Optimized self-nanoemulsifying drug delivery system of atazanavir with enhanced oral bioavailability: in vitro/in vivo characterization

Expert Opinion on Drug Delivery

Volumn 11, Issue 7, 2014, Pages 1023-1032

  Singh, Gurinder ^a   Pai, Roopa S ^a  

^a AL AMEEN COLLEGE OF PHARMACY   (India)

Author keywords

Bioavailability; Central composite design; in vitro in vivo correlation; Pharmacokinetic study; Self nanoemulsifying drug delivery system

Indexed keywords

ATAZANAVIR; LIPID; LONG CHAIN TRIACYLGLYCEROL; MAISINE 35 1; SORBITAN LAURATE; SURFACTANT; TRANSCUTOL P; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; COOLING; DISSOLUTION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG FORMULATION; DRUG HALF LIFE; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; HEATING; IN VITRO STUDY; IN VIVO STUDY; INTESTINE PERFUSION; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NANOEMULSION; NONHUMAN; ORAL DRUG ADMINISTRATION; PARTICLE SIZE; RAT; THERMODYNAMICS; TIME TO MAXIMUM PLASMA CONCENTRATION; ZETA POTENTIAL;

BIOAVAILABILITY; CENTRAL COMPOSITE DESIGN; IN VITRO/IN VIVO CORRELATION; PHARMACOKINETIC STUDY; SELF-NANOEMULSIFYING DRUG-DELIVERY SYSTEM;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DELIVERY SYSTEMS; EMULSIONS; HALF-LIFE; HIV PROTEASE INHIBITORS; MALE; NANOPARTICLES; OLIGOPEPTIDES; PYRIDINES; RATS; RATS, WISTAR; SOLUBILITY;

EID: 84903145263     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2014.913566     Document Type: Article

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