Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo

Journal of Hazardous Materials

Volumn 298, Issue , 2015, Pages 310-319

  Shi, Zhiqin ^a   Niu, Yujie ^a   Wang, Qian ^a   Shi, Lei ^a   Guo, Huicai ^a   Liu, Yi ^a   Zhu, Yue ^a   Liu, Shufeng ^b   Liu, Chao ^b   Chen, Xin ^c   Zhang, Rong ^a,b  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Hebei Key Laboratory of Laboratory Animal Science   (China)

^c Xiumen Community Health Service Centre   (China)

Author keywords

DNA damage; Nanoparticles; Nrf2; Oxidative stress; Titanium dioxide

Indexed keywords

AMINO ACIDS; CELLS; CYTOLOGY; DISEASES; GENE EXPRESSION; MAMMALS; NANOPARTICLES; OXIDATIVE STRESS; OXIDES; TITANIUM; TITANIUM DIOXIDE;

CATALYTIC SUBUNITS; DNA DAMAGES; DOSE-DEPENDENT MANNER; GLUTAMATE-CYSTEINE LIGASE; NRF2; REACTIVE OXYGEN SPECIES; TERT-BUTYLHYDROQUINONE (TBHQ); TITANIUM DIOXIDE NANOPARTICLES;

DNA;

DNA; GLUTAMATE CYSTEINE LIGASE; HEME OXYGENASE 1; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TERT BUTYLHYDROQUINONE; TITANIUM DIOXIDE NANOPARTICLE; TRANSCRIPTION FACTOR NRF2; 2-TERT-BUTYLHYDROQUINONE; HYDROQUINONE DERIVATIVE; NANOPARTICLE; NFE2L2 PROTEIN, MOUSE; TITANIUM; TITANIUM DIOXIDE;

DNA; ENZYME ACTIVITY; GENE EXPRESSION; GERM CELL; NANOTECHNOLOGY; OXIDATION; TITANIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL LEVEL; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVE SITE; FEMALE; GENOTOXICITY; HEPG2 CELL LINE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NANOTOXICOLOGY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; ANIMAL; BIOSYNTHESIS; CELL LINE; DRUG EFFECTS; GENETICS; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; KNOCKOUT MOUSE; METABOLISM; PARTICLE SIZE;

MUS;

ANIMALS; ANTIOXIDANT RESPONSE ELEMENTS; CELL LINE; DNA DAMAGE; FEMALE; HUMANS; HYDROQUINONES; MALE; METABOLIC NETWORKS AND PATHWAYS; MICE; MICE, INBRED ICR; MICE, KNOCKOUT; NANOPARTICLES; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PARTICLE SIZE; REACTIVE OXYGEN SPECIES; TITANIUM;

EID: 84931264313     PISSN: 03043894     EISSN: 18733336     Source Type: Journal    
DOI: 10.1016/j.jhazmat.2015.05.043     Document Type: Article

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