Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex

British Journal of Cancer

Volumn 111, Issue 4, 2014, Pages 736-748

  Ji, Q ^a   Zhang, L ^b   Liu, X ^a   Zhou, L ^a   Wang, W ^a   Han, Z ^a   Sui, H ^a   Tang, Y ^a   Wang, Y ^c   Liu, N ^a   Ren, J ^d   Hou, F ^d   Li, Q ^a  

^a SHUGUANG HOSPITAL AFFILIATED TO SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b EAST CHINA NORMAL UNIVERSITY   (China)

^c SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^d Shanghai Municipal Hospital of Traditional Chinese Medicine   (China)

Author keywords

colorectal cancer; MALAT1; PTBP2; SFPQ; tumour growth and metastasis

Indexed keywords

LONG UNTRANSLATED RNA; METASTASIS ASSOCIATED WITH LUNG ADENOCARCINOMA TRANSCRIPT 1; POLYPYRIMIDINE TRACT BINDING PROTEIN; POLYPYRIMIDINE TRACT BINDING PROTEIN ASSOCIATED SPLICING FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER PROGNOSIS; CANCER TISSUE; CARCINOGENESIS; CELL MIGRATION; CELL PROLIFERATION; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION ASSAY; GENE FUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; METASTASIS; MOLECULAR INTERACTION; MOUSE; NONHUMAN; NUDE MOUSE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN RNA BINDING; PROTO ONCOGENE; TUMOR GROWTH; TUMOR INVASION; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLORECTAL NEOPLASMS; FEMALE; HEK293 CELLS; HUMANS; MALE; MICE; MICE, NUDE; MIDDLE AGED; MULTIPROTEIN COMPLEXES; NEOPLASM TRANSPLANTATION; NERVE TISSUE PROTEINS; ONCOGENES; POLYPYRIMIDINE TRACT-BINDING PROTEIN; PROTEIN BINDING; PROTEIN TRANSPORT; RNA, LONG NONCODING; RNA-BINDING PROTEINS;

EID: 84906090333     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2014.383     Document Type: Article

References (40)

