Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Jiang, Baichun ^a   Zhao, Wei ^a   Yuan, Jupeng ^a   Qian, Yanyan ^a   Sun, Wenjie ^a   Zou, Yongxin ^a   Guo, Chenhong ^a   Chen, Bingxi ^a   Shao, Changshun ^a   Gong, Yaoqin ^a  

^a Shandong University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN CUL4B; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; COMPLEMENTARY DNA; CUL4B PROTEIN, HUMAN; CUL4B PROTEIN, MOUSE; CULLIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; FEMALE; GENE FREQUENCY; GENE MUTATION; HEMIZYGOSITY; HETEROZYGOSITY; HOMOLOGOUS RECOMBINATION; LETHALITY; MALE; MOUSE; NONHUMAN; PLACENTA DEVELOPMENT; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN DEGRADATION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ANIMAL; APOPTOSIS; C57BL MOUSE; CELL PROLIFERATION; CONGENITAL MALFORMATION; EMBRYO DEATH; ENZYMOLOGY; EXON; GENE DELETION; GENETICS; HEMIZYGOTE; HETEROZYGOTE; HUMAN; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PLACENTA; PREGNANCY; PRENATAL DEVELOPMENT; SPECIES DIFFERENCE; VASCULARIZATION; X CHROMOSOME INACTIVATION; X LINKED MENTAL RETARDATION;

MUS;

ANIMALS; APOPTOSIS; BASE SEQUENCE; CELL PROLIFERATION; CULLIN PROTEINS; DNA, COMPLEMENTARY; EMBRYO LOSS; EMBRYONIC DEVELOPMENT; EXONS; FEMALE; HEMIZYGOTE; HETEROZYGOTE; HUMANS; MALE; MENTAL RETARDATION, X-LINKED; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLACENTA; PREGNANCY; SEQUENCE DELETION; SPECIES SPECIFICITY; X CHROMOSOME INACTIVATION;

EID: 84861002253     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037070     Document Type: Article

References (40)

