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Volumn 98, Issue 5, 2013, Pages

Allele percentage of the BRAF V600E mutation in papillary thyroid carcinomas and corresponding lymph node metastases: No evidence for a role in tumor progression

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; TUMOR MARKER;

EID: 84877686708     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2012-3930     Document Type: Article
Times cited : (54)

References (48)
  • 1
    • 77952492684 scopus 로고    scopus 로고
    • Thyroid cancer survival in the United States: Observational data from 1973 to 2005
    • Davies L, Welch HG. Thyroid cancer survival in the United States: observational data from 1973 to 2005. Arch Otolaryngol Head Neck Surg. 2010;136:440-444.
    • (2010) Arch Otolaryngol Head Neck Surg , vol.136 , pp. 440-444
    • Davies, L.1    Welch, H.G.2
  • 3
    • 77952883863 scopus 로고    scopus 로고
    • Molecular prognostic markers in papillary and follicular thyroid cancer: Current status and future directions
    • Handkiewicz-Junak D, Czarniecka A, Jarzab B. Molecular prognostic markers in papillary and follicular thyroid cancer: current status and future directions. Mol Cell Endocrinol. 2010;322:8-28.
    • (2010) Mol Cell Endocrinol , vol.322 , pp. 8-28
    • Handkiewicz-Junak, D.1    Czarniecka, A.2    Jarzab, B.3
  • 4
    • 0037379904 scopus 로고    scopus 로고
    • High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
    • Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA. High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res. 2003; 63:1454-1457.
    • (2003) Cancer Res , vol.63 , pp. 1454-1457
    • Kimura, E.T.1    Nikiforova, M.N.2    Zhu, Z.3    Knauf, J.A.4    Nikiforov, Y.E.5    Fagin, J.A.6
  • 5
    • 0043170833 scopus 로고    scopus 로고
    • BRAF mutations and RET/PTCrearrangements are alternative events in the etiopathogenesis of PTC
    • Soares P, Trovisco V, Rocha AS, et al. BRAF mutations and RET/PTCrearrangements are alternative events in the etiopathogenesis of PTC. Oncogene. 2003;22:4578-4580.
    • (2003) Oncogene , vol.22 , pp. 4578-4580
    • Soares, P.1    Trovisco, V.2    Rocha, A.S.3
  • 6
    • 34548192281 scopus 로고    scopus 로고
    • The prevalence and prognostic value of BRAF mutation in thyroid cancer
    • Kebebew E, Weng J, Bauer J, et al. The prevalence and prognostic value of BRAF mutation in thyroid cancer. Ann Surg. 2007;246: 466-471.
    • (2007) Ann Surg , vol.246 , pp. 466-471
    • Kebebew, E.1    Weng, J.2    Bauer, J.3
  • 7
    • 35948938528 scopus 로고    scopus 로고
    • Association of BRAFV600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma
    • Lupi C, Giannini R, Ugolini C, et al. Association of BRAFV600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma. J Clin Endocrinol Metab. 2007;92:4085-4090.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4085-4090
    • Lupi, C.1    Giannini, R.2    Ugolini, C.3
  • 8
    • 53749086690 scopus 로고    scopus 로고
    • BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: A 15 year median follow-up study
    • Elisei R, Ugolini C, Viola D, et al. BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15 year median follow-up study. J Clin Endocrinol Metab. 2008;93:3943-3949.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 3943-3949
    • Elisei, R.1    Ugolini, C.2    Viola, D.3
  • 9
    • 84870726465 scopus 로고    scopus 로고
    • The BRAFV600E mutation is an independent, poor prognostic factor for the outcome of patients with low-risk intrathyroid papillary thyroid carcinoma: Single-institution results from a large cohort study
    • Elisei R, Viola D, Torregrossa L, et al. The BRAFV600E mutation is an independent, poor prognostic factor for the outcome of patients with low-risk intrathyroid papillary thyroid carcinoma: single-institution results from a large cohort study. J Clin Endocrinol Metab. 2012;97:4390-4398.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 4390-4398
    • Elisei, R.1    Viola, D.2    Torregrossa, L.3
  • 10
    • 78650976224 scopus 로고    scopus 로고
    • The BRAF mutation is predictive of aggressive clinicopathology characteristics in papillary thyroid microcarcinoma
    • Lin KL, Wang OC, Zhang XH, Dai XX, Hu XQ, Qu JM. The BRAF mutation is predictive of aggressive clinicopathology characteristics in papillary thyroid microcarcinoma. Ann Surg Oncol. 2010;17: 3294-3300.
