol.1 , Issue.2 , pp. 147-157
    • Gershanik, T.1    Benita, S.2
  • 18
    • 0034601204 scopus 로고    scopus 로고
    • Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs
    • Gershanik T, Benita S. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur J Pharm Biopharm 2000; 50(1): 179-88
    • (2000) Eur J Pharm Biopharm , vol.50 , Issue.1 , pp. 179-188
    • Gershanik, T.1    Benita, S.2
  • 19
    • 33847394968 scopus 로고    scopus 로고
    • Lipids and lipid-based formulations: Optimizing the oral delivery of lipophilic drugs
    • Porter CJ, Trevaskis NL, Charman WN. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov 2007; 6(3): 231-48
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.3 , pp. 231-248
    • Porter, C.J.1    Trevaskis, N.L.2    Charman, W.N.3
  • 20
    • 0342617694 scopus 로고    scopus 로고
    • Lipid-based vehicles for the oral delivery of poorly water soluble drugs
    • Humberstone AJ, Charman WN. Lipid-based vehicles for the oral delivery of poorly water soluble drugs. Adv Drug Deliv Rev 1997; 25(1): 103-28
    • (1997) Adv Drug Deliv Rev , vol.25 , Issue.1 , pp. 103-128
    • Humberstone, A.J.1    Charman, W.N.2
  • 22
    • 79851474101 scopus 로고    scopus 로고
    • Design and evaluation of self-nanoemulsifying drug delivery system of flutamide
    • Jeevana JB, Sreelakshmi K. Design and evaluation of self-nanoemulsifying drug delivery system of flutamide. J Young Pharm 2011; 3(1): 4-8
    • (2011) J Young Pharm , vol.3 , Issue.1 , pp. 4-8
    • Jeevana, J.B.1    Sreelakshmi, K.2
  • 23
    • 77952887062 scopus 로고    scopus 로고
    • Snedds containing bioenhancers for improvement of dissolution and oral absorption of lacidipine i: Development and optimization
    • Basalious EB, Shawky N, Badr-Eldin SM. SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: development and optimization. Int J Pharm 2010; 391(1-2): 203-11
    • (2010) Int J Pharm , vol.391 , Issue.1-2 , pp. 203-211
    • Basalious, E.B.1    Shawky, N.2    Badr-Eldin, S.M.3
  • 24
    • 0015174080 scopus 로고
    • Unstirred water layers and absorption across the intestinal mucosa
    • Dietschy JM, Sallee VL, Wilson FA. Unstirred water layers and absorption across the intestinal mucosa. Gastroenterology 1971; 61(6): 932-4
    • (1971) Gastroenterology , vol.61 , Issue.6 , pp. 932-934
    • Dietschy, J.M.1    Sallee, V.L.2    Wilson, F.A.3
  • 25
    • 0015209610 scopus 로고
    • Unstirred water layers in intestine: Rate determinant of fatty acid absorption from micellar solutions
    • Wilson FA, Sallee VL, Dietschy JM. Unstirred water layers in intestine: rate determinant of fatty acid absorption from micellar solutions. Science 1971; 174(13): 1031-3
    • (1971) Science , vol.174 , Issue.13 , pp. 1031-1033
    • Wilson, F.A.1    Sallee, V.L.2    Dietschy, J.M.3
  • 26
    • 0034049590 scopus 로고    scopus 로고
    • Effects of some non-ionic surfactants on transepithelial permeability in caco-2 cells
    • Dimitrijevic D, Shaw AJ, Florence AT. Effects of some non-ionic surfactants on transepithelial permeability in Caco-2 cells. J Pharm Pharmacol 2000; 52(2): 157-62
    • (2000) J Pharm Pharmacol , vol.52 , Issue.2 , pp. 157-162
    • Dimitrijevic, D.1    Shaw, A.J.2    Florence, A.T.3
  • 27
    • 0031820780 scopus 로고    scopus 로고
    • Effectiveness and toxicity screening of various absorption enhancers using Caco- 2 cell monolayers
    • Quan YS, Hattori K, Lundborg E, et al. Effectiveness and toxicity screening of various absorption enhancers using Caco- 2 cell monolayers. Biol Pharm Bull 1998; 21(6): 615-20
    • (1998) Biol Pharm Bull , vol.21 , Issue.6 , pp. 615-620
    • Quan, Y.S.1    Hattori, K.2    Lundborg, E.3
  • 28
    • 0033987108 scopus 로고    scopus 로고
    • Modification of ceftibuten transport by the addition of non-ionic surfactants
    • Koga K, Ohyashiki T, Murakami M, et al. Modification of ceftibuten transport by the addition of non-ionic surfactants. Eur J Pharm Biopharm 2000; 49(1): 17-25
    • (2000) Eur J Pharm Biopharm , vol.49 , Issue.1 , pp. 17-25
    • Koga, K.1    Ohyashiki, T.2    Murakami, M.3
  • 29
    • 0029079452 scopus 로고
    • Reversal of multidrug resistance phenotype by surfactants: Relationship to membrane lipid fluidity
