Serotonin, a possible intermediate between disturbed circadian rhythms and metabolic disease

Neuroscience

Volumn 301, Issue , 2015, Pages 155-167

  Versteeg, R I ^a   Serlie, M J ^a   Kalsbeek, A ^a,b   la Fleur, S E ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

Author keywords

Chronodisruption; Feeding behavior; Glucose metabolism; Serotonin; Suprachiasmatic nucleus

Indexed keywords

SEROTONIN; SEROTONIN RECEPTOR; GLUCOSE BLOOD LEVEL;

BRAIN REGION; CALORIC INTAKE; CARBOHYDRATE DIET; CIRCADIAN RHYTHM; DIENCEPHALON; ENERGY BALANCE; FEEDING BEHAVIOR; FRONTAL CORTEX; GLUCOSE METABOLISM; HIPPOCAMPUS; HUMAN; HYPOTHALAMUS; INSULIN RESISTANCE; LOCOMOTION; MACRONUTRIENT; METABOLIC DISORDER; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; REVIEW; SEROTONINERGIC SYSTEM; TEMPORAL CORTEX; WEIGHT GAIN; ANIMAL; ENERGY METABOLISM; GLUCOSE BLOOD LEVEL; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SUPRACHIASMATIC NUCLEUS;

ANIMALS; BLOOD GLUCOSE; CIRCADIAN RHYTHM; ENERGY METABOLISM; FEEDING BEHAVIOR; HUMANS; METABOLIC DISEASES; SEROTONIN; SUPRACHIASMATIC NUCLEUS;

EID: 84931272968     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.05.067     Document Type: Review

References (177)

1. Adams K.H., Pinborg L.H., Svarer C., Hasselbalch S.G., Holm S., Haugbol S., Madsen K., Frokjaer V., Martiny L., Paulson O.B., Knudsen G.M. A database of [(18)F]-altanserin binding to 5-HT(2A) receptors in normal volunteers: normative data and relationship to physiological and demographic variables. Neuroimage 2004, 21:1105-1113.
2. Amir S., Robinson B., Ratovitski T., Rea M.A., Stewart J., Simantov R. A role for serotonin in the circadian system revealed by the distribution of serotonin transporter and light-induced Fos immunoreactivity in the suprachiasmatic nucleus and intergeniculate leaflet. Neuroscience 1998, 84:1059-1073.
3. Andersohn F., Schade R., Suissa S., Garbe E. Long-term use of antidepressants for depressive disorders and the risk of diabetes mellitus. Am J Psychiatry 2009, 166:591-598.
4. Antle M.C., Marchant E.G., Niel L., Mistlberger R.E. Serotonin antagonists do not attenuate activity-induced phase shifts of circadian rhythms in the Syrian hamster. Brain Res 1998, 813:139-149.
5. Arble D.M., Bass J., Laposky A.D., Vitaterna M.H., Turek F.W. Circadian timing of food intake contributes to weight gain. Obesity (SilverSpring) 2009, 17:2100-2102.
6. Arble D.M., Sandoval D.A. CNS control of glucose metabolism: response to environmental challenges. Front Neurosci 2013, 7:20.
7. Astbury N.M., Taylor M.A., Macdonald I.A. Breakfast consumption affects appetite, energy intake, and the metabolic and endocrine responses to foods consumed later in the day in male habitual breakfast eaters. J Nutr 2011, 141:1381-1389.
8. Azmitia E.C., Segal M. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J Comparat Neurol 1978, 179:641-667.
9. Barassin S., Raison S., Saboureau M., Bienvenu C., Maitre M., Malan A., Pevet P. Circadian tryptophan hydroxylase levels and serotonin release in the suprachiasmatic nucleus of the rat. Eur J Neurosci 2002, 15:833-840.
10. Barclay J.L., Husse J., Bode B., Naujokat N., Meyer-Kovac J., Schmid S.M., Lehnert H., Oster H. Circadian desynchrony promotes metabolic disruption in a mouse model of shiftwork. PLoS One 2012, 7:e37150.
11. Baron K.G., Reid K.J., Horn L.V., Zee P.C. Contribution of evening macronutrient intake to total caloric intake and body mass index. Appetite 2013, 60:246-251.
12. Baron K.G., Reid K.J., Kern A.S., Zee P.C. Role of sleep timing in caloric intake and BMI. Obesity (SilverSpring) 2011, 19:1374-1381.
13. Berg C., Lappas G., Wolk A., Strandhagen E., Toren K., Rosengren A., Thelle D., Lissner L. Eating patterns and portion size associated with obesity in a Swedish population. Appetite 2009, 52:21-26.
14. Berteus F.H., Torgerson J.S., Sjostrom L., Lindroos A.K. Snacking frequency in relation to energy intake and food choices in obese men and women compared to a reference population. Int J Obes (Lond) 2005, 29:711-719.
15. Berthoud H.R. Multiple neural systems controlling food intake and body weight. Neurosci Biobehav Rev 2002, 26:393-428.
16. Blundell J.E., Latham C.J. Characterisation of adjustments to the structure of feeding behaviour following pharmacological treatment: effects of amphetamine and fenfluramine and the antagonism produced by pimozide and methergoline. Pharmacol Biochem Behav 1980, 12:717-722.