    • (2010) Ann Surg Oncol , vol.17 , pp. 3294-3300
    • Lin, K.L.1    Wang, O.C.2    Zhang, X.H.3    Dai, X.X.4    Hu, X.Q.5    Qu, J.M.6
  • 11
    • 84861988936 scopus 로고    scopus 로고
    • Papillary thyroid carcinomas with cervical lymph node metastases can be stratified into clinically relevant prognostic categories using oncogenic BRAF, number of nodal metastasis and extra-nodal extension
    • Ricarte-Filho J, Ganly I, Rivera M, et al. Papillary thyroid carcinomas with cervical lymph node metastases can be stratified into clinically relevant prognostic categories using oncogenic BRAF, number of nodal metastasis and extra-nodal extension. Thyroid. 2012;22: 575-584.
    • (2012) Thyroid , vol.22 , pp. 575-584
    • Ricarte-Filho, J.1    Ganly, I.2    Rivera, M.3
  • 12
    • 84864848268 scopus 로고    scopus 로고
    • BRAF (V600E) mutation in papillary thyroid carcinoma: Significant association with node metastases and extra thyroidal invasion
    • Chakraborty A, Narkar A, Mukhopadhyaya R, Kane S, D'Cruz A, Rajan MG. BRAF (V600E) mutation in papillary thyroid carcinoma: significant association with node metastases and extra thyroidal invasion. Endocr Pathol. 2012;23:83-93.
    • (2012) Endocr Pathol , vol.23 , pp. 83-93
    • Chakraborty, A.1    Narkar, A.2    Mukhopadhyaya, R.3    Kane, S.4    D'Cruz, A.5    Rajan, M.G.6
  • 13
    • 84857457602 scopus 로고    scopus 로고
    • BRAF V600E mutation is associated with tumor aggressiveness in papillary thyroid cancer
    • Kim SJ, Lee KE, Myong JP, et al. BRAF V600E mutation is associated with tumor aggressiveness in papillary thyroid cancer. World J Surg. 2012;36:310-317.
    • (2012) World J Surg , vol.36 , pp. 310-317
    • Kim, S.J.1    Lee, K.E.2    Myong, J.P.3
  • 14
    • 34250893789 scopus 로고    scopus 로고
    • Clincopathologic significance of BRAFV600E mutation in papillary carcinomas of the thyroid: A meta-analysis
    • Lee JH, Lee ES, Kim YS. Clincopathologic significance of BRAFV600E mutation in papillary carcinomas of the thyroid: a meta-analysis. Cancer. 2007;110:38-46.
    • (2007) Cancer , vol.110 , pp. 38-46
    • Lee, J.H.1    Lee, E.S.2    Kim, Y.S.3
  • 15
    • 84863385520 scopus 로고    scopus 로고
    • The association of the BRAF (V600E) mutation with prognostic factors and poor clinical outcome in papillary thyroid cancer: A meta-analysis
    • Kim TH, Park YJ, Lim JA, et al. The association of the BRAF (V600E) mutation with prognostic factors and poor clinical outcome in papillary thyroid cancer: a meta-analysis. Cancer. 2012; 118:1764-1773.
