Chrysin inhibits diabetic renal tubulointerstitial fibrosis through blocking epithelial to mesenchymal transition

Journal of Molecular Medicine

Volumn 93, Issue 7, 2015, Pages 759-772

  Kang, Min Kyung ^a   Park, Sin Hye ^a   Choi, Yean Jung ^a   Shin, Daekeun ^a   Kang, Young Hee ^a  

^a Hallym University   (South Korea)

Author keywords

Chrysin; Diabetic nephropathy; Epithelial to mesenchymal transition; High glucose; Tubulointerstitial fibrosis

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALVASCULIN; CHRYSIN; COLLAGEN TYPE 4; CONNECTIVE TISSUE GROWTH FACTOR; GELATINASE A; GELATINASE B; GLUCOSE; NERVE CELL ADHESION MOLECULE; OCCLUDIN; PROTEIN ZO1; UVOMORULIN; VIMENTIN; CADHERIN; COLLAGEN; FLAVONOID; MMP2 PROTEIN, HUMAN; OCLN PROTEIN, MOUSE; TJP1 PROTEIN, MOUSE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL MOTILITY; CELL TRANSDIFFERENTIATION; COLLAGEN FIBER; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DIABETIC RENAL TUBULOINTERSTITIAL FIBROSIS; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; HUMAN; HUMAN CELL; KIDNEY CELL; KIDNEY FIBROSIS; KIDNEY TUBULE BASEMENT MEMBRANE; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RENAL PROTECTION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CELL MOTION; CYTOLOGY; DIABETIC NEPHROPATHIES; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; FIBROSIS; HYPERGLYCEMIA; KIDNEY TUBULE; METABOLISM; PATHOLOGY;

ANIMALS; CADHERINS; CELL MOVEMENT; CELLS, CULTURED; COLLAGEN; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROSIS; FLAVONOIDS; HUMANS; HYPERGLYCEMIA; KIDNEY TUBULES; MALE; MATRIX METALLOPROTEINASE 2; MICE; MICE, INBRED C57BL; OCCLUDIN; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84931561134     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-015-1301-3     Document Type: Article

References (41)