    • Dudeja PK, Anderson KM, Harris JS, et al. Reversal of multidrug resistance phenotype by surfactants: relationship to membrane lipid fluidity. Arch Biochem Biophys 1995; 319(1): 309-15
    • (1995) Arch Biochem Biophys , vol.319 , Issue.1 , pp. 309-315
    • Dudeja, P.K.1    Anderson, K.M.2    Harris, J.S.3
  • 30
    • 34250822863 scopus 로고    scopus 로고
    • Mechanism of inhibition of pglycoprotein mediated efflux by vitamin e tpgs: Influence on atpase activity and membrane fluidity
    • Collnot EM, Baldes C, Wempe MF, et al. Mechanism of inhibition of Pglycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity. Mol Pharm 2007; 4(3): 465-74
    • (2007) Mol Pharm , vol.4 , Issue.3 , pp. 465-474
    • Collnot, E.M.1    Baldes, C.2    Wempe, M.F.3
  • 31
    • 0023447098 scopus 로고
    • Cellular localization of the multidrugresistance gene product P-glycoprotein in normal human tissues
    • Thiebaut F, Tsuruo T, Hamada H, et al. Cellular localization of the multidrugresistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci USA 1987; 84(21): 7735-8
    • (1987) Proc Natl Acad Sci USA , vol.84 , Issue.21 , pp. 7735-7738
    • Thiebaut, F.1    Tsuruo, T.2    Hamada, H.3
  • 32
    • 0023889448 scopus 로고
    • Tissue distribution of Pglycoprotein encoded by a multidrugresistant gene as revealed by a monoclonal antibody
    • Sugawara I, Kataoka I, Morishita Y, et al. Tissue distribution of Pglycoprotein encoded by a multidrugresistant gene as revealed by a monoclonal antibody, MRK 16. Cancer Res 1988; 48(7): 1926-9
    • (1988) MRK 16. Cancer Res , vol.48 , Issue.7 , pp. 1926-1929
    • Sugawara, I.1    Kataoka, I.2    Morishita, Y.3
  • 33
    • 0026764698 scopus 로고
    • Reversal of multidrug resistance by surfactants
    • Woodcock DM, Linsenmeyer ME, Chojnowski G, et al. Reversal of multidrug resistance by surfactants. Br J Cancer 1992; 66(1): 62-8
    • (1992) Br J Cancer , vol.66 , Issue.1 , pp. 62-68
    • Woodcock, D.M.1    Linsenmeyer, M.E.2    Chojnowski, G.3
  • 34
    • 0029875543 scopus 로고    scopus 로고
    • The use of surfactants to enhance the permeability of peptides through caco-2 cells by inhibition of an apically polarized efflux system
    • Nerurkar MM, Burton PS, Borchardt RT. The use of surfactants to enhance the permeability of peptides through Caco-2 cells by inhibition of an apically polarized efflux system. Pharm Res 1996; 13(4): 528-34
    • (1996) Pharm Res , vol.13 , Issue.4 , pp. 528-534
    • Nerurkar, M.M.1    Burton, P.S.2    Borchardt, R.T.3
  • 35
    • 39149124830 scopus 로고    scopus 로고
    • Lipid excipients and delivery systems for pharmaceutical development: A regulatory perspective
    • Chen ML. Lipid excipients and delivery systems for pharmaceutical development: a regulatory perspective. Adv Drug Deliv Rev 2008; 60(6): 768-77
    • (2008) Adv Drug Deliv Rev , vol.60 , Issue.6 , pp. 768-777
    • Chen, M.L.1
  • 36
    • 33847407473 scopus 로고    scopus 로고
    • Impact of cremophor-EL and polysorbate-80 on digoxin permeability across rat jejunum: Delineation of thermodynamic and transporter related events using the reciprocal permeability approach
    • Katneni K, Charman SA, Porter CJ. Impact of cremophor-EL and polysorbate-80 on digoxin permeability across rat jejunum: delineation of thermodynamic and transporter related events using the reciprocal permeability approach. J Pharm Sci 2007; 96(2): 280-93
    • (2007) J Pharm Sci , vol.96 , Issue.2 , pp. 280-293
    • Katneni, K.1    Charman, S.A.2    Porter, C.J.3
  • 37
    • 2642566037 scopus 로고    scopus 로고
    • Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats
    • Zhang H, Yao M, Morrison RA, et al. Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats. Arch Pharm Res 2003; 26(9): 768-72
    • (2003) Arch Pharm Res , vol.26 , Issue.9 , pp. 768-772
    • Zhang, H.1    Yao, M.2    Morrison, R.A.3
  • 38
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
    • Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog 1995; 13(3): 129-34
    • (1995) Mol Carcinog , vol.13 , Issue.3 , pp. 129-134
    • Wacher, V.J.1    Wu, C.Y.2    Benet, L.Z.3
  • 39
    • 0029012285 scopus 로고
    • Disposition and bioavailability of the beta 1-adrenoceptor antagonist talinolol in man
    • Trausch B, Oertel R, Richter K, et al. Disposition and bioavailability of the beta 1-adrenoceptor antagonist talinolol in man. Biopharm Drug Dispos 1995; 16(5): 403-14
