D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2dependent process

Gastroenterology

Volumn 140, Issue 2, 2011, Pages 560-571

  Lin, Rong ^a,b   Murtazina, Rakhilya ^a   Cha, Boyoung ^a   Chakraborty, Molee ^a   Sarker, Rafiquel ^a   Chen, Tiane ^a   Lin, Zhihong ^a   Hogema, Boris M ^c   De Jonge, Hugo R ^c   Seidler, Ursula ^d   Turner, Jerrold R ^e   Li, Xuhang ^a   Kovbasnjuk, Olga ^a   Donowitz, Mark ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d HANNOVER MEDICAL SCHOOL   (Germany)

^e UNIVERSITY OF CHICAGO   (United States)

Author keywords

Cholera Toxin; Exocytosis; Ezrin; Intestinal Na Absorption; NHERF2

Indexed keywords

CHOLERA TOXIN; EZRIN; GLUCOSE; PROTEIN KINASE B; SMALL INTERFERING RNA; SODIUM GLUCOSE COTRANSPORTER 1; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 3; SODIUM PROTON EXCHANGE REGULATORY CO FACTOR 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTINYLATION; BLEACHING; CELL ACTIVITY; CELL MOTILITY; CELL PH; CELL STRAIN CACO 2; CELL SURFACE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DIARRHEA; FLUORESCENCE; FLUOROMETRY; INTESTINE BRUSH BORDER; INTESTINE CELL; JEJUNUM; MALE; MOUSE; MULTIPHOTON MICROSCOPY; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; WILD TYPE;

EID: 79251561246     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.10.042     Document Type: Article

References (27)

1. N.C. Zachos, M. Tse, and M. Donowitz Molecular physiology of intestinal Na+/H+ exchanger Annu Rev Physiol 67 2005 411 443
2. Z. Hu, Y. Wang, and W.V. Graham MAPKAPK-2 is a critical signaling intermediate in NHE3 activation following Na+-glucose cotransport J Biol Chem 281 2006 24247 24253
3. J.R. Turner, and E.D. Black NHE3-dependent cytoplasmic alkalinization is triggered by Na(+)-glucose cotransport in intestinal epithelia Am J Physiol Cell Physiol 281 2001 C1533 C1541
4. H. Zhao, H. Shiue, and S. Palkon Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport Proc Natl Acad Sci U S A 101 2004 9485 9490
5. H. Shiue, M.W. Musch, and Y. Wang Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation J Biol Chem 280 2005 1688 1695
6. M. Donowitz, B. Cha, and N. Zachos NHERF Family and NHE3 regulation J Physiol 567 2005 3 11
7. M. Donowitz, and X. Li Regulatory binding partners and complexes of NHE3 Physiol Rev 87 2007 825 872
8. X. Li, H. Zhang, and A. Cheong Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependent J Physiol 556 2004 791 804
9. X. Li, and M. Donowitz Fractionation of subcellular membrane vesicles of epithelial and nonepithelial cells by OptiPrep density gradient ultracentrifugation Methods Mol Biol 440 2008 97 110
10. N. Broere, J. Hillesheim, and B. Tuo Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but not NHERF-2-deficient mice J Biol Chem 282 2007 37575 37584
11. R. Murtazina, O. Kovbasnjuk, and N.C. Zachos Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule J Biol Chem 282 2007 25141 25151
12. T. Ma, J.R. Thiagarajah, and H. Yang Verkman thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxininduced intestinal fluid secretion J Clin Invest 110 2002 1651 1658
13. R. Sarker, M. Grønborg, and B. Cha Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3 Mol Biol Cell 19 2008 3859 3870
14. B. Cha, M. Tse, and C. Yun The NHE3 juxtamembrane cytoplasmic domain directly binds ezrin: dual role in NHE3 trafficking and mobility in the brush border Mol Biol Cell 17 2006 2661 2673
15. J. Peti-Peterdi, I. Toma, and A. Sipos Multiphoton imaging of renal regulatory mechanisms Physiology (Bethesda) 24 2009 88 96
16. S.F. Barnett, D. Defeo-Jones, and S. Fu Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific akt inhibitors Biochem J 385 2005 399 408
17. B. Cha, A. Kenworthy, and R. Murtazina The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2, but is dependent on an intact actin cytoskeleton as determined by FRAP J Cell Sci 117 2004 3353 3365
18. J.L. Madara, and J.R. Pappenheimer Structural basis for physiological regulation of paracellular pathways in intestinal epithelia J Membr Biol 100 1987 149 164
19. J.B. Wade, P.A. Welling, and M. Donowitz Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK Am J Physiol Cell Physiol 280 2001 C192 C198
20. B. Cha, X.C. Zhu, and W. Chen NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid J Cell Sci 123 2010 2434 2443
21. S. Akhter, O. Kovbasnjuk, and X. Li Na(+)/H(+) exchanger 3 is in large complexes in the center of the apical surface of proximal tubule-derived OK cells Am J Physiol Cell Physiol 283 2002 C927 C940
22. I. Malyukova, K.F. Murray, and C. Zhu Macropinocytosis in Shiga toxin 1 uptake by human intestinal epithelial cells and transcellular transcytosis Am J Physiol Gastrointest Liver Physiol 296 2009 G78 G92
23. W. Xiong, I. Jordens, and E. Gonzalez GLUT4 is sorted to vesicles whose accumulation beneath and insertion into the plasma membrane are differentially regulated by insulin and selectively affected by insulin resistance Mol Biol Cell 21 2010 1375 1386
24. D. Biemesderfer, B. DeGray, and P.S. Aronson Active (9.6 s) and inactive (21 s) oligomers of NHE3 in microdomains of the renal brush border J Biol Chem 276 2001 10161 10167
25. A.A. McDonough, and D. Biemesderfer Does membrane trafficking play a role in regulating the sodium/hydrogen exchanger isoform 3 in the proximal tubule? Curr Opin Nephrol Hypertens 12 2003 533 541
26. A.A. McDonough Mechanisms of proximal tubule sodium transport regulation that link extracellular fluid volume and blood pressure Am J Physiol Regul Integr Comp Physiol 298 2010 R851 R861
27. A.D. Riquier, D.H. Lee, and A.A. McDonough Renal NHE3 and NaPi2 partition into distinct membrane domains Am J Physiol Cell Physiol 296 2009 C900 C910