Are the clinical and pathological features of differentiated thyroid carcinoma really changed over the last 35 years? Study on 4187 patients from a single Italian institution to answer this question

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 4, 2010, Pages 1516-1527

  Elisei, Rossella ^a   Molinaro, Eleonora ^a   Agate, Laura ^a   Bottici, Valeria ^a   Masserini, Lucio ^a   Ceccarelli, Claudia ^a   Lippi, Francesco ^a   Grasso, Lucia ^a   Basolo, Fulvio ^a   Bevilacqua, Generoso ^a   Miccoli, Paolo ^a   Di Coscio, Giancarlo ^a   Vitti, Paolo ^a   Pacini, Furio ^b   Pinchera, Aldo ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

IODINE 131; BIOLOGICAL MARKER; DIAGNOSTIC AGENT; RADIOACTIVE IODINE;

ADOLESCENT; ADULT; ADVANCED CANCER; AGED; AGGRESSIVENESS; ARTICLE; AUTOIMMUNE THYROIDITIS; CANCER INVASION; CANCER STAGING; CHILD; CLINICAL FEATURE; DISEASE ASSOCIATION; DISTANT METASTASIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; RADIOSURGERY; SCHOOL CHILD; SENESCENCE; SEX RATIO; SURVIVAL RATE; THYROID CARCINOMA; THYROIDECTOMY; TOXIC GOITER; TUMOR DIFFERENTIATION; TUMOR VOLUME; AGE; FOLLOW UP; GOITER; GRAVES DISEASE; ITALY; METASTASIS; MIDDLE AGED; ONSET AGE; PATHOLOGY; SEX DIFFERENCE; SURVIVAL; THYROID NODULE; THYROID TUMOR; TUMOR RECURRENCE; WHOLE BODY IMAGING;

ADOLESCENT; ADULT; AGE FACTORS; AGE OF ONSET; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; FEMALE; FOLLOW-UP STUDIES; GOITER; GRAVES DISEASE; HUMANS; IODINE RADIOISOTOPES; ITALY; MALE; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; PROGNOSIS; SEX FACTORS; SURVIVAL ANALYSIS; THYROID NEOPLASMS; THYROID NODULE; THYROIDITIS, AUTOIMMUNE; WHOLE BODY IMAGING; YOUNG ADULT;

EID: 77951652078     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-1536     Document Type: Article

References (55)

