메뉴 건너뛰기




Volumn 11, Issue 6, 2015, Pages 700-709

Down syndrome and Alzheimer's disease: Common pathways, common goals

(21)  Hartley, Dean a   Blumenthal, Thomas b   Carrillo, Maria a   DiPaolo, Gilbert c   Esralew, Lucille d   Gardiner, Katheleen b,e   Granholm, Ann Charlotte f   Iqbal, Khalid g   Krams, Michael h   Lemere, Cynthia i   Lott, Ira j   Mobley, William k   Ness, Seth h   Nixon, Ralph l   Potter, Huntington b,m   Reeves, Roger n   Sabbagh, Marwan o   Silverman, Wayne n,p   Tycko, Benjamin c   Whitten, Michelle q   more..


Author keywords

ADNI; Alzheimer's disease; Amyloid precursor protein; Animal models; Beta amyloid; Biomarkers; Clinical trials; Cognitive assessment; Dementia; Down syndrome; Drug discovery; DS Connect; Neuroimaging; Neuroinflammation; Tau; Trisomy 21; Ts65Dn; Workshop

Indexed keywords

4 AMINOBUTYRIC ACID; ALPHA TOCOPHEROL; AMYLOID BETA PROTEIN ANTIBODY; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; ATOMOXETINE; BETA SECRETASE; BRAIN DERIVED NEUROTROPHIC FACTOR; DROXIDOPA; EPIGALLOCATECHIN GALLATE; FLUORODEOXYGLUCOSE F 18; GAMMA SECRETASE; INOSITOL; MEMANTINE; NERVE GROWTH FACTOR; NICOTINE; PROTEIN S100B;

EID: 84931070277     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2014.10.007     Document Type: Article
Times cited : (203)

References (79)
  • 1
    • 84880117155 scopus 로고    scopus 로고
    • Down's syndrome, neuroinflammation, and Alzheimer neuropathogenesis
    • D.M. Wilcock, and W.S. Griffin Down's syndrome, neuroinflammation, and Alzheimer neuropathogenesis J Neuroinflammation 10 2013 84
    • (2013) J Neuroinflammation , vol.10 , pp. 84
    • Wilcock, D.M.1    Griffin, W.S.2
  • 2
    • 0024370171 scopus 로고
    • A prospective study of Alzheimer's disease in Down syndrome
    • F. Lai, and R.S. Williams A prospective study of Alzheimer's disease in Down syndrome Arch Neurol 46 1989 849 853
    • (1989) Arch Neurol , vol.46 , pp. 849-853
    • Lai, F.1    Williams, R.S.2
  • 3
    • 0021956826 scopus 로고
    • Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome
    • K. Wisniewski, H. Wisniewski, and G. Wen Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome Ann Neurol 17 1985 278 282
    • (1985) Ann Neurol , vol.17 , pp. 278-282
    • Wisniewski, K.1    Wisniewski, H.2    Wen, G.3
  • 4
    • 0023889961 scopus 로고
    • The pathological association between Down syndrome and Alzheimer disease
    • D.M. Mann The pathological association between Down syndrome and Alzheimer disease Mech Ageing Dev 43 1988 99 136
    • (1988) Mech Ageing Dev , vol.43 , pp. 99-136
    • Mann, D.M.1
  • 5
    • 0024342769 scopus 로고
    • Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease
    • B. Rumble, R. Retallack, C. Hilbich, G. Simms, G. Multhaup, R. Martins, et al. Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease N Engl J Med 320 1989 1446 1452
    • (1989) N Engl J Med , vol.320 , pp. 1446-1452
    • Rumble, B.1    Retallack, R.2    Hilbich, C.3    Simms, G.4    Multhaup, G.5    Martins, R.6
  • 6
    • 0030007964 scopus 로고    scopus 로고
    • Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: Implications for initial events in amyloid plaque formation
    • C.A. Lemere, J.K. Blusztajn, H. Yamaguchi, T. Wisniewski, T.C. Saido, and D.J. Selkoe Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation Neurobiol Dis 3 1996 16 32
    • (1996) Neurobiol Dis , vol.3 , pp. 16-32
    • Lemere, C.A.1    Blusztajn, J.K.2    Yamaguchi, H.3    Wisniewski, T.4    Saido, T.C.5    Selkoe, D.J.6