17. Bobrzynska K.J., Godfrey M.H., Mrosovsky N. Serotonergic stimulation and nonphotic phase-shifting in hamsters. Physiol Behav 1996, 59:221-230.
18. Bouwknecht J.A., van der Gugten J., Hijzen T.H., Maes R.A., Hen R., Olivier B. Male and female 5-HT(1B) receptor knockout mice have higher body weights than wildtypes. Physiol Behav 2001, 74:507-516.
19. Breisch S.T., Zemlan F.P., Hoebel B.G. Hyperphagia and obesity following serotonin depletion by intraventricular p-chlorophenylalanine. Science 1976, 192:382-385.
20. Breum L., Bjerre U., Bak J.F., Jacobsen S., Astrup A. Long-term effects of fluoxetine on glycemic control in obese patients with non-insulin-dependent diabetes mellitus or glucose intolerance: influence on muscle glycogen synthase and insulin receptor kinase activity. Metabolism 1995, 44:1570-1576.
21. Brown L.C., Majumdar S.R., Johnson J.A. Type of antidepressant therapy and risk of type 2 diabetes in people with depression. Diabetes Res Clin Pract 2008, 79:61-67.
22. Cagampang F.R., Inouye S.T. Diurnal and circadian changes of serotonin in the suprachiasmatic nuclei: regulation by light and an endogenous pacemaker. Brain Res 1994, 639:175-179.
23. Cailotto C., la Fleur S.E., Van Heijningen C., Wortel J., Kalsbeek A., Feenstra M., Pevet P., Buijs R.M. The suprachiasmatic nucleus controls the daily variation of plasma glucose via the autonomic output to the liver: are the clock genes involved?. Eur J Neurosci 2005, 22:2531-2540.
24. Cailotto C., van Heijningen C., van der Vliet J., van der Plasse G., Habold C., Kalsbeek A., Pevet P., Buijs R.M. Daily rhythms in metabolic liver enzymes and plasma glucose require a balance in the autonomic output to the liver. Endocrinology 2008, 149:1914-1925.
25. Carroll K.F., Nestel P.J. Diurnal variation in glucose tolerance and in insulin secretion in man. Diabetes 1973, 22:333-348.
26. Challet E. Interactions between light, mealtime and calorie restriction to control daily timing in mammals. J Comp Physiol B 2010, 180:631-644.
27. Challet E., Pevet P., Vivien-Roels B., Malan A. Phase-advanced daily rhythms of melatonin, body temperature, and locomotor activity in food-restricted rats fed during daytime. J Biol Rhythms 1997, 12:65-79.
28. Challet E., Scarbrough K., Penev P.D., Turek F.W. Roles of suprachiasmatic nuclei and intergeniculate leaflets in mediating the phase-shifting effects of a serotonergic agonist and their photic modulation during subjective day. J Biol Rhythms 1998, 13:410-421.
29. Chapelot D. The role of snacking in energy balance: a biobehavioral approach. J Nutr 2011, 141:158-162.
30. Chen X., Margolis K.J., Gershon M.D., Schwartz G.J., Sze J.Y. Reduced serotonin reuptake transporter (SERT) function causes insulin resistance and hepatic steatosis independent of food intake. PLoS One 2012, 7:e32511.
31. Clifton P.G., Lee M.D., Somerville E.M., Kennett G.A., Dourish C.T. 5-HT1B receptor knockout mice show a compensatory reduction in 5-HT2C receptor function. Eur J Neurosci 2003, 17:185-190.
32. Crane J.D., Palanivel R., Mottillo E.P., Bujak A.L., Wang H., Ford R.J., Collins A., Blumer R.M., Fullerton M.D., Yabut J.M., Kim J.J., Ghia J.E., Hamza S.M., Morrison K.M., Schertzer J.D., Dyck J.R., Khan W.I., Steinberg G.R. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nat Med 2014.
33. Croce N., Bracci M., Ceccarelli G., Barbadoro P., Prospero E., Santarellia L. Body mass index in shift workers: relation to diet and physical activity. G Ital Med Lav Ergon 2007, 29:488-489.
34. Curzon G., Gibson E.L., Oluyomi A.O. Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability. Trends Pharmacol Sci 1997, 18:21-25.
35. Cutrera R.A., Saboureau M., Pevet P. Phase-shifting effect of 8-OH-DPAT, a 5-HT1A/5-HT7 receptor agonist, on locomotor activity in golden hamster in constant darkness. Neurosci Lett 1996, 210:1-4.
36. Damiola F., Le Minh N., Preitner N., Kornmann B., Fleury-Olela F., Schibler U. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev 2000, 14:2950-2961.
37. Dourish C.T., Hutson P.H., Curzon G. Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the rat. Psychopharmacology (Berl) 1985, 86:197-204.
38. Dudley T.E., DiNardo L.A., Glass J.D. Endogenous regulation of serotonin release in the hamster suprachiasmatic nucleus. J Neurosci 1998, 18:5045-5052.
