Proliferation defects and genome instability in cells lacking cul4a

Oncogene

Volumn 28, Issue 26, 2009, Pages 2456-2465

  Kopanja, D ^a   Stoyanova, T ^a   Okur, M N ^a   Huang, E ^a   Bagchi, S ^b   Raychaudhuri, P ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Cul4A; Genome instability; p53; Proliferation

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; MUTANT PROTEIN; PROTEIN CUL4A; PROTEIN P53; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BREAST; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL DIVISION; CELL PROLIFERATION; CENTROSOME; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; DELETION MUTANT; DOWN REGULATION; EMBRYO; EMBRYO CELL; EMBRYO DEVELOPMENT; FIBROBLAST; GENE DELETION; GENOMIC INSTABILITY; LIVER; LIVER CELL DAMAGE; LIVER REGENERATION; MALE; MICRONUCLEUS; MITOSIS SPINDLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION; ULTRAVIOLET IRRADIATION; UNSCHEDULED DNA SYNTHESIS;

ANIMALS; CARBON TETRACHLORIDE; CELL DIVISION; CELL LINE; CELL PROLIFERATION; CENTROSOME; CHROMOSOMAL INSTABILITY; CULLIN PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DNA; DNA REPAIR; GENOMIC INSTABILITY; HEPATOCYTES; HUMANS; LIVER; MALE; MICE; S PHASE; SEQUENCE DELETION; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

MUS;

EID: 67650065015     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2009.86     Document Type: Article

References (29)

1. Abba MC, Fabris VT, Hu Y et al. (2007). Identification of novel amplification gene targets in mouse and human breast cancer at a syntenic cluster mapping to mouse ch8A1 and human ch13q34. Cancer Res 67: 4104-1112.
2. Banks D, Wu M, Higa LA, Quan J, Ye T, Kobayashi R et al. (2006). L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complex. Cell Cycle 5: 1719-1729.
3. Belzile JP, Duisit G, Rougeau N, Mercier J, Finzi A, Cohen EA.. (2007). HIV-1 Vpr-Mediated G2 Arrest Involves the DDB1-CUL4A(VPRBP) E3 Ubiquitin Ligase. PLoS Pathog 3: e85.
4. Bergametti F, Sitterlin D, Transy C. (2002). Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex. J Virol 76: 6495-6501.
5. Bondar T, Kalinina A, Khair L, Kopanja D, Bagchi S, Raychaudhuri P. (2006). Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving COP9 signalosome. Mol Cell Biol 26: 2531-2539.
6. Bondar T, Ponomarev A, Raychaudhuri P. (2004). Ddb1 is required for the proteolysis of the Schizosaccharomyces pombe replication inhibitor Spd1 during S phase and after DNA damage. J Biol Chem 279: 9937-9944.
7. Cang Y, Zhang J, Nicholas SA, Bastien J, Li B, Zhou P et al. (2006). Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells. Cell 127: 929-940.
8. Chen LC, Manjeshwar S, Lu Y, Moore D, Ljung BM et al. (1998). The human homologue for the Caenorhabditis elegans Cul-4 gene is amplified and overexpressed in primary breast cancers. Cancer Res 58: 3677-3683.
9. El-Mahdy MA, Zhu Q, Wang QE, Wani G, Praetorius-Ibba M, Wani AA. (2006). Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC. J Biol Chem 281: 13404-13411.
10. Fausto N. 1996. Hepatic regeneration. In: Zakim D and Boyer TD (eds) Hepatology A Text Book of Liver Diseases. W.B Saunders Co Philadelphia, pp 32-58.
11. Fukasawa K. (2005). Centrosome amplification, chromosome instability and cancer development. Cancer Lett 230: 6-19.
12. Higa LA, Mihaylov IS, sBanks DP, Zheng J, Zhang H. (2003).Radiation- mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. Nat Cell Biol 5: 10081015.
13. Higa LA, Yang X, Zheng J et al . (2006). Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation. Cell Cycle 5: 71-77.
14. Holmberg C, Fleck O, Hansen HA., Liu C, Slaaby R, Carr AM et al . (2005). Ddb1 controls genome stability and meiosis in fission yeast.Genes Dev 19: 853-862.
15. Kim Y, Kipreos ET. (2007). Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways. Cell Div 2: 18.
16. Li B, Ruiz JC, Chun KT. (2002). Cul4A is critical for early embryonic development. Mol Cell Biol 22: 4997-5005.
17. Li B, Ruiz JC, Chun KT. (2006). Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation duringerythropoiesis. Blood 107: 4291-4299.
18. Nag A, Bondar T, Shiv S, Raychaudhuri P. (2001). The XP-E gene product DDB2 is a specific target of cullin 4A in mammalian cell.Mol Cell Biol 21: 6738-6747.
19. Nag A, Bagchi S, Raychaudhuri P. (2004). Cul4A physically associates with MDM2 and participates in the proteolysis of p53. Cancer Res 64: 8152-8165.
20. Postic C, Magnuson MA. (2000). DNA excision in liver by an albumin-Cre transgene occurs progressively with age. Genesis 26: 149-150.
21. Schindl M, Gnant M, Schoppmann SF, Horvat R, Birner P. (2007). Overexpression of the human homologue for Caenorhabditis elegans cul-4 gene is associated with poor outcome in node-negative breast cancer. Anticancer Res 2: 949-952.
22. Serfas MS, Goufman E, Feuerman MH, Gartel AL, Tyner AL. (1997). P53-independent induction of p21Waf1/Cip1 expression in pericen- tral hepatocytes following carbon tetrachloride intoxication. Cell Growth & Diff 8: 951-961.
23. Shinmura K, Bennett RA, Tarapore P, Fukasawa K.. (2007). Direct evidence for the role of centrosomally localized p53 in the regulation of centrosome duplication. Oncogene 26: 2939-2944.
24. Smith ML, Ford JM, Hollander MC. (2000). P53-mediated DNArepair responses to UV radiation: studies of mouse cells lacking p53, p21 and/or gadd45 genes. Mol Cell Biol 20: 3705-3714.
25. Ulane CM, Horvath CM. (2002). Paramyxoviruses SV5 and HPIV2 Assemble STAT Protein Ubiquitin Ligase Complexes from Cellular Components. Virology 304: 160-166.
26. Waning DL, Li B, Jia N, Naaldijk Y, Goebel WS, HogenEsch H et al. (2008). Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis. Blood 112: 302-309.
27. Wertz I E, O'Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ et al. (2004). Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science 303: 1371-1374.
28. Yasui K, Arii S, Zhao C, Imoto I, Ueda M, Nagai H et al. (2002). TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas. Hepatology 35: 1476-1484.
29. Zhang Y, Morrone G, Zhang J, Chen X, Lu X, Ma L et al. (2003).Cul-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein. EMBO J 22: 6057-6067.