  • 7
    • 84880632451 scopus 로고    scopus 로고
    • Pyroglutamate-3 amyloid-beta deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models
    • J.L. Frost, K.X. Le, H. Cynis, E. Ekpo, M. Kleinschmidt, R.M. Palmour, et al. Pyroglutamate-3 amyloid-beta deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models Am J Pathol 183 2013 369 381
    • (2013) Am J Pathol , vol.183 , pp. 369-381
    • Frost, J.L.1    Le, K.X.2    Cynis, H.3    Ekpo, E.4    Kleinschmidt, M.5    Palmour, R.M.6
  • 8
  • 9
    • 79958729432 scopus 로고    scopus 로고
    • Positron emission tomography of brain beta-amyloid and tau levels in adults with Down syndrome
    • L.D. Nelson, P. Siddarth, V. Kepe, K.E. Scheibel, S.C. Huang, J.R. Barrio, et al. Positron emission tomography of brain beta-amyloid and tau levels in adults with Down syndrome Arch Neurol 68 2011 768 774
    • (2011) Arch Neurol , vol.68 , pp. 768-774
    • Nelson, L.D.1    Siddarth, P.2    Kepe, V.3    Scheibel, K.E.4    Huang, S.C.5    Barrio, J.R.6
  • 10
    • 0028962046 scopus 로고
    • Neuropathological changes in Down's syndrome hippocampal formation. Effect of age and apolipoprotein E genotype
    • B.T. Hyman, H.L. West, G.W. Rebeck, F. Lai, and D.M. Mann Neuropathological changes in Down's syndrome hippocampal formation. Effect of age and apolipoprotein E genotype Arch Neurol 52 1995 373 378
    • (1995) Arch Neurol , vol.52 , pp. 373-378
    • Hyman, B.T.1    West, H.L.2    Rebeck, G.W.3    Lai, F.4    Mann, D.M.5
  • 11
    • 0028948391 scopus 로고
    • Age-related distribution of neuropathological changes in the cerebral cortex of patients with Down's syndrome
    • P.R. Hof, C. Bouras, D.P. Perl, L. Sparks, N. Mehta, and J.H. Morrison Age-related distribution of neuropathological changes in the cerebral cortex of patients with Down's syndrome Arch Neurol 52 1995 379 391
    • (1995) Arch Neurol , vol.52 , pp. 379-391
    • Hof, P.R.1    Bouras, C.2    Perl, D.P.3    Sparks, L.4    Mehta, N.5    Morrison, J.H.6
  • 12
    • 0023189934 scopus 로고
    • Loss of neurones from cortical and subcortical areas in Down's syndrome patients at middle age
    • D.M.A. Mann, P.O. Yates, B. Marcyniuk, and C.R. Ravindra Loss of neurones from cortical and subcortical areas in Down's syndrome patients at middle age J Neurol Sci 80 1987 79 89
    • (1987) J Neurol Sci , vol.80 , pp. 79-89
    • Mann, D.M.A.1    Yates, P.O.2    Marcyniuk, B.3    Ravindra, C.R.4
  • 13
    • 0034854122 scopus 로고    scopus 로고
    • Down syndrome and Alzheimer's disease: A link between development and aging
    • I.T. Lott, and E. Head Down syndrome and Alzheimer's disease: a link between development and aging Ment Retard Dev Disabil Res Rev 7 2001 172 178
    • (2001) Ment Retard Dev Disabil Res Rev , vol.7 , pp. 172-178
    • Lott, I.T.1    Head, E.2
  • 14
    • 35349031679 scopus 로고    scopus 로고
    • Alzheimer's disease in Down syndrome: Neurobiology and risk
    • W.B. Zigman, and I.T. Lott Alzheimer's disease in Down syndrome: neurobiology and risk Ment Retard Dev Disabil Res Rev 13 2007 237 246
    • (2007) Ment Retard Dev Disabil Res Rev , vol.13 , pp. 237-246
    • Zigman, W.B.1    Lott, I.T.2
  • 16
    • 84858208717 scopus 로고    scopus 로고
    • Neuroinflammation in the aging down syndrome brain; lessons from Alzheimer's disease
    • D.M. Wilcock Neuroinflammation in the aging down syndrome brain; lessons from Alzheimer's disease Curr Gerontol Geriatr Res 2012 2012 170276
