메뉴 건너뛰기




Volumn 137, Issue 5, 2015, Pages 1001-1011

Time to re-consider the meaning of BRAF V600E mutation in papillary thyroid carcinoma

Author keywords

BRAF; molecular marker; papillary thyroid carcinoma

Indexed keywords

B RAF KINASE; B RAF KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; RADIOACTIVE IODINE; RAPAMYCIN; VEMURAFENIB; BRAF PROTEIN, HUMAN; GLUTAMINE; VALINE;

EID: 84931065402     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28976     Document Type: Review
Times cited : (44)

References (111)
  • 1
    • 79955751512 scopus 로고    scopus 로고
    • BRAFV600E: Implications for carcinogenesis and molecular therapy
    • Cantewell-Dorris ER, O'Leary JJ, Sheils OM,. BRAFV600E: implications for carcinogenesis and molecular therapy. Mol Cancer Ther 2011; 10: 385-94.
    • (2011) Mol Cancer Ther , vol.10 , pp. 385-394
    • Cantewell-Dorris, E.R.1    O'Leary, J.J.2    Sheils, O.M.3
  • 2
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C, et al., Mutations of the BRAF gene in human cancer. Nature 2002; 417: 949-54.
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 3
    • 34248227617 scopus 로고    scopus 로고
    • Toward a molecular classification of melanoma
    • Fecher LA, Cummings SD, Keefe MJ, et al., Toward a molecular classification of melanoma. JCO 2007; 25: 1606-20.
    • (2007) JCO , vol.25 , pp. 1606-1620
    • Fecher, L.A.1    Cummings, S.D.2    Keefe, M.J.3
  • 4
    • 77956030786 scopus 로고    scopus 로고
    • Inhibition of mutated, activated BRAF in metastatic melanoma
    • Flaherty KT, Puzanov I, Kim KB, et al., Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010; 363: 809-19.
    • (2010) N Engl J Med , vol.363 , pp. 809-819
    • Flaherty, K.T.1    Puzanov, I.2    Kim, K.B.3
  • 5
    • 73449101483 scopus 로고    scopus 로고
    • Molecular cytogenetics of cutaneous melanocytic lesions - Diagnostic, prognostic and therapeutic aspects
    • Blokx WAM, Marcory van Dijk MCRF, Ruiter DJ,. Molecular cytogenetics of cutaneous melanocytic lesions-diagnostic, prognostic and therapeutic aspects. Hystopathology 2010; 56: 121-32.
    • (2010) Hystopathology , vol.56 , pp. 121-132
    • Blokx, W.A.M.1    Marcory Van Dijk, M.2    Ruiter, D.J.3
  • 6
    • 84856271990 scopus 로고    scopus 로고
    • Are KRAS/BRAF mutations potent prognostic and/or predictive biomarkers in colorectal cancers?
    • Yokota T,. Are KRAS/BRAF mutations potent prognostic and/or predictive biomarkers in colorectal cancers? Anti-Cancer Agents Med Chem 2012; 12: 163-71.
    • (2012) Anti-Cancer Agents Med Chem , vol.12 , pp. 163-171
    • Yokota, T.1
  • 7
    • 84865408888 scopus 로고    scopus 로고
    • Clinicopathologic and genetic characterization of traditional serrated adenomas of the colon
    • Fu B, Yachida S, Morgan R, et al., Clinicopathologic and genetic characterization of traditional serrated adenomas of the colon. Am J Clin Pathol 2012; 138: 356-366.
    • (2012) Am J Clin Pathol , vol.138 , pp. 356-366
    • Fu, B.1    Yachida, S.2    Morgan, R.3
  • 8
    • 0037194728 scopus 로고    scopus 로고
    • Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
    • Rajagopalan H, Bardelli A, Lengauer C, et al., Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 2002; 418: 934.
    • (2002) Nature , vol.418 , pp. 934
    • Rajagopalan, H.1    Bardelli, A.2    Lengauer, C.3
  • 9
    • 79251490374 scopus 로고    scopus 로고
    • New driver mutations in non-small-cell lung cancer
    • Pao W, Girard N,. New driver mutations in non-small-cell lung cancer. Lancet Oncol 2011; 12: 175-80.
    • (2011) Lancet Oncol , vol.12 , pp. 175-180
    • Pao, W.1    Girard, N.2
  • 10
    • 84872930026 scopus 로고    scopus 로고
    • BRAF mutation is associated with early stage disease and improved outcome in patients with low-grade serous ovarian cancer
    • Grisham RN, Iyer G, Garg K, et al., BRAF mutation is associated with early stage disease and improved outcome in patients with low-grade serous ovarian cancer. Cancer 2013; 119: 548-54.
    • (2013) Cancer , vol.119 , pp. 548-554
    • Grisham, R.N.1    Iyer, G.2    Garg, K.3
  • 11
    • 0038664387 scopus 로고    scopus 로고
    • BRAF mutation in papillary thyroid carcinoma
    • Cohen Y, Xing M, Mambo E, et al., BRAF mutation in papillary thyroid carcinoma. J Natl Cancer Inst 2003; 95: 625-7.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 625-627
    • Cohen, Y.1    Xing, M.2    Mambo, E.3
  • 12
    • 0037379904 scopus 로고    scopus 로고
    • High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
    • Kimura ET, Nikiforova MN, Zhu Z, et al., High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res 2003; 63: 1454-7.
    • (2003) Cancer Res , vol.63 , pp. 1454-1457
    • Kimura, E.T.1    Nikiforova, M.N.2    Zhu, Z.3
  • 13
    • 0043170833 scopus 로고    scopus 로고
    • BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC
    • Soares P, Trovisco V, Rocha AS, et al., BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC. Oncogene 2003; 22: 4578-80.
    • (2003) Oncogene , vol.22 , pp. 4578-4580
    • Soares, P.1    Trovisco, V.2    Rocha, A.S.3
  • 14
    • 21544464303 scopus 로고    scopus 로고
    • Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients' age but not with tumour aggressiveness
    • Trovisco V, Soares P, Preto A, et al., Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients' age but not with tumour aggressiveness. Virchows Arch 2005; 446: 589-95.
    • (2005) Virchows Arch , vol.446 , pp. 589-595
    • Trovisco, V.1    Soares, P.2    Preto, A.3
  • 15
    • 21244457181 scopus 로고    scopus 로고
    • BRAF mutation in thyroid cancer
    • Xing M,. BRAF mutation in thyroid cancer. Endocr Relat Cancer 2005; 12: 245-62.
