PSF: Nuclear busy-body or nuclear facilitator?

Wiley Interdisciplinary Reviews: RNA

Volumn 6, Issue 4, 2015, Pages 351-367

  Yarosh, Christopher A ^a   Iacona, Joseph R ^b   Lutz, Carol S ^b   Lynch, Kristen W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; GLYCOGEN SYNTHASE KINASE 3; HISTONE DEACETYLASE 1; LONG UNTRANSLATED RNA; LONG UNTRANSLATED RNA NEAT1; MESSENGER RNA; NUCLEAR PROTEIN; NUCLEIC ACID BINDING PROTEIN; POLYPYRIMIDINE TRACT BINDING PROTEIN ASSOCIATED SPLICING FACTOR; PROTEIN P54NRB; RAD51 PROTEIN; RNA POLYMERASE II; STAT6 PROTEIN; UNCLASSIFIED DRUG; UNTRANSLATED RNA; PTB ASSOCIATED SPLICING FACTOR; RNA BINDING PROTEIN;

3' END PROCESSING; 3' UNTRANSLATED REGION; AMINO ACID SEQUENCE; APOPTOSIS; BIOGENESIS; CARBOXY TERMINAL SEQUENCE; CELL FUNCTION; CELL VIABILITY; CELLULAR DISTRIBUTION; COILED COIL DOMAIN; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GENE EXPRESSION; GENOMIC INSTABILITY; HUMAN; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; NONA PARASPECKLE DOMAIN; NONHUMAN; NUCLEAR RETENTION; PRIORITY JOURNAL; PROLINE RICH PROTEIN DOMAIN; PROLINE RRM LINKER; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; RCG BOX; REGULATORY MECHANISM; REVIEW; RNA PROCESSING; RNA RECOGNITION MOTIF; RNA SPLICING; RNA TRANSCRIPTION; RNA TRANSLATION; SEQUENCE HOMOLOGY; SPLICEOSOME; VIRUS INFECTION; ANIMAL; CHEMISTRY; METABOLISM; PROTEIN TERTIARY STRUCTURE;

ANIMALS; HUMANS; PROTEIN STRUCTURE, TERTIARY; PTB-ASSOCIATED SPLICING FACTOR; RNA-BINDING PROTEINS;

EID: 84931560485     PISSN: 17577004     EISSN: 17577012     Source Type: Journal    
DOI: 10.1002/wrna.1280     Document Type: Review

References (119)

1. Patton JG, Porro EB, Galceran J, Tempst P, Nadal-Ginard B. Cloning and characterization of PSF, a novel pre-mRNA splicing factor. Genes Dev 1993, 7:393-406.
2. Shav-Tal Y, Zipori D. PSF and p54(nrb)/NonO-multi-functional nuclear proteins. FEBS Lett 2002, 531:109-114.
3. Bond CS, Fox AH. Paraspeckles: nuclear bodies built on long noncoding RNA. J Cell Biol 2009, 186:637-644.
4. Passon DM, Lee M, Rackham O, Stanley WA, Sadowska A, Filipovska A, Fox AH, Bond CS. Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation. Proc Natl Acad Sci USA 2012, 109:4846-4850.
5. Fox AH, Bond CS, Lamond AI. P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner. Mol Biol Cell 2005, 16:5304-5315.
6. Kuwahara S, Ikei A, Taguchi Y, Tabuchi Y, Fujimoto N, Obinata M, Uesugi S, Kurihara Y. PSPC1, NONO, and SFPQ are expressed in mouse Sertoli cells and may function as coregulators of androgen receptor-mediated transcription. Biol Reprod 2006, 75:352-359.
7. Fox AH, Lamond AI. Paraspeckles. Cold Spring Harb Perspect Biol 2010, 2:a000687.
8. Chen LL, Carmichael GG. Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA. Mol Cell 2009, 35:467-478.
9. Sasaki YT, Hirose T. How to build a paraspeckle. Genome Biol 2009, 10:227.
10. Heyd F, Lynch KW. PSF controls expression of histone variants and cellular viability in thymocytes. Biochem Biophys Res Commun 2011, 414:743-749.