    • (2012) Curr Gerontol Geriatr Res , vol.2012
    • Wilcock, D.M.1
  • 18
    • 29444442794 scopus 로고    scopus 로고
    • APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
    • A. Rovelet-Lecrux, D. Hannequin, G. Raux, N. Le Meur, A. Laquerriere, A. Vital, et al. APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy Nat Genet 38 2006 24 26
    • (2006) Nat Genet , vol.38 , pp. 24-26
    • Rovelet-Lecrux, A.1    Hannequin, D.2    Raux, G.3    Le Meur, N.4    Laquerriere, A.5    Vital, A.6
  • 19
    • 33646886350 scopus 로고    scopus 로고
    • Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease
    • J. Theuns, N. Brouwers, S. Engelborghs, K. Sleegers, V. Bogaerts, E. Corsmit, et al. Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease Am J Hum Genet 78 2006 936 946
    • (2006) Am J Hum Genet , vol.78 , pp. 936-946
    • Theuns, J.1    Brouwers, N.2    Engelborghs, S.3    Sleegers, K.4    Bogaerts, V.5    Corsmit, E.6
  • 20
    • 37549040895 scopus 로고    scopus 로고
    • Promoter polymorphisms which modulate APP expression may increase susceptibility to Alzheimer's disease
    • H. Lv, L. Jia, and J. Jia Promoter polymorphisms which modulate APP expression may increase susceptibility to Alzheimer's disease Neurobiol Aging 29 2008 194 202
    • (2008) Neurobiol Aging , vol.29 , pp. 194-202
    • Lv, H.1    Jia, L.2    Jia, J.3
  • 22
    • 0033869715 scopus 로고    scopus 로고
    • Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: Differential effects of APOE genotype and presenilin mutations
    • A.M. Cataldo, C.M. Peterhoff, J.C. Troncoso, T. Gomez-Isla, B.T. Hyman, and R.A. Nixon Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations Am J Pathol 157 2000 277 286
    • (2000) Am J Pathol , vol.157 , pp. 277-286
    • Cataldo, A.M.1    Peterhoff, C.M.2    Troncoso, J.C.3    Gomez-Isla, T.4    Hyman, B.T.5    Nixon, R.A.6
  • 23
    • 33745512851 scopus 로고    scopus 로고
    • Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration
    • A. Salehi, J.D. Delcroix, P.V. Belichenko, K. Zhan, C. Wu, J.S. Valletta, et al. Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration Neuron 51 2006 29 42
    • (2006) Neuron , vol.51 , pp. 29-42
    • Salehi, A.1    Delcroix, J.D.2    Belichenko, P.V.3    Zhan, K.4    Wu, C.5    Valletta, J.S.6
  • 25
    • 0034097607 scopus 로고    scopus 로고
    • Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome
    • A.C. Granholm, L.A. Sanders, and L.S. Crnic Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome Exp Neurol 161 2000 647 663
    • (2000) Exp Neurol , vol.161 , pp. 647-663
    • Granholm, A.C.1    Sanders, L.A.2    Crnic, L.S.3
  • 27
    • 78049427173 scopus 로고    scopus 로고
    • Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression
    • S.D. Ginsberg, M.J. Alldred, S.E. Counts, A.M. Cataldo, R.L. Neve, Y. Jiang, et al. Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression Biol Psychiatry 68 2010 885 893
    • (2010) Biol Psychiatry , vol.68 , pp. 885-893
    • Ginsberg, S.D.1    Alldred, M.J.2    Counts, S.E.3    Cataldo, A.M.4    Neve, R.L.5    Jiang, Y.6
  • 28
    • 76549096350 scopus 로고    scopus 로고
    • Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition
    • Y. Jiang, K.A. Mullaney, C.M. Peterhoff, S. Che, S.D. Schmidt, A. Boyer-Boiteau, et al. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition Proc Natl Acad Sci U S A 107 2010 1630 1635
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 1630-1635
