Effect of chronic phenobarbitone administration on liver tumour formation in the C57BL/10J mouse

Food and Chemical Toxicology

Volumn 47, Issue 6, 2009, Pages 1333-1340

  Jones, Huw B ^a   Orton, Terry C ^a   Lake, Brian G ^b,c  

^a ASTRAZENECA   (United Kingdom)

^b LFI Molecular Sciences   (United Kingdom)

^c UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

C57BL 10J mice; Mode of action; Mouse liver tumours; Non genotoxic carcinogenesis; Sodium phenobarbitone

Indexed keywords

DNA; PHENOBARBITAL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; C57BL 10 MOUSE; DNA SYNTHESIS; DRUG EFFECT; FEMALE; LIVER ADENOMA; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER HYPERTROPHY; LIVER WEIGHT; MALE; MOUSE; NONHUMAN;

ANIMALS; BODY WEIGHT; DNA REPLICATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEPATOCYTES; HYPNOTICS AND SEDATIVES; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MICE; MICE, INBRED C57BL; ORGAN SIZE; PHENOBARBITAL;

ANIMALIA; MUS; RODENTIA;

EID: 67349147455     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2009.03.014     Document Type: Article

References (35)

1. Becker F.F. Morphological classification of mouse liver tumors based on biological characteristics. Cancer Res. 42 (1982) 3918-3923
2. Boorman G., Dixon D., Elwell M., Kerlin R., Morton D., Peters T., Regan K., and Sullivan J. Assessment of hyperplastic lesions in rodent carcinogenicity studies. Toxicol. Pathol. 31 (2003) 709-710
3. Bursch W., Chabicovsky M., Wastl U., Grasl-Kraupp B., Bukowska K., Taper H., and Schulte-Hermann R. Apoptosis in stages of mouse hepatocarcinogenesis: failure to counterbalance cell proliferation and to account for strain differences in tumor susceptibility. Toxicol. Sci. 85 (2005) 515-529
4. Collins, M.A., 1985. Studies on the induction of hepatic xenobiotic metabolising enzymes in rodents: relevance to nodule formation. PhD Thesis, University of Surrey, Guildford, Surrey, UK.
5. Collins M.A., Lake B.G., Evans J.G., Walker R., Gangolli S.D., and Conning D.M. Sustained induction of hepatic xenobiotic metabolising enzyme activities by phenobarbitone in C3H/He mice: relevance to nodule formation. Toxicology 33 (1984) 129-144
6. Mtv and DBA/2NCr mice. Carcinogenesis 7 (1986) 215-220
7. Dragani T.A. 10 years of mouse cancer modifier loci: human relevance. Cancer Res. 63 (2003) 3011-3018
8. Drinkwater N.R., and Ginsler J.J. Genetic control of hepatocarcinogenesis in C57BL/6J and C3H/HeJ inbred mice. Carcinogenesis 7 (1986) 1701-1707
9. Evans J.G., Collins M.A., Lake B.G., and Butler W.H. The histology and development of hepatic nodules and carcinoma in C3H/He and C57BL/6 mice following chronic phenobarbitone administration. Toxicol. Pathol. 20 (1992) 585-594
10. Evans J.G., Collins M.A., Savage S.A., Lake B.G., and Butler W.H. The histology and development of hepatic nodules in C3H/He mice following chronic administration of phenobarbitone. Carcinogenesis 7 (1986) 627-631
11. Gangolli S.D., Lake B.G., and Evans J.G. The histopathology and biochemistry of phenobarbitone-induced liver nodules in C3H mice. Arch. Toxicol. 10 Suppl. (1987) 95-107
12. Goldsworthy T.L., and Fransson-Steen R. Quantitation of the cancer process in C57BL/6J, B6C3F1 and C3H/HeJ mice. Toxicol. Pathol. 30 (2002) 97-105
13. Greaves P. The evaluation of potential human carcinogens: a histopathologist's point of view. Exp. Toxicol. Pathol. 48 (1996) 169-174
14. Hanigan M.H., Kemp C.J., Ginsler J.J., and Drinkwater N.R. Rapid growth of preneoplastic lesions in hepatocarcinogen-sensitive C3H/HeJ male mice relative to C57BL/6J male mice. Carcinogenesis 9 (1988) 885-890
15. Holsapple M.P., Pitot H.C., Cohen S.H., Boobis A.R., Klaunig J.E., Pastoor T., Dellarco V.L., and Dragan Y.P. Mode of action in relevance of rodent liver tumors to human cancer risk. Toxicol. Sci. 89 (2006) 51-56