    • (1995) Biopharm Drug Dispos , vol.16 , Issue.5 , pp. 403-414
    • Trausch, B.1    Oertel, R.2    Richter, K.3
  • 40
    • 84890571693 scopus 로고    scopus 로고
    • Improved oral bioavailability of bcs class 2 compounds by self nanoemulsifying drug delivery systems (snedds): The underlying mechanisms for amiodarone and talinolol
    • Elgart A, Cherniakov I, Aldouby Y, et al. Improved oral bioavailability of BCS class 2 compounds by self nanoemulsifying drug delivery systems (SNEDDS): the underlying mechanisms for amiodarone and talinolol. Pharm Res 2013; 30(12): 3029-44
    • (2013) Pharm Res , vol.30 , Issue.12 , pp. 3029-3044
    • Elgart, A.1    Cherniakov, I.2    Aldouby, Y.3
  • 41
    • 77149165406 scopus 로고    scopus 로고
    • Predicting drug disposition via application of a biopharmaceutics drug disposition classification system
    • Benet LZ. Predicting drug disposition via application of a biopharmaceutics drug disposition classification system. Basic Clin Pharmacol Toxicol 2010; 106(3): 162-7
    • (2010) Basic Clin Pharmacol Toxicol , vol.106 , Issue.3 , pp. 162-167
    • Benet, L.Z.1
  • 43
    • 48749112588 scopus 로고    scopus 로고
    • Xenobiotic transporters of the human organic anion transporting polypeptides (oatp) family
    • Hagenbuch B, Gui C. Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family. Xenobiotica 2008; 38(7-8): 778-801
    • (2008) Xenobiotica , vol.38 , Issue.7-8 , pp. 778-801
    • Hagenbuch, B.1    Gui, C.2
  • 44
    • 0036159433 scopus 로고    scopus 로고
    • Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine
    • Dresser GK, Bailey DG, Leake BF, et al. Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin Pharmacol Ther 2002; 71(1): 11-20
    • (2002) Clin Pharmacol Ther , vol.71 , Issue.1 , pp. 11-20
    • Dresser, G.K.1    Bailey, D.G.2    Leake, B.F.3
  • 45
    • 84865963648 scopus 로고    scopus 로고
    • Pharmaceutical excipients influence the function of human uptake transporting proteins
    • Engel A, Oswald S, Siegmund W, et al. Pharmaceutical excipients influence the function of human uptake transporting proteins. Mol Pharm 2012; 9(9): 2577-81
    • (2012) Mol Pharm , vol.9 , Issue.9 , pp. 2577-2581
    • Engel, A.1    Oswald, S.2    Siegmund, W.3
  • 46
    • 0024604149 scopus 로고
    • Cytochromes P-450 in the intestinal mucosa of man
    • Peters WH, Kremers PG. Cytochromes P-450 in the intestinal mucosa of man. Biochem Pharmacol 1989; 38(9): 1535-8
    • (1989) Biochem Pharmacol , vol.38 , Issue.9 , pp. 1535-1538
    • Peters, W.H.1    Kremers, P.G.2
  • 47
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome p-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 japanese and 30 caucasians
    • Shimada T, Yamazaki H, Mimura M, et al. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Ther 1994; 270(1): 414-23
    • (1994) J Pharmacol Exp Ther , vol.270 , Issue.1 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3
  • 48
    • 0025344378 scopus 로고
    • Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues
    • de Waziers I, Cugnenc PH, Yang CS, et al. Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues. J Pharmacol Exp Ther 1990; 253(1): 387-94
    • (1990) J Pharmacol Exp Ther , vol.253 , Issue.1 , pp. 387-394
    • De Waziers, I.1    Cugnenc, P.H.2    Yang, C.S.3
  • 49
    • 0026464616 scopus 로고
    • Identification of rifampin-inducible p450iiia4 (cyp3a4) in human small bowel enterocytes
    • Kolars JC, Schmiedlin-Ren P, Schuetz JD, et al. Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes. J Clin Invest 1992; 90(5): 1871-8
    • (1992) J Clin Invest , vol.90 , Issue.5 , pp. 1871-1878
    • Kolars, J.C.1    Schmiedlin-Ren, P.2    Schuetz, J.D.3
  • 50
    • 0032924934 scopus 로고    scopus 로고
    • Cytochrome P-450 3A4: Regulation and role in drug metabolism
    • Guengerich FP. Cytochrome P-450 3A4: regulation and role in drug metabolism. Annu Rev Pharmacol Toxicol 1999; 39: 1-17
    • (1999) Annu Rev Pharmacol Toxicol , vol.39 , pp. 1-17
    • Guengerich, F.P.1
  • 51
    • 0023588109 scopus 로고
    • Identification of glucocorticoidinducible cytochromes P-450 in the intestinal mucosa of rats and man
    • Watkins PB, Wrighton SA, Schuetz EG, et al. Identification of glucocorticoidinducible cytochromes P-450 in the intestinal mucosa of rats and man. J Clin Invest 1987; 80(4): 1029-36