1. Kent WD, Hall SF, Isotalo PA, Houlden RL, George RL, Groome PA 2007 Increased incidence of differentiated thyroid carcinoma and detection of subclinical disease. CMAJ 177:1357-1361
2. Davies L, Welch HG 2006 Increasing incidence of thyroid cancer in the United States, 1973-2002. JAMA 295:2164-2167
3. Colonna M, Guizard AV, Schvartz C, Velten M, Raverdy N, Molinie F, Delafosse P, Franc B, Grosclaude P 2007 A time trend analysis of papillary and follicular cancers as a function of tumour size: a study of data from six cancer registries in France (1983-2000). Eur J Cancer 43:891-900
4. Plesko I, Macfarlane GJ, Obsitnikova A, Vlasak V, Kramarova E 1994 Thyroid cancer in Slovakia, 1968-1990: incidence, mortality and histological types. Eur J Cancer Prev 3:345-349 (Pubitemid 24263978)
5. Farahati J, Geling M, Mäder U, Mörtl M, Luster M, Müller JG, Flentje M, Reiners C 2004 Changing trends of incidence and prognosis of thyroid carcinoma in lower Franconia, Germany, from 1981-1995. Thyroid 14:141-147
6. Scheiden R, Keipes M, Bock C, Dippel W, Kieffer N, Capesius C 2006 Thyroid cancer in Luxembourg: a national population-based data report (1983-1999). BMC Cancer 6:102
7. Reynolds RM, Weir J, Stockton DL, Brewster DH, Sandeep TC, Strachan MW 2005 Changing trends in incidence and mortality of thyroid cancer in Scotland. Clin Endocrinol (Oxf) 62:156-162
8. Harach HR, Escalante DA, Day ES 2002 Thyroid cancer and thyroiditis in Salta, Argentina: a 40-yr study in relation to iodine prophylaxis. Endocr Pathol 13:175-181
9. Chow SM, Law SC, Au SK, Mang O, Yau S, Yuen KT, Lau WH 2003 Changes in clinical presentation, management and outcome in 1348 patients with differentiated thyroid carcinoma: experience in a single institute in Hong Kong, 1960-2000. Clin Oncol (R Coll Radiol) 15:329-336
10. Enewold L, Zhu K, Ron E, Marrogi AJ, Stojadinovic A, Peoples GE, Devesa SS 2009 Rising thyroid cancer incidence in the United States by demographic and tumor characteristics, 1980-2005. Cancer Epidemiol Biomarkers Prev 18:784-791
11. National Cancer Institute 2007 Surveillance Epidemiology and End Results (SEER): Cancer Statistic Review 1973-2005. National Institutes of Health: www.cancer.gov
12. Pellegriti G, Scollo C, Lumera G, Regalbuto C, Vigneri R, Belfiore A 2004 Clinical behavior and outcome of papillary thyroid cancers smaller than 1.5 cm in diameter: study of 299 cases. J Clin Endocrinol Metab 89:3713-3720
13. Pearce EN, Braverman LE 2004 Papillary thyroid microcarcinoma outcomes and implications for treatment. J Clin Endocrinol Metab 89:3710-3712
14. Hay ID, Grant CS, van Heerden JA, Goellner JR, Ebersold JR, Bergstralh EJ 1992 Papillary thyroid microcarcinoma: a study of 535 cases observed in a 50-year period. Surgery 112:1139-1146; discussion 1146-1137
15. Baudin E, Travagli JP, Ropers J, Mancusi F, Bruno-Bossio G, Caillou B, Cailleux AF, Lumbroso JD, Parmentier C, Schlumberger M 1998 Microcarcinoma of the thyroid gland: the Gustave-Roussy Institute experience. Cancer 83:553-559
16. Rago T, Vitti P, Chiovato L, Mazzeo S, De Liperi A, Miccoli P, Viacava P, Bogazzi F, Martino E, Pinchera A 1998 Role of conventional ultrasonography and color flow-doppler sonography in predicting malignancy in 'cold' thyroid nodules. Eur J Endocrinol 138:41-46
17. Pacini F, Fugazzola L, Lippi F, Ceccarelli C, Centoni R, Miccoli P, Elisei R, Pinchera A 1992 Detection of thyroglobulin in fine needle aspirates of nonthyroidal neck masses: a clue to the diagnosis of metastatic differentiated thyroid cancer. J Clin Endocrinol Metab 74:1401-1404
