p38γ regulates interaction of nuclear PSF and RNA with the tumour-suppressor hDlg in response to osmotic shock

Journal of Cell Science

Volumn 123, Issue 15, 2010, Pages 2596-2604

  Sabio, Guadalupe ^a,b   Cerezo Guisado, María I ^a   Del Reino, Paloma ^a   Iñesta Vaquera, Francisco A ^a   Rousseau, Simon ^b,d   Arthur, J Simon C ^b   Campbell, David G ^b   Centeno, Francisco ^c   Cuenda, Ana ^a,b  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c UNIVERSITY OF EXTREMADURA   (Spain)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

hDlg; Inactive p38 ; Knock in mice; Osmotic shock; p38 ; PSF

Indexed keywords

DISC LARGE PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 12; NUCLEAR PROTEIN; POLYPYRIMIDINE TRACT BINDING PROTEIN; PROTEIN ASSOCIATED SPLICING FACTOR; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; DLG1 PROTEIN, HUMAN; MEMBRANE PROTEIN; PTB ASSOCIATED SPLICING FACTOR; PTB-ASSOCIATED SPLICING FACTOR; RNA; RNA BINDING PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL NUCLEUS; CELL STRESS; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYPEROSMOTIC STRESS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSMOTIC STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; ANIMAL; CELL LINE; GENETICS; HELA CELL; IMMUNOPRECIPITATION; MASS SPECTROMETRY; METABOLISM; MOUSE MUTANT; OSMOTIC PRESSURE; PHOSPHORYLATION; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PROTEIN BINDING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL LINE; HELA CELLS; HUMANS; IMMUNOPRECIPITATION; MEMBRANE PROTEINS; MICE; MICE, MUTANT STRAINS; MITOGEN-ACTIVATED PROTEIN KINASE 12; OSMOTIC PRESSURE; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROTEIN BINDING; RNA; RNA-BINDING PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 77955371720     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.066514     Document Type: Article

References (32)