    • (1987) J Clin Invest , vol.80 , Issue.4 , pp. 1029-1036
    • Watkins, P.B.1    Wrighton, S.A.2    Schuetz, E.G.3
  • 52
    • 0030002504 scopus 로고    scopus 로고
    • Intestinal drug metabolism and antitransport processes: A potential paradigm shift in oral drug delivery
    • Benet LZ, Wu CY, Hebert MF, et al. Intestinal drug metabolism and antitransport processes: a potential paradigm shift in oral drug delivery. J Control Release 1996; 39: 139-43
    • (1996) J Control Release , vol.39 , pp. 139-143
    • Benet, L.Z.1    Wu, C.Y.2    Hebert, M.F.3
  • 53
    • 80054948359 scopus 로고    scopus 로고
    • In vitro and in vivo small intestinal metabolism of cyp3a and ugt substrates in preclinical animals species and humans: Species differences
    • Komura H, Iwaki M. In vitro and in vivo small intestinal metabolism of CYP3A and UGT substrates in preclinical animals species and humans: species differences. Drug Metab Rev 2011; 43(4): 476-98
    • (2011) Drug Metab Rev , vol.43 , Issue.4 , pp. 476-498
    • Komura, H.1    Iwaki, M.2
  • 54
    • 48549096838 scopus 로고    scopus 로고
    • Species differences in in vitro and in vivo small intestinal metabolism of cyp3a substrates
    • Komura H, Iwaki M. Species differences in in vitro and in vivo small intestinal metabolism of CYP3A substrates. J Pharm Sci 2008; 97(5): 1775-800
    • (2008) J Pharm Sci , vol.97 , Issue.5 , pp. 1775-1800
    • Komura, H.1    Iwaki, M.2
  • 55
    • 33748290093 scopus 로고    scopus 로고
    • Preparation and evaluation of self-microemulsifying drug delivery systems (smedds) containing atorvastatin
    • Shen H, Zhong M. Preparation and evaluation of self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin. J Pharm Pharmacol 2006; 58(9): 1183-91
    • (2006) J Pharm Pharmacol , vol.58 , Issue.9 , pp. 1183-1191
    • Shen, H.1    Zhong, M.2
  • 56
    • 50149089760 scopus 로고    scopus 로고
    • Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration
    • Ren X, Mao X, Si L, et al. Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm 2008; 70(1): 279-88
    • (2008) Eur J Pharm Biopharm , vol.70 , Issue.1 , pp. 279-288
    • Ren, X.1    Mao, X.2    Si, L.3
  • 57
    • 59349110733 scopus 로고    scopus 로고
    • Nonionic surfactants are strong inhibitors of cytochrome P450 3A biotransformation activity in vitro and in vivo
    • Ren X, Mao X, Cao L, et al. Nonionic surfactants are strong inhibitors of cytochrome P450 3A biotransformation activity in vitro and in vivo. Eur J Pharm Sci 2009; 36(4-5): 401-11
    • (2009) Eur J Pharm Sci , vol.36 , Issue.4-5 , pp. 401-411
    • Ren, X.1    Mao, X.2    Cao, L.3
  • 58
    • 0002277225 scopus 로고
    • Anatomy and physiology of the lymphatics
    • In: William N Charman VJS editors CRC Press Inc Boka Raton, FL
    • CM OD. Anatomy and physiology of the lymphatics. In: William N, Charman VJS, editors. Lymphatic transport of drugs. CRC Press, Inc; Boka Raton, FL: 1992
    • (1992) Lymphatic Transport of Drugs
  • 59
    • 84931859021 scopus 로고    scopus 로고
    • Biochemistry and physiology of cholesterol and lipoprotein metabolism
    • In: Golan DE Tasjian AH Armstrong EJ Armstrong AW editors 3rd edition. Lippincott Williams & Wilkins Philadelphia, PA
    • Cohen DE, Armstrong EJ. Biochemistry and physiology of cholesterol and lipoprotein metabolism. In: Golan DE, Tasjian AH, Armstrong EJ, Armstrong AW, editors. Principles of pharmacology. 3rd edition. Lippincott Williams & Wilkins, Philadelphia, PA; 2011
    • (2011) Principles of Pharmacology
    • Cohen, D.E.1    Armstrong, E.J.2
  • 60
    • 0035984949 scopus 로고    scopus 로고
    • Lipid-based formulations for intestinal lymphatic delivery
    • O'Driscoll CM. Lipid-based formulations for intestinal lymphatic delivery. Eur J Pharm Sci 2002; 15(5): 405-15
    • (2002) Eur J Pharm Sci , vol.15 , Issue.5 , pp. 405-415
    • O'driscoll, C.M.1
  • 61
    • 0035940057 scopus 로고    scopus 로고
    • Intestinal lymphatic drug transport: An update
    • Porter CJ, Charman WN. Intestinal lymphatic drug transport: an update. Adv Drug Deliv Rev 2001; 50(1-2): 61-80
    • (2001) Adv Drug Deliv Rev , vol.50 , Issue.1-2 , pp. 61-80
    • Porter, C.J.1    Charman, W.N.2
  • 62
    • 0036744709 scopus 로고    scopus 로고