    • (2005) Endocr Relat Cancer , vol.12 , pp. 245-262
    • Xing, M.1
  • 16
    • 37349131738 scopus 로고    scopus 로고
    • BRAF mutation in papillary thyroid cancer: Pathogenic role, molecular bases, and clinical implications
    • Xing M,. BRAF mutation in papillary thyroid cancer: pathogenic role, molecular bases, and clinical implications. Endocr Rev 2007; 28: 742-62.
    • (2007) Endocr Rev , vol.28 , pp. 742-762
    • Xing, M.1
  • 17
    • 77952883863 scopus 로고    scopus 로고
    • Molecular prognostic markers in papillary and follicular thyroid cancer: Current status and future directions
    • Handkiewicz-Junak D, Czarniecka A, Jarzab B,. Molecular prognostic markers in papillary and follicular thyroid cancer: current status and future directions. Mol Cell Endocrinol 2010; 322: 8-28.
    • (2010) Mol Cell Endocrinol , vol.322 , pp. 8-28
    • Handkiewicz-Junak, D.1    Czarniecka, A.2    Jarzab, B.3
  • 18
    • 80053150200 scopus 로고    scopus 로고
    • Molecular genetics and diagnosis of thyroid cancer
    • Nikiforov YE, Nikiforova MN,. Molecular genetics and diagnosis of thyroid cancer. Nat Rev Endocrinol 2011; 7: 569-80.
    • (2011) Nat Rev Endocrinol , vol.7 , pp. 569-580
    • Nikiforov, Y.E.1    Nikiforova, M.N.2
  • 19
    • 2942692120 scopus 로고    scopus 로고
    • Detection of BRAF mutation on fine needle aspiration biopsy specimens: A new diagnostic tool for papillary thyroid cancer
    • Xing M, Tufano RP, Tufaro AP, et al., Detection of BRAF mutation on fine needle aspiration biopsy specimens: a new diagnostic tool for papillary thyroid cancer. J Clin Endocrinol Metab 2004; 89: 2867-72.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2867-2872
    • Xing, M.1    Tufano, R.P.2    Tufaro, A.P.3
  • 20
    • 68349104793 scopus 로고    scopus 로고
    • A morpho-molecular diagnosis of papillary thyroid carcinoma: BRAF V600E detection as an important tool in preoperative evaluation of fine-needle aspirates
    • Marchetti I, Lessi F, Mazzanti CM, et al., A morpho-molecular diagnosis of papillary thyroid carcinoma: BRAF V600E detection as an important tool in preoperative evaluation of fine-needle aspirates. Thyroid 2009; 19: 837-42.
    • (2009) Thyroid , vol.19 , pp. 837-842
    • Marchetti, I.1    Lessi, F.2    Mazzanti, C.M.3
  • 21
    • 77955351326 scopus 로고    scopus 로고
    • BRAFV600E mutation analysis in fine-needle aspiration cytology specimens for evaluation of thyroid nodule: A large series in a BRAFV600E-prevalent population
    • Kim SW, Lee JI, Kim JW, et al., BRAFV600E mutation analysis in fine-needle aspiration cytology specimens for evaluation of thyroid nodule: a large series in a BRAFV600E-prevalent population. J Clin Endocrinol Metab 2010; 95: 3693-700.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 3693-3700
    • Kim, S.W.1    Lee, J.I.2    Kim, J.W.3
  • 22
    • 80655147350 scopus 로고    scopus 로고
    • Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: A prospective analysis of 1056 FNA samples
    • Nikiforov YE, Ohori NP, Hodak SP, et al., Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples. J Clin Endocrinol Metab 2011; 96: 3390-7.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 3390-3397
    • Nikiforov, Y.E.1    Ohori, N.P.2    Hodak, S.P.3
  • 23
    • 84870733693 scopus 로고    scopus 로고
    • BRAF V600E mutation and its association with clinicopathological features of papillary thyroid cancer: A meta-analysis
    • Li C, Lee KC, Schneider EB, et al., BRAF V600E mutation and its association with clinicopathological features of papillary thyroid cancer: a meta-analysis. J Clin Endocrinol Metab 2012; 97: 4559-70.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 4559-4570
    • Li, C.1    Lee, K.C.2    Schneider, E.B.3
  • 24
    • 34248583886 scopus 로고    scopus 로고
    • MAP kinase signalling pathways in cancer
    • Dhillon AS, Hagan S, Rath O, et al., MAP kinase signalling pathways in cancer. Oncogene 2007; 26: 3279-90.
    • (2007) Oncogene , vol.26 , pp. 3279-3290
    • Dhillon, A.S.1    Hagan, S.2    Rath, O.3
  • 25
    • 20144372793 scopus 로고    scopus 로고
    • Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation
    • Knauf JA, Ma X, Smith EP, et al., Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation. Cancer Res 2005; 65: 4238-45.
    • (2005) Cancer Res , vol.65 , pp. 4238-4245
    • Knauf, J.A.1    Ma, X.2    Smith, E.P.3
  • 26
    • 79952180384 scopus 로고    scopus 로고
    • Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice
    • Franco AT, Malaguarnera R, Refetoff S, et al., Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice. Proc Natl Acad Sci USA 2011; 108: 1615-20.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 1615-1620
    • Franco, A.T.1    Malaguarnera, R.2    Refetoff, S.3
  • 27
    • 84055191090 scopus 로고    scopus 로고
    • Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation
    • Chakravarty D, Santos E, Ryder M, et al., Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation. J Clin Invest 2011; 121: 4700-11.