11. Melton AA, Jackson J, Wang J, Lynch KW. Combinatorial control of signal-induced exon repression by hnRNP L and PSF. Mol Cell Biol 2007, 27:6972-6984.
12. Ha K, Takeda Y, Dynan WS. Sequences in PSF/SFPQ mediate radioresistance and recruitment of PSF/SFPQ-containing complexes to DNA damage sites in human cells. DNA Repair (Amst) 2011, 10:252-259.
13. Kaneko S, Rozenblatt-Rosen O, Meyerson M, Manley JL. The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination. Genes Dev 2007, 21:1779-1789.
14. Lowery LA, Rubin J, Sive H. Whitesnake/sfpq is required for cell survival and neuronal development in the zebrafish. Dev Dyn 2007, 236:1347-1357.
15. Stamova BS, Tian Y, Nordahl CW, Shen MD, Rogers S, Amaral DG, Sharp FR. Evidence for differential alternative splicing in blood of young boys with autism spectrum disorders. Mol Autism 2013, 4:30.
16. Ke YD, Dramiga J, Schutz U, Kril JJ, Ittner LM, Schroder H, Gotz J. Tau-mediated nuclear depletion and cytoplasmic accumulation of SFPQ in Alzheimer's and Pick's disease. PLoS One 2012, 7:e35678.
17. Mathur M, Das S, Samuels HH. PSF-TFE3 oncoprotein in papillary renal cell carcinoma inactivates TFE3 and p53 through cytoplasmic sequestration. Oncogene 2003, 22:5031-5044.
18. Dolnik A, Engelmann JC, Scharfenberger-Schmeer M, Mauch J, Kelkenberg-Schade S, Haldemann B, Fries T, Kronke J, Kuhn MW, Paschka P, et al. Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing. Blood 2012, 120:e83-e92.
19. Duhoux FP, Auger N, De Wilde S, Wittnebel S, Ameye G, Bahloula K, Van den Berg C, Libouton JM, Saussoy P, Grand FH, et al. The t(1;9)(p34;q34) fusing ABL1 with SFPQ, a pre-mRNA processing gene, is recurrent in acute lymphoblastic leukemias. Leuk Res 2012, 35:e114-e117.
20. Jiang FN, He HC, Zhang YQ, Yang DL, Huang JH, Zhu YX, Mo RJ, Chen G, Yang SB, Chen YR, et al. An integrative proteomics and interaction network-based classifier for prostate cancer diagnosis. PLoS One 2013, 8:e63941.
21. Patton JG, Mayer SA, Tempst P, Nadal-Ginard B. Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing. Genes Dev 1991, 5:1237-1251.
22. Wahl MC, Will CL, Luhrmann R. The spliceosome: design principles of a dynamic RNP machine. Cell 2009, 136:701-718.
23. Papasaikas P, Tejedor JR, Vigevani L, Valcarcel J. Functional splicing network reveals extensive regulatory potential of the core spliceosomal machinery. Mol Cell 2015, 57:7-22.
24. Park JW, Parisky K, Celotto AM, Reenan RA, Graveley BR. Identification of alternative splicing regulators by RNA interference in Drosophila. Proc Natl Acad Sci USA 2004, 101:15974-15979.
25. Jurica MS, Moore MJ. Pre-mRNA splicing: awash in a sea of proteins. Mol Cell 2003, 12:5-14.
26. Makarov EM, Makarova OV, Urlaub H, Gentzel M, Will CL, Wilm M, Luhrmann R. Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome. Science 2002, 298:2205-2208.
27. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI. Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. EMBO J 2000, 19:6569-6581.
28. Gozani O, Patton JG, Reed R. A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction. EMBO J 1994, 13:3356-3367.
29. Lindsey LA, Crow AJ, Garcia-Blanco MA. A mammalian activity required for the second step of pre-messenger RNA splicing. J Biol Chem 1995, 270:13415-13421.
