Stimulation of triglyceride-rich lipoprotein secretion by polysorbate 80: In vitro and in vivo correlation using caco-2 cells and a cannulated rat intestinal lymphatic model

Pharmaceutical Research

Volumn 21, Issue 12, 2004, Pages 2320-2326

  Seeballuck, Fergal ^a   Lawless, Emma ^a   Ashford, Marianne B ^b   O'Driscoll, Caitriona M ^a,c  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b ASTRAZENECA   (United Kingdom)

^c UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Bioactive excipients; Caco 2; Lipoproteins; Mesenteric lymph; Polysorbate

Indexed keywords

CHYLOMICRON; CREMOPHOR; LIPOPROTEIN; OLEIC ACID; POLYSORBATE 60; POLYSORBATE 80; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SECRETION; CELL STRAIN CACO 2; CONTROLLED STUDY; DATA ANALYSIS; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; IN VIVO STUDY; INHIBITION KINETICS; INTESTINE; LIPOPROTEIN SECRETION; LYMPH NODE; LYMPH VESSEL; MALE; MESENTERY LYMPH NODE; MONOLAYER CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CACO-2 CELLS; CATHETERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DUODENUM; FATTY ACIDS; HUMANS; LIPOPROTEINS; LYMPHATIC VESSELS; MALE; MESENTERY; MODELS, BIOLOGICAL; POLYSORBATES; RATS; RATS, WISTAR; TRIGLYCERIDES;

EID: 17644402482     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11095-004-7684-4     Document Type: Article

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