    • (2011) J Clin Invest , vol.121 , pp. 4700-4711
    • Chakravarty, D.1    Santos, E.2    Ryder, M.3
  • 28
    • 84856798619 scopus 로고    scopus 로고
    • The primary occurrence of BRAF(V600E) is a rare clonal event in papillary thyroid carcinoma
    • Guerra A, Sapio MR, Marotta V, et al., The primary occurrence of BRAF(V600E) is a rare clonal event in papillary thyroid carcinoma. J Clin Endocrinol Metab 2012; 97: 517-24.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 517-524
    • Guerra, A.1    Sapio, M.R.2    Marotta, V.3
  • 29
    • 84863574283 scopus 로고    scopus 로고
    • A high percentage of BRAFV600E alleles in papillary thyroid carcinoma predicts a poorer outcome
    • Guerra A, Fugazzola L, Marotta V, et al., A high percentage of BRAFV600E alleles in papillary thyroid carcinoma predicts a poorer outcome. J Clin Endocrinol Metab 2012; 97: 2333-40.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 2333-2340
    • Guerra, A.1    Fugazzola, L.2    Marotta, V.3
  • 30
    • 84877686708 scopus 로고    scopus 로고
    • Allele percentage of the BRAF V600E mutation in papillary thyroid carcinomas and corresponding lymph node metastases: No evidence for a role in tumor progression
    • Gandolfi G, Sancisi V, Torricelli F, et al., Allele percentage of the BRAF V600E mutation in papillary thyroid carcinomas and corresponding lymph node metastases: no evidence for a role in tumor progression. J Clin Endocrinol Metab 2013; 98: 934-42.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 934-942
    • Gandolfi, G.1    Sancisi, V.2    Torricelli, F.3
  • 31
    • 84905867190 scopus 로고    scopus 로고
    • High sensitivity BRAF mutation analysis: BRAF V600E is acquired early during tumor development but is heterogeneously distributed in a subset of papillary thyroid carcinomas
    • De Biase D, Cesari V, Visani M, et al., High sensitivity BRAF mutation analysis: BRAF V600E is acquired early during tumor development but is heterogeneously distributed in a subset of papillary thyroid carcinomas. J Clin Endocrinol Metab 2014; doi:29:jc20134389.
    • (2014) J Clin Endocrinol Metab
    • De Biase, D.1    Cesari, V.2    Visani, M.3
  • 32
    • 76049098292 scopus 로고    scopus 로고
    • Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases
    • Baldus SE, Schaefer KL, Engers R, et al., Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases. Clin Cancer Res 2010; 16: 790-9.
    • (2010) Clin Cancer Res , vol.16 , pp. 790-799
    • Baldus, S.E.1    Schaefer, K.L.2    Engers, R.3
  • 33
    • 84871390702 scopus 로고    scopus 로고
    • Intratumoral molecular heterogeneity in a BRAF-mutant, BRAF inhibitor-resistant melanoma: A case illustrating the challenges for personalized medicine
    • Wilmott JS, Tembe V, Howle JR, et al., Intratumoral molecular heterogeneity in a BRAF-mutant, BRAF inhibitor-resistant melanoma: a case illustrating the challenges for personalized medicine. Mol Cancer Ther 2012; 11: 2704-08.
    • (2012) Mol Cancer Ther , vol.11 , pp. 2704-2708
    • Wilmott, J.S.1    Tembe, V.2    Howle, J.R.3
  • 34
    • 84855302859 scopus 로고    scopus 로고
    • Intra- and inter-tumor heterogeneity of BRAF(V600E) mutations in primary and metastatic melanoma
    • Yancovitz M, Litterman A, Yoon J, et al., Intra- and inter-tumor heterogeneity of BRAF(V600E) mutations in primary and metastatic melanoma. PLoS One 2012; 7: e29336.
    • (2012) PLoS One , vol.7 , pp. e29336
    • Yancovitz, M.1    Litterman, A.2    Yoon, J.3
  • 35
    • 84887472968 scopus 로고    scopus 로고
    • Targeted next-generation sequencing panel (ThyroSeq) for detection of mutations in thyroid cancer
    • Nikiforova MN, Wald AI, Roy S, et al., Targeted next-generation sequencing panel (ThyroSeq) for detection of mutations in thyroid cancer. J Clin Endocrinol Metab 2013; 98: E1852-60.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. E1852-E1860
    • Nikiforova, M.N.1    Wald, A.I.2    Roy, S.3
  • 36
    • 79959580390 scopus 로고    scopus 로고
    • Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody
    • Capper D, Preusser M, Habel A, et al., Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody. Acta Neuropathol 2011; 122: 11-19.
    • (2011) Acta Neuropathol , vol.122 , pp. 11-19
    • Capper, D.1    Preusser, M.2    Habel, A.3
  • 37
    • 84881512900 scopus 로고    scopus 로고
    • Immunohistochemical detection of mutated BRAF V600E supports the clonal origin of BRAF-induced thyroid cancers along the spectrum of disease progression
    • Ghossein RA, Katabi N, Fagin JA,. Immunohistochemical detection of mutated BRAF V600E supports the clonal origin of BRAF-induced thyroid cancers along the spectrum of disease progression. J Clin Endocrinol Metab 2013; 98: E1414-21.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. E1414-E1421
    • Ghossein, R.A.1    Katabi, N.2    Fagin, J.A.3
  • 38
    • 34249940475 scopus 로고    scopus 로고
    • Presence of BRAF V600E in very early stages of papillary thyroid carcinoma
    • Ugolini C, Giannini R, Lupi C, et al., Presence of BRAF V600E in very early stages of papillary thyroid carcinoma. Thyroid 2007; 17: 381-8.
    • (2007) Thyroid , vol.17 , pp. 381-388
    • Ugolini, C.1    Giannini, R.2    Lupi, C.3
  • 39
    • 84871923882 scopus 로고    scopus 로고
    • BRAFV600E mutation in papillary thyroid microcarcinoma: A genotype-phenotype correlation
    • Virk RK, van Dyke AL, Finkelstein A, et al., BRAFV600E mutation in papillary thyroid microcarcinoma: a genotype-phenotype correlation. Mod Pathol 2013; 26: 62-70.
    • (2013) Mod Pathol , vol.26 , pp. 62-70
    • Virk, R.K.1    Van Dyke, A.L.2    Finkelstein, A.3
  • 40
    • 84878879907 scopus 로고    scopus 로고
    • Papillary microcarcinoma of the thyroid: Clinical characteristics and BRAF(V600E) mutational status of 977 cases
    • Zheng X, Wei S, Han Y, et al., Papillary microcarcinoma of the thyroid: clinical characteristics and BRAF(V600E) mutational status of 977 cases. Ann Surg Oncol 2013; 20: 2266-73.
    • (2013) Ann Surg Oncol , vol.20 , pp. 2266-2273
    • Zheng, X.1    Wei, S.2    Han, Y.3
  • 41
    • 51649128260 scopus 로고    scopus 로고
    • Acquisition of BRAF gene mutations is not a requirement for nodal metastasis of papillary thyroid carcinoma
    • Trovisco V, Couto JP, Cameselle-Teijeiro J, et al., Acquisition of BRAF gene mutations is not a requirement for nodal metastasis of papillary thyroid carcinoma. Clin Endocrinol 2008; 69: 683-5.
