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Volumn 39, Issue 2-3, 1996, Pages 139-143

Intestinal drug metabolism and antitransport processes: A potential paradigm shift in oral drug delivery

Author keywords

Counter transport; Cyclosporin; Cytochrome P450 3A; Gut metabolism; P glycoprotein

Indexed keywords

CYCLOSPORIN; CYTOCHROME P450;

EID: 0030002504     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-3659(95)00147-6     Document Type: Conference Paper
Times cited : (189)

References (12)
  • 1
    • 0002637713 scopus 로고    scopus 로고
    • Factors influencing drug absorption and drug availability
    • G.S. Banker and C.T. Rhodes (Eds), Marcel Dekker, New York
    • B. Hoener and L.Z. Benet, Factors influencing drug absorption and drug availability, in: G.S. Banker and C.T. Rhodes (Eds), Modern Pharmaceutics, 3rd Edn, Marcel Dekker, New York, 1996, pp. 121-153.
    • (1996) Modern Pharmaceutics, 3rd Edn , pp. 121-153
    • Hoener, B.1    Benet, L.Z.2
  • 3
    • 0027366792 scopus 로고
    • Individual variation in first-pass metabolism
    • Y.K. Tam, Individual variation in first-pass metabolism, Clin. Pharmacokinet. 25 (1993) 300-328 .
    • (1993) Clin. Pharmacokinet. , vol.25 , pp. 300-328
    • Tam, Y.K.1
  • 5
    • 0023588109 scopus 로고
    • Identification of glucocorticoid-inducible cytochromes P-450 in intestinal mucosa of rats and man
    • P.B. Watkins, S.A. Wrighton, E.G. Schuetz, D.T. Molowa and P.S. Guzelian, Identification of glucocorticoid-inducible cytochromes P-450 in intestinal mucosa of rats and man. J. Clin. Invest. 80 (1987) 1029-1036.
    • (1987) J. Clin. Invest. , vol.80 , pp. 1029-1036
    • Watkins, P.B.1    Wrighton, S.A.2    Schuetz, E.G.3    Molowa, D.T.4    Guzelian, P.S.5
  • 6
    • 0026464616 scopus 로고
    • Identification of rifampin-inducible P450IIIA4 (CYP 3A4) in human small bowel enterocytes
    • J.C. Kolars, P. Schmiedlin-Ren, J.D. Schuetz, C. Fang and P.B. Watkins, Identification of rifampin-inducible P450IIIA4 (CYP 3A4) in human small bowel enterocytes. J. Clin. Invest. 90 (1992) 1871-1878.
    • (1992) J. Clin. Invest. , vol.90 , pp. 1871-1878
    • Kolars, J.C.1    Schmiedlin-Ren, P.2    Schuetz, J.D.3    Fang, C.4    Watkins, P.B.5
  • 7
    • 0025719746 scopus 로고
    • First-pass metabolism of cyclosporin by the gut
    • J.C. Kolars, W.M. Awni, R.M. Merion and P.B. Watkins, First-pass metabolism of cyclosporin by the gut, Lancet 338 (1991) 1488-1490.
    • (1991) Lancet , vol.338 , pp. 1488-1490
    • Kolars, J.C.1    Awni, W.M.2    Merion, R.M.3    Watkins, P.B.4
  • 8
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome P-450 3A and P-glycoprotein have implications for drug delivery and activity in cancer chemotherapy
    • V.J. Wacher, C.Y. Wu and L.Z. Benet, Overlapping substrate specificities and tissue distribution of cytochrome P-450 3A and P-glycoprotein have implications for drug delivery and activity in cancer chemotherapy, Mol. Carcinog. 13 (1995) 129-134.
    • (1995) Mol. Carcinog. , vol.13 , pp. 129-134
    • Wacher, V.J.1    Wu, C.Y.2    Benet, L.Z.3
  • 9
    • 0343207223 scopus 로고
    • Use of i.v. and oral drug levels from cyclosporine (CsA) with concomitant rifampin to differentiate gut absorption and metabolism
    • C.Y. Wu, M.F. Hebert and L.Z. Benet, Use of i.v. and oral drug levels from cyclosporine (CsA) with concomitant rifampin to differentiate gut absorption and metabolism, Pharm. Res. 10 (1993) S345.
    • (1993) Pharm. Res. , vol.10
    • Wu, C.Y.1    Hebert, M.F.2    Benet, L.Z.3
  • 11
    • 0026457407 scopus 로고
    • Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction
    • M.F. Hebert, J.P. Roberts, T. Prueksaritanont and L.Z. Benet, Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction, Clin. Pharmacol. Ther. 52 (1992) 453-455.
    • (1992) Clin. Pharmacol. Ther. , vol.52 , pp. 453-455
    • Hebert, M.F.1    Roberts, J.P.2    Prueksaritanont, T.3    Benet, L.Z.4
  • 12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.