    • Structured triglyceride vehicles for oral delivery of halofantrine: Examination of intestinal lymphatic transport and bioavailability in conscious rats
    • Holm R, Porter CJ, Müllertz A, et al. Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats. Pharm Res 2002; 19(9): 1354-61
    • (2002) Pharm Res , vol.19 , Issue.9 , pp. 1354-1361
    • Holm, R.1    Porter, C.J.2    Müllertz, A.3
  • 63
    • 0043122366 scopus 로고    scopus 로고
    • Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs
    • Khoo SM, Shackleford DM, Porter CJ, et al. Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs. Pharm Res 2003; 20(9): 1460-5
    • (2003) Pharm Res , vol.20 , Issue.9 , pp. 1460-1465
    • Khoo, S.M.1    Shackleford, D.M.2    Porter, C.J.3
  • 64
    • 17644402482 scopus 로고    scopus 로고
    • Stimulation of triglyceride-rich lipoprotein secretion by polysorbate 80: In vitro and in vivo correlation using caco-2 cells and a cannulated rat intestinal lymphatic model
    • Seeballuck F, Lawless E, Ashford MB, et al. Stimulation of triglyceride-rich lipoprotein secretion by polysorbate 80: in vitro and in vivo correlation using Caco-2 cells and a cannulated rat intestinal lymphatic model. Pharm Res 2004; 21(12): 2320-6
    • (2004) Pharm Res , vol.21 , Issue.12 , pp. 2320-2326
    • Seeballuck, F.1    Lawless, E.2    Ashford, M.B.3
  • 65
    • 50449093858 scopus 로고    scopus 로고
    • Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: The influence of polysorbate 60 and 80
    • Lind ML, Jacobsen J, Holm R, et al. Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80. Eur J Pharm Sci 2008; 35(3): 211-18
    • (2008) Eur J Pharm Sci , vol.35 , Issue.3 , pp. 211-218
    • Lind, M.L.1    Jacobsen, J.2    Holm, R.3
  • 66
    • 33751014029 scopus 로고    scopus 로고
    • Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system
    • Pouton CW. Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. Eur J Pharm Sci 2006; 29(3-4): 278-87
    • (2006) Eur J Pharm Sci , vol.29 , Issue.3-4 , pp. 278-287
    • Pouton, C.W.1
  • 67
    • 1342306882 scopus 로고    scopus 로고
    • A stepwise surgical procedure to investigate the lymphatic transport of lipid-based oral drug formulations: Cannulation of the mesenteric and thoracic lymph ducts within the rat
    • Boyd M, Risovic V, Jull P, et al. A stepwise surgical procedure to investigate the lymphatic transport of lipid-based oral drug formulations: cannulation of the mesenteric and thoracic lymph ducts within the rat. J Pharmacol Toxicol Methods 2004; 49(2): 115-20
    • (2004) J Pharmacol Toxicol Methods , vol.49 , Issue.2 , pp. 115-120
    • Boyd, M.1    Risovic, V.2    Jull, P.3
  • 68
    • 0034762181 scopus 로고    scopus 로고
    • A conscious dog model for assessing the absorption, enterocyte-based metabolism, and intestinal lymphatic transport of halofantrine
    • Khoo SM, Edwards GA, Porter CJ, et al. A conscious dog model for assessing the absorption, enterocyte-based metabolism, and intestinal lymphatic transport of halofantrine. J Pharm Sci 2001; 90(10): 1599-607
    • (2001) J Pharm Sci , vol.90 , Issue.10 , pp. 1599-1607
    • Khoo, S.M.1    Edwards, G.A.2    Porter, C.J.3
  • 69
    • 0035940082 scopus 로고    scopus 로고
    • Animal models for the study of intestinal lymphatic drug transport
    • Edwards GA, Porter CJ, Caliph SM, et al. Animal models for the study of intestinal lymphatic drug transport. Adv Drug Deliv Rev 2001; 50(1-2): 45-60
    • (2001) Adv Drug Deliv Rev , vol.50 , Issue.1-2 , pp. 45-60
    • Edwards, G.A.1    Porter, C.J.2    Caliph, S.M.3
  • 71
    • 27644453872 scopus 로고    scopus 로고
    • Uptake of lipophilic drugs by plasma derived isolated chylomicrons: Linear correlation with intestinal lymphatic bioavailability
    • Gershkovich P, Hoffman A. Uptake of lipophilic drugs by plasma derived isolated chylomicrons: linear correlation with intestinal lymphatic bioavailability. Eur J Pharm Sci 2005; 26(5): 394-404
    • (2005) Eur J Pharm Sci , vol.26 , Issue.5 , pp. 394-404
    • Gershkovich, P.1    Hoffman, A.2
  • 72
    • 58149218215 scopus 로고    scopus 로고
    • The role of molecular physicochemical properties and apolipoproteins in association of drugs with triglyceride-rich lipoproteins: In-silico prediction of uptake by chylomicrons
