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Volumn 96, Issue PA, 2015, Pages 42-54

IL-6 regulation of synaptic function in the CNS

Author keywords

Ca2+; Cerebellum; Cognitive function; Glia; Hippocampus; JAK STAT; MAPK; Memory; Neurologic disorders; NMDA

Indexed keywords

CALCIUM ION; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 6 RECEPTOR ALPHA; JANUS KINASE; JANUS KINASE 2 INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID; PROTEIN P42; PROTEIN P44; STAT PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 84930926269     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.10.023     Document Type: Article
Times cited : (184)

References (173)
  • 1
  • 3
    • 0032570035 scopus 로고    scopus 로고
    • Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain
    • J.L. Arruda, R.W. Colburn, A.J. Rickman, M.D. Rutkowski, and J.A. DeLeo Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain Brain Res. Mol. Brain Res. 62 1998 228 235
    • (1998) Brain Res. Mol. Brain Res. , vol.62 , pp. 228-235
    • Arruda, J.L.1    Colburn, R.W.2    Rickman, A.J.3    Rutkowski, M.D.4    Deleo, J.A.5
  • 4
    • 84870410831 scopus 로고    scopus 로고
    • Role of IL-6 in the etiology of hyperexcitable neuropsychiatric conditions: experimental evidence and therapeutic implications
    • M. Atzori, F. Garcia-Oscos, and J.A. Mendez Role of IL-6 in the etiology of hyperexcitable neuropsychiatric conditions: experimental evidence and therapeutic implications Future Med. Chem. 4 2012 2177 2192
    • (2012) Future Med. Chem. , vol.4 , pp. 2177-2192
    • Atzori, M.1    Garcia-Oscos, F.2    Mendez, J.A.3
  • 5
    • 62649131576 scopus 로고    scopus 로고
    • Impaired hippocampus-dependent and -independent learning in IL-6 deficient mice
    • P.C. Baier, U. May, J. Scheller, S. Rose-John, and T. Schiffelholz Impaired hippocampus-dependent and -independent learning in IL-6 deficient mice Behav. Brain Res. 200 2009 192 196
    • (2009) Behav. Brain Res. , vol.200 , pp. 192-196
    • Baier, P.C.1    May, U.2    Scheller, J.3    Rose-John, S.4    Schiffelholz, T.5
  • 8
    • 0028843876 scopus 로고
    • Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6
    • F.P. Bellinger, S.G. Madamba, I.L. Campbell, and G.R. Siggins Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6 Neurosci. Lett. 198 1995 95 98
    • (1995) Neurosci. Lett. , vol.198 , pp. 95-98
    • Bellinger, F.P.1    Madamba, S.G.2    Campbell, I.L.3    Siggins, G.R.4
  • 10
    • 70349652812 scopus 로고    scopus 로고
    • Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep
    • C. Benedict, J. Scheller, S. Rose-John, J. Born, and L. Marshall Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep FASEB J. 23 2009 3629 3636
    • (2009) FASEB J. , vol.23 , pp. 3629-3636
    • Benedict, C.1    Scheller, J.2    Rose-John, S.3    Born, J.4    Marshall, L.5
  • 11
    • 0026638409 scopus 로고
    • Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action
    • E.N. Benveniste Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action Am. J. Physiol. 263 1992 C1 C16
    • (1992) Am. J. Physiol. , vol.263 , pp. C1-C16
    • Benveniste, E.N.1
  • 12
    • 33747082450 scopus 로고    scopus 로고
    • Synergistic effects of cAMP-dependent signalling pathways and IL-1 on IL-6 production by H19-7/IGF-IR neuronal cells