30. Fu XD, Ares M Jr. Context-dependent control of alternative splicing by RNA-binding proteins. Nat Rev Genet 2014, 15:689-701.
31. Ray P, Kar A, Fushimi K, Havlioglu N, Chen X, Wu JY. PSF suppresses tau exon 10 inclusion by interacting with a stem-loop structure downstream of exon 10. J Mol Neurosci 2011, 45:453-466.
32. Heyd F, Lynch KW. Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing. Mol Cell 2010, 40:126-137.
33. Kim KK, Kim YC, Adelstein RS, Kawamoto S. Fox-3 and PSF interact to activate neural cell-specific alternative splicing. Nucleic Acids Res 2011, 39:3064-3078.
34. Cho S, Moon H, Loh TJ, Oh HK, Williams DR, Liao DJ, Zhou J, Green MR, Zheng X, Shen H. PSF contacts exon 7 of SMN2 pre-mRNA to promote exon 7 inclusion. Biochim Biophys Acta 2014, 1839:517-525.
35. Jiang Z, Cote J, Kwon JM, Goate AM, Wu JY. Aberrant splicing of tau pre-mRNA caused by intronic mutations associated with the inherited dementia frontotemporal dementia with Parkinsonism linked to chromosome 17. Mol Cell Biol 2000, 20:4036-4048.
36. Cartegni L, Krainer AR. Disruption of an SF2/ASF-dependent exonic splicing enhancer in SMN2 causes spinal muscular atrophy in the absence of SMN1. Nat Genet 2002, 30:377-384.
37. Peng R, Dye BT, Perez I, Barnard DC, Thompson AB, Patton JG. PSF and p54nrb bind a conserved stem in U5 snRNA. RNA 2002, 8:1334-1347.
38. O'Connor JP, Alwine JC, Lutz CS. Identification of a novel, non-snRNP protein complex containing U1A protein. RNA 1997, 3:1444-1455.
39. Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC. The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. RNA 1998, 4:1493-1499.
40. Hall-Pogar T, Liang S, Hague LK, Lutz CS. Specific trans-acting proteins interact with auxiliary RNA polyadenylation elements in the COX-2 3'-UTR. RNA 2007, 13:1103-1115.
41. Liang S, Lutz CS. p54nrb is a component of the snRNP-free U1A (SF-A) complex that promotes pre-mRNA cleavage during polyadenylation. RNA 2006, 12:111-121.
42. Danckwardt S, Kaufmann I, Gentzel M, Foerstner KU, Gantzert AS, Gehring NH, Neu-Yilik G, Bork P, Keller W, Wilm M, et al. Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals. EMBO J 2007, 26:2658-2669.
43. Rosonina E, Ip JY, Calarco JA, Bakowski MA, Emili A, McCracken S, Tucker P, Ingles CJ, Blencowe BJ. Role for PSF in mediating transcriptional activator-dependent stimulation of pre-mRNA processing in vivo. Mol Cell Biol 2005, 25:6734-6746.
44. Shi Y, Di Giammartino DC, Taylor D, Sarkeshik A, Rice WJ, Yates JR III, Frank J, Manley JL. Molecular architecture of the human pre-mRNA 3' processing complex. Mol Cell 2009, 33:365-376.
45. Nakagawa S, Hirose T. Paraspeckle nuclear bodies-useful uselessness? Cell Mol Life Sci 2012, 69:3027-3036.
46. Zhang Z, Carmichael GG. The fate of dsRNA in the nucleus: a p54(nrb)-containing complex mediates the nuclear retention of promiscuously A-to-I edited RNAs. Cell 2001, 106:465-475.
47. Hundley HA, Bass BL. ADAR editing in double-stranded UTRs and other noncoding RNA sequences. Trends Biochem Sci 2010, 35:377-383.
