Inhibition of autophagy rescues palmitic acid-induced necroptosis of endothelial cells

Journal of Biological Chemistry

Volumn 287, Issue 25, 2012, Pages 21110-21120

  Khan, Muhammad Jadoon ^a   Alam, Muhammad Rizwan ^a   Waldeck Weiermair, Markus ^a   Karsten, Felix ^a   Groschner, Lukas ^a   Riederer, Monika ^a   Hallström, Seth ^a   Rockenfeller, Patrick ^b   Konya, Viktoria ^a   Heinemann, Akos ^a   Madeo, Frank ^b   Graier, Wolfgang F ^a   Malli, Roland ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANNEXINS; ATP DEPLETION; AUTOPHAGY; CASPASES; CELL-DEATH PATHWAYS; CELLULAR DYSFUNCTION; LOW LEVEL; MOLECULAR PATHWAYS; MRNA LEVEL; NOVEL STRATEGIES; PHARMACOLOGICAL INHIBITORS; PROPIDIUM IODIDE; RECEPTOR-INTERACTING PROTEINS; TETRAACETIC ACID; UBIQUITIN; VACUOLAR PROTEIN SORTING;

CELL DEATH; ETHANE; GENES; NUCLEIC ACIDS; PALMITIC ACID; PROTEINS; SATURATED FATTY ACIDS; TISSUE;

ENDOTHELIAL CELLS;

1,2 BIS(O AMINOPHOXY)ETHANE N,N,N',N' TETRAACETIC ACID(ACETOXYMETHYL)ESTER; ADENOSINE TRIPHOSPHATE; CALCIUM CHELATING AGENT; CASPASE; LIPOCORTIN 5; MESSENGER RNA; PALMITIC ACID; PROPIDIUM IODIDE; RECEPTOR INTERACTING PROTEIN KINASE 1; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; UBIQUITIN THIOLESTERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHAGY; AUTOPHAGY RELATED PROTEIN 7 GENE; CALCIUM SIGNALING; CELL ASSAY; CELL DEATH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; FETUS; GENE; GENE FUNCTION; GENE SILENCING; HUMAN; HUMAN CELL; LIPOTOXICITY; NECROPTOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; UPREGULATION; VACUOLAR PROTEIN SORTING 34 GENE;

AUTOPHAGY; CALCIUM SIGNALING; CELLS, CULTURED; CHELATING AGENTS; CLASS III PHOSPHATIDYLINOSITOL 3-KINASES; EGTAZIC ACID; ENDOTHELIAL CELLS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; NECROSIS; PALMITIC ACID; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-ACTIVATING ENZYMES;

EID: 84862277244     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.319129     Document Type: Article

References (47)

