Abrogation of adenosine A1 receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses

Diabetologia

Volumn 58, Issue 7, 2015, Pages 1610-1620

  Yang, Ting ^a   Gao, Xiang ^b   Sandberg, Monica ^b   Zollbrecht, Christa ^a   Zhang, Xing Mei ^a   Hezel, Michael ^a   Liu, Ming ^a   Peleli, Maria ^a   Lai, En Yin ^c   Harris, Robert A ^a   Persson, A Erik G ^b   Fredholm, Bertil B ^a   Jansson, Leif ^b   Carlström, Mattias ^a,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c GEORGETOWN UNIVERSITY   (United States)

Author keywords

Insulin sensitivity and resistance; Islets; Metabolic physiology in vivo; Metabolic syndrome; Oxidative stress; Type 2 diabetes; Visceral adipose tissue

Indexed keywords

ADENOSINE A1 RECEPTOR; ANGIOTENSIN II; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; CYBB PROTEIN, MOUSE; CYTOKINE; MEMBRANE PROTEIN;

ABDOMINAL FAT; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIOLE; ARTICLE; BLOOD VESSEL REACTIVITY; BODY COMPOSITION; BODY WEIGHT; CD4+ T LYMPHOCYTE; CELL SUSPENSION; CHEMOLUMINESCENCE; CLEARANCE; COMPARATIVE STUDY; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; INTRAABDOMINAL FAT; MACROPHAGE; METABOLIC REGULATION; MICROVASCULATURE; MODULATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ADIPOSE TISSUE; ANIMAL; BLOOD FLOW; C57BL MOUSE; FEMALE; GENETICS; GLUCOSE INTOLERANCE; INSULIN RESISTANCE; KNOCKOUT MOUSE; MALE; METABOLISM; PHYSIOLOGY; VASCULARIZATION;

ADIPOSE TISSUE; AGING; ANGIOTENSIN II; ANIMALS; BODY COMPOSITION; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; FEMALE; GLUCOSE INTOLERANCE; INFLAMMATION; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE; MEMBRANE GLYCOPROTEINS; METABOLISM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NADPH OXIDASE; OXIDATIVE STRESS; RECEPTOR, ADENOSINE A1; REGIONAL BLOOD FLOW; SIGNAL TRANSDUCTION;

EID: 84931576794     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3570-3     Document Type: Article

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