39. Erritzoe D., Frokjaer V.G., Haahr M.T., Kalbitzer J., Svarer C., Holst K.K., Hansen D.L., Jernigan T.L., Lehel S., Knudsen G.M. Cerebral serotonin transporter binding is inversely related to body mass index. Neuroimage 2010, 52:284-289.
40. Erritzoe D., Frokjaer V.G., Haugbol S., Marner L., Svarer C., Holst K., Baare W.F., Rasmussen P.M., Madsen J., Paulson O.B., Knudsen G.M. Brain serotonin 2A receptor binding: relations to body mass index, tobacco and alcohol use. Neuroimage 2009, 46:23-30.
41. Farshchi H.R., Taylor M.A., Macdonald I.A. Regular meal frequency creates more appropriate insulin sensitivity and lipid profiles compared with irregular meal frequency in healthy lean women. Eur J Clin Nutr 2004, 58:1071-1077.
42. Farshchi H.R., Taylor M.A., Macdonald I.A. Beneficial metabolic effects of regular meal frequency on dietary thermogenesis, insulin sensitivity, and fasting lipid profiles in healthy obese women. Am J Clin Nutr 2005, 81:16-24.
43. Farshchi H.R., Taylor M.A., Macdonald I.A. Deleterious effects of omitting breakfast on insulin sensitivity and fasting lipid profiles in healthy lean women. Am J Clin Nutr 2005, 81:388-396.
44. Fava M., Judge R., Hoog S.L., Nilsson M.E., Koke S.C. Fluoxetine versus sertraline and paroxetine in major depressive disorder: changes in weight with long-term treatment. J Clin Psychiatry 2000, 61:863-867.
45. Fidler M.C., Sanchez M., Raether B., Weissman N.J., Smith S.R., Shanahan W.R., Anderson C.M. A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial. J Clin Endocrinol Metab 2011, 96:3067-3077. Group BCT.
46. Fisas A., Codony X., Romero G., Dordal A., Giraldo J., Merce R., Holenz J., Vrang N., Sorensen R.V., Heal D., Buschmann H., Pauwels P.J. Chronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese rats. Br J Pharmacol 2006, 148:973-983.
47. Fjellstrom Mealtime and meal patterns from a cultural perspective. Scand J Nutr 2004, 48:161-164.
48. Fletcher P.J., Paterson I.A. A comparison of the effects of tryptamine and 5-hydroxytryptamine on feeding following injection into the paraventricular nucleus of the hypothalamus. Pharmacol Biochem Behav 1989, 32:907-911.
49. Fuse Y., Hirao A., Kuroda H., Otsuka M., Tahara Y., Shibata S. Differential roles of breakfast only (one meal per day) and a bigger breakfast with a small dinner (two meals per day) in mice fed a high-fat diet with regard to induced obesity and lipid metabolism. J Circadian Rhythms 2012, 10:4.
50. Garaulet M., Gomez-Abellan P. Timing of food intake and obesity: a novel association. Physiol Behav 2014, 134:44-50.
51. Garaulet M., Gomez-Abellan P., Alburquerque-Bejar J.J., Lee Y.C., Ordovas J.M., Scheer F.A. Timing of food intake predicts weight loss effectiveness. Int J Obes (Lond) 2013, 37:604-611.
52. Garfield A.S., Burke L.K., Shaw J., Evans M.L., Heisler L.K. Distribution of cells responsive to 5-HT(6) receptor antagonist-induced hypophagia. Behav Brain Res 2014, 266:201-206.
53. Gershon M.D. Review article: serotonin receptors and transporters - roles in normal and abnormal gastrointestinal motility. Alimentary Pharmacol Therapeut 2004, 20(Suppl 7):3-14.
54. Glass J.D., DiNardo L.A., Ehlen J.C. Dorsal raphe nuclear stimulation of SCN serotonin release and circadian phase-resetting. Brain Res 2000, 859:224-232.
55. Glass J.D., Grossman G.H., Farnbauch L., DiNardo L. Midbrain raphe modulation of nonphotic circadian clock resetting and 5-HT release in the mammalian suprachiasmatic nucleus. J Neurosci 2003, 23:7451-7460.
56. Glass J.D., Randolph W.W., Ferreira S.A., Rea M.A., Hauser U.E., Blank J.L., De Vries M.J. Diurnal variation in 5-hydroxyindole-acetic acid output in the suprachiasmatic region of the Siberian hamster assessed by in vivo microdialysis: evidence for nocturnal activation of serotonin release. Neuroendocrinology 1992, 56:582-590.
57. Gomez R., Huber J., Tombini G., Barros H.M. Acute effect of different antidepressants on glycemia in diabetic and non-diabetic rats. Braz J Med Biol Res 2001, 34:57-64.
58. Gooley J.J., Lu J., Chou T.C., Scammell T.E., Saper C.B. Melanopsin in cells of origin of the retinohypothalamic tract. Nat Neurosci 2001, 4:1165.
59. Grahame-Smith D.G. The biosynthesis of 5-hydroxytryptamine in brain. Biochem J 1967, 105:351-360.
60. Guy-Grand B. Clinical studies with dexfenfluramine: from past to future. Obes Res 1995, 3(Suppl 4):491S-496S.
61. Guy-Grand B., Apfelbaum M., Crepaldi G., Gries A., Lefebvre P., Turner P. International trial of long-term dexfenfluramine in obesity. Lancet 1989, 2:1142-1145.
