Selective cell death of hyperploid neurons in Alzheimer's disease

American Journal of Pathology

Volumn 177, Issue 1, 2010, Pages 15-20

  Arendt, Thomas ^a   Brückner, Martina K ^a   Mosch, Birgit ^a   Lösche, Andreas ^b  

^a Paul Flechsig Institute   (Germany)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

AGED; ALZHEIMER DISEASE; ARTICLE; CELL DEATH; CLINICAL ARTICLE; CONTROLLED STUDY; DIPLOIDY; DISEASE COURSE; HUMAN; HUMAN TISSUE; NERVE CELL; PRIORITY JOURNAL;

EID: 77954568360     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.2353/ajpath.2010.090955     Document Type: Article

References (48)

1. Muotri AR, Gage FH: Generation of neuronal variability and complexity. Nature 2006, 441:1087-1093
2. Iourov IY, Vorsanova SG, Liehr T, Yurov YB: Aneuploidy in the normal. Alzheimer's disease and ataxia-telangiectasia brain: differential expression and pathological meaning Neurobiol Dis 2009, 34:212-220
3. Kaushal D, Contos JJ, Treuner K, Yang AH, Kingsbury MA, Rehen SK, McConnell MJ, Okabe M, Barlow C, Chun J: Alteration of gene expression by chromosome loss in the postnatal mouse brain. J Neurosci 2003, 23:5599-5606 (Pubitemid 36807837)
4. Kingsbury MA, Friedman B, McConnell MJ, Rehen SK, Yang AH, Kaushal D, Chun J: Aneuploid neurons are functionally active and integrated into brain circuitry. Proc Natl Acad Sci U S A 2005, 102:6143-6147 (Pubitemid 40594269)
5. Mosch B, Morawski M, Mittag A, Lenz D, Tarnok A, Arendt T: Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease. J Neurosci 2007, 27:6859-6867 (Pubitemid 47015903)
6. Pack SD, Weil RJ, Vortmeyer AO, Zeng W, Li J, Okamoto H, Furuta M, Pak E, Lubensky IA, Oldfield EH, Zhuang Z: Individual adult human neurons display aneuploidy: detection by fluorescence in situ hybridization and single neuron PCR. Cell Cycle 2005, 4:1758-1760 (Pubitemid 41827321)
7. Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J: Chromosomal variation in neurons of the developing and adult mammalian nervous system. Proc Natl Acad Sci U S A 2001, 98:13361-13366 (Pubitemid 33051368)
8. Rehen SK, Yung YC, McCreight MP, Kaushal D, Yang AH, Almeida BS, Kingsbury MA, Cabral KM, McConnell MJ, Anliker B, Fontanoz M, Chun J: Constitutional aneuploidy in the normal human brain. J Neurosci 2005, 25:2176-2180 (Pubitemid 40322258)
9. Westra JW, Peterson SE, Yung YC, Mutoh T, Barral S, Chun J: Aneuploid mosaicism in the developing and adult cerebellar cortex. J Comp Neurol 2008, 507:1944-1951 (Pubitemid 351468210)
10. Yang AH, Kaushal D, Rehen SK, Kriedt K, Kingsbury MA, McConnell MJ, Chun J: Chromosome segregation defects contribute to aneuploidy in normal neural progenitor cells. J Neurosci 2003, 23:10454-10462 (Pubitemid 37444622)
11. Yurov YB, Iourov IY, Monakhov VV, Soloviev IV, Vostrikov VM, Vorsanova SG: The variation of aneuploidy frequency in the developing and adult human brain revealed by an interphase FISH study. J Histochem Cytochem 2005, 53:385-390
12. Yurov YB, Iourov IY, Vorsanova SG, Liehr T, Kolotii AD, Kutsev SI, Pellestor F, Beresheva AK, Demidova IA, Kravets VS, Monakhov VV, Soloviev IV: Aneuploidy and confined chromosomal mosaicism in the developing human brain. PLoS ONE 2007, 2:e558 (Pubitemid 351260217)
13. Bregnard A, Knüsel A, Kuenzle CC: Are all the neuronal nuclei polyploid? Histochemistry 1975, 43:59-61
14. Swartz FJ, Bhatnagar KP: Are CNS neurons polyploid? A critical analysis based upon cytophotometric study of the DNA content of cerebellar and olfactory bulbar neurons of the bat. Brain Res 1981, 208:267-281
15. Osada T, Kusakabe H, Akutsu H, Yagi T, Yanagimachi R: Adult murine neurons: their chromatin and chromosome changes and failure to support embryonic development as revealed by nuclear transfer. Cytogenet Genome Res 2002, 97:7-12 (Pubitemid 37499872)
16. Harrison RH, Kuo HC, Scriven PN, Handyside AH, Ogilvie CM: Lack of cell cycle checkpoints in human cleavage stage embryos revealed by a clonal pattern of chromosomal mosaicism analysed by sequential multicolour FISH. Zygote 2000, 8:217-224
17. Voullaire L, Slater H, Williamson R, Wilton L: Chromosome analysis of blastomeres from human embryos by using comparative genomic hybridization. Hum Genet 2000, 106:210-217 (Pubitemid 30156426)
18. Blaschke AJ, Staley K, Chun J: Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex. Development 1996, 122:1165-1174 (Pubitemid 26123891)
19. Torres EM, Williams BR, Amon A: Aneuploidy: Cells losing their balance. Genetics 2008, 179:737-746
20. Williams BR, Prabhu VR, Hunter KE, Glazier CM, Whittaker CA, Housman DE, Amon A: Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science 2008, 322:703-709