    • Gershkovich P, Fanous J, Qadri B, et al. The role of molecular physicochemical properties and apolipoproteins in association of drugs with triglyceride-rich lipoproteins: in-silico prediction of uptake by chylomicrons. J Pharm Pharmacol 2009; 61(1): 31-9
    • (2009) J Pharm Pharmacol , vol.61 , Issue.1 , pp. 31-39
    • Gershkovich, P.1    Fanous, J.2    Qadri, B.3
  • 73
    • 0031914282 scopus 로고    scopus 로고
    • Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly watersoluble ltb4 inhibitor
    • Hauss DJ, Fogal SE, Ficorilli JV, et al. Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly watersoluble LTB4 inhibitor. J Pharm Sci 1998; 87(2): 164-9
    • (1998) J Pharm Sci , vol.87 , Issue.2 , pp. 164-169
    • Hauss, D.J.1    Fogal, S.E.2    Ficorilli, J.V.3
  • 74
    • 79952279850 scopus 로고    scopus 로고
    • Examination of lymphatic transport of puerarin in unconscious lymph ductcannulated rats after administration in microemulsion drug delivery systems
    • Wu H, Zhou A, Lu C, et al. Examination of lymphatic transport of puerarin in unconscious lymph ductcannulated rats after administration in microemulsion drug delivery systems. Eur J Pharm Sci 2011; 42(4): 348-53
    • (2011) Eur J Pharm Sci , vol.42 , Issue.4 , pp. 348-353
    • Wu, H.1    Zhou, A.2    Lu, C.3
  • 75
    • 43249122851 scopus 로고    scopus 로고
    • Bioavailability of probucol from lipid and surfactant based formulations in minipigs: Influence of droplet size and dietary state
    • Nielsen FS, Petersen KB, Mullertz A. Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state. Eur J Pharm Biopharm 2008; 69(2): 553-62
    • (2008) Eur J Pharm Biopharm , vol.69 , Issue.2 , pp. 553-562
    • Nielsen, F.S.1    Petersen, K.B.2    Mullertz, A.3
  • 76
    • 0028079609 scopus 로고
    • Influence of a fat-rich meal on the pharmacokinetics of a new oral formulation of cyclosporine in a crossover comparison with the market formulation
    • Mueller EA, Kovarik JM, van Bree JB, et al. Influence of a fat-rich meal on the pharmacokinetics of a new oral formulation of cyclosporine in a crossover comparison with the market formulation. Pharm Res 1994; 11(1): 151-5
    • (1994) Pharm Res , vol.11 , Issue.1 , pp. 151-155
    • Mueller, E.A.1    Kovarik, J.M.2    Van Bree, J.B.3
  • 77
    • 0030711065 scopus 로고    scopus 로고
    • Tacrolimus an update of its pharmacology and clinical efficacy in the management of organ transplantation
    • Spencer CM, Goa KL, Gillis JC. Tacrolimus. An update of its pharmacology and clinical efficacy in the management of organ transplantation. Drugs 1997; 54(6): 925-75
    • (1997) Drugs , vol.54 , Issue.6 , pp. 925-975
    • Spencer, C.M.1    Goa, K.L.2    Gillis, J.C.3
  • 78
    • 0032864766 scopus 로고    scopus 로고
    • Tacrolimus in solid organ transplantation: An update
    • Shapiro R. Tacrolimus in solid organ transplantation: an update. Transplant Proc 1999; 31(6): 2203-5
    • (1999) Transplant Proc , vol.31 , Issue.6 , pp. 2203-2205
    • Shapiro, R.1
  • 79
    • 0036352082 scopus 로고    scopus 로고
    • Roles of the jejunum and ileum in the first-pass effect as absorptive barriers for orally administered tacrolimus
    • Shimomura M, Masuda S, Saito H, et al. Roles of the jejunum and ileum in the first-pass effect as absorptive barriers for orally administered tacrolimus. J Surg Res 2002; 103(2): 215-22
    • (2002) J Surg Res , vol.103 , Issue.2 , pp. 215-222
    • Shimomura, M.1    Masuda, S.2    Saito, H.3
  • 80
    • 84860713780 scopus 로고    scopus 로고
    • Lipospheres and pro-nano lipospheres for delivery of poorly water soluble compounds
    • Elgart A, Cherniakov I, Aldouby Y, et al. Lipospheres and pro-nano lipospheres for delivery of poorly water soluble compounds. Chem Phys Lipids 2012; 165(4): 438-53
    • (2012) Chem Phys Lipids , vol.165 , Issue.4 , pp. 438-453
    • Elgart, A.1    Cherniakov, I.2    Aldouby, Y.3
  • 81
    • 17844393071 scopus 로고    scopus 로고
    • There are no useful cyp3a probes that quantitatively predict the in vivo kinetics of other cyp3a substrates and no expectation that one will be found
    • Benet LZ. There are no useful CYP3A probes that quantitatively predict the in vivo kinetics of other CYP3A substrates and no expectation that one will be found. Mol Interv 2005; 5(2): 79-83
    • (2005) Mol Interv , vol.5 , Issue.2 , pp. 79-83
    • Benet, L.Z.1