48. Prasanth KV, Prasanth SG, Xuan Z, Hearn S, Freier SM, Bennett CF, Zhang MQ, Spector DL. Regulating gene expression through RNA nuclear retention. Cell 2005, 123:249-263.
49. Sharathchandra A, Lal R, Khan D, Das S. Annexin A2 and PSF proteins interact with p53 IRES and regulate translation of p53 mRNA. RNA Biol 2012, 9:1429-1439.
50. King HA, Cobbold LC, Pichon X, Poyry T, Wilson LA, Booden H, Jukes-Jones R, Cain K, Lilley KS, Bushell M, et al. Remodelling of a polypyrimidine tract-binding protein complex during apoptosis activates cellular IRESs. Cell Death Differ 2014, 21:161-171.
51. Filbin ME, Kieft JS. Toward a structural understanding of IRES RNA function. Curr Opin Struct Biol 2009, 19:267-276.
52. Roepcke S, Stahlberg S, Klein H, Schulz MH, Theobald L, Gohlke S, Vingron M, Walther DJ. A tandem sequence motif acts as a distance-dependent enhancer in a set of genes involved in translation by binding the proteins NonO and SFPQ. BMC Genomics 2011, 12:624.
53. Emili A, Shales M, McCracken S, Xie W, Tucker PW, Kobayashi R, Blencowe BJ, Ingles CJ. Splicing and transcription-associated proteins PSF and p54nrb/nonO bind to the RNA polymerase II CTD. RNA 2002, 8:1102-1111.
54. Moore MJ, Proudfoot NJ. Pre-mRNA processing reaches back to transcription and ahead to translation. Cell 2009, 136:688-700.
55. Wu X, Yoo Y, Okuhama NN, Tucker PW, Liu G, Guan JL. Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners. Nat Cell Biol 2006, 8:756-763.
56. Ferrai C, Naum-Ongania G, Longobardi E, Palazzolo M, Disanza A, Diaz VM, Crippa MP, Scita G, Blasi F. Induction of HoxB transcription by retinoic acid requires actin polymerization. Mol Biol Cell 2009, 20:3543-3551.
57. Mathur M, Tucker PW, Samuels HH. PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors. Mol Cell Biol 2001, 21:2298-2311.
58. Dong X, Sweet J, Challis JR, Brown T, Lye SJ. Transcriptional activity of androgen receptor is modulated by two RNA splicing factors, PSF and p54nrb. Mol Cell Biol 2007, 27:4863-4875.
59. Duong HA, Robles MS, Knutti D, Weitz CJ. A molecular mechanism for circadian clock negative feedback. Science 2011, 332:1436-1439.
60. Dong L, Zhang X, Fu X, Gao X, Zhu M, Wang X, Yang Z, Jensen ON, Saarikettu J, Yao Z, et al. PTB-associated splicing factor (PSF) functions as a repressor of STAT6-mediated Ig epsilon gene transcription by recruitment of HDAC1. J Biol Chem 2011, 286:3451-3459.
61. Imamura K, Imamachi N, Akizuki G, Kumakura M, Kawaguchi A, Nagata K, Kato A, Kawaguchi Y, Sato H, Yoneda M, et al. Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli. Mol Cell 2014, 53:393-406.
62. Wang G, Cui Y, Zhang G, Garen A, Song X. Regulation of proto-oncogene transcription, cell proliferation, and tumorigenesis in mice by PSF protein and a VL30 noncoding RNA. Proc Natl Acad Sci USA 2009, 106:16794-16798.
63. Dutertre M, Lambert S, Carreira A, Amor-Gueret M, Vagner S. DNA damage: RNA-binding proteins protect from near and far. Trends Biochem Sci 2014, 39:141-149.
64. Morozumi Y, Takizawa Y, Takaku M, Kurumizaka H. Human PSF binds to RAD51 and modulates its homologous-pairing and strand-exchange activities. Nucleic Acids Res 2009, 37:4296-4307.