    • (2008) Clin Endocrinol , vol.69 , pp. 683-685
    • Trovisco, V.1    Couto, J.P.2    Cameselle-Teijeiro, J.3
  • 42
    • 24344505403 scopus 로고    scopus 로고
    • High prevalence and possible de novo formation of BRAF mutation in metastasized papillary thyroid cancer in lymph nodes
    • Vasko V, Hu S, Wu G, et al., High prevalence and possible de novo formation of BRAF mutation in metastasized papillary thyroid cancer in lymph nodes. J Clin Endocrinol Metab 2005; 90: 5265-9.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5265-5269
    • Vasko, V.1    Hu, S.2    Wu, G.3
  • 43
    • 33847201454 scopus 로고    scopus 로고
    • A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors
    • Dankort D, Filenova E, Collado M, et al., A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes Dev 2007; 21: 379-84.
    • (2007) Genes Dev , vol.21 , pp. 379-384
    • Dankort, D.1    Filenova, E.2    Collado, M.3
  • 44
    • 65649147543 scopus 로고    scopus 로고
    • Braf(V600E) cooperates with Pten loss to induce metastatic melanoma
    • Dankort D, Curley DP, Cartlidge RA, et al., Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat Genet 2009; 41: 544-52.
    • (2009) Nat Genet , vol.41 , pp. 544-552
    • Dankort, D.1    Curley, D.P.2    Cartlidge, R.A.3
  • 45
    • 84886475553 scopus 로고    scopus 로고
    • Postnatal expression of BRAFV600E does not induce thyroid cancer in mouse models of thyroid papillary carcinoma
    • Shimamura M, Nakahara M, Orim F, et al., Postnatal expression of BRAFV600E does not induce thyroid cancer in mouse models of thyroid papillary carcinoma. Endocrinology 2013; 154: 4423-30.
    • (2013) Endocrinology , vol.154 , pp. 4423-4430
    • Shimamura, M.1    Nakahara, M.2    Orim, F.3
  • 46
  • 47
    • 0141453014 scopus 로고    scopus 로고
    • Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers
    • Namba H, Nakashima M, Hayashi T, et al., Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers. J Clin Endocrinol Metab 2003; 88: 4393-7.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 4393-4397
    • Namba, H.1    Nakashima, M.2    Hayashi, T.3
  • 48
    • 10744222003 scopus 로고    scopus 로고
    • BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas
    • Nikiforova MN, Kimura ET, Gandhi M, et al., BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas. J Clin Endocrinol Metab 2003; 88: 5399-404.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5399-5404
    • Nikiforova, M.N.1    Kimura, E.T.2    Gandhi, M.3
  • 49
    • 9144219691 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in papillary thyroid carcinoma in a Korean population
    • Kim KH, Kang DW, Kim SH, et al., Mutations of the BRAF gene in papillary thyroid carcinoma in a Korean population. Yonsei Med J 2004; 45: 818-21.
    • (2004) Yonsei Med J , vol.45 , pp. 818-821
    • Kim, K.H.1    Kang, D.W.2    Kim, S.H.3
  • 50
    • 28744442816 scopus 로고    scopus 로고
    • BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer
    • Xing M, Westra WH, Tufano RP, et al., BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer. J Clin Endocrinol Metab 2005; 90: 6373-9.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 6373-6379
    • Xing, M.1    Westra, W.H.2    Tufano, R.P.3
  • 51
    • 33750308218 scopus 로고    scopus 로고
    • Lymphatic mapping establishes the role of BRAF gene mutation in papillary thyroid carcinoma
    • Kim J, Giuliano AE, Turner RR, et al., Lymphatic mapping establishes the role of BRAF gene mutation in papillary thyroid carcinoma. Ann Surg 2006; 244: 799-804.
    • (2006) Ann Surg , vol.244 , pp. 799-804
    • Kim, J.1    Giuliano, A.E.2    Turner, R.R.3
  • 52
    • 33747369828 scopus 로고    scopus 로고
    • The BRAF mutation is useful for prediction of clinical recurrence in low-risk patients with conventional papillary thyroid carcinoma
    • Kim TY, Kim WB, Rhee YS, et al., The BRAF mutation is useful for prediction of clinical recurrence in low-risk patients with conventional papillary thyroid carcinoma. Clin Endocrinol (Oxf) 2006; 65: 364-8.
    • (2006) Clin Endocrinol (Oxf) , vol.65 , pp. 364-368
    • Kim, T.Y.1    Kim, W.B.2    Rhee, Y.S.3
  • 53
    • 33645964942 scopus 로고    scopus 로고
    • The oncogene BRAFV600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I-targeting to the membrane
    • Riesco-Eizaguirre G, Gutierrez-Martinez P, Garcia-Cabezas M, et al., The oncogene BRAFV600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I-targeting to the membrane. Endocr Relat Cancer 2006; 13: 257-69.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 257-269
    • Riesco-Eizaguirre, G.1    Gutierrez-Martinez, P.2    Garcia-Cabezas, M.3
  • 54
    • 34548762563 scopus 로고    scopus 로고
    • BRAF V600E mutation and p27 kip1 expression in papillary carcinomas of the thyroid
    • Rodolico V, Cabibi D, Pizzolanti G, et al., BRAF V600E mutation and p27 kip1 expression in papillary carcinomas of the thyroid
    • (2007) Cancer , vol.110 , pp. 1218-1226
    • Rodolico, V.1    Cabibi, D.2    Pizzolanti, G.3
  • 55
    • 35948938528 scopus 로고    scopus 로고
    • Association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma
    • Lupi C, Giannini R, Ugolini C, et al., Association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma. J Clin Endocrinol Metab 2007; 92: 4085-90.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4085-4090
    • Lupi, C.1    Giannini, R.2    Ugolini, C.3
  • 56
    • 34548192281 scopus 로고    scopus 로고
    • The prevalence and prognostic value of BRAF mutation in thyroid cancer
    • Kebebew E, Weng J, Bauer J, et al., The prevalence and prognostic value of BRAF mutation in thyroid cancer. Ann Surg 2007; 246: 466-70.