1. Brookheart, R. T., Michel, C. I., and Schaffer, J. E. (2009) As a matter of fat. Cell Metab. 10, 9-12
2. Unger, R., and Zhou, Y. (2001) Lipotoxicity of beta cells in obesity and in other causes of fatty acid spillover. Diabetes 1, S118-S121 (Pubitemid 32148232)
3. Borradaile, N. M., and Schaffer, J. E. (2005) Lipotoxicity in the heart. Curr. Hypertens. Rep. 7, 412-417 (Pubitemid 43136936)
4. Pfaffenbach, K. T., Gentile, C. L., Nivala, A. M., Wang, D., Wei, Y., and Pagliassotti, M. J. (2010) Linking endoplasmic reticulum stress to cell death in hepatocytes. Roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death. Am. J. Physiol. Endocrinol. Metab. 298, E1027-E1035
5. Mayer, C. M., and Belsham, D. D. (2010) Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons. Rescue of resistance and apoptosis through adenosine 5′-monophosphate-activated protein kinase activation. Endocrinology. 151, 576-585
6. Meyers, M. R., and Gokce, N. (2007) Endothelial dysfunction in obesity. Etiological role in atherosclerosis. Curr. Opin. Endocrinol. Diabetes Obes. 14, 365-369 (Pubitemid 47368087)
7. Rockenfeller, P., Ring, J., Muschett, V., Beranek, A., Buettner, S., and Carmona-Gutierrez, D., Eisenberg, T., Khoury, C., Rechberger, G., Kohlwein, S. D., Kroemer, G., and Madeo, F. (2010) Fatty acids trigger mitochondrion- dependent necrosis. Cell Cycle 9, 2836-2842
8. Choi, S. E., Lee, S. M., Lee, Y. J., Li, L. J., Lee, S. J., Lee, J. H., Kim, Y., Jun, H. S., Lee, K. W., and Kang, Y. (2009) Protective role of autophagy in palmitate-induced INS-1 beta cell death. Endocrinology 150, 126-134
9. Almaguel, F. G., Liu, J. W., Pacheco, F. J., De Leon, D., Casiano, C. A., and De Leon, M. (2010) Lipotoxicity-mediated cell dysfunction and death involve lysosomal membrane permeabilization and cathepsin L activity. Brain Res. 1318, 133-143
10. Kristensen, A. R., Schandorff, S., Høyer-Hansen, M., Nielsen, M. O., Jäättelä, M., Dengjel, J., and Andersen, J. S. (2008) Ordered organelle degradation during starvation-induced autophagy. Mol. Cell Proteomics 7, 2419-2428
11. Scherz-Shouval, R., and Elazar, Z. (2007) ROS, mitochondria and the regulation of autophagy. Trends Cell Biol. 17, 422-427 (Pubitemid 47499043)
12. Galluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., Gottlieb, E., Green, D. R., Hengartner, M. O., Kepp, O., Knight, R. A., Kumar, S., Lipton, S. A., Lu, X., Madeo, F., Malorni, W., Mehlen, P., Nuñez, G., Peter, M. E., Piacentini, M., Rubinsztein, D. C., Shi, Y., Simon, H. U., Vandenabeele, P., White, E., Yuan, J., Zhivotovsky, B., Melino, G., and Kroemer, G. (2012) Molecular definitions of cell death subroutines. Recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 19, 107-120
13. Yuan, J., and Kroemer, G. (2010) Alternative cell death mechanisms in development and beyond. Genes Dev. 24, 2592-2602
14. Samara, C., Syntichaki, P., and Tavernarakis, N. (2008) Autophagy is required for necrotic cell death in Caenorhabditis elegans. Cell Death Differ. 15, 105-112 (Pubitemid 350286178)
15. Levine, B., and Yuan, J. (2005) Autophagy in cell death. An innocent convict? J. Clin. Invest. 115, 2679-2688 (Pubitemid 41434392)
16. Espert, L., Denizot, M., Grimaldi, M., Robert-Hebmann, V., Gay, B., Varbanov, M., Codogno, P., Biard-Piechaczyk, M. (2006) Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. J. Clin. Invest. 116, 2161-2172 (Pubitemid 44162325)
17. Ullman, E., Fan, Y., Stawowczyk, M., Chen, H. M., Yue, Z., and Zong, W. (2008) Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress. Cell Death Differ. 15, 422-425
18. Edgell, C. J., McDonald, C. C., and Graham, J. B. (1983) Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc. Natl. Acad. Sci. U.S.A. 80, 3734-3737 (Pubitemid 13063134)
19. 2+ signaling and NO production in endothelial cells. Antioxid. Redox Signal. 5, 147-153
20. Høyer-Hansen, M., Bastholm, L., Szyniarowski, P., Campanella, M., Szabadkai, G., and Farkas, T., Bianchi, K., Fehrenbacher, N., Elling, F., Rizzuto, R., Mathiasen, I. S., and Jäättelä, M. (2007) Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-β, and Bcl-2. Mol. Cell. 25, 193-205
21. Gao, P., Bauvy, C., Souquère, S., Tonelli, G., Liu, L., Zhu, Y., Qiao, Z., Bakula, D., Proikas-Cezanne, T., Pierron, G., Codogno, P., Chen, Q., and Mehrpour, M. (2010) The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells. J. Biol. Chem. 285, 25570-25581
22. Stegmeier, F., Sowa, M. E., Nalepa, G., Gygi, S. P., Harper, J. W., and Elledge, S. J. (2007) The tumor suppressor CYLD regulates entry into mitosis. Proc. Natl. Acad. Sci. U.S.A. 104, 8869-8874 (Pubitemid 47175403)