    • Jiang, Y.1    Mullaney, K.A.2    Peterhoff, C.M.3    Che, S.4    Schmidt, S.D.5    Boyer-Boiteau, A.6
  • 29
    • 58649119608 scopus 로고    scopus 로고
    • Significant effect of APOE epsilon 4 genotype on the risk of dementia in Alzheimer's disease and mortality in persons with Down syndrome
    • V.P. Prasher, S.G. Sajith, S.D. Rees, A. Patel, S. Tewari, N. Schupf, et al. Significant effect of APOE epsilon 4 genotype on the risk of dementia in Alzheimer's disease and mortality in persons with Down syndrome Int J Geriatr Psychiatry 23 2008 1134 1140
    • (2008) Int J Geriatr Psychiatry , vol.23 , pp. 1134-1140
    • Prasher, V.P.1    Sajith, S.G.2    Rees, S.D.3    Patel, A.4    Tewari, S.5    Schupf, N.6
  • 30
    • 0029844434 scopus 로고    scopus 로고
    • Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome
    • N. Schupf, D. Kapell, J.H. Lee, W. Zigman, B. Canto, B. Tycko, et al. Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome Ann Neurol 40 1996 799 801
    • (1996) Ann Neurol , vol.40 , pp. 799-801
    • Schupf, N.1    Kapell, D.2    Lee, J.H.3    Zigman, W.4    Canto, B.5    Tycko, B.6
  • 31
    • 0028670363 scopus 로고
    • Apolipoprotein E epsilon 2 allele promotes longevity and protects patients with Down's syndrome from dementia
    • M.C. Royston, D. Mann, S. Pickering-Brown, F. Owen, R. Perry, R. Raghavan, et al. Apolipoprotein E epsilon 2 allele promotes longevity and protects patients with Down's syndrome from dementia Neuroreport 5 1994 2583 2585
    • (1994) Neuroreport , vol.5 , pp. 2583-2585
    • Royston, M.C.1    Mann, D.2    Pickering-Brown, S.3    Owen, F.4    Perry, R.5    Raghavan, R.6
  • 32
    • 33846430088 scopus 로고    scopus 로고
    • Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome
    • W.K. Dowjat, T. Adayev, I. Kuchna, K. Nowicki, S. Palminiello, Y.W. Hwang, et al. Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome Neurosci Lett 413 2007 77 81
    • (2007) Neurosci Lett , vol.413 , pp. 77-81
    • Dowjat, W.K.1    Adayev, T.2    Kuchna, I.3    Nowicki, K.4    Palminiello, S.5    Hwang, Y.W.6
  • 33
    • 80051737020 scopus 로고    scopus 로고
    • Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A
    • W. Qian, H. Liang, J. Shi, N. Jin, I. Grundke-Iqbal, K. Iqbal, et al. Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A Nucleic Acids Res 39 2011 6161 6171
    • (2011) Nucleic Acids Res , vol.39 , pp. 6161-6171
    • Qian, W.1    Liang, H.2    Shi, J.3    Jin, N.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 34
    • 51349109221 scopus 로고    scopus 로고
    • Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome
    • F. Liu, Z. Liang, J. Wegiel, Y.W. Hwang, K. Iqbal, I. Grundke-Iqbal, et al. Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome FASEB J 22 2008 3224 3233
    • (2008) FASEB J , vol.22 , pp. 3224-3233
    • Liu, F.1    Liang, Z.2    Wegiel, J.3    Hwang, Y.W.4    Iqbal, K.5    Grundke-Iqbal, I.6
  • 35
    • 78650679575 scopus 로고    scopus 로고
    • Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome
    • J. Wegiel, W. Kaczmarski, M. Barua, I. Kuchna, K. Nowicki, K.C. Wang, et al. Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome J Neuropathol Exp Neurol 70 2011 36 50
    • (2011) J Neuropathol Exp Neurol , vol.70 , pp. 36-50
    • Wegiel, J.1    Kaczmarski, W.2    Barua, M.3    Kuchna, I.4    Nowicki, K.5    Wang, K.C.6
  • 36
    • 39749196069 scopus 로고    scopus 로고
    • Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: Evidence for a functional link between Down syndrome and Alzheimer's disease