18. Mazzaferri EL, Robbins RJ, Spencer CA, Braverman LE, Pacini F, Wartofsky L, Haugen BR, Sherman SI, Cooper DS, Braunstein GD, Lee S, Davies TF, Arafah BM, Ladenson PW, Pinchera A 2003 A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J Clin Endocrinol Metab 88:1433-1441 (Pubitemid 36623351)
19. Pacini F, Molinaro E, Lippi F, Castagna MG, Agate L, Ceccarelli C, Taddei D, Elisei R, Capezzone M, Pinchera A 2001 Prediction of disease status by recombinant human TSH-stimulated serum Tg in the postsurgical follow-up of differentiated thyroid carcinoma. J Clin Endocrinol Metab 86:5686-5690
20. LiVolsi VA, Asa SL 2002 Endocrine pathology. Philadelphia: Churchill Livingstone
21. De Lellis RA WE 2004 Tumors of thyroid and parathyroid. In: De Lellis RA LR, Heitz PU, Eng C, ed. Pathology and genetics of tumours of endocrine organs (World Health Organization classification of tumours). Lyon, France: IARC Press; 49-133
22. Sobin L 2002 TNM classification of malignant tumors. 6th ed. New York: John Wiley, Sons
23. Chem KT, Rosai J 1977 Follicular variant of thyroid papillary carcinoma: a clinicopathologic study of six cases. Am J Surg Pathol 1:123-130
24. Rosaí J, Zampi G, Carcangiu ML 1983 Papillary carcinoma of the thyroid. A discussion of its several morphologic expressions, with particular emphasis on the follicular variant. Am J Surg Pathol 7:809-817 (Pubitemid 14222468)
25. DeGroot LJ, Kaplan EL, McCormick M, Straus FH 1990 Natural history, treatment, and course of papillary thyroid carcinoma. J Clin Endocrinol Metab 71:414-424 (Pubitemid 20261828)
26. Spencer CA 2004 Challenges of serum thyroglobulin (Tg) measurement in the presence of Tg autoantibodies. J Clin Endocrinol Metab 89:3702-3704
27. Mariotti S, Cupini C, Giani C, Lari R, Rolleri E, Falco A, Marchisio M, Pinchera A 1982 Evaluation of a solid-phase immunoradiometric assay (IRMA) for serum thyroglobulin: effect of anti-thyroglobulin autoantibody. Clin Chim Acta 123:347-355
28. Tsuda K, Namba H, Nomura T, Yokoyama N, Yamashita S, Izumi M,Nagataki S 1995 Automated measurement of urinary iodine with use of ultraviolet irradiation. Clin Chem 41:581-585
29. Pacini F, Capezzone M, Elisei R, Ceccarelli C, Taddei D, Pinchera A 2002 Diagnostic 131-iodine whole-body scan may be avoided in thyroid cancer patients who have undetectable stimulated serum Tg levels after initial treatment. J Clin Endocrinol Metab 87:1499-1501
30. Kwak JY, Kim EK, Youk JH, Kim MJ, Son EJ, Choi SH, Oh KK 2008 Extrathyroid extension of well-differentiated papillary thyroid microcarcinoma on US. Thyroid 18:609-614
31. Nam-Goong IS, Kim HY, Gong G, Lee HK, Hong SJ, Kim WB, Shong YK 2004 Ultrasonography-guided fine-needle aspiration of thyroid incidentaloma: correlation with pathological findings. Clin Endocrinol (Oxf) 60:21-28
32. Tan GH, Gharib H, Reading CC 1995 Solitary thyroid nodule. Comparison between palpation and ultrasonography. Arch Intern Med 155:2418-2423
33. Steele SR, Martin MJ, Mullenix PS, Azarow KS, Andersen CA 2005 The significance of incidental thyroid abnormalities identified during carotid duplex ultrasonography. Arch Surg 140:981-985
34. Burgess JR, Dwyer T, McArdle K, Tucker P, Shugg D 2000 The changing incidence and spectrum of thyroid carcinoma in Tasmania (1978-1998) during a transition from iodine sufficiency to iodine deficiency. J Clin Endocrinol Metab 85:1513-1517
35. Gomez Segovia I, Gallowitsch HJ, Kresnik E, Kumnig G, Igerc I, Matschnig S, Stronegger WJ, Lind P 2004 Descriptive epidemiology of thyroid carcinoma in Carinthia, Austria: 1984-2001. Histopathologic features and tumor classification of 734 cases under elevated general iodination of table salt since 1990: population-based age-stratified analysis on thyroid carcinoma incidence. Thyroid 14:277-286