1. Petroski MD, Deshaies RJ, (2005) Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol 6: 9-20.
2. Bosu DR, Kipreos ET, (2008) Cullin-RING ubiquitin ligases: global regulation and activation cycles. Cell Div 3: 7.
3. Sarikas A, Hartmann T, Pan ZQ, (2011) The cullin protein family. Genome Biol 12: 220.
4. Zou Y, Mi J, Cui J, Lu D, Zhang X, et al. (2009) Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression. J Biol Chem 284: 33320-33332.
5. Higa LA, Zhang H, (2007) Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy. Cell Div 2: 5.
6. Angers S, Li T, Yi X, MacCoss MJ, Moon RT, et al. (2006) Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Nature 443: 590-593.
7. Higa LA, Wu M, Ye T, Kobayashi R, Sun H, et al. (2006) CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. Nat Cell Biol 8: 1277-1283.
8. He YJ, McCall CM, Hu J, Zeng Y, Xiong Y, (2006) DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. Genes Dev 20: 2949-2954.
9. Jin J, Arias EE, Chen J, Harper JW, Walter JC, (2006) A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol Cell 23: 709-721.
10. Leung-Pineda V, Huh J, Piwnica-Worms H, (2009) DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. Cancer Res 69: 2630-2637.
11. Waning DL, Li B, Jia N, Naaldijk Y, Goebel WS, et al. (2008) Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis. Blood 112: 320-329.
12. Nakagawa T, Xiong Y, (2011) X-Linked Mental Retardation Gene CUL4B Targets Ubiquitylation of H3K4 Methyltransferase Component WDR5 and Regulates Neuronal Gene Expression. Mol Cell 43: 381-391.
13. Li X, Lu D, He F, Zhou H, Liu Q, et al. (2011) Cullin 4B protein ubiquitin ligase targets peroxiredoxin III for degradation. J Biol Chem 286: 32344-32354.
14. Kerzendorfer C, Whibley A, Carpenter G, Outwin E, Chiang SC, et al. (2010) Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks. Hum Mol Genet 19: 1324-1334.
15. Ohtake F, Baba A, Takada I, Okada M, Iwasaki K, et al. (2007) Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature 446: 562-566.
16. Tarpey PS, Raymond FL, O'Meara S, Edkins S, Teague J, et al. (2007) Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. Am J Hum Genet 80: 345-352.
17. Zou Y, Liu Q, Chen B, Zhang X, Guo C, et al. (2007) Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation. Am J Hum Genet 80: 561-566.
18. Badura-Stronka M, Jamsheer A, Materna-Kiryluk A, Sowinska A, Kiryluk K, et al. (2010) A novel nonsense mutation in CUL4B gene in three brothers with X-linked mental retardation syndrome. Clin Genet 77: 141-144.
19. Isidor B, Pichon O, Baron S, David A, Le Caignec C, (2010) Deletion of the CUL4B gene in a boy with mental retardation, minor facial anomalies, short stature, hypogonadism, and ataxia. Am J Med Genet A 152A: 175-180.
20. Ravn K, Lindquist S, Nielsen K, Dahm T, Tumer Z, (2012) Deletion of CUL4B leads to concordant phenotype in a monozygotic twin pair. Clin Genet.
21. Li B, Ruiz JC, Chun KT, (2002) CUL-4A is critical for early embryonic development. Mol Cell Biol 22: 4997-5005.
22. Liu L, Lee S, Zhang J, Peters SB, Hannah J, et al. (2009) CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis. Mol Cell 34: 451-460.
23. Kopanja D, Roy N, Stoyanova T, Hess RA, Bagchi S, et al. (2011) Cul4A is essential for spermatogenesis and male fertility. Dev Biol 352: 278-287.
24. Yin Y, Lin C, Kim ST, Roig I, Chen H, et al. (2011) The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis. Dev Biol 356: 51-62.
25. Kopanja D, Stoyanova T, Okur MN, Huang E, Bagchi S, et al. (2009) Proliferation defects and genome instability in cells lacking Cul4A. Oncogene 28: 2456-2465.
26. Higa LA, Yang X, Zheng J, Banks D, Wu M, et al. (2006) Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation. Cell Cycle 5: 71-77.
27. Dealy MJ, Nguyen KV, Lo J, Gstaiger M, Krek W, et al. (1999) Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E. Nat Genet 23: 245-248.
28. Singer JD, Gurian-West M, Clurman B, Roberts JM, (1999) Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. Genes Dev 13: 2375-2387.
29. Wang Y, Penfold S, Tang X, Hattori N, Riley P, et al. (1999) Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E. Curr Biol 9: 1191-1194.
30. Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, et al. (2003) Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. Proc Natl Acad Sci U S A 100: 9855-9860.
31. Cox BJ, Vollmer M, Tamplin O, Lu M, Biechele S, et al. (2010) Phenotypic annotation of the mouse X chromosome. Genome Res 20: 1154-1164.
32. Garrick D, Sharpe JA, Arkell R, Dobbie L, Smith AJ, et al. (2006) Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues. PLoS Genet 2: e58.
33. Berube NG, Mangelsdorf M, Jagla M, Vanderluit J, Garrick D, et al. (2005) The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis. J Clin Invest 115: 258-267.
34. Zhao X, D DA, Lim WK, Brahmachary M, Carro MS, et al. (2009) The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain. Dev Cell 17: 210-221.
35. Doronkin S, Djagaeva I, Beckendorf SK, (2003) The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis. Dev Cell 4: 699-710.
36. Spruck CH, Won KA, Reed SI, (1999) Deregulated cyclin E induces chromosome instability. Nature 401: 297-300.
37. Gascoin-Lachambre G, Buffat C, Rebourcet R, Chelbi ST, Rigourd V, et al. (2010) Cullins in human intra-uterine growth restriction: expressional and epigenetic alterations. Placenta 31: 151-157.
38. Muers MR, Sharpe JA, Garrick D, Sloane-Stanley J, Nolan PM, et al. (2007) Defining the cause of skewed X-chromosome inactivation in X-linked mental retardation by use of a mouse model. Am J Hum Genet 80: 1138-1149.
39. Lakso M, Pichel JG, Gorman JR, Sauer B, Okamoto Y, et al. (1996) Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A 93: 5860-5865.
40. Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, et al. (1999) Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23: 99-103.