    • (2007) Ann Surg , vol.246 , pp. 466-470
    • Kebebew, E.1    Weng, J.2    Bauer, J.3
  • 57
    • 84870726465 scopus 로고    scopus 로고
    • The BRAF(V600E) mutation is an independent, poor prognostic factor for the outcome of patients with low-risk intrathyroid papillary thyroid carcinoma: Single-institution results from a large cohort study
    • Elisei R, Viola D, Torregrossa L, et al., The BRAF(V600E) mutation is an independent, poor prognostic factor for the outcome of patients with low-risk intrathyroid papillary thyroid carcinoma: single-institution results from a large cohort study. J Clin Endocrinol Metab 2012; 97: 4390-8.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 4390-4398
    • Elisei, R.1    Viola, D.2    Torregrossa, L.3
  • 58
    • 33745074644 scopus 로고    scopus 로고
    • Correlation between B-RAFV600E mutation and clinico-pathologic parameters in papillary thyroid carcinoma: Data from a multicentric Italian study and review of the literature
    • Fugazzola L, Puxeddu E, Avenia N, et al., Correlation between B-RAFV600E mutation and clinico-pathologic parameters in papillary thyroid carcinoma: data from a multicentric Italian study and review of the literature. Endocr Relat Cancer 2006; 13: 455-64.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 455-464
    • Fugazzola, L.1    Puxeddu, E.2    Avenia, N.3
  • 59
    • 77951652078 scopus 로고    scopus 로고
    • Are the clinical and pathological features of differentiated thyroid carcinoma really changed over the last 35 years? Study on 4187 patients from a single Italian institution to answer this question
    • Elisei R, Molinaro E, Agate L, et al., Are the clinical and pathological features of differentiated thyroid carcinoma really changed over the last 35 years? Study on 4187 patients from a single Italian institution to answer this question. J Clin Endocrinol Metab 2010; 95: 1516-27.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1516-1527
    • Elisei, R.1    Molinaro, E.2    Agate, L.3
  • 60
    • 4143051232 scopus 로고    scopus 로고
    • BRAF mutations in an Italian cohort of thyroid cancers
    • Fugazzola L, Mannavola D, Cirello V, et al., BRAF mutations in an Italian cohort of thyroid cancers. Clin Endocrinol (Oxf) 2004; 61: 239-43.
    • (2004) Clin Endocrinol (Oxf) , vol.61 , pp. 239-243
    • Fugazzola, L.1    Mannavola, D.2    Cirello, V.3
  • 61
    • 2442568538 scopus 로고    scopus 로고
    • BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas
    • Puxeddu E, Moretti S, Elisei R, et al., BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas. J Clin Endocrinol Metab 2004; 89: 2414-20.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2414-2420
    • Puxeddu, E.1    Moretti, S.2    Elisei, R.3
  • 62
    • 27744512441 scopus 로고    scopus 로고
    • The BRAF mutation is not associated with poor prognostic factors in Korean patients with conventional papillary thyroid microcarcinoma
    • Kim TY, Kim WB, Song JY, et al., The BRAF mutation is not associated with poor prognostic factors in Korean patients with conventional papillary thyroid microcarcinoma. Clin Endocrinol (Oxf) 2005; 63: 588-93.
    • (2005) Clin Endocrinol (Oxf) , vol.63 , pp. 588-593
    • Kim, T.Y.1    Kim, W.B.2    Song, J.Y.3
  • 63
    • 26644473629 scopus 로고    scopus 로고
    • No correlation between BRAFV600E mutation and clinicopathological features of papillary thyroid carcinomas in Taiwan
    • Liu RT, Chen YJ, Chou FF, et al., No correlation between BRAFV600E mutation and clinicopathological features of papillary thyroid carcinomas in Taiwan. Clin Endocrinol (Oxf) 2005; 63: 461-6.
    • (2005) Clin Endocrinol (Oxf) , vol.63 , pp. 461-466
    • Liu, R.T.1    Chen, Y.J.2    Chou, F.F.3
  • 64
    • 33644586429 scopus 로고    scopus 로고
    • Detection of BRAF mutation in thyroid papillary carcinomas by mutant allele-specific PCR amplification (MASA)
    • Sapio MR, Posca D, Troncone G, et al., Detection of BRAF mutation in thyroid papillary carcinomas by mutant allele-specific PCR amplification (MASA). Eur J Endocrinol 2006; 154: 341-8.
    • (2006) Eur J Endocrinol , vol.154 , pp. 341-348
    • Sapio, M.R.1    Posca, D.2    Troncone, G.3
  • 65
    • 84892424941 scopus 로고    scopus 로고
    • Lack of association of BRAF mutation with negative prognostic indicators in papillary thyroid carcinoma: The University of California, San Francisco, experience
    • Gouveia C, Can NT, Bostrom A, et al., Lack of association of BRAF mutation with negative prognostic indicators in papillary thyroid carcinoma: the University of California, San Francisco, experience. JAMA Otolaryngol Head Neck Surg 2013; 139: 1164-7.
    • (2013) JAMA Otolaryngol Head Neck Surg , vol.139 , pp. 1164-1167
    • Gouveia, C.1    Can, N.T.2    Bostrom, A.3
  • 66
    • 34250893789 scopus 로고    scopus 로고
    • Clinicopathologic significance of BRAF V600E mutation in papillary carcinomas of the thyroid: A meta-analysis
    • Lee JH, Lee ES, Kim YS,. Clinicopathologic significance of BRAF V600E mutation in papillary carcinomas of the thyroid: a meta-analysis. Cancer 2007; 110: 38-46.
    • (2007) Cancer , vol.110 , pp. 38-46
    • Lee, J.H.1    Lee, E.S.2    Kim, Y.S.3
  • 67
    • 84866311243 scopus 로고    scopus 로고
    • BRAF mutation in papillary thyroid cancer and its value in tailoring initial treatment: A systematic review and meta-analysis
    • Tufano RP, Teixeira GV, Bishop J, et al., BRAF mutation in papillary thyroid cancer and its value in tailoring initial treatment: a systematic review and meta-analysis. Medicine 2012; 91: 274-86.
    • (2012) Medicine , vol.91 , pp. 274-286
    • Tufano, R.P.1    Teixeira, G.V.2    Bishop, J.3
  • 68
    • 84863385520 scopus 로고    scopus 로고
    • The association of the BRAF(V600E) mutation with prognostic factors and poor clinical outcome in papillary thyroid cancer: A meta-analysis
    • Kim TH, Park YJ, Lim JA, et al., The association of the BRAF(V600E) mutation with prognostic factors and poor clinical outcome in papillary thyroid cancer: a meta-analysis. Cancer 2012; 118: 1764-73.
    • (2012) Cancer , vol.118 , pp. 1764-1773
    • Kim, T.H.1    Park, Y.J.2    Lim, J.A.3
  • 69
    • 33745136727 scopus 로고    scopus 로고
    • B-RAF mutations in the etiopathogenesis, diagnosis, and prognosis of thyroid carcinomas
    • Trovisco V, Soares P, Sobrinho-Simões M,. B-RAF mutations in the etiopathogenesis, diagnosis, and prognosis of thyroid carcinomas. Hum Pathol 2006; 37: 781-6.
