A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation

Molecular Cell

Volumn 58, Issue 5, 2015, Pages 794-803

  Zha, Zhengyu ^a,b,c,d   Han, Xiaoran ^a,b,c   Smith, Matthew D ^d   Liu, Yang ^d   Giguère, Patrick M ^d   Kopanja, Dragana ^e   Raychaudhuri, Pradip ^e   Siderovski, David P ^d,g   Guan, Kun Liang ^a,b,f   Lei, Qun Ying ^a,b   Xiong, Yue ^a,b,d  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF ILLINOIS   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; G PROTEIN COUPLED RECEPTOR KINASE 2; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; PROTEIN CUL4A; PROTEIN DDB1; PROTEIN ROC1; RING FINGER PROTEIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ADRBK1 PROTEIN, HUMAN; DDB1 PROTEIN, HUMAN; DNA BINDING PROTEIN; DTL PROTEIN, HUMAN; NUCLEAR PROTEIN;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION; ENZYME PHOSPHORYLATION; FEEDBACK SYSTEM; GENE DELETION; HEART HYPERTROPHY; HUMAN; HUMAN CELL; MALE; MOUSE; NEWBORN; NONHUMAN; PKA; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN STABILITY; RAT; SIGNAL TRANSDUCTION; STEADY STATE; UBIQUITINATION; UPREGULATION; ANIMAL; FEMALE; HEK293 CELL LINE; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; PROTEIN DEGRADATION; WISTAR RAT;

ANIMALS; DNA-BINDING PROTEINS; FEMALE; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GTP-BINDING PROTEIN BETA SUBUNITS; HEK293 CELLS; HUMANS; MALE; MICE, KNOCKOUT; NUCLEAR PROTEINS; PROTEIN STABILITY; PROTEOLYSIS; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84931091401     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2015.04.017     Document Type: Article

References (33)

