Rapamycin Inhibition of mTOR Reduces Levels of the Na+/H+ Exchanger 3 in Intestines of Mice and Humans, Leading to Diarrhea

Gastroenterology

Volumn 149, Issue 1, 2015, Pages 151-162

  Yang, Jun ^a   Zhao, Xiaofeng ^a   Patel, Archana ^a   Potru, Rachana ^a   Azizi Ghannad, Sadra ^a   Dolinger, Michael ^a   Cao, James ^a   Bartholomew, Catherine ^a   Mazurkiewicz, Joseph ^a   Conti, David ^a   Jones, David ^a   Huang, Yunfei ^a   Zhu, Xinjun Cindy ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

Immunosuppression; mTOR; Sodium Transport; Transplantation

Indexed keywords

AUTOPHAGY PROTEIN 7; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EZRIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEIN KINASE B; PROTEIN P62; PROTEIN S6; RAPAMYCIN; S6 KINASE; SODIUM PROTON EXCHANGE PROTEIN 3; TACROLIMUS; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ATG7 PROTEIN, HUMAN; PHOSPHOPROTEIN; SODIUM PROTON EXCHANGE PROTEIN; SODIUM-HYDROGEN EXCHANGER 3; SODIUM-HYDROGEN EXCHANGER REGULATORY FACTOR; TARGET OF RAPAMYCIN KINASE; UBIQUITIN PROTEIN LIGASE;

ADULT; AGED; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BIOTINYLATION; CLINICAL ARTICLE; CONTROLLED STUDY; DIARRHEA; DOWN REGULATION; DRUG BLOOD LEVEL; DRUG MEGADOSE; GENE DELETION; HUMAN; HUMAN TISSUE; ILEUM; INTESTINE BIOPSY; INTESTINE BRUSH BORDER; INTESTINE EPITHELIUM CELL; INTESTINE PERFUSION; KIDNEY TRANSPLANTATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RETROSPECTIVE STUDY; SINGLE DRUG DOSE; SODIUM ABSORPTION; WATER ABSORPTION; ANIMAL; BIOPSY; CASE CONTROL STUDY; FEMALE; METABOLISM; MIDDLE AGED; RAT; SPRAGUE DAWLEY RAT;

ADULT; ANIMALS; ANTI-BACTERIAL AGENTS; BIOPSY; CASE-CONTROL STUDIES; DIARRHEA; FEMALE; HUMANS; MALE; MICE; MIDDLE AGED; PHOSPHOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SIROLIMUS; SODIUM-HYDROGEN ANTIPORTER; TOR SERINE-THREONINE KINASES; UBIQUITIN-ACTIVATING ENZYMES;

EID: 84931400185     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2015.03.046     Document Type: Article

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