    • (2006) Hum Pathol , vol.37 , pp. 781-786
    • Trovisco, V.1    Soares, P.2    Sobrinho-Simões, M.3
  • 70
    • 53749086690 scopus 로고    scopus 로고
    • BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: A 15-year median follow-up study
    • Elisei R, Ugolini C, Viola D, et al., BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study. J Clin Endocrinol Metab 2008; 93: 3943-9.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 3943-3949
    • Elisei, R.1    Ugolini, C.2    Viola, D.3
  • 71
    • 84868626681 scopus 로고    scopus 로고
    • Prediction of occult central lymph node metastasis in papillary thyroid carcinoma by preoperative BRAF analysis using fine-needle aspiration biopsy: A prospective study
    • Joo JY, Park JY, Yoon YH, et al., Prediction of occult central lymph node metastasis in papillary thyroid carcinoma by preoperative BRAF analysis using fine-needle aspiration biopsy: a prospective study. J Clin Endocrinol Metab 2012; 97: 3996-4003.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 3996-4003
    • Joo, J.Y.1    Park, J.Y.2    Yoon, Y.H.3
  • 72
    • 84884931733 scopus 로고    scopus 로고
    • Clinicopathologic implications of the BRAF(V600E) mutation in papillary thyroid cancer: A subgroup analysis of 3130 cases in a single center
    • Lim JY, Hong SW, Lee YS, et al., Clinicopathologic implications of the BRAF(V600E) mutation in papillary thyroid cancer: a subgroup analysis of 3130 cases in a single center. Thyroid 2013; 23: 1423-30.
    • (2013) Thyroid , vol.23 , pp. 1423-1430
    • Lim, J.Y.1    Hong, S.W.2    Lee, Y.S.3
  • 73
    • 84897041838 scopus 로고    scopus 로고
    • The BRAF V600E mutation in papillary thyroid cancer with positive or suspected pre-surgical cytological finding is not associated with advanced stages or worse prognosis
    • Barbaro D, Incensati RM, Materazzi G, et al., The BRAF V600E mutation in papillary thyroid cancer with positive or suspected pre-surgical cytological finding is not associated with advanced stages or worse prognosis. Endocrine 2014; 45: 462-8.
    • (2014) Endocrine , vol.45 , pp. 462-468
    • Barbaro, D.1    Incensati, R.M.2    Materazzi, G.3
  • 74
    • 84883691685 scopus 로고    scopus 로고
    • Does BRAF V600E mutation predict aggressive features in papillary thyroid cancer? Results from four endocrine surgery centers
    • Li C, Aragon Han P, Lee KC, et al., Does BRAF V600E mutation predict aggressive features in papillary thyroid cancer? Results from four endocrine surgery centers. J Clin Endocrinol Metab 2013; 98: 3702-12.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 3702-3712
    • Li, C.1    Aragon Han, P.2    Lee, K.C.3
  • 75
    • 84875952085 scopus 로고    scopus 로고
    • Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer
    • Xing M, Alzahrani AS, Carson KA, et al., Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer. JAMA 2013; 309: 1493-501.
    • (2013) JAMA , vol.309 , pp. 1493-1501
    • Xing, M.1    Alzahrani, A.S.2    Carson, K.A.3
  • 76
    • 84866184930 scopus 로고    scopus 로고
    • BRAFV600E mutation does not mean distant metastasis in thyroid papillary carcinomas
    • Sancisi V, Nicoli D, Ragazzi M, et al., BRAFV600E mutation does not mean distant metastasis in thyroid papillary carcinomas. J Clin Endocrinol Metab 2012; 97: E1745-9.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. E1745-E1749
    • Sancisi, V.1    Nicoli, D.2    Ragazzi, M.3
  • 77
    • 62549101651 scopus 로고    scopus 로고
    • BRAF mutation in papillary thyroid carcinoma in a Japanese population: Its lack of correlation with high-risk clinicopathological features and disease-free survival of patients
    • Ito Y, Yoshida H, Maruo R, et al., BRAF mutation in papillary thyroid carcinoma in a Japanese population: its lack of correlation with high-risk clinicopathological features and disease-free survival of patients. Endocr J 2009; 56: 89-97.
    • (2009) Endocr J , vol.56 , pp. 89-97
    • Ito, Y.1    Yoshida, H.2    Maruo, R.3
  • 78
    • 40749104889 scopus 로고    scopus 로고
    • BRAF mutation associated with other genetic events identifies a subset of aggressive papillary thyroid carcinoma
    • Costa AM, Herrero A, Fresno MF, et al., BRAF mutation associated with other genetic events identifies a subset of aggressive papillary thyroid carcinoma. Clin Endocrinol 2008; 68: 618-34.
    • (2008) Clin Endocrinol , vol.68 , pp. 618-634
    • Costa, A.M.1    Herrero, A.2    Fresno, M.F.3
  • 79
    • 84894647237 scopus 로고    scopus 로고
    • BRAF(V600E) mutation analysis in papillary thyroid carcinoma: Is it useful for all patients?
    • Ito Y, Yoshida H, Kihara M, et al., BRAF(V600E) mutation analysis in papillary thyroid carcinoma: is it useful for all patients? World J Surg 2014; 38: 679-87.
    • (2014) World J Surg , vol.38 , pp. 679-687
    • Ito, Y.1    Yoshida, H.2    Kihara, M.3
  • 80
    • 84866175310 scopus 로고    scopus 로고
    • A piece of the puzzle: What does BRAF status mean in the management of patients with papillary thyroid carcinoma?
    • Sarne DH,. A piece of the puzzle: what does BRAF status mean in the management of patients with papillary thyroid carcinoma? J Clin Endocrinol Metab 2012; 97: 3094-6.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 3094-3096
    • Sarne, D.H.1
  • 81
    • 84875931932 scopus 로고    scopus 로고
    • Molecular testing in thyroid cancer: BRAF mutation status and mortality
    • Cappola AR, Mandel SJ,. Molecular testing in thyroid cancer: BRAF mutation status and mortality. JAMA 2013; 309: 1529-30.
    • (2013) JAMA , vol.309 , pp. 1529-1530
    • Cappola, A.R.1    Mandel, S.J.2
  • 82
    • 6044219917 scopus 로고    scopus 로고
    • Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer
    • Frattini M, Ferrario C, Bressan P, et al., Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer. Oncogene 2004; 23: 7436-40.