1. Angers S., Li T., Yi X., MacCoss M.J., Moon R.T., Zheng N. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Nature 2006, 443:590-593.
2. Cang Y., Zhang J., Nicholas S.A., Bastien J., Li B., Zhou P., Goff S.P. Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells. Cell 2006, 127:929-940.
3. Chen L.-C., Manjeshwar S., Lu Y., Moore D., Ljung B.-M., Kuo W.-L., Dairkee S.H., Wernick M., Collins C., Smith H.S. The human homologue for the Caenorhabditis elegans cul-4 gene is amplified and overexpressed in primary breast cancers. Cancer Res. 1998, 58:3677-3683.
4. Cox B.J., Vollmer M., Tamplin O., Lu M., Biechele S., Gertsenstein M., van Campenhout C., Floss T., Kühn R., Wurst W., et al. Phenotypic annotation of the mouse X chromosome. Genome Res. 2010, 20:1154-1164.
5. DeWire S.M., Ahn S., Lefkowitz R.J., Shenoy S.K. Beta-arrestins and cell signaling. Annu. Rev. Physiol. 2007, 69:483-510.
6. Dupré D.J., Robitaille M., Rebois R.V., Hébert T.E. The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes. Annu. Rev. Pharmacol. Toxicol. 2009, 49:31-56.
7. Evron T., Daigle T.L., Caron M.G. GRK2: multiple roles beyond G protein-coupled receptor desensitization. Trends Pharmacol. Sci. 2012, 33:154-164.
8. Giguère P.M., Laroche G., Oestreich E.A., Siderovski D.P. G-protein signaling modulator-3 regulates heterotrimeric G-protein dynamics through dual association with Gβ and Gαi protein subunits. J. Biol. Chem. 2012, 287:4863-4874.
9. Gurevich E.V., Tesmer J.J., Mushegian A., Gurevich V.V. G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol. Ther. 2012, 133:40-69.
10. Hu J., McCall C.M., Ohta T., Xiong Y. Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Nat. Cell Biol. 2004, 6:1003-1009.
11. Jiang B., Zhao W., Yuan J., Qian Y., Sun W., Zou Y., Guo C., Chen B., Shao C., Gong Y. Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development. PLoS ONE 2012, 7:e37070.
12. Koch W.J., Rockman H.A., Samama P., Hamilton R.A., Bond R.A., Milano C.A., Lefkowitz R.J. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science 1995, 268:1350-1353.
13. Kopanja D., Stoyanova T., Okur M.N., Huang E., Bagchi S., Raychaudhuri P. Proliferation defects and genome instability in cells lacking Cul4A. Oncogene 2009, 28:2456-2465.
14. Lefkowitz R.J., Shenoy S.K. Transduction of receptor signals by beta-arrestins. Science 2005, 308:512-517.
15. Leosco D., Fortunato F., Rengo G., Iaccarino G., Sanzari E., Golino L., Zincarelli C., Canonico V., Marchese M., Koch W.J., Rengo F. Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease. Neurosci. Lett. 2007, 415:279-282.
16. Liu S., Premont R.T., Kontos C.D., Zhu S., Rockey D.C. A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension. Nat. Med. 2005, 11:952-958.
17. Liu L., Lee S., Zhang J., Peters S.B., Hannah J., Zhang Y., Yin Y., Koff A., Ma L., Zhou P. CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis. Mol. Cell 2009, 34:451-460.
18. Liu L., Yin Y., Li Y., Prevedel L., Lacy E.H., Ma L., Zhou P. Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis. Cell Res. 2012, 22:1258-1269.
19. Lodowski D.T., Pitcher J.A., Capel W.D., Lefkowitz R.J., Tesmer J.J. Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma. Science 2003, 300:1256-1262.
20. Maddika S., Chen J. Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat. Cell Biol. 2009, 11:409-419.
21. Morisco C., Lembo G., Trimarco B. Insulin resistance and cardiovascular risk: New insights from molecular and cellular biology. Trends Cardiovasc. Med. 2006, 16:183-188.
22. Nakagawa T., Xiong Y. X-linked mental retardation gene CUL4B targets ubiquitylation of H3K4 methyltransferase component WDR5 and regulates neuronal gene expression. Mol. Cell 2011, 43:381-391.
23. Northup J.K., Sternweis P.C., Smigel M.D., Schleifer L.S., Ross E.M., Gilman A.G. Purification of the regulatory component of adenylate cyclase. Proc. Natl. Acad. Sci. USA 1980, 77:6516-6520.
24. Penela P., Ruiz-Gómez A., Castaño J.G., Mayor F. Degradation of the G protein-coupled receptor kinase 2 by the proteasome pathway. J. Biol. Chem. 1998, 273:35238-35244.
25. Premont R.T., Gainetdinov R.R. Physiological roles of G protein-coupled receptor kinases and arrestins. Annu. Rev. Physiol. 2007, 69:511-534.
26. Rapić-Otrin V., Navazza V., Nardo T., Botta E., McLenigan M., Bisi D.C., Levine A.S., Stefanini M. True XP group E patients have a defective UV-damaged DNA binding protein complex and mutations in DDB2 which reveal the functional domains of its p48 product. Hum. Mol. Genet. 2003, 12:1507-1522.
27. Rockman H.A., Koch W.J., Lefkowitz R.J. Seven-transmembrane-spanning receptors and heart function. Nature 2002, 415:206-212.
28. Salcedo A., Mayor F., Penela P. Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2. EMBO J. 2006, 25:4752-4762.
29. Shenoy S.K., Lefkowitz R.J. Seven-transmembrane receptor signaling through beta-arrestin. Sci. STKE 2005, 2005:cm10.
30. Siderovski D.P., Kimple A.J., Willard F.S., Begley T.P. Large G-Proteins. Wiley Encyclopedia of Chemical Biology 2007, John Wiley & Sons, Inc.
31. Ungerer M., Böhm M., Elce J.S., Erdmann E., Lohse M.J. Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. Circulation 1993, 87:454-463.
32. Wan Y., Yang Z., Guo J., Zhang Q., Zeng L., Song W., Xiao Y., Zhu X. Misfolded Gβ is recruited to cytoplasmic dynein by Nudel for efficient clearance. Cell Res. 2012, 22:1140-1154.
33. Yu X., Huang S., Patterson E., Garrett M.W., Kaufman K.M., Metcalf J.P., Zhu M., Dunn S.T., Kem D.C. Proteasome degradation of GRK2 during ischemia and ventricular tachyarrhythmias in a canine model of myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 2005, 289:H1960-H1967.