1. Chuang PY, Menon MC, He JC (2013) Molecular targets for treatment of kidney fibrosis. J Mol Med (Berl) 91:549–559
2. Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119:1420–1428
3. Kanasaki K, Taduri G, Koya D (2013) Diabetic nephropathy: the role of inflammation in fibroblast activation and kidney fibrosis. Front Endocrinol (Lausanne) 4:7
4. Carew RM, Wang B, Kantharidis P (2012) The role of EMT in renal fibrosis. Cell Tissue Res 347:103–116
5. He J, Xu Y, Koya D, Kanasaki K (2013) Role of the endothelial-to-mesenchymal transition in renal fibrosis of chronic kidney disease. Clin Exp Nephrol 17:488–497
6. Kriz W, Kaissling B, Le Hir M (2011) Epithelial-mesenchymal transition in kidney fibrosis: fact or fantasy? J Clin Invest 121:468–474
7. Strutz F, Zeisberg M, Ziyadeh FN, Yang CQ, Kalluri R, Müller GA, Neilson EG (2002) Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int 61:1714–1728
8. Hackett TL (2012) Epithelial-mesenchymal transition in the pathophysiology of airway remodeling in asthma. Curr Opin Allergy Clin Immunol 12:53–59
9. Hills CE, Squires PE (2010) TGF-beta1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy. Am J Nephrol 31:68–74
10. Loeffler I, Wolf G (2014) Transforming growth factor-β and the progression of renal disease. Nephrol Dial Transplant 29(Suppl 1):i37–i45
11. Kang MK, Li J, Kim JL, Gong JH, Kwak SN, Park JH, Lee JY, Lim SS, Kang YH (2012) Purple corn anthocyanins inhibit diabetes-associated glomerular monocyte activation and macrophage infiltration. Am J Physiol Renal Physiol 303:F1060–F1069
12. Papadimitriou A, Peixoto EB, Silva KC, Lopes de Faria JM, Lopes de Faria JB (2014) Increase in AMPK brought about by cocoa is renoprotective in experimental diabetes mellitus by reducing NOX4/TGFβ-1 signaling. J Nutr Biochem 25:773–784
13. Wen D, Huang X, Zhang M, Zhang L, Chen J, Gu Y, Hao CM (2013) Resveratrol attenuates diabetic nephropathy via modulating angiogenesis. PLoS One 8:e82336
14. Li J, Lim SS, Lee ES, Gong JH, Shin D, Kang IJ, Kang YH (2011) Isoangustone A suppresses mesangial fibrosis and inflammation in human renal mesangial cells. Exp Biol Med (Maywood) 236:435–444
15. Yang YS, Wang CJ, Huang CN, Chen ML, Chen MJ, Peng CH (2013) Polyphenols of Hibiscus sabdariffa improved diabetic nephropathy via attenuating renal epithelial mesenchymal transition. J Agric Food Chem 61:7545–7551
16. Wang JY, Gao YB, Zhang N, Zou DW, Xu LP, Zhu ZY, Li JY, Zhou SN, Cui FQ, Zeng XJ et al (2014) Tongxinluo ameliorates renal structure and function by regulating miR-21-induced epithelial-to-mesenchymal transition in diabetic nephropathy. Am J Physiol Renal Physiol 306:F486–F495
17. Li R, Wang Y, Liu Y, Chen Q, Fu W, Wang H, Cai H, Peng W, Zhang X (2013) Curcumin inhibits transforming growth factor-β1-induced EMT via PPARγ pathway, not Smad pathway in renal tubular epithelial cells. PLoS One 8:e58848
18. Yang B, Huang J, Xiang T, Yin X, Luo X, Huang J, Luo F, Li H, Li H, Ren G (2014) Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrix metalloproteinase-10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway. J Appl Toxicol 34:105–112
19. Feng X, Qin H, Shi Q, Zhang Y, Zhou F, Wu H, Ding S, Niu Z, Lu Y, Shen P (2014) Chrysin attenuates inflammation by regulating M1/M2 status via activating PPARγ. Biochem Pharmacol 89:503–514
20. Mantawy EM, El-Bakly WM, Esmat A, Badr AM, El-Demerdash E (2014) Chrysin alleviates acute doxorubicin cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis. Eur J Pharmacol 728:107–118
21. Ta N, Walle T (2007) Aromatase inhibition by bioavailable methylated flavones. J Steroid Biochem Mol Biol 107:127–129
22. Scanlon CS, Van Tubergen EA, Inglehart RC, D’Silva NJ (2013) Biomarkers of epithelial-mesenchymal transition in squamous cell carcinoma. J Dent Res 92:114–121
23. Bonegio R, Susztak K (2012) Notch signaling in diabetic nephropathy. Exp Cell Res 318:986–992
24. Qi W, Chen X, Poronnik P, Pollock CA (2006) The renal cortical fibroblast in renal tubulointerstitial fibrosis. Int J Biochem Cell Biol 38:1–5
25. Catania JM, Chen G, Parrish AR (2007) Role of matrix metalloproteinases in renal pathophysiologies. Am J Physiol Renal Physiol 292:F905–F911
26. Rao R (2009) Occludin phosphorylation in regulation of epithelial tight junctions. Ann N Y Acad Sci 1165:62–68
27. Li J, Lee YS, Choi JS, Sung HY, Kim JK, Lim SS, Kang YH (2010) Roasted licorice extracts dampen high glucose-induced mesangial hyperplasia and matrix deposition through blocking Akt activation and TGF-beta signaling. Phytomedicine 17:800–810
28. Zhou Q, Zeng R, Xu C, Liu L, Chen L, Kou P, Pei G, Bai S, Zhang Y, Li C et al (2012) Erbin inhibits TGF-β1-induced EMT in renal tubular epithelial cells through an ERK-dependent pathway. J Mol Med (Berl) 90:563–574
29. Garud MS, Kulkarni YA (2014) Hyperglycemia to nephropathy via transforming growth factor beta. Curr Diabetes Rev 10:182–189
30. Pushpavalli G, Kalaiarasi P, Veeramani C, Pugalendi KV (2010) Effect of chrysin on hepatoprotective and antioxidant status in d-galactosamine-induced hepatitis in rats. Eur J Pharmacol 631:36–41
31. Dou W, Zhang J, Zhang E, Sun A, Ding L, Chou G, Wang Z, Mani S (2013) Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-κB signaling pathway. J Pharmacol Exp Ther 345:473–482
32. Lirdprapamongkol K, Sakurai H, Abdelhamed S, Yokoyama S, Maruyama T, Athikomkulchai S, Viriyaroj A, Awale S, Yagita H, Ruchirawat S et al (2013) A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells. Oncol Rep 30:2357–2364
33. Mohammed HA, Ba LA, Burkholz T, Schumann E, Diesel B, Zapp J, Kiemer AK, Ries C, Hartmann RW, Hosny M et al (2011) Facile synthesis of chrysin-derivatives with promising activities as aromatase inhibitors. Nat Prod Commun 6:31–34
34. Ahad A, Ganai AA, Mujeeb M, Siddiqui WA (2014) Chrysin, an anti-inflammatory molecule, abrogates renal dysfunction in type 2 diabetic rats. Toxicol Appl Pharmacol 279:1–7
35. Radisky DC, Kenny PA, Bissell MJ (2007) Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT? J Cell Biochem 101:830–839
36. Du X, Shimizu A, Masuda Y, Kuwahara N, Arai T, Kataoka M, Uchiyama M, Kaneko T, Akimoto T, Iino Y et al (2012) Involvement of matrix metalloproteinase-2 in the development of renal interstitial fibrosis in mouse obstructive nephropathy. Lab Invest 92:1149–1160
37. Sounni NE, Devy L, Hajitou A, Frankenne F, Munaut C, Gilles C, Deroanne C, Thompson EW, Foidart JM, Noel A (2002) MT1-MMP expression promotes tumor growth and angiogenesis through an up-regulation of vascular endothelial growth factor expression. FASEB J 16:555–564
38. Li X, Yamagata K, Nishita M, Endo M, Arfian N, Rikitake Y, Emoto N, Hirata K, Tanaka Y, Minami Y (2013) Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition of tubular epithelial cells during renal fibrosis. Genes Cells 18:608–619
39. Lee DB, Huang E, Ward HJ (2006) Tight junction biology and kidney dysfunction. Am J Physiol Renal Physiol 290:F20–F34
40. Ikenouchi J, Matsuda M, Furuse M, Tsukita S (2003) Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. J Cell Sci 116:1959–1967
41. Zhang K, Zhang H, Xiang H, Liu J, Liu Y, Zhang X, Wang J, Tang (2013) TGF-β1 induces the dissolution of tight junctions in human renal proximal tubular cells: role of the RhoA/ROCK signaling pathway. Int J Mol Med 32:464–468