    • (2012) Cancer , vol.118 , pp. 1764-1773
    • Kim, T.H.1    Park, Y.J.2    Lim, J.A.3
  • 16
    • 84870733693 scopus 로고    scopus 로고
    • BRAFV600E mutation and its association with clinicopathological features of papillary thyroid cancer: A meta-analysis
    • Li C, Lee KC, Schneider EB, Zeiger MA. BRAFV600E mutation and its association with clinicopathological features of papillary thyroid cancer: a meta-analysis. J Clin Endocrinol Metab. 2012;97:4559-4570.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 4559-4570
    • Li, C.1    Lee, K.C.2    Schneider, E.B.3    Zeiger, M.A.4
  • 17
    • 26644473629 scopus 로고    scopus 로고
    • No correlation between BRAFV600E mutation and clinicopathological features of papillary thyroid carcinomas in Taiwan
    • Liu RT, Chen YJ, Chou FF, et al. No correlation between BRAFV600E mutation and clinicopathological features of papillary thyroid carcinomas in Taiwan. Clin Endocrinol (Oxf). 2005;63: 461-466.
    • (2005) Clin Endocrinol (Oxf) , vol.63 , pp. 461-466
    • Liu, R.T.1    Chen, Y.J.2    Chou, F.F.3
  • 18
    • 33745074644 scopus 로고    scopus 로고
    • Correlation between B-RAFV600Emutation and clinico-pathologic parameters in papillary thyroid carcinoma: Data from a multicentric Italian study and review of the literature
    • Fugazzola L, Puxeddu E, Avenia N, et al. Correlation between B-RAFV600Emutation and clinico-pathologic parameters in papillary thyroid carcinoma: data from a multicentric Italian study and review of the literature. Endocr Relat Cancer. 2006;13:455-464.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 455-464
    • Fugazzola, L.1    Puxeddu, E.2    Avenia, N.3
  • 19
    • 62549101651 scopus 로고    scopus 로고
    • BRAF mutation in papillary thyroid carcinoma in a Japanese population: Its lack of correlation with high-risk clinicopathological features and disease free-survival
    • Ito Y, Yoshida H, Maruo R, et al. BRAF mutation in papillary thyroid carcinoma in a Japanese population: its lack of correlation with high-risk clinicopathological features and disease free-survival. Endocr J. 2009;56:89-97.
    • (2009) Endocr J , vol.56 , pp. 89-97
    • Ito, Y.1    Yoshida, H.2    Maruo, R.3
  • 20
    • 80052415888 scopus 로고    scopus 로고
    • The preeminence of growth pattern and invasiveness and the limited influence of BRAF and RAS mutations in the occurrence of papillary thyroid carcinoma lymph node metastases
    • Eloy C, Santos J, Soares P, Sobrinho-Simoes M. The preeminence of growth pattern and invasiveness and the limited influence of BRAF and RAS mutations in the occurrence of papillary thyroid carcinoma lymph node metastases. Virchows Arch. 2011;459:265-276.
    • (2011) Virchows Arch , vol.459 , pp. 265-276
    • Eloy, C.1    Santos, J.2    Soares, P.3    Sobrinho-Simoes, M.4
  • 21
    • 79954579610 scopus 로고    scopus 로고
    • A high throughput proteomic approach provides distinct signatures for thyroid cancer behaviour
    • Cheng S, Serra S, Mercado M, Ezzat S, Asa SL. A high throughput proteomic approach provides distinct signatures for thyroid cancer behaviour. Clin Cancer Res. 2011;17:2385-2394.
    • (2011) Clin Cancer Res , vol.17 , pp. 2385-2394
    • Cheng, S.1    Serra, S.2    Mercado, M.3    Ezzat, S.4    Asa, S.L.5
  • 22
    • 84855953674 scopus 로고    scopus 로고
    • The role of molecular markers and tumor histological type in central lymph node metastasis of papillary thyroid carcinoma
    • Paulson L, Shindo M, Schuff K, Corless C. The role of molecular markers and tumor histological type in central lymph node metastasis of papillary thyroid carcinoma. Arch Otolaryngol Head Neck Surg. 2012;138:44-49.
