Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: Evidence for hepatic CYP2B induction and hepatocyte proliferation

Toxicological Sciences

Volumn 108, Issue 1, 2009, Pages 69-80

  Deguchi, Yoshihito ^a   Yamada, Tomoya ^a   Hirose, Yukihiro ^a   Nagahori, Hirohisa ^a   Kushida, Masahiko ^a   Sumida, Kayo ^a   Sukata, Tokuo ^a   Tomigahara, Yoshitaka ^a   Nishioka, Kazuhiko ^a   Uwagawa, Satoshi ^a   Kawamura, Satoshi ^a   Okuno, Yasuyoshi ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

Author keywords

Constitutive androstane receptor (CAR); Hepatocarcinogenesis; Nongenotoxic; Phenobarbital; RNA interference (RNAi); Toxicogenomics

Indexed keywords

ANTIOXIDANT; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2B; CYTOCHROME P450 2B1; CYTOCHROME P450 3A; DNA; LIVER ENZYME; MESSENGER RNA; METOFLUTHRIN; PHENOBARBITAL; PYRETHROID; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COMMUNICATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA MICROARRAY; DNA REPLICATION; FEMALE; GAP JUNCTION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE SILENCING; HYPERTROPHY; LIVER CARCINOGENESIS; LIVER CELL; LIVER MICROSOME; LIVER TUMOR; LIVER WEIGHT; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN CONTENT; RAT; RNA INTERFERENCE; SMOOTH ENDOPLASMIC RETICULUM; TOXICOGENETICS; UPREGULATION;

ANIMALS; APOPTOSIS; ARYL HYDROCARBON HYDROXYLASES; CELL PROLIFERATION; CYCLOPROPANES; CYTOCHROME P-450 CYP2B1; DISEASE MODELS, ANIMAL; FEMALE; FLUOROBENZENES; GENE EXPRESSION REGULATION, NEOPLASTIC; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICROSOMES, LIVER; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; PHENOBARBITAL; PYRETHRINS; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA INTERFERENCE; STATISTICS, NONPARAMETRIC;

RATTUS; RATTUS NORVEGICUS;

EID: 61349148779     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp006     Document Type: Article

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