  • 82
    • 0034072565 scopus 로고    scopus 로고
    • Dramatic inhibition of amiodarone metabolism induced by grapefruit juice
    • Libersa CC, Brique SA, Motte KB, et al. Dramatic inhibition of amiodarone metabolism induced by grapefruit juice. Br J Clin Pharmacol 2000; 49(4): 373-8
    • (2000) Br J Clin Pharmacol , vol.49 , Issue.4 , pp. 373-378
    • Libersa, C.C.1    Brique, S.A.2    Motte, K.B.3
  • 83
    • 0025337223 scopus 로고
    • Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration
    • Gupta SK, Manfro RC, Tomlanovich SJ, et al. Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration. J Clin Pharmacol 1990; 30(7): 643-53
    • (1990) J Clin Pharmacol , vol.30 , Issue.7 , pp. 643-653
    • Gupta, S.K.1    Manfro, R.C.2    Tomlanovich, S.J.3
  • 84
    • 0028820208 scopus 로고
    • Differentiation of absorption and firstpass gut and hepatic metabolism in humans: Studies with cyclosporine
    • Wu CY, Benet LZ, Hebert MF, et al. Differentiation of absorption and firstpass gut and hepatic metabolism in humans: studies with cyclosporine. Clin Pharmacol Ther 1995; 58(5): 492-7
    • (1995) Clin Pharmacol Ther , vol.58 , Issue.5 , pp. 492-497
    • Wu, C.Y.1    Benet, L.Z.2    Hebert, M.F.3
  • 85
    • 17644380257 scopus 로고    scopus 로고
    • Predicting drug disposition via application of BCS: Transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system
    • Wu CY, Benet LZ. Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm Res 2005; 22(1): 11-23
    • (2005) Pharm Res , vol.22 , Issue.1 , pp. 11-23
    • Wu, C.Y.1    Benet, L.Z.2
  • 86
    • 36849061528 scopus 로고    scopus 로고
    • Improving the high variable bioavailability of griseofulvin by sedds
    • Arida AI, Al-Tabakha MM, Hamoury HA. Improving the high variable bioavailability of griseofulvin by SEDDS. Chem Pharm Bull (Tokyo) 2007; 55(12): 1713-19
    • (2007) Chem Pharm Bull (Tokyo , vol.55 , Issue.12 , pp. 1713-1719
    • Arida, A.I.1    Al-Tabakha, M.M.2    Hamoury, H.A.3
  • 87
    • 60749119779 scopus 로고    scopus 로고
    • The use of liquid selfmicroemulsifying drug delivery systems based on peanut oil/tween 80 in the delivery of griseofulvin
    • Ofokansi KC, Chukwu KI, Ugwuanyi SI. The use of liquid selfmicroemulsifying drug delivery systems based on peanut oil/tween 80 in the delivery of griseofulvin. Drug Dev Ind Pharm 2009; 35(2): 185-91
    • (2009) Drug Dev Ind Pharm , vol.35 , Issue.2 , pp. 185-191
    • Ofokansi, K.C.1    Chukwu, K.I.2    Ugwuanyi, S.I.3
  • 88
    • 34548094059 scopus 로고    scopus 로고
    • Bioavailability assessment of vitamin A self-nanoemulsified drug delivery systems in rats: A comparative study
    • Taha E, Ghorab D, Zaghloul AA. Bioavailability assessment of vitamin A self-nanoemulsified drug delivery systems in rats: a comparative study. Med Princ Pract 2007; 16(5): 355-9
    • (2007) Med Princ Pract , vol.16 , Issue.5 , pp. 355-359
    • Taha, E.1    Ghorab, D.2    Zaghloul, A.A.3
  • 89
    • 0028329964 scopus 로고
    • Improved dose linearity of cyclosporine pharmacokinetics from a microemulsion formulation
    • Mueller EA, Kovarik JM, van Bree JB, et al. Improved dose linearity of cyclosporine pharmacokinetics from a microemulsion formulation. Pharm Res 1994; 11(2): 301-4
    • (1994) Pharm Res , vol.11 , Issue.2 , pp. 301-304
    • Mueller, E.A.1    Kovarik, J.M.2    Van Bree, J.B.3
  • 90
    • 44849087456 scopus 로고    scopus 로고
    • Design and evaluation of self-microemulsifying drug delivery system (smedds) of tacrolimus
    • Borhade V, Nair H, Hegde D. Design and evaluation of self-microemulsifying drug delivery system (SMEDDS) of tacrolimus. AAPS PharmSciTech 2008; 9(1): 13-21
    • (2008) AAPS PharmSciTech , vol.9 , Issue.1 , pp. 13-21
    • Borhade, V.1    Nair, H.2    Hegde, D.3
  • 91
    • 55949089032 scopus 로고    scopus 로고
    • A new self-emulsifying drug delivery system (sedds) for poorly soluble drugs: Characterization, dissolution, in vitro digestion and incorporation into solid pellets
    • Abdalla A, Klein S, Mader K. A new self-emulsifying drug delivery system (SEDDS) for poorly soluble drugs: characterization, dissolution, in vitro digestion and incorporation into solid pellets. Eur J Pharm Sci 2008; 35(5): 457-64
    • (2008) Eur J Pharm Sci , vol.35 , Issue.5 , pp. 457-464