1. Alepuz, P. M., Jovanovic, A., Reiser, V. and Ammerer, G. (2001). Stress-induced map kinase Hog1 is part of transcription activation complexes. Mol. Cell 7, 767-777. (Pubitemid 32436437)
2. Balda, M. S. and Matter, K. (2000). The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression. EMBO J. 19, 2024-2033.
3. Brummelkamp, T. R., Bernards, R. and Agami, R. (2002). A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550-553. (Pubitemid 34408678)
4. Burg, M. B., Ferraris, J. D. and Dmitrieva, N. I. (2007). Cellular response to hyperosmotic stresses. Physiol. Rev. 87, 1441-1474.
5. Buxade, M., Morrice, N., Krebs, D. L. and Proud, C. G. (2008). The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha. J. Biol. Chem. 283, 57-65.
6. Cobbold, L. C., Spriggs, K. A., Haines, S. J., Dobbyn, H. C., Hayes, C., de Moor, C. H., Lilley, K. S., Bushell, M. and Willis, A. E. (2008). Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs. Mol. Cell. Biol. 28, 40-49.
7. Cuenda, A. and Rousseau, S. (2007). p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim. Biophys. Acta 1773, 1358-1375. (Pubitemid 47125981)
8. Cuenda, A., Cohen, P., Buee-Scherrer, V. and Goedert, M. (1997). Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). EMBO J. 16, 295-305. (Pubitemid 27049387)
9. Figueroa, A., Kotani, H., Toda, Y., Mazan-Mamczarz, K., Mueller, E. C., Otto, A., Disch, L., Norman, M., Ramdasi, R. M., Keshtgar, M. et al. (2009). Novel roles of hakai in cell proliferation and oncogenesis. Mol. Biol. Cell 20, 3533-3542.
10. Fox, A. H., Lam, Y. W., Leung, A. K., Lyon, C. E., Andersen, J., Mann, M. and Lamond, A. I. (2002). Paraspeckles: a novel nuclear domain. Curr. Biol. 12, 13-25.
11. Funke, L., Dakoji, S. and Bredt, D. S. (2005). Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions. Annu. Rev. Biochem. 74, 219-245. (Pubitemid 40995507)
12. Garcia-Mata, R., Dubash, A. D., Sharek, L., Carr, H. S., Frost, J. A. and Burridge, K. (2007). The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity. Mol. Cell. Biol. 27, 8683-8697.
13. Goedert, M., Cuenda, A., Craxton, M., Jakes, R. and Cohen, P. (1997). Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. EMBO J. 16, 3563-3571.
14. Hasegawa, M., Cuenda, A., Spillantini, M. G., Thomas, G. M., Buee-Scherrer, V., Cohen, P. and Goedert, M. (1999). Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition. J. Biol. Chem. 274, 12626-12631.
15. Hayashi, T., Tsujino, T., Iwata, S., Nonaka, H., Emoto, N., Yano, Y., Otani, S., Hayashi, Y., Itoh, H. and Yokoyama, M. (2002). Decreased ornithine decarboxylase activity in the kidneys of Dahl salt-sensitive rats. Hypertens. Res. 25, 787-795. (Pubitemid 35153769)
16. Hsueh, Y. P., Wang, T. F., Yang, F. C. and Sheng, M. (2000). Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2. Nature 404, 298-302.
17. Humbert, P., Russell, S. and Richardson, H. (2003). Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. BioEssays 25, 542-553. (Pubitemid 36702323)
18. Inesta-Vaquera, F. A., Centeno, F., del Reino, P., Sabio, G., Peggie, M. and Cuenda, A. (2009). Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation. FEBS J. 276, 387-400.
19. Knebel, A., Morrice, N. and Cohen, P. (2001). A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. EMBO J. 20, 4360-4369.
20. Krummel, M. F. and Macara, I. (2006). Maintenance and modulation of T cell polarity. Nat. Immunol. 7, 1143-1149.
21. Kuma, Y., Sabio, G., Bain, J., Shpiro, N., Marquez, R. and Cuenda, A. (2005). BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo. J. Biol. Chem. 280, 19472-19479. (Pubitemid 41379467)
22. Laprise, P., Viel, A. and Rivard, N. (2004). Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells. J. Biol. Chem. 279, 10157-10166.
23. Mauceri, D., Gardoni, F., Marcello, E. and Di Luca, M. (2007). Dual role of CaMKII-dependent SAP97 phosphorylation in mediating trafficking and insertion of NMDA receptor subunit NR2A. J. Neurochem. 100, 1032-1046. (Pubitemid 46213927)
24. Proft, M. and Struhl, K. (2002). Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress. Mol. Cell 9, 1307-1317.
25. Roberts, S., Calautti, E., Vanderweil, S., Nguyen, H. O., Foley, A., Baden, H. P. and Viel, A. (2007). Changes in localization of human discs large (hDlg) during keratinocyte differentiation are [corrected] associated with expression of alternatively spliced hDlg variants. Exp. Cell Res. 313, 2521-2530. (Pubitemid 46977350)
26. Rousseau, S., Morrice, N., Peggie, M., Campbell, D. G., Gaestel, M. and Cohen, P. (2002). Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAPK2 and its interaction with cytokine mRNAs. EMBO J. 21, 6505-6514.
27. Sabio, G., Reuver, S., Feijoo, C., Hasegawa, M., Thomas, G. M., Centeno, F., Kuhlendahl, S., Leal-Ortiz, S., Goedert, M., Garner, C. et al. (2004). Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2. Biochem. J. 380, 19-30.
28. Sabio, G., Arthur, J. S., Kuma, Y., Peggie, M., Carr, J., Murray-Tait, V., Centeno, F., Goedert, M., Morrice, N. A. and Cuenda, A. (2005). p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. EMBO J. 24, 1134-1145.
29. Shav-Tal, Y. and Zipori, D. (2002). PSF and p54(nrb)/NonO-multi- functional nuclear proteins. FEBS Lett. 531, 109-114.
30. Tang, J., Qi, X., Mercola, D., Han, J. and Chen, G. (2005). Essential role of p38gamma in K-Ras transformation independent of phosphorylation. J. Biol. Chem. 280, 23910-23917. (Pubitemid 40884879)
31. Wood, C. D., Thornton, T. M., Sabio, G., Davis, R. A. and Rincon, M. (2009). Nuclear localization of p38 MAPK in response to DNA damage. Int. J. Biol. Sci. 5, 428-437.
32. Zolotukhin, A. S., Michalowski, D., Bear, J., Smulevitch, S. V., Traish, A. M., Peng, R., Patton, J., Shatsky, I. N. and Felber, B. K. (2003). PSF acts through the human immunodeficiency virus type 1 mRNA instability elements to regulate virus expression. Mol. Cell. Biol. 23, 6618-6630.