Acetyl-CoA carboxylase 2 suppression rescues human proximal tubular cells from palmitic acid induced lipotoxicity via autophagy

Biochemical and Biophysical Research Communications

Volumn 463, Issue 3, 2015, Pages 364-369

  Xin, Wei ^a   Zhao, Xu ^a   Liu, Lei ^a   Xu, Ying ^a   Li, Zhaoping ^a   Chen, Liyong ^a   Wang, Xiaojie ^a   Yi, Fan ^b   Wan, Qiang ^a  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

ACC2; Autophagy; Diabetic nephropathy; Fatty acid oxidation; Lipotoxicity

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE 2; BECLIN 1; FATTY ACID; PALMITIC ACID; PROTEIN P62; UNCLASSIFIED DRUG; ACACB PROTEIN, HUMAN;

ARTICLE; AUTOPHAGY; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DIABETIC NEPHROPATHY; FATTY ACID OXIDATION; GENE SILENCING; HUMAN; HUMAN CELL; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; LIPID STORAGE; LIPOTOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; CELL LINE; CELL SURVIVAL; CYTOLOGY; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY;

MAMMALIA;

ACETYL-COA CARBOXYLASE; AUTOPHAGY; CELL LINE; CELL SURVIVAL; DIABETIC NEPHROPATHIES; GENE SILENCING; HUMANS; KIDNEY TUBULES, PROXIMAL; OXIDATION-REDUCTION; PALMITIC ACID;

EID: 84930930035     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.05.070     Document Type: Article

References (40)