62. Haahr M.E., Rasmussen P.M., Madsen K., Marner L., Ratner C., Gillings N., Baare W.F., Knudsen G.M. Obesity is associated with high serotonin 4 receptor availability in the brain reward circuitry. Neuroimage 2012, 61:884-888.
63. Haddock C.K., Poston W.S., Dill P.L., Foreyt J.P., Ericsson M. Pharmacotherapy for obesity: a quantitative analysis of four decades of published randomized clinical trials. Int J Obes Relat Metab Disord 2002, 26:262-273.
64. Halford J.C., Harrold J.A., Boyland E.J., Lawton C.L., Blundell J.E. Serotonergic drugs: effects on appetite expression and use for the treatment of obesity. Drugs 2007, 67:27-55.
65. Hayashi A., Sonoda R., Kimura Y., Takasu T., Suzuki M., Sasamata M., Miyata K. Antiobesity effect of YM348, a novel 5-HT2C receptor agonist, in Zucker rats. Brain Res 2004, 1011:221-227.
66. Heal D.J., Smith S.L., Fisas A., Codony X., Buschmann H. Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders. Pharmacol Ther 2008, 117:207-231.
67. Heisler L.K., Kanarek R.B., Gerstein A. Fluoxetine decreases fat and protein intakes but not carbohydrate intake in male rats. Pharmacol Biochem Behav 1997, 58:767-773.
68. Homberg J.R., la Fleur S.E., Cuppen E. Serotonin transporter deficiency increases abdominal fat in female, but not male rats. Obesity 2010, 18:137-145.
69. Howarth N.C., Huang T.T., Roberts S.B., Lin B.H., McCrory M.A. Eating patterns and dietary composition in relation to BMI in younger and older adults. Int J Obes (Lond) 2007, 31:675-684.
70. Huang X.F., Huang X., Han M., Chen F., Storlien L., Lawrence A.J. 5-HT2A/2C receptor and 5-HT transporter densities in mice prone or resistant to chronic high-fat diet-induced obesity: a quantitative autoradiography study. Brain Res 2004, 1018:227-235.
71. Isaac R., Boura-Halfon S., Gurevitch D., Shainskaya A., Levkovitz Y., Zick Y. Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic beta cells. J Biol Chem 2013, 288:5682-5693.
72. Jacobs B.L., Wilkinson L.O., Fornal C.A. The role of brain serotonin. Neurophysiol Perspect Neuropsychopharmacol 1990, 3:473-479.
73. Jakubowicz D., Barnea M., Wainstein J., Froy O. Effects of caloric intake timing on insulin resistance and hyperandrogenism in lean women with polycystic ovary syndrome. Clin Sci (Lond) 2013, 125:423-432.
74. Jakubowicz D., Froy O., Wainstein J., Boaz M. Meal timing and composition influence ghrelin levels, appetite scores and weight loss maintenance in overweight and obese adults. Steroids 2012, 77:323-331.
75. James W.P., Astrup A., Finer N., Hilsted J., Kopelman P., Rossner S., Saris W.H., Van Gaal L.F. Effect of sibutramine on weight maintenance after weight loss: a randomised trial. STORM Study Group. Sibutramine Trial of Obesity Reduction and Maintenance. Lancet 2000, 356:2119-2125.
76. Jang H., Lee G., Kong J., Choi G., Park Y.J., Kim J.B. Feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice. PLoS One 2012, 7:e49993.
77. Kalsbeek A., la Fleur S., Fliers E. Circadian control of glucose metabolism. Mol Metab 2014, 3:372-383.
78. Kalsbeek A., Palm I.F., la Fleur S.E., Scheer F.A., Perreau-Lenz S., Ruiter M., Kreier F., Cailotto C., Buijs R.M. SCN outputs and the hypothalamic balance of life. J Biol Rhythms 2006, 21:458-469.
79. Kalsbeek A., Ruiter M., la Fleur S.E., Van Heijningen C., Buijs R.M. The diurnal modulation of hormonal responses in the rat varies with different stimuli. J Neuroendocrinol 2003, 15:1144-1155.
80. Kalsbeek A., Strubbe J.H. Circadian control of insulin secretion is independent of the temporal distribution of feeding. Physiol Behav 1998, 63:553-558.
81. Kang Y.M., Chen J.Y., Ouyang W., Qiao J.T., Reyes-Vazquez C., Dafny N. Serotonin modulates hypothalamic neuronal activity. Int J Neurosci 2004, 114:299-319.
82. Karlsson B., Knutsson A., Lindahl B. Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27,485 people. Occup Environ Med 2001, 58:747-752.
83. Kennaway D.J., Moyer R.W. Serotonin 5-HT2c agonists mimic the effect of light pulses on circadian rhythms. Brain Res 1998, 806:257-270.
84. Kennett G.A., Curzon G. Potencies of antagonists indicate that 5-HT1C receptors mediate 1-3(chlorophenyl)piperazine-induced hypophagia. Br J Pharmacol 1991, 103:2016-2020.
