Oral bioavailability of cinnarizine in dogs: Relation to SNEDDS droplet size, drug solubility and in vitro precipitation

European Journal of Pharmaceutical Sciences

Volumn 48, Issue 1-2, 2013, Pages 339-350

  Larsen, Anne T ^a   Ohlsson, Anja G ^a   Polentarutti, Britta ^b   Barker, Richard A ^c   Phillips, Andrew R ^c   Abu Rmaileh, Ragheb ^c   Dickinson, Paul A ^c   Abrahamsson, Bertil ^b   Østergaard, Jesper ^a   Müllertz, Anette ^a,d  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b ASTRAZENECA R AND D   (Sweden)

^c ASTRAZENECA   (United Kingdom)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Bioavailability; Cinnarizine; Lipolysis; Oral delivery; Self nanoemulsifying drug delivery systems

Indexed keywords

CINNARIZINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; DOG; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; IN VITRO STUDY; LIPOLYSIS; MAXIMUM PLASMA CONCENTRATION; NANOEMULSION; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; STOMACH PH; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHEMICAL PRECIPITATION; CINNARIZINE; DOGS; DRUG DELIVERY SYSTEMS; LIPOLYSIS; MALE; SOLUBILITY;

EID: 84871441882     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.11.004     Document Type: Article

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