21. Lengauer C, Kinzler KW, Vogelstein B: Genetic instabilities in human cancers. Nature 1998, 396:643-649
22. Hassold T, Hunt P: To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet 2001, 2:280-291 (Pubitemid 33674776)
23. Yang Y, Geldmacher DS, Herrup K: DNA replication precedes neuronal cell death in Alzheimer's disease. J Neurosci 2001, 21:2661-2668 (Pubitemid 32298208)
24. Yurov YB, Iourov IY, Vorsanova SG, Demidova IA, Kravetz VS, Beresheva AK, Kolotii AD, Monakchov VV, Uranova NA, Vostrikov VM, Soloviev IV, Liehr T: The schizophrenia brain exhibits low-level aneuploidy involving chromosome 1. Schizophr Res 2008, 98:139-147
25. Yurov YB, Vorsanova SG, Iourov IY, Demidova IA, Beresheva AK, Kravetz VS, Monakhov VV, Kolotii AD, Voinova-Ulas VY, Gorbachevskaya NL: Unexplained autism is frequently associated with lowlevel mosaic aneuploidy. J Med Genet 2007, 44:521-525
26. Morris JC: The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 1993, 43:2412-2414
27. Berg L, McKeel DW Jr, Miller JP, Storandt M, Rubin EH, Morris JC, Baty J, Coats M, Norton J, Goate AM, Price JL, Gearing M, Mirra SS, Saunders AM: Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype. Arch Neurol 1998, 55:326-335 (Pubitemid 28146197)
28. Braak H, Braak E: Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991, 82:239-259
29. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991, 41:479-486
30. NIA criteria: The National Institute on Aging and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's disease. Neurobiol Aging 1997, 18:S1
31. Mosch B, Mittag A, Lenz D, Arendt T, Tárnok A: Laser scanning cytometry in human brain slices. Cytometry A 2006, 69:135-138
32. Braak H, Braak E: Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis. Acta Neuropathol 1996, 92:197-201 (Pubitemid 26248463)
33. Arendt T: Alzheimer's disease as a disorder of mechanisms underlaying structural brain self-organization. Neurosci 2001, 102:723-765
34. Arendt T, Brückner MK, Gertz HJ, Marcova L: Cortical distribution of neurofibrillary tangles in Alzheimer's disease matches the pattern of neurons that retain their capacity of plastic remodelling in the adult brain. Neuroscience 1998, 83:991-1002 (Pubitemid 28114194)
35. Rapoport SI: Brain evolution and Alzheimer's disease. Rev Neurol (Paris) 1988, 144:79-90
36. Kriegstein A, Noctor S, Martinez-Cerdeno V: Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion. Nat Rev Neurosci 2006, 7:883-890 (Pubitemid 44624180)
37. Krubitzer L, Kahn DM: Nature versus nurture revisited: an old idea with a new twist. Prog Neurobiol 2003, 70:33-52 (Pubitemid 36966640)
38. Takahashi T, Nowakowski RS, Caviness VS Jr: The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall. J Neurosci 1995, 15:6046-6057
39. Kornack DR, Rakic P: Changes in cell-cycle kinetics during the development and evolution of primate neocortex. Proc Natl Acad Sci USA 1998, 95:1242-1246
40. Hill RS, Walsh CA: Molecular insights into human brain evolution. Nature 2005, 437:64-67 (Pubitemid 41613427)
41. Morillo SM, Escoll P, de la Hera A, Frade JM: Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor. Proc Natl Acad Sci USA 2010, 107:109-114
42. Ignatius MJ, Chandler CR, Shooter EM: Nerve growth factor-treated, neurite-bearing PC12 cells continue to synthesize DNA. J Neurosci 1985, 5:343-351
43. Rohrer H, Thoenen H: Relationship between differentiation and terminal mitosis: chick sensory and ciliary neurons differentiate after terminal mitosis of precursor cells, whereas sympathetic neurons continue to divide after differentiation. J Neurosci 1987, 7:3739-3748 (Pubitemid 18000701)
44. Frade JM, Bovolenta P, Martínez-Morales JR, Arribas A, Barbas JA, Rodríguez-Tébar A: Control of early cell death by BDNF in the chick retina. Development 1997, 124:3313-3320 (Pubitemid 27440446)
45. Arendt T, Brückner MK: Perisomatic sprouts immunoreactive for nerve growth factor receptor and neurofibrillary degeneration affect different neuronal populations in the basal nucleus in patients with Alzheimer's disease. Neurosci Lett 1992, 148(1-2):63-66 (Pubitemid 23007705)
46. Hock C, Heese K, Hulette C, Rosenberg C, Otten U: Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. Arch Neurol 2000, 57:846-851 (Pubitemid 30397187)
47. Arendt T. Differentiation and De-Differentiation - Neuronal Cell Cycle Regulation During Development and Age-Related Neurodegenerative Disorders. In: Lajtha A, Perez-Polo JR, Rossner S. (eds.) Handbook of Neurochemistry and Molecular Neurobiology. Development and Aging Changes in the Nervous System. Springer 2008, pp. 157-213
48. Vincent I, Rosado M, Davies P: Mitotic mechanisms in Alzheimer's disease? J Cell Biol 1996, 132:413-425