The adapter protein Nck: Role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytes

Protein Science

Volumn 19, Issue 4, 2010, Pages 658-669

  Lettau, Marcus ^a   Pieper, Jennifer ^a   Gerneth, Alyn ^a   Lengl Janßen, Beate ^a   Voss, Matthias ^a   Linkermann, Andreas ^a   Schmidt, Hendrik ^a   Gelhaus, Christoph ^a   Leippe, Matthias ^a   Kabelitz, Dieter ^a   Janssen, Ottmar ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Adapter protein; FYB; HIP55; Nck; NONO; Protein protein interaction; SFPQ; SH2 domain; SH3 domain; T cell

Indexed keywords

ADAPTOR PROTEIN; BINDING PROTEIN; HYBRID PROTEIN; NCK PROTEIN; NUCLEAR PROTEIN; PERVANADATE; PROTEIN ADAP; PROTEIN CD3 EPSILON; PROTEIN HIP55; PROTEIN KINASE FYN; PROTEIN NONO; PROTEIN SFPQ; PROTEIN SH2; PROTEIN SH3; PROTEIN SLP76; PROTEIN WIPF1; UNCLASSIFIED DRUG; WISKOTT ALDRICH SYNDROME PROTEIN;

ARTICLE; CELL LYSATE; CELLULAR DISTRIBUTION; CYTOSKELETON; GEL; HUMAN; HUMAN CELL; LASER MICROSCOPY; MASS SPECTROMETRY; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BINDING SITES; HUMANS; JURKAT CELLS; MICROSCOPY, CONFOCAL; ONCOGENE PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SRC HOMOLOGY DOMAINS; T-LYMPHOCYTES;

EID: 77950263357     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.334     Document Type: Article

References (37)