85. Kiss J., Leranth C., Halasz B. Serotoninergic endings on VIP-neurons in the suprachiasmatic nucleus and on ACTH-neurons in the arcuate nucleus of the rat hypothalamus. A combination of high resolution autoradiography and electron microscopic immunocytochemistry. Neurosci Lett 1984, 44:119-124.
86. Kitchener S.J., Dourish C.T. An examination of the behavioural specificity of hypophagia induced by 5-HT1B, 5-HT1C and 5-HT2 receptor agonists using the post-prandial satiety sequence in rats. Psychopharmacology (Berl) 1994, 113:369-377.
87. Koopman K.E., Booij J., Fliers E., Serlie M.J., la Fleur S.E. Diet-induced changes in the Lean Brain: Hypercaloric high-fat-high-sugar snacking decreases serotonin transporters in the human hypothalamic region. Mol Metab 2013, 2:417-422.
88. Korner J., Woods S.C., Woodworth K.A. Regulation of energy homeostasis and health consequences in obesity. Am J Med 2009, 122:S12-18.
89. Kornmann B., Schaad O., Bujard H., Takahashi J.S., Schibler U. System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock. PLoS Biol 2007, 5:e34.
90. Koskela A.K., Kaurijoki S., Pietilainen K.H., Karhunen L., Pesonen U., Kuikka J.T., Kaprio J., Rissanen A. Serotonin transporter binding and acquired obesity - an imaging study of monozygotic twin pairs. Physiol Behav 2008, 93:724-732.
91. Kuikka J.T., Tammela L., Karhunen L., Rissanen A., Bergstrom K.A., Naukkarinen H., Vanninen E., Karhu J., Lappalainen R., Repo-Tiihonen E., Tiihonen J., Uusitupa M. Reduced serotonin transporter binding in binge eating women. Psychopharmacology (Berl) 2001, 155:310-314.
92. la Fleur S.E. Daily rhythms in glucose metabolism: suprachiasmatic nucleus output to peripheral tissue. J Neuroendocrinol 2003, 15:315-322.
93. la Fleur S.E., Fliers E., Kalsbeek A. Neuroscience of glucose homeostasis. Handb Clin Neurol 2014, 126:341-351.
94. la Fleur S.E., Kalsbeek A., Wortel J., Buijs R.M. A suprachiasmatic nucleus generated rhythm in basal glucose concentrations. J Neuroendocrinol 1999, 11:643-652.
95. la Fleur S.E., Kalsbeek A., Wortel J., Fekkes M.L., Buijs R.M. A daily rhythm in glucose tolerance: a role for the suprachiasmatic nucleus. Diabetes 2001, 50:1237-1243.
96. Lam D.D., Heisler L.K. Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes. Expert Rev Mol Med 2007, 9:1-24.
97. Lechin F., van der Dijs B., Hernandez-Adrian G. Dorsal raphe vs. median raphe serotonergic antagonism. Anatomical, physiological, behavioral, neuroendocrinological, neuropharmacological and clinical evidences: relevance for neuropharmacological therapy. Prog Neuropsychopharmacol Biol Psychiatry 2006, 30:565-585.
98. Lee A., Ader M., Bray G.A., Bergman R.N. Diurnal variation in glucose tolerance. Cyclic suppression of insulin action and insulin secretion in normal-weight, but not obese, subjects. Diabetes 1992, 41:750-759.
99. Legutko R., Gannon R.L. Serotonin transporter localization in the hamster suprachiasmatic nucleus. Brain Res 2001, 893:77-83.
100. Leibowitz S.F. Brain monoamines and peptides: role in the control of eating behavior. Fed Proc 1986, 45:1396-1403.
101. Leibowitz S.F., Alexander J.T., Cheung W.K., Weiss G.F. Effects of serotonin and the serotonin blocker metergoline on meal patterns and macronutrient selection. Pharmacol Biochem Behav 1993, 45:185-194.
102. Li Z., Maglione M., Tu W., Mojica W., Arterburn D., Shugarman L.R., Hilton L., Suttorp M., Solomon V., Shekelle P.G., Morton S.C. Meta-analysis: pharmacologic treatment of obesity. Ann Intern Med 2005, 142:532-546.
103. Lund J., Arendt J., Hampton S.M., English J., Morgan L.M. Postprandial hormone and metabolic responses amongst shift workers in Antarctica. J Endocrinol 2001, 171:557-564.
104. Lundgren J.D., Newberg A.B., Allison K.C., Wintering N.A., Ploessl K., Stunkard A.J. 123I-ADAM SPECT imaging of serotonin transporter binding in patients with night eating syndrome: a preliminary report. Psychiatry Res 2008, 162:214-220.
105. Luo S., Luo J., Cincotta A.H. Suprachiasmatic nuclei monoamine metabolism of glucose tolerant versus intolerant hamsters. Neuroreport 1999, 10:2073-2077.
106. Maheux P., Ducros F., Bourque J., Garon J., Chiasson J.L. Fluoxetine improves insulin sensitivity in obese patients with non-insulin-dependent diabetes mellitus independently of weight loss. Int J Obes Relat Metab Disord 1997, 21:97-102.
