Dual-responsive mPEG-PLGA-PGlu hybrid-core nanoparticles with a high drug loading to reverse the multidrug resistance of breast cancer: An in vitro and in vivo evaluation

Acta Biomaterialia

Volumn 16, Issue 1, 2015, Pages 156-168

  Xu, Helin ^a   Yang, Dan ^a   Cai, Cuifang ^b   Gou, Jingxin ^b   Zhang, Yu ^b   Wang, Lihui ^a   Zhong, Haijun ^a   Tang, Xing ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b NANCHANG UNIVERSITY   (China)

Author keywords

Doxorubicin; Enzyme sensitive; Multidrug resistance; Nanoparticles; pH sensitive

Indexed keywords

AMINO ACIDS; DISEASES; DRUG DELIVERY; ENZYMES; HISTOLOGY; PH SENSORS; TOXICITY; TUMORS;

BREAST CANCER; DOXORUBICIN; DOXORUBICIN HYDROCHLORIDE; ENZYME-SENSITIVE; HIGH DRUG LOADINGS; HYBRID CORES; IN-VITRO; MULTIDRUG RESISTANCE; PH SENSITIVE; VITRO AND IN VIVO;

NANOPARTICLES;

DOXORUBICIN; MACROGOL; MONOMETHOXY (POLYETHYLENE GLYCOL) B P (D,L LACTIC CO GLYCOLIC ACID) B P (L GLUTAMIC ACID); NANOPARTICLE; POLYGLUTAMIC ACID; POLYGLYCOLIC ACID; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; MACROGOL DERIVATIVE; MONOMETHOXY(POLYETHYLENE GLYCOL)-B-POLY(LACTIC-CO-GLYCOLIC ACID)-B-POLY(GLUTAMIC ACID); POLYESTER; PROTEINASE K;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CELL LINE; CELL NUCLEUS; CONTROLLED STUDY; DRUG RELEASE; DRUG UPTAKE; EX VIVO STUDY; FLUORESCENCE IMAGING; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; MOUSE; MULTIDRUG RESISTANCE; NANOENCAPSULATION; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; TUMOR XENOGRAFT; ANALOGS AND DERIVATIVES; ANIMAL; BREAST NEOPLASMS; CELL DEATH; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; ENDOCYTOSIS; FEMALE; MCF 7 CELL LINE; METABOLISM; NEAR INFRARED SPECTROSCOPY; PATHOLOGY; PH; RABBIT; SYNTHESIS; ULTRASTRUCTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL DEATH; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ENDOCYTOSIS; ENDOPEPTIDASE K; FEMALE; HEMOLYSIS; HUMANS; HYDROGEN-ION CONCENTRATION; MCF-7 CELLS; MICE; NANOPARTICLES; POLYESTERS; POLYETHYLENE GLYCOLS; POLYGLUTAMIC ACID; RABBITS; SPECTROSCOPY, NEAR-INFRARED;

EID: 84930946038     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2015.01.039     Document Type: Article

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