    • S.R. Ryoo, H.J. Cho, H.W. Lee, H.K. Jeong, C. Radnaabazar, Y.S. Kim, et al. Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease J Neurochem 104 2008 1333 1344
    • (2008) J Neurochem , vol.104 , pp. 1333-1344
    • Ryoo, S.R.1    Cho, H.J.2    Lee, H.W.3    Jeong, H.K.4    Radnaabazar, C.5    Kim, Y.S.6
  • 37
    • 84896716499 scopus 로고    scopus 로고
    • DYRK1A: A potential drug target for multiple Down syndrome neuropathologies
    • W. Becker, U. Soppa, and F.J. Tejedor DYRK1A: a potential drug target for multiple Down syndrome neuropathologies CNS Neurol Disord Drug Targets 13 2014 26 33
    • (2014) CNS Neurol Disord Drug Targets , vol.13 , pp. 26-33
    • Becker, W.1    Soppa, U.2    Tejedor, F.J.3
  • 38
    • 48249116002 scopus 로고    scopus 로고
    • Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome
    • S.V. Voronov, S.G. Frere, S. Giovedi, E.A. Pollina, C. Borel, H. Zhang, et al. Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome Proc Natl Acad Sci U S A 105 2008 9415 9420
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 9415-9420
    • Voronov, S.V.1    Frere, S.G.2    Giovedi, S.3    Pollina, E.A.4    Borel, C.5    Zhang, H.6
  • 39
    • 84864018180 scopus 로고    scopus 로고
    • Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes
    • J.C. Cossec, J. Lavaur, D.E. Berman, I. Rivals, A. Hoischen, S. Stora, et al. Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes Hum Mol Genet 21 2012 3156 3172
    • (2012) Hum Mol Genet , vol.21 , pp. 3156-3172
    • Cossec, J.C.1    Lavaur, J.2    Berman, D.E.3    Rivals, I.4    Hoischen, A.5    Stora, S.6
  • 40
    • 42649090113 scopus 로고    scopus 로고
    • Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism
    • D.E. Berman, C. Dall'Armi, S.V. Voronov, L.B. McIntire, H. Zhang, A.Z. Moore, et al. Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism Nat Neurosci 11 2008 547 554
    • (2008) Nat Neurosci , vol.11 , pp. 547-554
    • Berman, D.E.1    Dall'Armi, C.2    Voronov, S.V.3    McIntire, L.B.4    Zhang, H.5    Moore, A.Z.6
  • 42
    • 84864949729 scopus 로고    scopus 로고
    • Apolipoprotein e: Essential catalyst of the Alzheimer amyloid cascade
    • H. Potter, and T. Wisniewski Apolipoprotein e: essential catalyst of the Alzheimer amyloid cascade Int J Alzheimers Dis 2012 2012 489428
    • (2012) Int J Alzheimers Dis , vol.2012
    • Potter, H.1    Wisniewski, T.2
  • 44
    • 9144267928 scopus 로고    scopus 로고
    • Minocycline prevents cholinergic loss in a mouse model of Down's syndrome
    • C.L. Hunter, D. Bachman, and A.C. Granholm Minocycline prevents cholinergic loss in a mouse model of Down's syndrome Ann Neurol 56 2004 675 688
    • (2004) Ann Neurol , vol.56 , pp. 675-688
    • Hunter, C.L.1    Bachman, D.2    Granholm, A.C.3
  • 45
    • 0033888999 scopus 로고    scopus 로고
    • Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease
    • S.E. Stoltzner, T.J. Grenfell, C. Mori, K.E. Wisniewski, T.M. Wisniewski, D.J. Selkoe, et al. Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease Am J Pathol 156 2000 489 499
    • (2000) Am J Pathol , vol.156 , pp. 489-499
    • Stoltzner, S.E.1    Grenfell, T.J.2    Mori, C.3    Wisniewski, K.E.4    Wisniewski, T.M.5    Selkoe, D.J.6
  • 47
    • 0033033062 scopus 로고    scopus 로고
    • Chromosome missegregation and trisomy 21 mosaicism in Alzheimer's disease
    • L.N. Geller, and H. Potter Chromosome missegregation and trisomy 21 mosaicism in Alzheimer's disease Neurobiol Dis 6 1999 167 179
