A1 receptor deficiency causes increased insulin and glucagon secretion in mice

Biochemical Pharmacology

Volumn 74, Issue 11, 2007, Pages 1628-1635

  Johansson, Stina M ^a   Salehi, Albert ^b   Sandström, Marie E ^a   Westerblad, Håkan ^a   Lundquist, Ingmar ^b   Carlsson, Per Ola ^c   Fredholm, Bertil B ^a   Katz, Abram ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

A1 receptor; Adenosine; Glucose uptake; Insulin sensitivity; Islet hormone secretion; Metabolism

Indexed keywords

ADENOSINE A1 RECEPTOR; GLUCAGON; HEMOGLOBIN A1C; INSULIN; MESSENGER RNA; RECEPTOR SUBTYPE; DEOXYGLUCOSE; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; GENOTYPE; GLUCAGON RELEASE; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; INSULIN BLOOD LEVEL; INSULIN RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PANCREAS PERFUSION; PRIORITY JOURNAL; SKELETAL MUSCLE; ANIMAL; BLOOD; C57BL MOUSE; CYTOLOGY; DRUG EFFECT; FEMALE; GENETICS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; METABOLISM; MOUSE MUTANT; MOUSE STRAIN; MUSCLE CONTRACTION; PANCREAS ISLET; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION; TIME;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DEOXYGLUCOSE; FEMALE; GENOTYPE; GLUCAGON; GLUCOSE; GLUCOSE TOLERANCE TEST; HEMOGLOBIN A, GLYCOSYLATED; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENOUS; INSULIN; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; MUSCLE CONTRACTION; MUSCLE, SKELETAL; RECEPTOR, ADENOSINE A1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS;

EID: 35349004692     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.08.006     Document Type: Article

References (50)