23. 2+ entry. J. Cell Sci. 123, 2553-2564
24. Shcherbo, D., Souslova, E. A., Goedhart, J., Chepurnykh, T. V., Gaintzeva, A., Shemiakina, I. I., Gadella, T. W., Lukyanov, S., and Chudakov, D. M. (2009) Practical and reliable FRET/FLIM pair of fluorescent proteins. BMC Biotechnol. 9, 24
25. Roh, M. S., Kim, C. W., Park, B. S., Kim, G. C., Jeong, J. H., Kwon, H. C., Suh, D. J., Cho, K. H., Yee, S. B., and Yoo, Y. H. (2004) Mechanism of histone deacetylase inhibitor trichostatin A-induced apoptosis in human osteosarcoma cells. Apoptosis 9, 583-589 (Pubitemid 39158634)
26. Ricchi, M., Odoardi, M. R., Carulli, L., Anzivino, C., Ballestri, S., Pinetti, A., Fantoni, L. I., Marra, F., Bertolotti, M., Banni, S., Lonardo, A., Carulli, N., Loria, P. (2009) Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. J. Gastroenterol. Hepatol. 24, 830-840
27. Ilangovan, R., Marshall, W. L., Hua, Y., and Zhou, J. (2003) Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells. J. Biol. Chem. 278, 30993-30999 (Pubitemid 36994612)
28. Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., and Kroemer, G. (2010) Molecular mechanisms of necroptosis. An ordered cellular explosion. Nat. Rev. Mol. Cell Biol. 11, 700-714
29. Cho, Y. S., Challa, S., Moquin, D., Genga, R., Ray, T. D., Guildford, M., and Chan, F. K. (2009) Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 137, 1112-1123
30. O'Donnell, M. A., Perez-Jimenez, E., Oberst, A., Ng, A., Massoumi, R., Xavier, R., Green, D. R., and Ting, A. T. (2011) Caspase 8 inhibits programmed necrosis by processing CYLD. Nat. Cell Biol. 13, 1437-1442
31. Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., and Yoshimori, T. (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19, 5720-5728
32. Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., et al. (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4, 151-175
33. Blommaart, E. F., Krause, U., Schellens, J. P., Vreeling- Sindelárová, H., and Meijer, A. J. (1997) The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur. J. Biochem. 243, 240-246 (Pubitemid 27060408)
34. Seglen, P. O., and Gordon, P. B. (1982) 3-Methyladenine. Specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc. Natl. Acad. Sci. U.S.A. 79, 1889-1892 (Pubitemid 12088533)
35. 2+ increase. Cell Signal. 22, 914-925
36. Tait, S. W., and Green, D. R. (2008) Caspase-independent cell death. Leaving the set without the final cut. Oncogene 27, 6452-6461
37. Tsujimoto, Y. (1997) Apoptosis and necrosis. Intracellular ATP level as a determinant for cell death modes. Cell Death Differ. 4, 429-434
38. Johnson, V. L., Ko, S. C., Holmstrom, T. H., Eriksson, J. E., and Chow, S. C. (2000) Effector caspases are dispensable for the early nuclear morphological changes during chemical-induced apoptosis. J. Cell Sci. 113, 2941-2953
39. Vanlangenakker, N., Bertrand, M. J., Bogaert, P., Vandenabeele, P., and Vanden Berghe, T. (2011) TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members. Cell Death Dis. 2, e230
40. Upton, J. W., Kaiser, W. J., and Mocarski, E. S. (2010) Virus inhibition of RIP3-dependent necrosis. Cell Host Microbe. 7, 302-313
41. Mei, S., Ni, H. M., Manley, S., Bockus, A., Kassel, K. M., Luyendyk, J. P., Copple, B. L., and Ding, W. X. (2011) Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes. J. Pharmacol. Exp. Ther. 339, 487-498
42. Las, G., Serada, S. B., Wikstrom, J. D., Twig, G., and Shirihai, O. S. (2011) Fatty acids suppress autophagic turnover in beta cells. J. Biol. Chem. 286, 42534-42544
43. Csordas, A., Kreutmayer, S., Ploner, C., Braun, P. R., Karlas, A., Backovic, A., Wick, G., and Bernhard, D. (2011) Cigarette smoke extract induces prolonged endoplasmic reticulum stress and autophagic cell death in human umbilical vein endothelial cells. Cardiovasc. Res. 92, 141-148
44. Kroemer, G., and Jäättelä, M. (2005) Lysosomes and autophagy in cell death control. Nat. Rev. Cancer 5, 886-897 (Pubitemid 41746033)
45. 2+ homeostasis in beta cells. Am. J. Physiol. Endocrinol. Metab. 296, E690-E701
46. Zhivotovsky, B., and Orrenius, S. (2011) Calcium and cell death mechanisms. A perspective from the cell death community. Cell Calcium 50, 211-221
47. Fu, M., Li, L., Albrecht, T., Johnson, J. D., Kojic, L. D., and Nabi, I. R. (2011) Autocrine motility factor/phosphoglucose isomerase regulates ER stress and cell death through control of ER calcium release. Cell Death Differ. 18, 1057-1070