107. Malek Z.S., Dardente H., Pevet P., Raison S. Tissue-specific expression of tryptophan hydroxylase mRNAs in the rat midbrain: anatomical evidence and daily profiles. Eur J Neurosci 2005, 22:895-901.
108. Malek Z.S., Pevet P., Raison S. Circadian change in tryptophan hydroxylase protein levels within the rat intergeniculate leaflets and raphe nuclei. Neuroscience 2004, 125:749-758.
109. Manrique C., Bosler O., Becquet D., Hery F., Faudon M., Francois-Bellan A.M. Post-lesion up-regulation of 5-HT1B binding sites in the suprachiasmatic nucleus may be reversed after spontaneous or graft-induced serotonin reinnervation. Brain Res 1998, 788:332-336.
110. Markianos M., Evangelopoulos M.E., Koutsis G., Sfagos C. Elevated CSF serotonin and dopamine metabolite levels in overweight subjects. Obesity 2013, 21:1139-1142.
111. Marks S.J., Moore N.R., Clark M.L., Strauss B.J., Hockaday T.D. Reduction of visceral adipose tissue and improvement of metabolic indices: effect of dexfenfluramine in NIDDM. Obes Res 1996, 4:1-7.
112. Mendoza J., Graff C., Dardente H., Pevet P., Challet E. Feeding cues alter clock gene oscillations and photic responses in the suprachiasmatic nuclei of mice exposed to a light/dark cycle. J Neurosci 2005, 25:1514-1522.
113. Meyer-Bernstein E.L., Blanchard J.H., Morin L.P. The serotonergic projection from the median raphe nucleus to the suprachiasmatic nucleus modulates activity phase onset, but not other circadian rhythm parameters. Brain Res 1997, 755:112-120.
114. Meyer-Bernstein E.L., Morin L.P. Differential serotonergic innervation of the suprachiasmatic nucleus and the intergeniculate leaflet and its role in circadian rhythm modulation. J Neurosci 1996, 16:2097-2111.
115. Moore R.Y., Halaris A.E., Jones B.E. Serotonin neurons of the midbrain raphe: ascending projections. J Comparat Neurol 1978, 180:417-438.
116. Morin L.P., Meyer-Bernstein E.L. The ascending serotonergic system in the hamster: comparison with projections of the dorsal and median raphe nuclei. Neuroscience 1999, 91:81-105.
117. Munsters M.J., Saris W.H. Effects of meal frequency on metabolic profiles and substrate partitioning in lean healthy males. PLoS One 2012, 7:e38632.
118. Nagai K., Nishio T., Nakagawa H., Nakamura S., Fukuda Y. Effect of bilateral lesions of the suprachiasmatic nuclei on the circadian rhythm of food-intake. Brain Res 1978, 142:384-389.
119. Nishio T., Shiosaka S., Nakagawa H., Sakumoto T., Satoh K. Circadian feeding rhythm after hypothalamic knife-cut isolating suprachiasmatic nucleus. Physiol Behav 1979, 23:763-769.
120. Nonogaki K., Strack A.M., Dallman M.F., Tecott L.H. Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene. Nat Med 1998, 4:1152-1156.
121. O'Neil P.M., Smith S.R., Weissman N.J., Fidler M.C., Sanchez M., Zhang J., Raether B., Anderson C.M., Shanahan W.R. Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus: the BLOOM-DM study. Obesity 2012, 20:1426-1436.
122. Orosco M., Nicolaidis S. Spontaneous feeding-related monoaminergic changes in the rostromedial hypothalamus revealed by microdialysis. Physiol Behav 1992, 52:1015-1019.
123. Palmer M.A., Capra S., Baines S.K. Association between eating frequency, weight, and health. Nutr Rev 2009, 67:379-390.
124. Park S., Harrold J.A., Widdowson P.S., Williams G. Increased binding at 5-HT(1A), 5-HT(1B), and 5-HT(2A) receptors and 5-HT transporters in diet-induced obese rats. Brain Res 1999, 847:90-97.
125. Patton D.F., Mistlberger R.E. Circadian adaptations to meal timing: neuroendocrine mechanisms. Front Neurosci 2013, 7:185.
126. Paulus E.V., Mintz E.M. Developmental disruption of the serotonin system alters circadian rhythms. Physiol Behav 2012, 105:257-263.
127. Pereira M.A., Jacobs D.R., Pins J.J., Raatz S.K., Gross M.D., Slavin J.L., Seaquist E.R. Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults. Am J Clin Nutr 2002, 75:848-855.
128. Pestell R.G., Crock P.A., Ward G.M., Alford F.P., Best J.D. Fenfluramine increases insulin action in patients with NIDDM. Diabetes Care 1989, 12:252-258.
129. Petrov T., Krukoff T.L., Jhamandas J.H. The hypothalamic paraventricular and lateral parabrachial nuclei receive collaterals from raphe nucleus neurons: a combined double retrograde and immunocytochemical study. J Comparat Neurol 1992, 318:18-26.