    • (1999) Neurobiol Dis , vol.6 , pp. 167-179
    • Geller, L.N.1    Potter, H.2
  • 48
    • 77954568360 scopus 로고    scopus 로고
    • Selective cell death of hyperploid neurons in Alzheimer's disease
    • T. Arendt, M.K. Bruckner, B. Mosch, and A. Losche Selective cell death of hyperploid neurons in Alzheimer's disease Am J Pathol 177 2010 15 20
    • (2010) Am J Pathol , vol.177 , pp. 15-20
    • Arendt, T.1    Bruckner, M.K.2    Mosch, B.3    Losche, A.4
  • 49
    • 79955592308 scopus 로고    scopus 로고
    • Alzheimer Abeta disrupts the mitotic spindle and directly inhibits mitotic microtubule motors
    • S.I. Borysov, A. Granic, J. Padmanabhan, C.E. Walczak, and H. Potter Alzheimer Abeta disrupts the mitotic spindle and directly inhibits mitotic microtubule motors Cell Cycle 10 2011 1397 1410
    • (2011) Cell Cycle , vol.10 , pp. 1397-1410
    • Borysov, S.I.1    Granic, A.2    Padmanabhan, J.3    Walczak, C.E.4    Potter, H.5
  • 50
    • 81855191923 scopus 로고    scopus 로고
    • Rescue of synaptic failure and alleviation of learning and memory impairments in a trisomic mouse model of down syndrome
    • J. Blanchard, S. Bolognin, M.O. Chohan, A. Rabe, K. Iqbal, and I. Grundke-Iqbal Rescue of synaptic failure and alleviation of learning and memory impairments in a trisomic mouse model of down syndrome J Neuropathol Exp Neurol 70 2011 1070 1079
    • (2011) J Neuropathol Exp Neurol , vol.70 , pp. 1070-1079
    • Blanchard, J.1    Bolognin, S.2    Chohan, M.O.3    Rabe, A.4    Iqbal, K.5    Grundke-Iqbal, I.6
  • 51
    • 80051549592 scopus 로고    scopus 로고
    • Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions
    • X. Sturgeon, and K.J. Gardiner Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions Mamm Genome 22 2011 261 271
    • (2011) Mamm Genome , vol.22 , pp. 261-271
    • Sturgeon, X.1    Gardiner, K.J.2
  • 52
    • 34548795562 scopus 로고    scopus 로고
    • Synaptic and cognitive abnormalities in mouse models of Down syndrome: Exploring genotype-phenotype relationships
    • P.V. Belichenko, A.M. Kleschevnikov, A. Salehi, C.J. Epstein, and W.C. Mobley Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships J Comp Neurol 504 2007 329 345
    • (2007) J Comp Neurol , vol.504 , pp. 329-345
    • Belichenko, P.V.1    Kleschevnikov, A.M.2    Salehi, A.3    Epstein, C.J.4    Mobley, W.C.5
  • 54
    • 0033980511 scopus 로고    scopus 로고
    • Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice
    • J.T. Richtsmeier, L.L. Baxter, and R.H. Reeves Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice Dev Dyn 217 2000 137 145
    • (2000) Dev Dyn , vol.217 , pp. 137-145
    • Richtsmeier, J.T.1    Baxter, L.L.2    Reeves, R.H.3
  • 58
    • 75149166144 scopus 로고    scopus 로고
    • Molecular basis of pharmacotherapies for cognition in Down syndrome
    • K.J. Gardiner Molecular basis of pharmacotherapies for cognition in Down syndrome Trends Pharmacol Sci 31 2010 66 73
    • (2010) Trends Pharmacol Sci , vol.31 , pp. 66-73
    • Gardiner, K.J.1
  • 59
    • 84860325458 scopus 로고    scopus 로고
    • Discoveries in Down syndrome: Moving basic science to clinical care
    • A.M. Kleschevnikov, P.V. Belichenko, A. Salehi, and C. Wu Discoveries in Down syndrome: moving basic science to clinical care Prog Brain Res 197 2012 199 221
    • (2012) Prog Brain Res , vol.197 , pp. 199-221
    • Kleschevnikov, A.M.1    Belichenko, P.V.2    Salehi, A.3    Wu, C.4
