mTORC2 protein-mediated protein kinase B (Akt) serine 473 phosphorylation is not required for Akt1 activity in human platelets

Journal of Biological Chemistry

Volumn 286, Issue 28, 2011, Pages 24553-24560

  Moore, Samantha F ^a   Hunter, Roger W ^a   Hers, Ingeborg ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION LOOPS; CELL SURVIVAL; GLYCOGEN SYNTHASE KINASE-3; HYDROPHOBIC MOTIFS; INSULIN-LIKE GROWTH FACTOR; MAMMALIAN TARGET; PHOSPHOLIPASE C; PROTEIN KINASE B; RAPAMYCIN; SIGNALING PATHWAYS; SMALL MOLECULES;

AMINO ACIDS; ANTIBIOTICS; ENZYMES; MAMMALS; PLATELETS; PROTEINS;

PHOSPHORYLATION;

GLYCOGEN SYNTHASE KINASE 3BETA; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOLIPASE C; PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEIN KINASE C; RAPAMYCIN; SERINE; SOMATOMEDIN C; THREONINE; THROMBIN; 1 (4 (4 PROPIONYLPIPERAZIN 1 YL) 3 (TRIFLUOROMETHYL)PHENYL) 9 (QUINOLIN 3 YL)BENZO(H)(1,6)NAPHTHYRIDIN 2(1H) ONE; 1-(4-(4-PROPIONYLPIPERAZIN-1-YL)-3-(TRIFLUOROMETHYL)PHENYL)-9-(QUINOLIN-3-YL)BENZO(H)(1,6)NAPHTHYRIDIN-2(1H)-ONE; AKT1 PROTEIN, HUMAN; AKT1S1 PROTEIN, HUMAN; AKT2 PROTEIN, HUMAN; ANTINEOPLASTIC ANTIBIOTIC; CRTC2 PROTEIN, HUMAN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; NAPHTHYRIDINE DERIVATIVE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTION FACTOR;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE AGGREGATION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

MAMMALIA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANTIBIOTICS, ANTINEOPLASTIC; BLOOD PLATELETS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MAP KINASE SIGNALING SYSTEM; NAPHTHYRIDINES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SERINE; SIROLIMUS; THROMBIN; TRANSCRIPTION FACTORS; TYPE C PHOSPHOLIPASES;

EID: 79960149722     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.202341     Document Type: Article

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