65. Rajesh C, Baker DK, Pierce AJ, Pittman DL. The splicing-factor related protein SFPQ/PSF interacts with RAD51D and is necessary for homology-directed repair and sister chromatid cohesion. Nucleic Acids Res 2011, 39:132-145.
66. Salton M, Lerenthal Y, Wang SY, Chen DJ, Shiloh Y. Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response. Cell Cycle 2010, 9:1568-1576.
67. Akhmedov AT, Lopez BS. Human 100-kDa homologous DNA-pairing protein is the splicing factor PSF and promotes DNA strand invasion. Nucleic Acids Res 2000, 28:3022-3030.
68. Zolotukhin AS, Michalowski D, Bear J, Smulevitch SV, Traish AM, Peng R, Patton J, Shatsky IN, Felber BK. PSF acts through the human immunodeficiency virus type 1 mRNA instability elements to regulate virus expression. Mol Cell Biol 2003, 23:6618-6630.
69. Kula A, Gharu L, Marcello A. HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3. Virology 2013, 435:329-340.
70. Greco-Stewart VS, Thibault CS, Pelchat M. Binding of the polypyrimidine tract-binding protein-associated splicing factor (PSF) to the hepatitis δ virus RNA. Virology 2006, 356:35-44.
71. Landeras-Bueno S, Jorba N, Perez-Cidoncha M, Ortin J. The splicing factor proline-glutamine rich (SFPQ/PSF) is involved in influenza virus transcription. PLoS Pathog 2011, 7:e1002397.
72. Tsukahara T, Haniu H, Matsuda Y. PTB-associated splicing factor (PSF) is a PPARγ-binding protein and growth regulator of colon cancer cells. PLoS One 2013, 8:e58749.
73. Tsukahara T, Matsuda Y, Haniu H. PSF knockdown enhances apoptosis via downregulation of LC3B in human colon cancer cells. Biomed Res Int 2013, 2013:204973.
74. Shav-Tal Y, Cohen M, Lapter S, Dye B, Patton JG, Vandekerckhove J, Zipori D. Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions. Mol Biol Cell 2001, 12:2328-2340.
75. Shav-Tal Y, Lee B, Bar-Haim S, Vandekerckhove J, Zipori D. Enhanced proteolysis of pre-mRNA splicing factors in myeloid cells. Exp Hematol 2000, 28:1029-1038.
76. Kiledjian M, Dreyfuss G. Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box. EMBO J 1992, 11:2655-2664.
77. Thandapani P, O'Connor TR, Bailey TL, Richard S. Defining the RGG/RG motif. Mol Cell 2013, 50:613-623.
78. Ong SE, Mittler G, Mann M. Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. Nat Methods 2004, 1:119-126.
79. Snijders AP, Hung ML, Wilson SA, Dickman MJ. Analysis of arginine and lysine methylation utilizing peptide separations at neutral pH and electron transfer dissociation mass spectrometry. J Am Soc Mass Spectrom 2010, 21:88-96.
80. Lettau M, Pieper J, Gerneth A, Lengl-Janssen B, Voss M, Linkermann A, Schmidt H, Gelhaus C, Leippe M, Kabelitz D, et al. The adapter protein Nck: role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytes. Protein Sci 2010, 19:658-669.
81. Query CC, Bentley RC, Keene JD. A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein. Cell 1989, 57:89-101.
82. Kenan DJ, Query CC, Keene JD. RNA recognition: towards identifying determinants of specificity. Trends Biochem Sci 1991, 16:214-220.
83. Maris C, Dominguez C, Allain FH. The RNA recognition motif, a plastic RNA-binding platform to regulate post-transcriptional gene expression. FEBS J 2005, 272:2118-2131.
84. Daubner GM, Clery A, Allain FH. RRM-RNA recognition: NMR or crystallography...and new findings. Curr Opin Struct Biol 2013, 23:100-108.
85. Oubridge C, Ito N, Evans PR, Teo CH, Nagai K. Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. Nature 1994, 372:432-438.