1. J.E. Schaffer Lipotoxicity: when tissues overeat Curr. Opin. Lipidol. 14 2003 281 287
2. J. Garbarino, and S.L. Sturley Saturated with fat: new perspectives on lipotoxicity Curr. Opin. Clin. Nutr. Metab. Care 12 2009 110 116
3. Anonymous USRDS: the United States renal data system Am. J. Kidney. Dis. 42 2003 1 230
4. P. Kimmelstiel, and C. Wilson Intercapillary Lesions in the Glomeruli of the Kidney Am. J. Pathol. 12 1936 83 98 87
5. S. Kume, T. Uzu, and S. Araki et al. Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet J. Am. Soc. Nephrol. 18 2007 2715 2723
6. Z. Wang, T. Jiang, and J. Li et al. Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes Diabetes 54 2005 2328 2335
7. T. Jiang, X.X. Wang, and P. Scherzer et al. Farnesoid X receptor modulates renal lipid metabolism, fibrosis, and diabetic nephropathy Diabetes 56 2007 2485 2493
8. J.F. Moorhead, M.K. Chan, and M. El-Nahas et al. Lipid nephrotoxicity in chronic progressive glomerular and tubulo-interstitial disease Lancet 2 1982 1309 1311
9. R.S. Balaban, and L.J. Mandel Metabolic substrate utilization by rabbit proximal tubule. An NADH fluorescence study Am. J. Physiol. 254 1988 F407 F416
10. S.R. Gullans, P.C. Brazy, and L.J. Mandel et al. Stimulation of phosphate transport in the proximal tubule by metabolic substrates Am. J. Physiol. 247 1984 F582 F587
11. K.G. Thampy, and S.J. Wakil Regulation of acetyl-coenzyme A carboxylase. I. Purification and properties of two forms of acetyl-coenzyme A carboxylase from rat liver J. Biol. Chem. 263 1988 6447 6453
12. L. Abu-Elheiga, M.M. Matzuk, and K.A. Abo-Hashema et al. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2 Science 291 2001 2613 2616
13. N. Mizushima, B. Levine, and A.M. Cuervo et al. Autophagy fights disease through cellular self-digestion Nature 451 2008 1069 1075
14. T. Hara, K. Nakamura, and M. Matsui et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice Nature 441 2006 885 889
15. X. Wang, J. Liu, and J. Zhen et al. Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy Kidney. Int. 86 2014 712 725
16. R. Singh, S. Kaushik, and Y. Wang et al. Autophagy regulates lipid metabolism Nature 458 2009 1131 1135
17. Y. Zhang, S. Goldman, and R. Baerga et al. Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis Proc. Natl. Acad. Sci. U. S. A. 106 2009 19860 19865
18. Y. Xu, J. Huang, and W. Xin et al. Lipid accumulation is ahead of epithelial-to-mesenchymal transition and therapeutic intervention by acetyl-CoA carboxylase 2 silence in diabetic nephropathy Metabolism 63 2014 716 726
19. M.J. Khan, M. Rizwan Alam, and M. Waldeck-Weiermair et al. Inhibition of autophagy rescues palmitic acid-induced necroptosis of endothelial cells J. Biol. Chem. 287 2012 21110 21120
20. H. Ning, G. Lin, and T.F. Lue et al. Mesenchymal stem cell marker Stro-1 is a 75 kd endothelial antigen Biochem. Biophys. Res. Commun. 413 2011 353 357
21. H. Jun, Z. Song, and W. Chen et al. In vivo and in vitro effects of SREBP-1 on diabetic renal tubular lipid accumulation and RNAi-mediated gene silencing study Histochem. Cell Biol. 131 2009 327 345
22. R.L. Dobbins, L.S. Szczepaniak, and B. Bentley et al. Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats Diabetes 50 2001 123 130
23. G. Boden Effects of free fatty acids (FFA) on glucose metabolism: significance for insulin resistance and type 2 diabetes Exp. Clin. Endocrinol. Diabetes 111 2003 121 124
24. J. Ni, K.L. Ma, and C.X. Wang et al. Activation of renin-angiotensin system is involved in dyslipidemia-mediated renal injuries in apolipoprotein E knockout mice and HK-2 cells Lipids. Health. Dis. 12 2013 49
25. M.J. Czaja Autophagy in health and disease. 2. Regulation of lipid metabolism and storage by autophagy: pathophysiological implications Am. J. Physiol. Cell Physiol. 298 2010 C973 C978
26. K.R. Hallows, P.F. Mount, and N.M. Pastor-Soler et al. Role of the energy sensor AMP-activated protein kinase in renal physiology and disease Am. J. Physiol. Ren. Physiol. 298 2010 F1067 F1077
27. Q.Q. Tu, R.Y. Zheng, and J. Li et al. Palmitic acid induces autophagy in hepatocytes via JNK2 activation Acta. Pharmacol. Sin. 35 2014 504 512
28. K. Yamahara, S. Kume, and D. Koya et al. Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions J. Am. Soc. Nephrol. 24 2013 1769 1781
29. A. Takahashi, T. Kimura, and Y. Takabatake et al. Autophagy guards against cisplatin-induced acute kidney injury Am. J. Pathol. 180 2012 517 525
30. J. Yuan, and G. Kroemer Alternative cell death mechanisms in development and beyond Genes. Dev. 24 2010 2592 2602
31. G. Kroemer, and M. Jaattela Lysosomes and autophagy in cell death control Nat. Rev. Cancer. 5 2005 886 897
32. J. Kim, M. Kundu, and B. Viollet et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 Nat. Cell Biol. 13 2011 132 141
33. S. Kume, M.C. Thomas, and D. Koya Nutrient sensing, autophagy, and diabetic nephropathy Diabetes 61 2012 23 29
34. C. Ebato, T. Uchida, and M. Arakawa et al. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet Cell Metab. 8 2008 325 332
35. R. Singh, Y. Xiang, and Y. Wang et al. Autophagy regulates adipose mass and differentiation in mice J. Clin. Invest. 119 2009 3329 3339
36. H. Koga, S. Kaushik, and A.M. Cuervo Altered lipid content inhibits autophagic vesicular fusion FASEB. J. 24 2010 3052 3065
37. O. Tehlivets, K. Scheuringer, and S.D. Kohlwein Fatty acid synthesis and elongation in yeast Biochim. Biophys. Acta. 1771 2007 255 270
38. L. Galdieri, J. Chang, and S. Mehrotra et al. Yeast phospholipase C is required for normal acetyl-CoA homeostasis and global histone acetylation J. Biol. Chem. 288 2013 27986 27998
39. L. Galdieri, T. Zhang, and D. Rogerson et al. Protein acetylation and acetyl coenzyme a metabolism in budding yeast Eukaryot. Cell 13 2014 1472 1483
40. S. Schroeder, T. Pendl, and A. Zimmermann et al. Acetyl-coenzyme A: a metabolic master regulator of autophagy and longevity Autophagy 10 2014 1335 1337