    • Abdalla, A.1    Klein, S.2    Mader, K.3
  • 92
    • 39149091886 scopus 로고    scopus 로고
    • Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs
    • Cuine JF, McEvoy CL, Charman WN, et al. Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs. J Pharm Sci 2008; 97(2): 995-1012
    • (2008) J Pharm Sci , vol.97 , Issue.2 , pp. 995-1012
    • Cuine, J.F.1    McEvoy, C.L.2    Charman, W.N.3
  • 93
    • 77955286114 scopus 로고    scopus 로고
    • Contributions of human cytochrome P450 enzymes to glyburide metabolism
    • Zhou L, Naraharisetti SB, Liu L, et al. Contributions of human cytochrome P450 enzymes to glyburide metabolism. Biopharm Drug Dispos 2010; 31(4): 228-42
    • (2010) Biopharm Drug Dispos , vol.31 , Issue.4 , pp. 228-242
    • Zhou, L.1    Naraharisetti, S.B.2    Liu, L.3
  • 94
    • 70349238697 scopus 로고    scopus 로고
    • Design of lipid-based formulations for oral administration of poorly watersoluble drugs: Precipitation of drug after dispersion of formulations in aqueous solution
    • Mohsin K, Long MA, Pouton CW. Design of lipid-based formulations for oral administration of poorly watersoluble drugs: precipitation of drug after dispersion of formulations in aqueous solution. J Pharm Sci 2009; 98(10): 3582-95
    • (2009) J Pharm Sci , vol.98 , Issue.10 , pp. 3582-3595
    • Mohsin, K.1    Long, M.A.2    Pouton, C.W.3
  • 95
    • 84909986008 scopus 로고    scopus 로고
    • Improved oral bioavailability of glyburide by a selfnanoemulsifying drug delivery system
    • Liu H, Shang K, Liu W, et al. Improved oral bioavailability of glyburide by a selfnanoemulsifying drug delivery system. J Microencapsul 2014; 31(3): 277-83
    • (2014) J Microencapsul , vol.31 , Issue.3 , pp. 277-283
    • Liu, H.1    Shang, K.2    Liu, W.3
  • 96
    • 84903145263 scopus 로고    scopus 로고
    • Optimized selfnanoemulsifying drug delivery system of atazanavir with enhanced oral bioavailability: In vitro/in vivo characterization
    • Singh G, Pai RS. Optimized selfnanoemulsifying drug delivery system of atazanavir with enhanced oral bioavailability: in vitro/in vivo characterization. Expert Opin Drug Deliv 2014; 11(7): 1023-32
    • (2014) Expert Opin Drug Deliv , vol.11 , Issue.7 , pp. 1023-1032
    • Singh, G.1    Pai, R.S.2
  • 97
    • 84897443886 scopus 로고    scopus 로고
    • Formulation characterization and in vivo evaluation of selfnanoemulsifying drug delivery system for oral delivery of valsartan
    • Chopra M, Nayak UY, Gurram AK, et al. Formulation, characterization and In vivo evaluation of selfnanoemulsifying drug delivery system for oral delivery of valsartan. Cur Nutr Food Sci 2014; 10(2): 263-70
    • (2014) Cur Nutr Food Sci , vol.10 , Issue.2 , pp. 263-270
    • Chopra, M.1    Nayak, U.Y.2    Gurram, A.K.3
  • 98
    • 84922381584 scopus 로고    scopus 로고
    • Self-nanoemulsifying drug delivery system (snedds) of the poorly watersoluble grapefruit flavonoid naringenin: Design, characterization, in vitro and in vivo evaluation
    • Epub ahead of print
    • Khan AW, Kotta S, Ansari SH, et al. Self-nanoemulsifying drug delivery system (SNEDDS) of the poorly watersoluble grapefruit flavonoid Naringenin: design, characterization, in vitro and in vivo evaluation. Drug Deliv 2014. [Epub ahead of print
    • (2014) Drug Deliv
    • Khan, A.W.1    Kotta, S.2    Ansari, S.H.3
  • 99
    • 84862658209 scopus 로고    scopus 로고
    • Nanoemulsions as self-emulsified drug delivery carriers for enhanced permeability of the poorly water-soluble selective b1-adrenoreceptor blocker talinolol
    • Ghai D, Sinha VR. Nanoemulsions as self-emulsified drug delivery carriers for enhanced permeability of the poorly water-soluble selective b1-adrenoreceptor blocker talinolol. Nanomedicine 2012; 8(5): 618-26
    • (2012) Nanomedicine , vol.8 , Issue.5 , pp. 618-626
    • Ghai, D.1    Sinha, V.R.2
  • 100
    • 84883377214 scopus 로고    scopus 로고
    • Self nano-emulsifying simvastatin based tablets: Design and in vitro/in vivo evaluation
    • Abdelbary G, Amin M, Salah S. Self nano-emulsifying simvastatin based tablets: design and in vitro/in vivo evaluation. Pharm Dev Technol 2013; 18(6): 1294-304
    • (2013) Pharm Dev Technol , vol.18 , Issue.6 , pp. 1294-1304
    • Abdelbary, G.1    Amin, M.2    Salah, S.3


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