130. Piernas C., Popkin B.M. Snacking increased among U.S. adults between 1977 and 2006. J Nutr 2010, 140:325-332.
131. Poncet L., Denoroy L., Jouvet M. Daily variations in in vivo tryptophan hydroxylation and in the contents of serotonin and 5-hydroxyindoleacetic acid in discrete brain areas of the rat. J Neural Transm Gen Sect 1993, 92:137-150.
132. Potter van Loon B.J., Radder J.K., Frolich M., Krans H.M., Zwinderman A.H., Meinders A.E. Fluoxetine increases insulin action in obese nondiabetic and in obese non-insulin-dependent diabetic individuals. Int J Obes Relat Metab Disord 1992, 16:79-85.
133. Proietto J., Thorburn A.W., Fabris S., Harrison L.C. Effects of dexfenfluramine on glucose turnover in non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 1994, 23:127-134.
134. Prosser R.A. Serotonin phase-shifts the mouse suprachiasmatic circadian clock in vitro. Brain Res 2003, 966:110-115.
135. Qin L.Q., Li J., Wang Y., Wang J., Xu J.Y., Kaneko T. The effects of nocturnal life on endocrine circadian patterns in healthy adults. Life Sci 2003, 73:2467-2475.
136. Raeder M.B., Bjelland I., Emil V.S., Steen V.M. Obesity, dyslipidemia, and diabetes with selective serotonin reuptake inhibitors: the Hordaland Health Study. J Clin Psychiatry 2006, 67:1974-1982.
137. Rosmond R., Bouchard C., Bjorntorp P. 5-HT2A receptor gene promoter polymorphism in relation to abdominal obesity and cortisol. Obes Res 2002, 10:585-589.
138. Rouch C., Nicolaidis S., Orosco M. Determination, using microdialysis, of hypothalamic serotonin variations in response to different macronutrients. Physiol Behav 1999, 65:653-657.
139. Saderi N., Cazarez-Marquez F., Buijs F.N., Salgado-Delgado R.C., Guzman-Ruiz M.A., del Carmen Basualdo M., Escobar C., Buijs R.M. The NPY intergeniculate leaflet projections to the suprachiasmatic nucleus transmit metabolic conditions. Neuroscience 2013, 246:291-300.
140. Salgado-Delgado R.C., Saderi N., Basualdo Mdel C., Guerrero-Vargas N.N., Escobar C., Buijs R.M. Shift work or food intake during the rest phase promotes metabolic disruption and desynchrony of liver genes in male rats. PLoS One 2013, 8:e60052.
141. Sanchez S., Sanchez C., Paredes S.D., Cubero J., Rodriguez A.B., Barriga C. Circadian variations of serotonin in plasma and different brain regions of rats. Mol Cell Biochem 2008, 317:105-111.
142. Sawchenko P.E., Swanson L.W., Steinbusch H.W., Verhofstad A.A. The distribution and cells of origin of serotonergic inputs to the paraventricular and supraoptic nuclei of the rat. Brain Res 1983, 277:355-360.
143. Scheen A.J., Paolisso G., Salvatore T., Lefebvre P.J. Improvement of insulin-induced glucose disposal in obese patients with NIDDM after 1-wk treatment with d-fenfluramine. Diabetes Care 1991, 14:325-332.
144. Scheer F.A., Hilton M.F., Mantzoros C.S., Shea S.A. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci USA 2009, 106:4453-4458.
145. Schmidt M., Johannesdottir S.A., Lemeshow S., Lash T.L., Ulrichsen S.P., Botker H.E., Toft S.H. Obesity in young men, and individual and combined risks of type 2 diabetes, cardiovascular morbidity and death before 55 years of age: a Danish 33-year follow-up study. BMJ Open 2013, 3.
146. Schreiber R., De Vry J. Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat. Prog Neuropsychopharmacol Biol Psychiatry 2002, 26:441-449.
147. Schwartz M.W., Woods S.C., Porte D., Seeley R.J., Baskin D.G. Central nervous system control of food intake. Nature 2000, 404:661-671.
148. Simansky K.J. Serotonergic control of the organization of feeding and satiety. Behav Brain Res 1996, 73:37-42.
149. Simansky K.J., Vaidya A.H. Behavioral mechanisms for the anorectic action of the serotonin (5-HT) uptake inhibitor sertraline in rats: comparison with directly acting 5-HT agonists. Brain Res Bull 1990, 25:953-960.
150. Simon C., Weibel L., Brandenberger G. Twenty-four-hour rhythms of plasma glucose and insulin secretion rate in regular night workers. Am J Physiol Endocrinol Metab 2000, 278:E413-420.
151. Smith B.M., Thomsen W.J., Grottick A.J. The potential use of selective 5-HT2C agonists in treating obesity. Expert Opin Investig Drugs 2006, 15:257-266.
152. Smith S.A., Pogson C.L. Tryptophan and the control of plasma glucose concentrations in the rat. Biochem J 1977, 168:495-506.
153. Sohn J.W., Xu Y., Jones J.E., Wickman K., Williams K.W., Elmquist J.K. Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron 2011, 71:488-497.
154. Sprouse J., Reynolds L., Braselton J., Schmidt A. Serotonin-induced phase advances of SCN neuronal firing in vitro: a possible role for 5-HT5A receptors?. Synapse 2004, 54:111-118.