    • (2004) Oncogene , vol.23 , pp. 7436-7440
    • Frattini, M.1    Ferrario, C.2    Bressan, P.3
  • 83
    • 79954579610 scopus 로고    scopus 로고
    • A high-throughput proteomic approach provides distinct signatures for thyroid cancer behavior
    • Cheng S, Serra S, Mercado M, et al., A high-throughput proteomic approach provides distinct signatures for thyroid cancer behavior. Clin Cancer Res 2011; 17: 2385-94.
    • (2011) Clin Cancer Res , vol.17 , pp. 2385-2394
    • Cheng, S.1    Serra, S.2    Mercado, M.3
  • 84
    • 27144556185 scopus 로고    scopus 로고
    • Molecular classification of papillary thyroid carcinoma: Distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis
    • Giordano TJ, Kuick R, Thomas DG, et al., Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis. Oncogene 2005; 24: 6646-56.
    • (2005) Oncogene , vol.24 , pp. 6646-6656
    • Giordano, T.J.1    Kuick, R.2    Thomas, D.G.3
  • 85
    • 33748747215 scopus 로고    scopus 로고
    • Influence of the BRAF V600E mutation on expression of vascular endothelial growth factor in papillary thyroid cancer
    • Jo YS, Li S, Song JH, et al., Influence of the BRAF V600E mutation on expression of vascular endothelial growth factor in papillary thyroid cancer. J Clin Endocrinol Metab 2006; 91: 3667-70.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3667-3670
    • Jo, Y.S.1    Li, S.2    Song, J.H.3
  • 86
    • 77953766335 scopus 로고    scopus 로고
    • B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression
    • Nucera C, Porrello A, Antonello ZA, et al., B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Proc Natl Acad Sci USA 2010; 107: 10649-54.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 10649-10654
    • Nucera, C.1    Porrello, A.2    Antonello, Z.A.3
  • 87
    • 84863987340 scopus 로고    scopus 로고
    • TGF-beta/Smad pathway and BRAF mutation play different roles in circumscribed and infiltrative papillary thyroid carcinoma
    • Eloy C, Santos J, Cameselle-Teijeiro J, et al., TGF-beta/Smad pathway and BRAF mutation play different roles in circumscribed and infiltrative papillary thyroid carcinoma. Virchows Arch 2012; 460: 587-600.
    • (2012) Virchows Arch , vol.460 , pp. 587-600
    • Eloy, C.1    Santos, J.2    Cameselle-Teijeiro, J.3
  • 88
    • 84873675700 scopus 로고    scopus 로고
    • Prognostic implications of miR-146b expression and its functional role in papillary thyroid carcinoma
    • Chou CK, Yang KD, Chou FF, et al., Prognostic implications of miR-146b expression and its functional role in papillary thyroid carcinoma. J Clin Endocrinol Metab 2013; 98: E196-205.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. E196-E205
    • Chou, C.K.1    Yang, K.D.2    Chou, F.F.3
  • 89
    • 84878720708 scopus 로고    scopus 로고
    • RAC1b overexpression in papillary thyroid carcinoma: A role to unravel
    • Silva AL, Carmo F, Bugalho MJ,. RAC1b overexpression in papillary thyroid carcinoma: a role to unravel. Eur J Endocrinol 2013; 168: 795-804.
    • (2013) Eur J Endocrinol , vol.168 , pp. 795-804
    • Silva, A.L.1    Carmo, F.2    Bugalho, M.J.3
  • 90
    • 84867259293 scopus 로고    scopus 로고
    • In papillary thyroid carcinoma BRAFV600E is associated with increased expression of the urokinase plasminogen activator and its cognate receptor, but not with disease-free interval
    • Ulisse S, Baldini E, Sorrenti S, et al., In papillary thyroid carcinoma BRAFV600E is associated with increased expression of the urokinase plasminogen activator and its cognate receptor, but not with disease-free interval. Clin Endocrinol 2012; 77: 780-6.
    • (2012) Clin Endocrinol , vol.77 , pp. 780-786
    • Ulisse, S.1    Baldini, E.2    Sorrenti, S.3
  • 91
    • 84884524540 scopus 로고    scopus 로고
    • Frequency of TERT promoter mutations in human cancers
    • Vinagre J, Almeida A, Põpulo H, et al., Frequency of TERT promoter mutations in human cancers. Nat Commun 2013; 4: 2185.
    • (2013) Nat Commun , vol.4 , pp. 2185
    • Vinagre, J.1    Almeida, A.2    Põpulo, H.3
  • 92
    • 84899908886 scopus 로고    scopus 로고
    • TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomas
    • Melo M, Rocha AG, Vinagre J, et al., TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomas. J Clin Endocrinol Metab 2014; 99: E754-65.
    • (2014) J Clin Endocrinol Metab , vol.99 , pp. E754-E765
    • Melo, M.1    Rocha, A.G.2    Vinagre, J.3
  • 93
    • 84883711485 scopus 로고    scopus 로고
    • Frequent somatic TERT promoter mutations in thyroid cancer: Higher prevalence in advanced forms of the disease
    • Landa I, Ganly I, Chan TA, et al., Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease. J Clin Endocrinol Metab 2013; 98: E1562-6.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. E1562-E1566
    • Landa, I.1    Ganly, I.2    Chan, T.A.3
  • 94
    • 84902303028 scopus 로고    scopus 로고
    • TERT promoter mutations and their association with BRAF V600E mutation and aggressive clinicopathological characteristics of thyroid cancer
    • Liu X, Qu S, Liu R, et al., TERT promoter mutations and their association with BRAF V600E mutation and aggressive clinicopathological characteristics of thyroid cancer. J Clin Endocrinol Metab 2014; doi: 10.1210/jc.2013-4048.
    • (2014) J Clin Endocrinol Metab
    • Liu, X.1    Qu, S.2    Liu, R.3
  • 95
    • 75149188152 scopus 로고    scopus 로고
    • Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells
    • Salerno P, De Falco V, Tamburrino A, et al., Cytostatic activity of adenosine triphosphate-competitive kinase inhibitors in BRAF mutant thyroid carcinoma cells. J Clin Endocrinol Metab 2010; 95: 450-5.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 450-455
    • Salerno, P.1    De Falco, V.2    Tamburrino, A.3
  • 96
    • 79151475164 scopus 로고    scopus 로고
    • The BRAFT1799A mutation confers sensitivity of thyroid cancer cells to the BRAFV600E inhibitor PLX4032 (RG7204)
    • Xing J, Liu R, Xing M, et al., The BRAFT1799A mutation confers sensitivity of thyroid cancer cells to the BRAFV600E inhibitor PLX4032 (RG7204). Biochem Biophys Res Commun 2011; 404: 958-62.