1. Bartels CL, Tsongalis GJ (2009) MicroRNAs: novel biomarkers for human cancer. Clin Chem 55(4): 623-631.
2. Bernards R, Weinberg RA (2002) A progression puzzle. Nature 418(6900): 823.
3. Carthew RW, Sontheimer EJ (2009) Origins and mechanisms of miRNAs and siRNAs. Cell 136(4): 642-655.
4. Chaumeil J, Augui S, Chow JC, Heard E (2008) Combined immuno-fluorescence, RNA fluorescent in situ hybridization, and DNA fluorescent in situ hybridization to study chromatin changes, transcriptional activity, nuclear organization, and X-chromosome inactivation. Methods Mol Biol 463: 297-308.
5. Christofori G (2006) New signals from the invasive front. Nature 441(7092): 444-450.
6. De Backer O, Arden KC, Boretti M, Vantomme V, De Smet C, Czekay S, Viars CS, De Plaen E, Brasseur F, Chomez P, Van den Eynde B, Boon T, van der Bruggen P (1999) Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. Cancer Res 59(13): 3157-3165.
7. Eddy SR (2001) Non-coding RNA genes and the modern RNA world. Nat Rev Genet 2(12): 919-929.
8. Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61(5): 759-767.
9. Fidler IJ (2003) The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 3(6): 453-458.
10. Galbán S, Kuwano Y, Pullmann Jr R, Martindale JL, Kim HH, Lal A, Abdelmohsen K, Yang X, Dang Y, Liu JO, Lewis SM, Holcik M, Gorospe M (2008) RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1. Mol Cell Biol 28(1): 93-107.
11. Gandellini P, Folini M, Longoni N, Pennati M, Binda M, Colecchia M, Salvioni R, Supino R, Moretti R, Limonta P, Valdagni R, Daidone MG, Zaffaroni N (2009) miR-205 exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon. Cancer Res 69(6): 2287-2295.
12. Gozani O, Patton JG, Reed R (1994) A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction. EMBO J 13(14): 3356-3367.
13. Guo FJ, Li YL, Liu Y, Wang JJ, Li YH, Li GC (2010) Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion. Acta Biochim Biophys Sin (Shanghai) 42(3): 224-229.
14. Gutschner T, Hämmerle M, Diederichs S (2013) MALAT1-a paradigm for long noncoding RNA function in cancer. J Mol Med (Berl) 91(7): 791-801.
15. Gutschner T, Hämmerle M, Eissmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Gross M, Zörnig M, MacLeod AR, Spector DL, Diederichs S (2013) The non-coding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res 73(3): 1180-1189.
16. Guttman M, Amit I, Garber M, French C, Lin MF, Feldser D, Huarte M, Zuk O, Carey BW, Cassady JP, Cabili MN, Jaenisch R, Mikkelsen TS, Jacks T, Hacohen N, Bernstein BE, Kellis M, Regev A, Rinn JL, Lander ES (2009) Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 458(7235): 223-227.
17. He X, Pool M, Darcy KM, Lim SB, Auersperg N, Coon JS, Beck WT (2007) Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro. Oncogene 26(34): 4961-4968.
18. Hutchinson JN, Ensminger AW, Clemson CM, Lynch CR, Lawrence JB, Chess A (2007) A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains. BMC Genomics 8: 39.
19. Ji P, Diederichs S, Wang W, Böing S, Metzger R, Schneider PM, Tidow N, Brandt B, Buerger H, Bulk E, Thomas M, Berdel WE, Serve H, Müller-Tidow C (2003) MALAT-1, a novel noncoding RNA, and thymosin b4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene 22(39): 8031-8041.
20. Ji Q, Liu X, Fu X, Zhang L, Sui H, Zhou L, Sun J, Cai J, Qin J, Ren J, Li Q (2013) Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/b-catenin signal pathway. PLoS One 8(11): e78700.
21. Kapranov P, Cheng J, Dike S, Nix DA, Duttagupta R, Willingham AT, Stadler PF, Hertel J, Hackermüller J, Hofacker IL, Bell I, Cheung E, Drenkow J, Dumais E, Patel S, Helt G, Ganesh M, Ghosh S, Piccolboni A, Sementchenko V, Tammana H, Gingeras TR (2007) RNA maps reveal new RNA classes and a possible function for pervasive transcription. Science 316(5830): 1484-1488.
22. Lai MC, Yang Z, Zhou L, Zhu QQ, Xie HY, Zhang F, Wu LM, Chen LM, Zheng SS (2012) Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation. Med Oncol 29(3): 1810-1816.
23. Li L, Feng TT, Lian YY, Zhang GF, Garen A, Song X (2009) Role of human noncoding RNAs in the control of tumorigenesis. Proc Natl Acad Sci USA 106(31): 12956-12961.
24. Lin R, Maeda S, Liu C, Karin M, Edgington TS (2007) A large noncoding RNA is a marker for murine hepatocellular carcinomas and a spectrum of human carcinomas. Oncogene 26(6): 851-858.
25. Meissner M, Dechat T, Gerner C, Grimm R, Foisner R, Sauermann G (2000) Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB. J Cell Biochem 76(4): 559-566.
26. Patton JG, Mayer SA, Tempst P, Nadal-Ginard B (1991) Characterization and molecular cloning of polypyrimdine tract-binding protein: a component of a complex necessary for pre-mRNA splicing. Genes Dev 5(7): 1237-1251.
27. Patton JG, Porto EB, Galceran J, Temps P, Nadal-Ginard Bl (1993) Cloning and characterization of PSF, a novel pre-mRNA splicing factor. Genes Dev 7(3): 393-406.
28. Rajesh C, Baker DK, Pierce AJ, Pittman DL (2011) The splicing-factor related protein SFPQ/PSF interacts with RAD51D and is necessary for homology-directed repair and sister chromatid cohesion. Nucleic Acids Res 39(1): 132-145.
29. Rossi S, Sevignani C, Nnadi SC, Siracusa LD, Calin GA (2008) Cancer-associated genomic regions (CAGRs) and noncoding RNAs: bioinformatics and therapeutic implications. Mamm Genome 19(7-8): 526-540.
30. Schmidt LH, Spieker T, Koschmieder S, Schäffers S, Humberg J, Jungen D, Bulk E, Hascher A, Wittmer D, Marra A, Hillejan L, Wiebe K, Berdel WE, Wiewrodt R, Muller-Tidow C (2011) The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth. J Thorac Oncol 6(12): 1984-1992.
31. Sephton CF, Cenik C, Kucukural A, Dammer EB, Cenik B, Han Y, Dewey CM, Roth FP, Herz J, Peng J, Moore MJ, Yu G (2011) Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes. J Biol Chem 286(2): 1204-1215.
32. Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y (2006) Colorectal cancer: genetics of development and metastasis. J Gastroenterol 41(3): 185-192.
33. Tripathi V, Ellis JD, Shen Z, Song DY, Pan Q, Watt AT, Freier SM, Bennett CF, Sharma A, Bubulya PA, Blencowe BJ, Prasanth SG, Prasanth KV (2010) The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol Cell 39(6): 925-938.
34. Tseng JJ, Hsieh YT, Hsu SL, Chou MM (2009) Metastasis associated lung adenocarcinoma transcript 1 is up-regulated in placenta previa increta/percreta and strongly associated with trophoblast-like cell invasion in vitro. Mol Hum Reprod 15(11): 725-731.
35. Wang G, Cui Y, Zhang GF, Garen A, Song X (2009) Regulation of proto-oncogene transcription, cell proliferation, and tumorigenesis in mice by PSF protein and a VL30 noncoding RNA. Proc Natl Acad Sci USA 106(39): 16794-16798.
36. Watson AJ, Collins PD (2011) Colon cancer: a civilization disorder. Dig Dis 29(2): 222-228.
37. Wenger RH, Stiehl DP, Camenisch G (2005) Integration of oxygen signaling at the consensus HRE. Sci STKE 2005(306): re12.
38. Wilusz JE, Freier SM, Spector DL (2008) 3-end processing of a long nuclear retained noncoding RNA yields a tRNA-like cytoplasmic RNA. Cell 135(5): 919-932.
39. Xu CA, Yang MH, Tian J, Wang XY, Li ZG (2011) MALAT-1: a long non-coding RNA and its important 3 end functional motif in colorectal cancer metastasis. Int J Oncol 39(1): 169-175.
40. Ying L, Chen Q, Wang YW, Zhou ZH, Huang YR, Qiu F (2012) Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition. Mol Biosyst 8(9): 2289-2294.