155. Stewart G.O., Stein G.R., Davis T.M., Findlater P. Dexfenfluramine in type II diabetes: effect on weight and diabetes control. Med J Aust 1993, 158:167-169.
156. Strubbe J.H., van Dijk G. The temporal organization of ingestive behaviour and its interaction with regulation of energy balance. Neurosci Biobehav Rev 2002, 26:485-498.
157. Sugimoto Y., Kimura I., Yamada J., Watanabe Y., Takeuchi N., Horisaka K. Effects of serotonin on blood glucose and insulin levels of glucose- and streptozotocin-treated mice. Jpn J Pharmacol 1990, 54:93-96.
158. Tecott L.H., Sun L.M., Akana S.F., Strack A.M., Lowenstein D.H., Dallman M.F., Julius D. Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 1995, 374:542-546.
159. Ushijima K., Koyanagi S., Sato Y., Ogata T., Matsunaga N., Fujimura A., Ohdo S. Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain. Mol Pharmacol 2012, 82:264-270.
160. Ushijima K., Sakaguchi H., Sato Y., To H., Koyanagi S., Higuchi S., Ohdo S. Chronopharmacological study of antidepressants in forced swimming test of mice. J Pharmacol Exp Ther 2005, 315:764-770.
161. van de Kar L.D., Lorens S.A. Differential serotonergic innervation of individual hypothalamic nuclei and other forebrain regions by the dorsal and median midbrain raphe nuclei. Brain Res 1979, 162:45-54.
162. Vickers S.P., Clifton P.G., Dourish C.T., Tecott L.H. Reduced satiating effect of d-fenfluramine in serotonin 5-HT(2C) receptor mutant mice. Psychopharmacology (Berl) 1999, 143:309-314.
163. Vickers S.P., Dourish C.T., Kennett G.A. Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors. Neuropharmacology 2001, 41:200-209.
164. Waldbillig R.J., Bartness T.J., Stanley B.G. Increased food intake, body weight, and adiposity in rats after regional neurochemical depletion of serotonin. J Comp Physiol Psychol 1981, 95:391-405.
165. Walther D.J., Peter J.U., Bashammakh S., Hortnagl H., Voits M., Fink H., Bader M. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 2003, 299:76.
166. Wang J.B., Patterson R.E., Ang A., Emond J.A., Shetty N., Arab L. Timing of energy intake during the day is associated with the risk of obesity in adults. J Hum Nutr Diet 2014, 27(Suppl 2):255-262.
167. Weiner N., Clement H.W., Gemsa D., Wesemann W. Circadian and seasonal rhythms of 5-HT receptor subtypes, membrane anisotropy and 5-HT release in hippocampus and cortex of the rat. Neurochem Int 1992, 21:7-14.
168. Weintraub M., Sundaresan P.R., Madan M., Schuster B., Balder A., Lasagna L., Cox C. Long-term weight control study. I (weeks 0 to 34). The enhancement of behavior modification, caloric restriction, and exercise by fenfluramine plus phentermine versus placebo. Clin Pharmacol Ther 1992, 51:586-594.
169. Weltzin T.E., Fernstrom M.H., Fernstrom J.D., Neuberger S.K., Kaye W.H. Acute tryptophan depletion and increased food intake and irritability in bulimia nervosa. Am J Psychiatry 1995, 152:1668-1671.
170. Willoughby J.O., Blessing W.W. Origin of serotonin innervation of the arcuate and ventromedial hypothalamic region. Brain Res 1987, 418:170-173.
171. Woolley M.L., Bentley J.C., Sleight A.J., Marsden C.A., Fone K.C. A role for 5-ht6 receptors in retention of spatial learning in the Morris water maze. Neuropharmacology 2001, 41:210-219.
172. Wozniak K.M., Linnoila M. Hyperglycemic properties of serotonin receptor antagonists. Life Sci 1991, 49:101-109.
173. Xu Y., Berglund E.D., Sohn J.W., Holland W.L., Chuang J.C., Fukuda M., Rossi J., Williams K.W., Jones J.E., Zigman J.M., Lowell B.B., Scherer P.E., Elmquist J.K. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci 2010, 13:1457-1459.
174. Yamada J., Sugimoto Y., Kimura I., Takeuchi N., Horisaka K. Serotonin-induced hypoglycemia and increased serum insulin levels in mice. Life Sci 1989, 45:1931-1936.
175. Yi C.X., Serlie M.J., Ackermans M.T., Foppen E., Buijs R.M., Sauerwein H.P., Fliers E., Kalsbeek A. A major role for perifornical orexin neurons in the control of glucose metabolism in rats. Diabetes 2009, 58:1998-2005.
176. Yi C.X., van der Vliet J., Dai J., Yin G., Ru L., Buijs R.M. Ventromedial arcuate nucleus communicates peripheral metabolic information to the suprachiasmatic nucleus. Endocrinology 2006, 147:283-294.
177. Yoshida C., Shikata N., Seki S., Koyama N., Noguchi Y. Early nocturnal meal skipping alters the peripheral clock and increases lipogenesis in mice. Nutr Metab (Lond) 2012, 9:78.