    • (2012) Arch Otolaryngol Head Neck Surg , vol.138 , pp. 44-49
    • Paulson, L.1    Shindo, M.2    Schuff, K.3    Corless, C.4
  • 23
    • 84855426419 scopus 로고    scopus 로고
    • Oncogenic alterations in papillary thyroid cancers of young patients
    • Sassolas G, Hafdi-Nejjari Z, Ferraro A, et al. Oncogenic alterations in papillary thyroid cancers of young patients. Thyroid. 2012;22: 17-26.
    • (2012) Thyroid , vol.22 , pp. 17-26
    • Sassolas, G.1    Hafdi-Nejjari, Z.2    Ferraro, A.3
  • 24
    • 84856706936 scopus 로고    scopus 로고
    • BRAFV 600 Emutation does not serve as a prognostic factor in Korean patients with papillary thyroid carcinoma
    • Ahn D, Park JS, Sohn JH, et al. BRAFV600Emutation does not serve as a prognostic factor in Korean patients with papillary thyroid carcinoma. Auris Nasus Larynx. 2012;39:198-203.
    • (2012) Auris Nasus Larynx , vol.39 , pp. 198-203
    • Ahn, D.1    Park, J.S.2    Sohn, J.H.3
  • 25
    • 84859099960 scopus 로고    scopus 로고
    • Is the BRAF(V600E) mutation useful as a predictor of preoperative risk in papillary thyroid cancer?
    • Nam JK, Jung CK, Song BJ, et al. Is the BRAF(V600E) mutation useful as a predictor of preoperative risk in papillary thyroid cancer? Am J Surg. 2012;203:436-441.
    • (2012) Am J Surg , vol.203 , pp. 436-441
    • Nam, J.K.1    Jung, C.K.2    Song, B.J.3
  • 26
    • 84869495830 scopus 로고    scopus 로고
    • Is BRAF mutation associated with lymph node metastasis in patients with papillary thyroid cancer?
    • Lee KC, Li C, Schneider EB, et al. Is BRAF mutation associated with lymph node metastasis in patients with papillary thyroid cancer? Surgery. 2012;152:977-988.
    • (2012) Surgery , vol.152 , pp. 977-988
    • Lee, K.C.1    Li, C.2    Schneider, E.B.3
  • 27
    • 21544464303 scopus 로고    scopus 로고
    • Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients' age but not with tumour aggressiveness
    • Trovisco V, Soares P, Preto A, et al. Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients' age but not with tumour aggressiveness. Virchows Arch. 2005;446:589-595.
    • (2005) Virchows Arch , vol.446 , pp. 589-595
    • Trovisco, V.1    Soares, P.2    Preto, A.3
  • 28
    • 51649128260 scopus 로고    scopus 로고
    • Acquisition of BRAF gene mutations is not a requirement for nodal metastasis of papillary thyroid carcinoma
    • Trovisco V, Couto JP, Cameselle-Teijeiro J, et al. Acquisition of BRAF gene mutations is not a requirement for nodal metastasis of papillary thyroid carcinoma. Clin Endocrinol (Oxf). 2008;69:683-685.
    • (2008) Clin Endocrinol (Oxf) , vol.69 , pp. 683-685
    • Trovisco, V.1    Couto, J.P.2    Cameselle-Teijeiro, J.3
  • 30
    • 75149121483 scopus 로고    scopus 로고
    • Papillary microcarcinoma in comparison with larger papillary thyroid carcinoma in BRAF(V600E) mutation, clinicopathological features, and immunohistochemical findings
    • Park YJ, Kim YA, Lee YJ, et al. Papillary microcarcinoma in comparison with larger papillary thyroid carcinoma in BRAF(V600E) mutation, clinicopathological features, and immunohistochemical findings. Head Neck. 2010;32:38-45.
    • (2010) Head Neck , vol.32 , pp. 38-45
    • Park, Y.J.1    Kim, Y.A.2    Lee, Y.J.3
  • 31
    • 20144372793 scopus 로고    scopus 로고
    • Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation
    • Knauf JA, Ma X, Smith EP, et al. Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation. Cancer Res. 2005; 65:4238-4245.