1. Fredholm B.B., IJzerman A.P., Jacobson K.A., Klotz K.N., and Linden J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53 (2001) 527-552
2. Fredholm B.B., Bättig K., Holmén J., Nehlig A., and Zvartau E.E. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 51 (1999) 83-133
3. van Dam R.M., and Hu F.B. Coffee consumption and risk of type 2 diabetes: a systematic review. J Am Med Assoc 294 (2005) 97-104
4. van Dam R.M., and Feskens E.J. Coffee consumption and risk of type 2 diabetes mellitus. Lancet 360 (2002) 1477-1478
5. Schwabe U., Schonhofer P.S., and Ebert R. Facilatation by adenosine of the action of insulin on the accumulation of adenosine 3′,5′-monophosphate lipolysisand glucose oxidation in isolated fat cells. Eur J Biochem 46 (1974) 537
6. Crist G.H., Xu B., Lanoue K.F., and Lang C.H. Tissue-specific effects of in vivo adenosine receptor blockade on glucose uptake in Zucker rats. FASEB J 12 (1998) 1301-1308
7. Dong Q., Ginsberg H.N., and Erlanger B.F. Overexpression of the A1 adenosine receptor in adipose tissue protects mice from obesity-related insulin resistance. Diabetes Obes Metab 3 (2001) 360-366
8. Xu B., Berkich D.A., Crist G.H., and LaNoue K.F. A1 adenosine receptor antagonism improves glucose tolerance in Zucker rats. Am J Physiol 274 (1998) E271-E279
9. Ismail N.A., El Denshary E.E., and Montague W. Adenosine and the regulation of insulin secretion by isolated rat islets of Langerhans. Biochem J 164 (1977) 409-413
10. Campbell I.L., and Taylor K.W. Effects of adenosine, 2-deoxyadenosine and N6-phenylisopropyladenosine on rat islet function and metabolism. Biochem J 204 (1982) 689-696
11. Hillaire-Buys D., Gross R., Loubatières-Mariani M.M., and Ribes G. Effect of pertussis toxin on A1-receptor-mediated inhibition of insulin secretion. Br J Pharmacol 96 (1989) 3-4
12. Petrack B., Czernik A.J., Ansell J., and Cassidy J. Potentiation of arginine-induced glucagon secretion by adenosine. Life Sci 28 (1981) 2611-2615
13. Chapal J., Loubatières-Mariani M.M., Roye M., and Zerbib A. Effects of adenosine, adenosine triphosphate and structural analogues on glucagon secretion from the perfused pancreas of rat in vitro. Br J Pharmacol 83 (1984) 927-933
14. Chapal J., Loubatières-Mariani M.M., Petit P., and Roye M. Evidence for an A2-subtype adenosine receptor on pancreatic glucagon secreting cells. Br J Pharmacol 86 (1985) 565-569
15. Vergauwen L., Hespel P., and Richter E.A. Adenosine receptors mediate synergistic stimulation of glucose uptake and transport by insulin and by contractions in rat skeletal muscle. J Clin Invest 93 (1994) 974-981
16. Han D.H., Hansen P.A., Nolte L.A., and Holloszy J.O. Removal of adenosine decreases the responsiveness of muscle glucose transport to insulin and contractions. Diabetes 47 (1998) 1671-1675
17. Cheng J.T., Chi T.C., and Liu I.M. Activation of adenosine A1 receptors by drugs to lower plasma glucose in streptozotocin-induced diabetic rats. Auton Neurosci 83 (2000) 127-133
18. Thong F.S., Derave W., Kiens B., Graham T.E., Ursø B., Wojtaszewski J.F., et al. Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise. Diabetes 51 (2002) 583-590
19. Leighton B., Lozeman F.J., Vlachonikolis I.G., Challiss R.A., Pitcher J.A., and Newsholme E.A. Effects of adenosine deaminase on the sensitivity of glucose transport, glycolysis and glycogen synthesis to insulin in muscles of the rat. Int J Biochem 20 (1988) 23-27
20. Budohoski L., Challiss R.A., McManus B., and Newsholme E.A. Effects of analogues of adenosine and methyl xanthines on insulin sensitivity in soleus muscle of the rat. FEBS Lett 167 (1984) 1-4
21. Espinal J., Challiss R.A., and Newsholme E.A. Effect of adenosine deaminase and an adenosine analogue on insulin sensitivity in soleus muscle of the rat. FEBS Lett 158 (1983) 103-106
22. Challis R.A., Budohoski L., McManus B., and Newsholme E.A. Effects of an adenosine-receptor antagonist on insulin-resistance in soleus muscle from obese Zucker rats. Biochem J 221 (1984) 915-917
23. Johansson B., Halldner L., Dunwiddie T.V., Masino S.A., Poelchen W., Giménez-Llort L., et al. Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc Natl Acad Sci USA 98 (2001) 9407-9412
24. Turner C.P., Seli M., Ment L., Stewart W., Yan H., Johansson B., et al. A1 adenosine receptors mediate hypoxia-induced ventriculomegaly. Proc Natl Acad Sci USA 100 (2003) 11718-11722
25. Rerup C., and Lundquist I. Blood glucose level in mice. 1. Evaluation of a new technique of multiple serial sampling. Acta Endocrinol 52 (1966) 357-367
26. Johansson M., Jansson L., and Carlsson P.O. Improved vascular engraftment and function of autotransplanted pancreatic islets as a result of partial pancreatectomy in the mouse and rat. Diabetologia 50 (2007) 1257-1266