86. Dominguez C, Fisette JF, Chabot B, Allain FH. Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs. Nat Struct Mol Biol 2010, 17:853-861.
87. Singh M, Wang Z, Koo BK, Patel A, Cascio D, Collins K, Feigon J. Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65. Mol Cell 2012, 47:16-26.
88. Hardin JW, Hu YX, McKay DB. Structure of the RNA binding domain of a DEAD-box helicase bound to its ribosomal RNA target reveals a novel mode of recognition by an RNA recognition motif. J Mol Biol 2010, 402:412-427.
89. Ray D, Kazan H, Cook KB, Weirauch MT, Najafabadi HS, Li X, Gueroussov S, Albu M, Zheng H, Yang A, et al. A compendium of RNA-binding motifs for decoding gene regulation. Nature 2013, 499:172-177.
90. Clery A, Sinha R, Anczukow O, Corrionero A, Moursy A, Daubner GM, Valcarcel J, Krainer AR, Allain FH. Isolated pseudo-RNA-recognition motifs of SR proteins can regulate splicing using a noncanonical mode of RNA recognition. Proc Natl Acad Sci USA 2008, 110:E2802-E2811.
91. Dye BT, Patton JG. An RNA recognition motif (RRM) is required for the localization of PTB-associated splicing factor (PSF) to subnuclear speckles. Exp Cell Res 2001, 263:131-144.
92. Han TW, Kato M, Xie S, Wu LC, Mirzaei H, Pei J, Chen M, Xie Y, Allen J, Xiao G, et al. Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies. Cell 2012, 149:768-779.
93. Kato M, Han TW, Xie S, Shi K, Du X, Wu LC, Mirzaei H, Goldsmith EJ, Longgood J, Pei J, et al. Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell 2012, 149:753-767.
94. Li P, Banjade S, Cheng HC, Kim S, Chen B, Guo L, Llaguno M, Hollingsworth JV, King DS, Banani SF, et al. Phase transitions in the assembly of multivalent signalling proteins. Nature 2012, 483:336-340.
95. Heyd F, Lynch KW. DEGRADE, MOVE, REGROUP: signaling control of splicing proteins. Trends Biochem Sci 2011, 36:397-404.
96. Buxade M, Morrice N, Krebs DL, Proud CG. The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor α. J Biol Chem 2008, 283:57-65.
97. Huang CJ, Tang Z, Lin RJ, Tucker PW. Phosphorylation by SR kinases regulates the binding of PTB-associated splicing factor (PSF) to the pre-mRNA polypyrimidine tract. FEBS Lett 2007, 581:223-232.
98. Jahn SC, Law ME, Corsino PE, Rowe TC, Davis BJ, Law BK. Assembly, activation, and substrate specificity of cyclin D1/Cdk2 complexes. Biochemistry 2013, 52:3489-3501.
99. Rosenberger U, Lehmann I, Weise C, Franke P, Hucho F, Buchner K. Identification of PSF as a protein kinase Cα-binding protein in the cell nucleus. J Cell Biochem 2002, 86:394-402.
100. Sury MD, McShane E, Hernandez-Miranda LR, Birchmeier C, Selbach M. Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins Sfpq and Nono during neuronal differentiation. Mol Cell Proteomics 2015, 14:50-65.
101. Galietta A, Gunby RH, Redaelli S, Stano P, Carniti C, Bachi A, Tucker PW, Tartari CJ, Huang CJ, Colombo E, et al. NPM/ALK binds and phosphorylates the RNA/DNA-binding protein PSF in anaplastic large-cell lymphoma. Blood 2007, 110:2600-2609.
102. Lukong KE, Huot ME, Richard S. BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest. Cell Signal 2009, 21:1415-1422.
103. Hirano K, Erdodi F, Patton JG, Hartshorne DJ. Interaction of protein phosphatase type 1 with a splicing factor. FEBS Lett 1996, 389:191-194.