    • (2005) Cancer Res , vol.65 , pp. 4238-4245
    • Knauf, J.A.1    Ma, X.2    Smith, E.P.3
  • 32
    • 84856798619 scopus 로고    scopus 로고
    • The primary occurrence of BRAF(V600E) is a rare clonal event in papillary thyroid carcinoma
    • Guerra A, Sapio MR, Marotta V, et al. The primary occurrence of BRAF(V600E) is a rare clonal event in papillary thyroid carcinoma. J Clin Endocrinol Metab. 2012;97:517-524.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 517-524
    • Guerra, A.1    Sapio, M.R.2    Marotta, V.3
  • 33
    • 84863574283 scopus 로고    scopus 로고
    • A high percentage of BRAFV600Ealleles in papillary thyroid carcinoma predicts a poorer outcome
    • Guerra A, Fugazzola L, Marotta V, et al. A high percentage of BRAFV600Ealleles in papillary thyroid carcinoma predicts a poorer outcome. J Clin Endocrinol Metab. 2012;97:2333-2340.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 2333-2340
    • Guerra, A.1    Fugazzola, L.2    Marotta, V.3
  • 34
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med. 2012;366:883-892.
    • (2012) N Engl J Med , vol.366 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3
  • 37
    • 84867239494 scopus 로고    scopus 로고
    • Runx2 isoform i controls a panel of proinvasive genes driving aggressiveness of papillary thyroid carcinomas
    • Sancisi V, Borettini G, Maramotti S, et al. Runx2 isoform I controls a panel of proinvasive genes driving aggressiveness of papillary thyroid carcinomas. J Clin Endocrinol Metab. 2012;97:2006-2015.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 2006-2015
    • Sancisi, V.1    Borettini, G.2    Maramotti, S.3
  • 38
    • 79952986530 scopus 로고    scopus 로고
    • Inhibitor of DNA binding-1 induces mesenchymal features and promotes invasiveness in thyroid tumour cells
    • Ciarrocchi A, Piana S, Valcavi R, Gardini G, Casali B. Inhibitor of DNA binding-1 induces mesenchymal features and promotes invasiveness in thyroid tumour cells. Eur J Cancer. 2011;47:934-945.
    • (2011) Eur J Cancer , vol.47 , pp. 934-945
    • Ciarrocchi, A.1    Piana, S.2    Valcavi, R.3    Gardini, G.4    Casali, B.5
  • 39
    • 84866175310 scopus 로고    scopus 로고
    • A piece of the puzzle: What does BRAF status mean in the management of patients with papillary thyroid carcinoma?
    • Sarne DH. A piece of the puzzle: what does BRAF status mean in the management of patients with papillary thyroid carcinoma? J Clin Endocrinol Metab. 2012;97:3094-3096.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 3094-3096
    • Sarne, D.H.1
  • 40
    • 84862867061 scopus 로고    scopus 로고
    • Reoperative central compartment dissection for patients with recurrent/persistent papillary thyroid cancer: Efficacy, safety, and the association of the BRAF mutation
    • Tufano RP, Bishop J, Wu G. Reoperative central compartment dissection for patients with recurrent/persistent papillary thyroid cancer: efficacy, safety, and the association of the BRAF mutation. Laryngoscope. 2012;122:1634-1640.
    • (2012) Laryngoscope , vol.122 , pp. 1634-1640
    • Tufano, R.P.1    Bishop, J.2    Wu, G.3
  • 41
    • 84875210994 scopus 로고    scopus 로고
    • Papillary thyroid microcarcinoma with fatal outcome: Evidence of tumor progression in lymph node metastases: Report of 3 cases, with morphological and molecular analysis
    • [published online October 15, 2012]. doi: 10.1016/j.humpath.2012.06.019
    • Piana S, Ragazzi M, Tallini G, et al. Papillary thyroid microcarcinoma with fatal outcome: evidence of tumor progression in lymph node metastases: report of 3 cases, with morphological and molecular analysis [published online October 15, 2012]. Hum Pathol. doi: 10.1016/j.humpath.2012.06.019.