27. Jing X., Li D.Q., Olofsson C.S., Salehi A., Surve V.V., Caballero J., et al. CaV2.3 calcium channels control second-phase insulin release. J Clin Invest 115 (2005) 146-154
28. Sandström M.E., Zhang S.J., Bruton J., Silva J.P., Reid M.B., Westerblad H., et al. Role of reactive oxygen species in contraction-mediated glucose transport in mouse skeletal muscle. J Physiol 575 (2006) 251-262
29. Shashkin P., Koshkin A., Langley D., Ren J.M., Westerblad H., and Katz A. Effects of CGS 9343B (a putative calmodulin antagonist) on isolated skeletal muscle. Dissociation of signaling pathways for insulin-mediated activation of glycogen synthase and hexose transport. J Biol Chem 270 (1995) 25613-25618
30. Halldner L., Lopes L.V., Daré E., Lindström K., Johansson B., Ledent C., et al. Binding of adenosine receptor ligands to brain of adenosine receptor knock-out mice: evidence that CGS 21680 binds to A1 receptors in hippocampus. Naunyn Schmiedebergs Arch Pharmacol 370 (2004) 270-278
31. Chunn J.L., Young H.W., Banerjee S.K., Colasurdo G.N., and Blackburn M.R. Adenosine-dependent airway inflammation and hyperresponsiveness in partially adenosine deaminase-deficient mice. J Immunol 167 (2001) 4676-4685
32. Heding L. A simplified insulin radioimmunoassaymethod. In: Donato L., Milhaud G., and Sirchis J. (Eds). Labelled proteins in tracer studies (1966), Euratom, Brussels 345-350
33. Panagiotidis G., Salehi A.A., Westermark P., and Lundquist I. Homologous islet amyloid polypeptide: effects on plasma levels of glucagon, insulin and glucose in the mouse. Diabetes Res Clin Pract 18 (1992) 167-171
34. Salehi A., Chen D., Håkanson R., Nordin G., and Lundquist I. Gastrectomy induces impaired insulin and glucagon secretion: evidence for a gastro-insular axis in mice. J Physiol 514 (1999) 579-591
35. Vannucci S.J., Klim C.M., Martin L.F., and LaNoue K.F. A1-adenosine receptor-mediated inhibition of adipocyte adenylate cyclase and lipolysis in Zucker rats. Am J Physiol 257 (1989) E871-E878
36. Fredholm B.B. Effect of adenosine, adenosine analogues and drugs inhibiting adenosine inactivation on lipolysis in rat fat cells. Acta Physiol Scand 102 (1978) 191-198
37. Cheng J.T., Liu I.M., Chi T.C., Shinozuka K., Lu F.H., Wu T.J., et al. Role of adenosine in insulin-stimulated release of leptin from isolated white adipocytes of Wistar rats. Diabetes 49 (2000) 20-24
38. Yang J.N., Tiselius C., Daré E., Johansson B., Valen G., and Fredholm B.B. Sex differences in mouse heart rate and body temperature and in their regulation by adenosine A1 receptors. Acta Physiol (Oxf) 190 (2007) 63-75
39. DeFronzo R.A., Gunnarsson R., Björkman O., Olsson M., and Wahren J. Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest 76 (1985) 149-155
40. Claus T.H., and Pilkis S.J. Regulation by insulin of gluconeogenesis in isolated rat hepatocytes. Biochim Biophys Acta 421 (1976) 246-262
41. Joost H.G., and Steinfelder H.J. Modulation of insulin sensitivity by adenosine. Effects on glucose transport, lipid synthesis, and insulin receptors of the adipocyte. Mol Pharmacol 22 (1982) 614-618
42. Martin S.E., and Bockman E.L. Adenosine regulates blood flow and glucose uptake in adipose tissue of dogs. Am J Physiol 250 (1986) H1127-H1135
43. Law W.R., and Raymond R.M. Adenosine potentiates insulin-stimulated myocardinal glucose uptake in vivo. Am J Physiol 254 (1988) 970-975
44. Angello D.A., Berne R.M., and Coddington N.M. Adenosine and insulin mediate glucose uptake in normoxic rat hearts by different mechanisms. Am J Physiol 265 (1993) H880-H885
45. Hillaire-Buys D., Chapal J., Bertrand G., Petit P., and Loubatières-Mariani M.M. Purinergic receptors on insulin-secreting cells. Fundam Clin Pharmacol 8 (1994) 117-127
46. Hillaire-Buys D., Bertrand G., Gross R., and Loubatières-Mariani M.M. Evidence for an inhibitory A1 subtype adenosine receptor on pancreatic insulin-secreting cells. Eur J Pharmacol 136 (1987) 109-112
47. Hashiguchi H., Nakazaki M., Koriyama N., Fukudome M., Aso K., and Tei C. Cyclic AMP/cAMP-GEF pathway amplifies insulin exocytosis induced by Ca2+ and ATP in rat islet beta-cells. Diabetes Metab Res Rev 22 (2006) 64-71
48. Rüsing D., Müller C.E., and Verspohl E.J. The impact of adenosine and A(2B) receptors on glucose homoeostasis. J Pharm Pharmacol 58 (2006) 1639-1645
49. Olofsson C.S., Göpel S.O., Barg S., Galvanovskis J., Ma X., Salehi A., et al. Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells. Pflugers Arch 444 (2002) 43-51
50. Samols E., Marri G., and Marks V. Interrelationship of glucagon, insulin and glucose. The insulinogenic effect of glucagon. Diabetes 15 (1966) 855-866