  • 60
    • 84862333723 scopus 로고    scopus 로고
    • Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities
    • N. Rueda, J. Florez, and C. Martinez-Cue Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities Neural Plast 2012 2012 584071
    • (2012) Neural Plast , vol.2012
    • Rueda, N.1    Florez, J.2    Martinez-Cue, C.3
  • 61
    • 77954461956 scopus 로고    scopus 로고
    • A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions
    • T. Yu, Z. Li, Z. Jia, S.J. Clapcote, C. Liu, S. Li, et al. A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions Hum Mol Genet 19 2010 2780 2791
    • (2010) Hum Mol Genet , vol.19 , pp. 2780-2791
    • Yu, T.1    Li, Z.2    Jia, Z.3    Clapcote, S.J.4    Liu, C.5    Li, S.6
  • 62
    • 77952316871 scopus 로고    scopus 로고
    • Cognitive deficits and associated neurological complications in individuals with Down's syndrome
    • I.T. Lott, and M. Dierssen Cognitive deficits and associated neurological complications in individuals with Down's syndrome Lancet Neurol 9 2010 623 633
    • (2010) Lancet Neurol , vol.9 , pp. 623-633
    • Lott, I.T.1    Dierssen, M.2
  • 64
    • 79960193987 scopus 로고    scopus 로고
    • Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar beta-amyloid in adults with down syndrome: Safety, acceptability, and feasibility
    • J. Landt, J.C. D'Abrera, A.J. Holland, F.I. Aigbirhio, T.D. Fryer, R. Canales, et al. Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar beta-amyloid in adults with down syndrome: safety, acceptability, and feasibility Arch Neurol 68 2011 890 896
    • (2011) Arch Neurol , vol.68 , pp. 890-896
    • Landt, J.1    D'Abrera, J.C.2    Holland, A.J.3    Aigbirhio, F.I.4    Fryer, T.D.5    Canales, R.6
  • 65
    • 81355154155 scopus 로고    scopus 로고
    • Positron emission tomography and neuropathologic estimates of fibrillar amyloid-beta in a patient with Down syndrome and Alzheimer disease
    • M.N. Sabbagh, A. Fleisher, K. Chen, J. Rogers, C. Berk, E. Reiman, et al. Positron emission tomography and neuropathologic estimates of fibrillar amyloid-beta in a patient with Down syndrome and Alzheimer disease Arch Neurol 68 2011 1461 1466
    • (2011) Arch Neurol , vol.68 , pp. 1461-1466
    • Sabbagh, M.N.1    Fleisher, A.2    Chen, K.3    Rogers, J.4    Berk, C.5    Reiman, E.6
  • 66
    • 84860330689 scopus 로고    scopus 로고
    • Neurological phenotypes for Down syndrome across the life span
    • I.T. Lott Neurological phenotypes for Down syndrome across the life span Prog Brain Res 197 2012 101 121
    • (2012) Prog Brain Res , vol.197 , pp. 101-121
    • Lott, I.T.1
  • 67
    • 33745028432 scopus 로고    scopus 로고
    • Neuroanatomy of Down syndrome in vivo: A model of preclinical Alzheimer's disease
    • S.J. Teipel, and H. Hampel Neuroanatomy of Down syndrome in vivo: a model of preclinical Alzheimer's disease Behav Genet 36 2006 405 415
    • (2006) Behav Genet , vol.36 , pp. 405-415
    • Teipel, S.J.1    Hampel, H.2
  • 68
    • 84894031575 scopus 로고    scopus 로고
    • Dementia in Down's syndrome: An MRI comparison with Alzheimer's disease in the general population
    • D. Mullins, E. Daly, A. Simmons, F. Beacher, C.M. Foy, S. Lovestone, et al. Dementia in Down's syndrome: an MRI comparison with Alzheimer's disease in the general population J Neurodev Disord 5 2013 19
    • (2013) J Neurodev Disord , vol.5 , pp. 19
    • Mullins, D.1    Daly, E.2    Simmons, A.3    Beacher, F.4    Foy, C.M.5    Lovestone, S.6
  • 69