    • (2011) Biochem Biophys Res Commun , vol.404 , pp. 958-962
    • Xing, J.1    Liu, R.2    Xing, M.3
  • 97
    • 77957089182 scopus 로고    scopus 로고
    • The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
    • Joseph EW, Pratilas CA, Poulikakos PI, et al., The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner. Proc Natl Acad Sci USA 2010; 107: 14903-8.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14903-14908
    • Joseph, E.W.1    Pratilas, C.A.2    Poulikakos, P.I.3
  • 98
    • 84868481873 scopus 로고    scopus 로고
    • Vemurafenib: The first drug approved for BRAF-mutant cancer
    • Bollag G, Tsai J, Zhang J, et al., Vemurafenib: the first drug approved for BRAF-mutant cancer. Nat Rev Drug Discov 2012; 11: 873-86.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 873-886
    • Bollag, G.1    Tsai, J.2    Zhang, J.3
  • 99
    • 84868224906 scopus 로고    scopus 로고
    • Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
    • Flaherty KT, Infante JR, Daud A, et al., Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 2012; 367: 1694-703.
    • (2012) N Engl J Med , vol.367 , pp. 1694-1703
    • Flaherty, K.T.1    Infante, J.R.2    Daud, A.3
  • 100
    • 84863230465 scopus 로고    scopus 로고
    • Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
    • Prahallad A, Sun C, Huang S, et al., Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 2012; 483: 100-3.
    • (2012) Nature , vol.483 , pp. 100-103
    • Prahallad, A.1    Sun, C.2    Huang, S.3
  • 101
    • 84861863158 scopus 로고    scopus 로고
    • EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib
    • Corcoran RB, Ebi H, Turke AB, et al., EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. Cancer Discov 2012; 2: 227-35.
    • (2012) Cancer Discov , vol.2 , pp. 227-235
    • Corcoran, R.B.1    Ebi, H.2    Turke, A.B.3
  • 102
    • 84877631604 scopus 로고    scopus 로고
    • Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas
    • Montero-Conde C, Ruiz-Llorente S, Dominguez JM, et al., Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas. Cancer Discov 2013; 3: 520-33.
    • (2013) Cancer Discov , vol.3 , pp. 520-533
    • Montero-Conde, C.1    Ruiz-Llorente, S.2    Dominguez, J.M.3
  • 103
    • 84883482902 scopus 로고    scopus 로고
    • Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436)
    • Nathanson KL, Martin AM, Wubbenhorst B, et al., Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436). Clin Cancer Res 2013; 19: 4868-78.
    • (2013) Clin Cancer Res , vol.19 , pp. 4868-4878
    • Nathanson, K.L.1    Martin, A.M.2    Wubbenhorst, B.3
  • 104
    • 80054118460 scopus 로고    scopus 로고
    • Synergistic action of a RAF inhibitor and a dual PI3K/mTOR inhibitor in thyroid cancer
    • Jin N, Jiang T, Rosen DM, et al., Synergistic action of a RAF inhibitor and a dual PI3K/mTOR inhibitor in thyroid cancer. Clin Cancer Res 2011; 17: 6482-9.
    • (2011) Clin Cancer Res , vol.17 , pp. 6482-6489
    • Jin, N.1    Jiang, T.2    Rosen, D.M.3
  • 105
    • 84873360893 scopus 로고    scopus 로고
    • Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents
    • Mao M, Tian F, Mariadason JM, et al., Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents. Clin Cancer Res 2013; 19: 657-67.
    • (2013) Clin Cancer Res , vol.19 , pp. 657-667
    • Mao, M.1    Tian, F.2    Mariadason, J.M.3
  • 106
    • 33845588905 scopus 로고    scopus 로고
    • Lack of association between BRAF V600E mutation and mitogen-activated protein kinase activation in papillary thyroid carcinoma
    • Zuo H, Nakamura Y, Yasuoka H, et al., Lack of association between BRAF V600E mutation and mitogen-activated protein kinase activation in papillary thyroid carcinoma. Pathol Int 2007; 57: 12-20.
    • (2007) Pathol Int , vol.57 , pp. 12-20
    • Zuo, H.1    Nakamura, Y.2    Yasuoka, H.3
  • 107
    • 84863566153 scopus 로고    scopus 로고
    • MTOR pathway overactivation in BRAF mutated papillary thyroid carcinoma
    • Faustino A, Couto JP, Põpulo H, et al., mTOR pathway overactivation in BRAF mutated papillary thyroid carcinoma. J Clin Endocrinol Metab 2012; 97: E1139-49.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. E1139-E1149
    • Faustino, A.1    Couto, J.P.2    Põpulo, H.3
  • 108
    • 36949011598 scopus 로고    scopus 로고
    • Molecular characteristics in papillary thyroid cancers (PTCs) with no 131I uptake
    • Mian C, Barollo S, Pennelli G, et al., Molecular characteristics in papillary thyroid cancers (PTCs) with no 131I uptake. Clin Endocrinol 2008; 68: 108-16.
    • (2008) Clin Endocrinol , vol.68 , pp. 108-116
    • Mian, C.1    Barollo, S.2    Pennelli, G.3
  • 109
    • 77957123687 scopus 로고    scopus 로고
    • BRAF in primary and recurrent papillary thyroid cancers: The relationship with (131)I and 2-[(18)F]fluoro-2-deoxy-D-glucose uptake ability
    • Barollo S, Pennelli G, Vianello F, et al., BRAF in primary and recurrent papillary thyroid cancers: the relationship with (131)I and 2-[(18)F]fluoro-2-deoxy-D-glucose uptake ability. Eur J Endocrinol 2010; 163: 659-63.
    • (2010) Eur J Endocrinol , vol.163 , pp. 659-663
    • Barollo, S.1    Pennelli, G.2    Vianello, F.3
  • 110
    • 84873681262 scopus 로고    scopus 로고
    • Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer
    • Ho AL, Grewal RK, Leboeuf R, et al., Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer. N Engl J Med 2013; 368: 623-32.
    • (2013) N Engl J Med , vol.368 , pp. 623-632
    • Ho, A.L.1    Grewal, R.K.2    Leboeuf, R.3
  • 111
    • 77952492684 scopus 로고    scopus 로고
    • Thyroid cancer survival in the United States: Observational data from 1973 to 2005
    • Davies L, Welch HG,. Thyroid cancer survival in the United States: observational data from 1973 to 2005. Arch Otolaryngol Head Neck Surg 2010; 136: 440-4.
    • (2010) Arch Otolaryngol Head Neck Surg , vol.136 , pp. 440-444
    • Davies, L.1    Welch, H.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.