In vitro efficacy of paclitaxel-loaded dual-responsive shell cross-linked polymer nanoparticles having orthogonally degradable disulfide cross-linked corona and polyester core domains

Molecular Pharmaceutics

Volumn 10, Issue 3, 2013, Pages 1092-1099

  Samarajeewa, Sandani ^a   Shrestha, Ritu ^a   Elsabahy, Mahmoud ^a,c   Karwa, Amolkumar ^b   Li, Ang ^a   Zentay, Ryan P ^a   Kostelc, James G ^b   Dorshow, Richard B ^b,d   Wooley, Karen L ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b Covidien Pharmaceuticals R and D ^*  (United States)

^c Assiut University   (Egypt)

^d MediBeacon LLC   (United States)

Author keywords

cell viability; degradable; disulfide cross linker; paclitaxel; poly(DL lactic acid); poly(DL lactide); polymeric nanoparticles

Indexed keywords

CYSTAMINE; DISULFIDE; DOXORUBICIN; GLUTATHIONE; LACTIC ACID; NANOPARTICLE; PACLITAXEL; POLYESTER; POLYLACTIC ACID; POLYMER;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG RELEASE; FEMALE; HUMAN; HUMAN CELL; HYDROLYSIS; HYDROPHOBICITY; IC 50; IN VITRO STUDY; OVARY ADENOCARCINOMA; PH; POLYMERIZATION; PRIORITY JOURNAL;

EID: 84874625977     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp3005897     Document Type: Article

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