104. Liu L, Xie N, Rennie P, Challis JR, Gleave M, Lye SJ, Dong X. Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF. Mol Endocrinol 2012, 25:1197-1210.
105. Sumanasekera C, Kelemen O, Beullens M, Aubol BE, Adams JA, Sunkara M, Morris A, Bollen M, Andreadis A, Stamm S. C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1. Nucleic Acids Res 2012, 40:4025-4039.
106. Zhong N, Kim CY, Rizzu P, Geula C, Porter DR, Pothos EN, Squitieri F, Heutink P, Xu J. DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. J Biol Chem 2006, 281:20940-20948.
107. Sabio G, Cerezo-Guisado MI, Del Reino P, Inesta-Vaquera FA, Rousseau S, Arthur JS, Campbell DG, Centeno F, Cuenda A. p38γ regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock. J Cell Sci 2010, 123:2596-2604.
108. Krietsch J, Caron MC, Gagne JP, Ethier C, Vignard J, Vincent M, Rouleau M, Hendzel MJ, Poirier GG, Masson JY. PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks. Nucleic Acids Res 2012, 40:10287-10301.
109. Shav-Tal Y, Blechman J, Darzacq X, Montagna C, Dye BT, Patton JG, Singer RH, Zipori D. Dynamic sorting of nuclear components into distinct nucleolar caps during transcriptional inhibition. Mol Biol Cell 2005, 16:2395-2413.
110. Shav-Tal Y, Lee BC, Bar-Haim S, Schori H, Zipori D. Reorganization of nuclear factors during myeloid differentiation. J Cell Biochem 2001, 81:379-392.
111. Satoh T, Katano-Toki A, Tomaru T, Yoshino S, Ishizuka T, Horiguchi K, Nakajima Y, Ishii S, Ozawa A, Shibusawa N, et al. Coordinated regulation of transcription and alternative splicing by the thyroid hormone receptor and its associating coregulators. Biochem Biophys Res Commun 2014, 451:24-29.
112. Figueroa A, Kotani H, Toda Y, Mazan-Mamczarz K, Mueller EC, Otto A, Disch L, Norman M, Ramdasi RM, Keshtgar M, et al. Novel roles of hakai in cell proliferation and oncogenesis. Mol Biol Cell 2009, 20:3533-3542.
113. Song X, Sui A, Garen A. Binding of mouse VL30 retrotransposon RNA to PSF protein induces genes repressed by PSF: effects on steroidogenesis and oncogenesis. Proc Natl Acad Sci USA 2004, 101:621-626.
114. Hirose T, Virnicchi G, Tanigawa A, Naganuma T, Li R, Kimura H, Yokoi T, Nakagawa S, Benard M, Fox AH, et al. NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies. Mol Biol Cell 2014, 25:169-183.
115. Song X, Sun Y, Garen A. Roles of PSF protein and VL30 RNA in reversible gene regulation. Proc Natl Acad Sci USA 2005, 102:12189-12193.
116. Li L, Feng T, Lian Y, Zhang G, Garen A, Song X. Role of human noncoding RNAs in the control of tumorigenesis. Proc Natl Acad Sci USA 2009, 106:12956-12961.
117. Takayama K, Horie-Inoue K, Katayama S, Suzuki T, Tsutsumi S, Ikeda K, Urano T, Fujimura T, Takagi K, Takahashi S, et al. Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer. EMBO J 2013, 32:1665-1680.
118. Ji Q, Zhang L, Liu X, Zhou L, Wang W, Han Z, Sui H, Tang Y, Wang Y, Liu N, et al. Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex. Br J Cancer 2014, 111:736-748.
119. Lee M, Sadowska A, Bekere I, Ho D, Gully BS, Lu Y, Iyer KS, Trewhella J, Fox AH, Bond CS. The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation. Nucl Acids Res 2015. doi: 10.1093/nar/gkv156. Available at: http://nar.oxfordjournals.org/content/early/2015/03/12/nar.gkv156.full.