36. Belfiore A, La Rosa GL, Padova G, Sava L, Ippolito O, Vigneri R 1987 The frequency of cold thyroid nodules and thyroid malignancies in patients from an iodine-deficient area. Cancer 60:3096-3102
37. Aghini-Lombardi F, Antonangeli L, Pinchera A, Leoli F, Rago T, Bartolomei AM, Vitti P 1997 Effect of iodized salt on thyroid volume of children living in an area previously characterized by moderate iodine deficiency. J Clin Endocrinol Metab 82:1136-1139
38. Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA 2003 High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res 63:1454-1457 (Pubitemid 36373628)
39. Guan H, Ji M, Bao R, Yu H, Wang Y, Hou P, Zhang Y, Shan Z, Teng W, Xing M 2009 Association of high iodine intake with the T1799A BRAF mutation in papillary thyroid cancer. J Clin Endocrinol Metab 94:1612-1617
40. Albores-Saavedra J, Henson DE, Glazer E, Schwartz AM 2007 Changing patterns in the incidence and survival of thyroid cancer with follicular phenotype: papillary, follicular, and anaplastic: a morphological and epidemiological study. Endocr Pathol 18:1-7
41. Kim DL, Song KH, Kim SK 2008 High prevalence of carcinoma in ultrasonography-guided fine needle aspiration cytology of thyroid nodules. Endocr J 55:135-142
42. Marcocci C, Vitti P, Cetani F, Catalano F, Concetti R, Pinchera A 1991 Thyroid ultrasonography helps to identify patients with diffuse lymphocytic thyroiditis who are prone to develop hypothyroidism. J Clin Endocrinol Metab 72:209-213
43. Carlé A, Laurberg P, Pedersen IB, Knudsen N, Perrild H, Ovesen L, Rasmussen LB, Jorgensen T 2006 Epidemiology of subtypes of hypothyroidism in Denmark. Eur J Endocrinol 154:21-28
44. Roudebush CP, Asteris GT, DeGroot LJ 1978 Natural history of radiation-associated thyroid cancer. Arch Intern Med 138: 1631-1634
45. Greenspan FS 1977 Radiation exposure and thyroid cancer. JAMA 237:2089-2091
46. Roti E, degli Uberti EC, Bondanelli M, Braverman LE 2008 Thyroid papillary microcarcinoma: a descriptive and meta-analysis study. Eur J Endocrinol 159:659-673
47. Bondeson L, Ljungberg O 1981 Occult thyroid carcinoma at autopsy in Malmo, Sweden. Cancer 47:319-323
48. Harach HR, Franssila KO, Wasenius VM 1985 Occult papillary carcinoma of the thyroid: a "normal" finding in Finland. A systematic autopsy study. Cancer 56:531-538
49. Ricarte-Filho JC, Ryder M, Chitale DA, Rivera M, Heguy A, Ladanyi M, Janakiraman M, Solit D, Knauf JA, Tuttle RM, Ghossein RA, Fagin JA 2009 Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1. Cancer Res 69:4885-4893
50. Gemsenjäger E, Heitz PU, Seifert B, Martina B, Schweizer I 2001 Differentiated thyroid carcinoma. Follow-up of 264 patients from one institution for up to 25 years. Swiss Med Wkly 131:157-163
51. Hu A, Clark J, Payne RJ, Eski S, Walfish PG, Freeman JL 2007 Extrathyroidal extension in well-differentiated thyroid cancer: macroscopic vs microscopic as a predictor of outcome. Arch Otolaryngol Head Neck Surg 133:644-649
52. Loh KC, Greenspan FS, Gee L, Miller TR, Yeo PP 1997 Pathological tumor-node-metastasis (pTNM) staging for papillary and follicular thyroid carcinomas: a retrospective analysis of 700 patients. J Clin Endocrinol Metab 82:3553-3562 (Pubitemid 27509336)
53. Cushing SL, Palme CE, Audet N, Eski S, Walfish PG, Freeman JL 2004 Prognostic factors in well-differentiated thyroid carcinoma. Laryngoscope 114:2110-2115 (Pubitemid 39602473)
54. Mazzaferri EL, Jhiang SM 1994 Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med 97:418-428
55. Pacini F, Elisei R, Capezzone M, Miccoli P, Molinaro E, Basolo F, Agate L, Bottici V, Raffaelli M, Pinchera A 2001 Contralateral papillary thyroid cancer is frequent at completion thyroidectomy with no difference in low- and high-risk patients. Thyroid 11: 877-881