    • 84861939416 scopus 로고    scopus 로고
    • Mild cognitive impairment identified in older individuals with Down syndrome by reduced telomere signal numbers and shorter telomeres measured in microns
    • E.C. Jenkins, L. Ye, M. Velinov, S.J. Krinsky-McHale, W.B. Zigman, N. Schupf, et al. Mild cognitive impairment identified in older individuals with Down syndrome by reduced telomere signal numbers and shorter telomeres measured in microns Am J Med Genet B Neuropsychiatr Genet 159b 2012 598 604
    • (2012) Am J Med Genet B Neuropsychiatr Genet , vol.159 B , pp. 598-604
    • Jenkins, E.C.1    Ye, L.2    Velinov, M.3    Krinsky-McHale, S.J.4    Zigman, W.B.5    Schupf, N.6
  • 70
    • 78349266860 scopus 로고    scopus 로고
    • Change in plasma Ass peptides and onset of dementia in adults with Down syndrome
    • N. Schupf, W.B. Zigman, M.X. Tang, D. Pang, R. Mayeux, P. Mehta, et al. Change in plasma Ass peptides and onset of dementia in adults with Down syndrome Neurology 75 2010 1639 1644
    • (2010) Neurology , vol.75 , pp. 1639-1644
    • Schupf, N.1    Zigman, W.B.2    Tang, M.X.3    Pang, D.4    Mayeux, R.5    Mehta, P.6
  • 74
    • 80054012572 scopus 로고    scopus 로고
    • Down syndrome and attention-deficit/hyperactivity disorder (ADHD)
    • S. Ekstein, B. Glick, M. Weill, B. Kay, and I. Berger Down syndrome and attention-deficit/hyperactivity disorder (ADHD) J Child Neurol 26 2011 1290 1295
    • (2011) J Child Neurol , vol.26 , pp. 1290-1295
    • Ekstein, S.1    Glick, B.2    Weill, M.3    Kay, B.4    Berger, I.5
  • 75
    • 84883050999 scopus 로고    scopus 로고
    • Inhibition and impulsivity: Behavioral and neural basis of response control
    • A. Bari, and T.W. Robbins Inhibition and impulsivity: behavioral and neural basis of response control Prog Neurobiol 108 2013 44 79
    • (2013) Prog Neurobiol , vol.108 , pp. 44-79
    • Bari, A.1    Robbins, T.W.2
  • 76
    • 84879714443 scopus 로고    scopus 로고
    • Ascending monoaminergic systems alterations in Alzheimer's disease. Translating basic science into clinical care
    • L. Trillo, D. Das, W. Hsieh, B. Medina, S. Moghadam, B. Lin, et al. Ascending monoaminergic systems alterations in Alzheimer's disease. Translating basic science into clinical care Neurosci Biobehav Rev 37 2013 1363 1379
    • (2013) Neurosci Biobehav Rev , vol.37 , pp. 1363-1379
    • Trillo, L.1    Das, D.2    Hsieh, W.3    Medina, B.4    Moghadam, S.5    Lin, B.6
  • 77
    • 60849137841 scopus 로고    scopus 로고
    • Induction of toll-like receptor 9 signaling as a method for ameliorating Alzheimer's disease-related pathology
    • H. Scholtzova, R.J. Kascsak, K.A. Bates, A. Boutajangout, D.J. Kerr, H.C. Meeker, et al. Induction of toll-like receptor 9 signaling as a method for ameliorating Alzheimer's disease-related pathology J Neurosci 29 2009 1846 1854
    • (2009) J Neurosci , vol.29 , pp. 1846-1854
    • Scholtzova, H.1    Kascsak, R.J.2    Bates, K.A.3    Boutajangout, A.4    Kerr, D.J.5    Meeker, H.C.6
  • 79
    • 84655164829 scopus 로고    scopus 로고
    • Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn
    • L.G. Reinholdt, Y. Ding, G.J. Gilbert, A. Czechanski, J.P. Solzak, R.J. Roper, et al. Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn Mamm Genome 22 2011 685 691
    • (2011) Mamm Genome , vol.22 , pp. 685-691
    • Reinholdt, L.G.1    Ding, Y.2    Gilbert, G.J.3    Czechanski, A.4    Solzak, J.P.5    Roper, R.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.