1. Lettau M, Pieper J, Janssen O (2009) Nck adapter proteins: functional versatility in T cells. Cell Commun Signal 7:1.
2. Buday L, Wunderlich L, Tamas P (2002) The Nck family of adapter proteins: regulators of actin cytoskeleton. Cell Signal 14:723-731.
3. Bladt F, Aippersbach E, Gelkop S, Strasser GA, Nash P, Tafuri A, Gertler FB, Pawson T (2003) The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol 23:4586-4597.
4. Guan S, Chen M, Woodley D, Li W (2007) Nckbeta adapter controls neuritogenesis by maintaining the cellular paxillin level. Mol Cell Biol 27:6001-6011.
5. Burkhardt JK, Carrizosa E, Shaffer MH (2008) The actin cytoskeleton in T cell activation. Annu Rev Immunol 26:233-259.
6. Isaaz S, Baetz K, Olsen K, Podack E, Griffiths GM (1995) Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway. Eur J Immunol 25:1071-1079.
7. Barda-Saad M, Braiman A, Titerence R, Bunnell SC, Barr VA, Samelson LE (2005) Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton. Nat Immunol 6:80-89.
8. Gil D, Schamel WW, Montoya M, Sanchez-Madrid F, Alarcon B (2002) Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. Cell 109:901-912.
9. Lettau M, Qian J, Linkermann A, Latreille M, Larose L, Kabelitz D, Janssen O (2006) The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapse. Proc Natl Acad Sci USA 103:5911-5916.
10. Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O (2001) Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor. FEBS Lett 509: 255-262.
11. Kremer BE, Adang LA, Macara IG (2007) Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. Cell 130:837-850.
12. Lawe DC, Hahn C, Wong AJ (1997) The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68. Oncogene 14: 223-231.
13. Frese S, Schubert WD, Findeis AC, Marquardt T, Roske YS, Stradal TE, Heinz DW (2006) The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains. J Biol Chem 281: 18236-18245.
14. Hoefen RJ, Berk BC (2006) The multifunctional GIT family of proteins. J Cell Sci 119:1469-1475.
15. Phee H, Abraham RT, Weiss A (2005) Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1. Nat Immunol 6:608-617.
16. Rivero-Lezcano OM, Sameshima JH, Marcilla A, Robbins KC (1994) Physical association between Src homology 3 elements and the protein product of the ccbl proto-oncogene. J Biol Chem 269:17363-17366.
17. Han J, Kori R, Shui JW, Chen YR, Yao Z, Tan TH (2003) The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase activation in T cell receptor signaling. J Biol Chem 278:52195-52202.
18. Larbolette O, Wollscheid B, Schweikert J, Nielsen PJ, Wienands J (1999) SH3P7 is a cytoskeleton adapter protein and is coupled to signal transduction from lymphocyte antigen receptors. Mol Cell Biol 19:1539-1546.
19. Han J, Shui JW, Zhang X, Zheng B, Han S, Tan TH (2005) HIP-55 is important for T-cell proliferation, cytokine production, and immune responses. Mol Cell Biol 25:6869-6878.
20. Le Bras S, Foucault I, Foussat A, Brignone C, Acuto O, Deckert M (2004) Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis. J Biol Chem 279:15550-15560.
21. Togni M, Lindquist J, Gerber A, Kolsch U, Hamm-Baarke A, Kliche S, Schraven B (2004) The role of adaptor proteins in lymphocyte activation. Mol Immunol 41:615-630.
22. Peterson EJ (2003) The TCR ADAPts to integrin-mediated cell adhesion. Immunol Rev 192:113-121.
23. da Silva AJ, Janssen O, Rudd CE (1993) T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T). J Exp Med 178:2107-2113.
24. Liu J, Kang H, Raab M, da Silva AJ, Kraeft SK, Rudd CE (1998) FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. Proc Natl Acad Sci USA 95:8779-8784.
25. Marie-Cardine A, Hendricks-Taylor LR, Boerth NJ, Zhao H, Schraven B, Koretzky GA (1998) Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130. J Biol Chem 273:25789-25795.
26. Wang H, Rudd CE (2008) SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion. Trends Cell Biol 18:486-493.
27. Zhao ZS, Manser E, Lim L (2000) Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation. Mol Cell Biol 20:3906-3917.
28. Bomsztyk K, Denisenko O, Ostrowski J (2004) hnRNP K: one protein multiple processes. Bioessays 26:629-638.
29. Tapia-Paez I, Tammimies K, Massinen S, Roy AL, Kere J (2008) The complex of TFII-I, PARP1, and SFPQ proteins regulates the DYX1C1 gene implicated in neuronal migration and dyslexia. FASEB J 22:3001-3009.
30. Shav-Tal Y, Lee B, Bar-Haim S, Vandekerckhove J, Zipori D (2000) Enhanced proteolysis of pre-mRNA splicing factors in myeloid cells. Exp Hematol 28:1029-1038.
31. Shav-Tal Y, Zipori D (2002) PSF and p54(nrb)/NonO-multi-functional nuclear proteins. FEBS Lett 531: 109-114.
32. Wu X, Yoo Y, Okuhama NN, Tucker PW, Liu G, Guan JL (2006) Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners. Nat Cell Biol 8:756-763.
33. Schmidt H, Gelhaus C, Lucius R, Nebendahl M, Leippe M, Janssen O (2009) Enrichment and analysis of secretory lysosomes from lymphocyte populations. BMC Immunol 10:41.
34. Lettau M, Qian J, Kabelitz D, Janssen O (2004) Activation-dependent FasL expression in T lymphocytes and natural killer cells. Signal Transduct 4:206-211.
35. Kebache S, Zuo D, Chevet E, Larose L (2002) Modulation of protein translation by Nck-1. Proc Natl Acad Sci USA 99:5406-5411.
36. Lussier G, Larose L (1997) A casein kinase I activity is constitutively associated with Nck. J Biol Chem 272: 2688-2694.
37. Lettau M, Beyer A, Janssen O (2007) Novel monoclonal antibodies for the investigation of PCH family proteins. Signal Transduct 7:320-328.