16. Huang W., Zhang J., Washington M., Liu J., Parant J.M., Lozano G., and Moore D.D. Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Mol. Endocrinol. 19 (2005) 1646-1653
17. IARC, 1997. International Classification of Rodent Tumours. Part 1 - The Rat, vol. 10. Digestive System. Editor in Chief: U. Mohr. IARC Scientific Publications No: 122. IARC Press, Lyon, pp. 65-75.
18. IARC, 2001. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, vol. 79. Some Thyrotropic Agents. IARC Press, Lyon.
19. Kemp C.J., and Drinkwater N.R. Genetic variation in liver tumor susceptibility, plasma testosterone levels, and androgen receptor binding in six inbred strains of mice. Cancer Res. 49 (1989) 5044-5047
20. Kolaja K.L., Stevenson D.E., Johnson J.T., Walborg Jr. E.F., and Klaunig J.E. Subchronic effects of dieldrin and phenobarbital on hepatic DNA synthesis in mice and rats. Fundam. Appl. Toxicol. 29 (1996) 219-228
21. Manenti G., Galvan A., Falvella F.S., Pascale R.M., Spada E., Milani S., Neira A.G., Feo F., and Dragani T.A. Genetic control of resistance to hepatocarcinogenesis by the mouse Hpcr3 locus. Hepatology 48 (2008) 617-623
22. Maronpot R.R., Montgomery C.A., Boorman G.A., and McConnell E.E. National Toxicology Program Nomenclature for hepatoproliferative lesions of rats. Toxicol. Pathol. 14 (1986) 263-273
23. Nims R.W., and Lubet R.A. The CYP2B subfamily. In: Ioannides C. (Ed). Cytochromes P450: Metabolic and Toxicological Aspects (1996), CRC Press, Boca Raton 135-160
24. Orton T.C., Doughty S.E., Kalinowski A.E., Lord P.G., and Wadsworth P.F. Expression of growth factors and growth factor receptors in the liver of C57BL/10J mice following administration of phenobarbitone. Carcinogenesis 17 (1996) 973-981
25. Pelkonen O., Mäenpää J., Taavitsainen P., Rautio A., and Raunio H. Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica 28 (1998) 1203-1253
26. Peto, R., Pike, M.C., Day, N.E., Gray, R.G., Lee, P.N., Parish, S., Peto, J., Richards, S., Wahrendorf, J., 1980. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Supplement 2. Guidelines for Simple, Sensitive Significance Tests for Carcinogenic Effects in Long-term Animal Experiments. IARC Press, Lyon.
27. Phillips J.C., Price R.J., Cunninghame M.E., Osimitz T.G., Cockburn A., Gabriel K.L., Preiss F., Butler W.H., and Lake B.G. Effect of piperonyl butoxide on cell replication and xenobiotic metabolism in the livers of CD-1 mice and F344 rats. Fundam. Appl. Toxicol. 38 (1997) 64-74
28. Poole T.M., and Drinkwater N.R. Strain dependent effects of sex hormones on hepatocarcinogenesis in mice. Carcinogenesis 17 (1996) 191-196
29. Tennekes H.A., Wright A.S., Dix K.M., and Koeman J.H. Effects of dieldrin, diet, and bedding on enzyme function and tumour incidence in livers of male CF-1 mice. Cancer Res. 41 (1981) 3615-3620
30. Tien E.S., and Negishi M. Nuclear receptors CAR and PXR in the regulation of hepatic metabolism. Xenobiotica 36 (2006) 1152-1163
31. Vesselinovitch S.D. The sex-dependent difference in the development of liver tumors in mice administered dimethylnitrosamine. Cancer Res. 29 (1969) 1024-1027
32. Wei P., Zhang J., Egan-Hafley M., Liang S., and Moore D.D. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. Nature 407 (2000) 920-923
33. Whysner J., Ross P.M., and Williams G.M. Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion. Pharmacol. Ther. 71 (1996) 153-191
34. Yamamoto Y., Moore R., Goldsworthy T.L., Negishi M., and Maronpot R.R. The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice. Cancer Res. 64 (2004) 7197-7200
35. Yoshinari K., Tien E., Negishi M., and Honkakoski P. Receptor-mediated regulation of cytochromes P450. In: Ioannides C. (Ed). Cytochromes P450: Role in the Metabolism and Toxicity of Drugs and Other Xenobiotics (2008), RSC Publishing, Cambridge 417-448