Pharmaceutical excipients influence the function of human uptake transporting proteins

Molecular Pharmaceutics

Volumn 9, Issue 9, 2012, Pages 2577-2581

  Engel, Anett ^a   Oswald, Stefan ^a   Siegmund, Werner ^a   Keiser, Markus ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Cremophor; excipient; HEK cells; hydroxypropyl yclodextrin; NTCP; OATP; polyethylene glycol; Solutol; uptake transporter

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; BROMSULFOPHTHALEIN; CARRIER PROTEIN; CREMOPHOR; ESTRADIOL 17 GLUCURONIDE; ESTRONE SULFATE; EXCIPIENT; MACROGOL 400; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1A2; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B1; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B3; ORGANIC ANION TRANSPORTING POLYPEPTIDE 2B1; PREDNISOLONE; SOLUBILIZER; SOLUTOL HS 15; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; EMBRYO; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN TRANSPORT;

BETA-CYCLODEXTRINS; BIOLOGICAL TRANSPORT; CELL LINE; ESTRADIOL; ESTRONE; EXCIPIENTS; GLYCEROL; HEK293 CELLS; HUMANS; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; POLYETHYLENE GLYCOLS; STEARIC ACIDS; SULFOBROMOPHTHALEIN; SYMPORTERS; TAUROCHOLIC ACID;

EID: 84865963648     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp3001815     Document Type: Article

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