    • Hum Pathol
    • Piana, S.1    Ragazzi, M.2    Tallini, G.3
  • 42
    • 84878879907 scopus 로고    scopus 로고
    • Papillary microcarcinoma of the thyroid: Clinical characteristics and BRAF(V600E) mutational status of 977 cases
    • [published online January 31, 2013]. doi:10.1245/s10434-012-2851-z
    • Zheng X, Wei S, Han Y, et al. Papillary microcarcinoma of the thyroid: clinical characteristics and BRAF(V600E) mutational status of 977 cases [published online January 31, 2013]. Ann Surg Oncol. doi:10.1245/s10434-012- 2851-z.
    • Ann Surg Oncol
    • Zheng, X.1    Wei, S.2    Han, Y.3
  • 43
    • 24344505403 scopus 로고    scopus 로고
    • High prevalence and possible de novo formation of BRAF mutation in metastasized papillary thyroid cancer in lymph nodes
    • Vasko V, Hu S, Wu G, et al. High prevalence and possible de novo formation of BRAF mutation in metastasized papillary thyroid cancer in lymph nodes. J Clin Endocrinol Metab. 2005;90:5265-5269.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 5265-5269
    • Vasko, V.1    Hu, S.2    Wu, G.3
  • 44
    • 0033941269 scopus 로고    scopus 로고
    • Molecular genetic changes in metastatic primary Barrett's adenocarcinoma and related lymph node metastases: Comparison with nonmetastatic Barrett's adenocarcinoma
    • Walch AK, Zitzelsberger HF, Bink K, et al. Molecular genetic changes in metastatic primary Barrett's adenocarcinoma and related lymph node metastases: comparison with nonmetastatic Barrett's adenocarcinoma. Mod Pathol. 2000;13:814-824.
    • (2000) Mod Pathol , vol.13 , pp. 814-824
    • Walch, A.K.1    Zitzelsberger, H.F.2    Bink, K.3
  • 45
    • 81555209828 scopus 로고    scopus 로고
    • Heterogeneous amplification of ERBB2 in primary lesions is responsible for the discordant ERBB2 status of primary and metastatic lesions in gastric carcinoma
    • Kim MA, Lee HJ Yang HK, Bang YJ, Kim WH. Heterogeneous amplification of ERBB2 in primary lesions is responsible for the discordant ERBB2 status of primary and metastatic lesions in gastric carcinoma. Histopathology. 2011;59:822-831.
    • (2011) Histopathology , vol.59 , pp. 822-831
    • Kim, M.A.1    Lee Yang, H.J.H.K.2    Bang, Y.J.3    Kim, W.H.4
  • 46
    • 84862587175 scopus 로고    scopus 로고
    • Immunohistochemical consistency between primary tumors and lymph node metastases of gastric neuroendocrine carcinoma
    • Uchiyama C, Tamura S, Nakatsuka S, et al. Immunohistochemical consistency between primary tumors and lymph node metastases of gastric neuroendocrine carcinoma. World J Surg Oncol. 2012;10: 115.
    • (2012) World J Surg Oncol , vol.10 , pp. 115
    • Uchiyama, C.1    Tamura, S.2    Nakatsuka, S.3
  • 47
    • 84861163796 scopus 로고    scopus 로고
    • Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis
    • Vredeveld LC, Possik PA, Smit MA, et al. Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis. Genes Dev. 2012;26:1055-1069.
    • (2012) Genes Dev , vol.26 , pp. 1055-1069
    • Vredeveld, L.C.1    Possik, P.A.2    Smit, M.A.3
  • 48
    • 84862109270 scopus 로고    scopus 로고
    • Immunohistochemical detection of the BRAF V600E-mutated protein in papillary thyroid carcinoma
    • Koperek O, Kornauth C, Capper D, et al. Immunohistochemical detection of the BRAF V600E-mutated protein in papillary thyroid carcinoma. Am J Surg Pathol. 2012;36:844-850.
    • (2012) Am J Surg Pathol , vol.36 , pp. 844-850
    • Koperek, O.1    Kornauth, C.2    Capper, D.3


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