    • A. Bergamaschi, M. Corsi, and M.J. Garnier Synergistic effects of cAMP-dependent signalling pathways and IL-1 on IL-6 production by H19-7/IGF-IR neuronal cells Cell. Signal. 18 2006 1679 1684
    • (2006) Cell. Signal. , vol.18 , pp. 1679-1684
    • Bergamaschi, A.1    Corsi, M.2    Garnier, M.J.3
  • 15
    • 11844300757 scopus 로고    scopus 로고
    • Postsynaptic signaling networks: cellular cogwheels underlying long-term plasticity
    • R.D. Blitzer, R. Iyengar, and E.M. Landau Postsynaptic signaling networks: cellular cogwheels underlying long-term plasticity Biol. Psychiatry 57 2005 113 119
    • (2005) Biol. Psychiatry , vol.57 , pp. 113-119
    • Blitzer, R.D.1    Iyengar, R.2    Landau, E.M.3
  • 16
    • 84861970203 scopus 로고    scopus 로고
    • Interleukin-6 trans-signaling in the senescent mouse brain is involved in infection-related deficits in contextual fear conditioning
    • M.D. Burton, and R.W. Johnson Interleukin-6 trans-signaling in the senescent mouse brain is involved in infection-related deficits in contextual fear conditioning Brain, Behav. Immun. 26 2012 732 738
    • (2012) Brain, Behav. Immun. , vol.26 , pp. 732-738
    • Burton, M.D.1    Johnson, R.W.2
  • 17
    • 0032077767 scopus 로고    scopus 로고
    • Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology
    • I.L. Campbell Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology Brain Res. Brain Res. Rev. 26 1998 327 336
    • (1998) Brain Res. Brain Res. Rev. , vol.26 , pp. 327-336
    • Campbell, I.L.1
  • 20
    • 40949111508 scopus 로고    scopus 로고
    • Interleukin-6 and nerve growth factor upregulation correlates with improved outcome in children with severe traumatic brain injury
    • A. Chiaretti, A. Antonelli, A. Mastrangelo, P. Pezzotti, L. Tortorolo, F. Tosi, and O. Genovese Interleukin-6 and nerve growth factor upregulation correlates with improved outcome in children with severe traumatic brain injury J. Neurotrauma 25 2008 225 234
    • (2008) J. Neurotrauma , vol.25 , pp. 225-234
    • Chiaretti, A.1    Antonelli, A.2    Mastrangelo, A.3    Pezzotti, P.4    Tortorolo, L.5    Tosi, F.6    Genovese, O.7
  • 21
    • 70349395723 scopus 로고    scopus 로고
    • Targeting the JAK2/STAT3 axis in Alzheimer's disease
    • T. Chiba, M. Yamada, and S. Aiso Targeting the JAK2/STAT3 axis in Alzheimer's disease Expert Opin. Ther. Targets 13 2009 1155 1167
    • (2009) Expert Opin. Ther. Targets , vol.13 , pp. 1155-1167
    • Chiba, T.1    Yamada, M.2    Aiso, S.3
  • 22
    • 0142184521 scopus 로고    scopus 로고
    • Upregulation of gp130 and differential activation of STAT and p42/44 MAPK in the rat hippocampus following kainic acid-induced seizures
    • J.S. Choi, S.Y. Kim, H.J. Park, J.H. Cha, Y.S. Choi, J.E. Kang, J.W. Chung, M.H. Chun, and M.Y. Lee Upregulation of gp130 and differential activation of STAT and p42/44 MAPK in the rat hippocampus following kainic acid-induced seizures Brain Res. Mol. Brain Res. 119 2003 10 18
    • (2003) Brain Res. Mol. Brain Res. , vol.119 , pp. 10-18
    • Choi, J.S.1    Kim, S.Y.2    Park, H.J.3    Cha, J.H.4    Choi, Y.S.5    Kang, J.E.6    Chung, J.W.7    Chun, M.H.8    Lee, M.Y.9
  • 23
    • 84898879651 scopus 로고    scopus 로고
    • Human astrocytes: secretome profiles of cytokines and chemokines
    • S.S. Choi, H.J. Lee, I. Lim, J. Satoh, and S.U. Kim Human astrocytes: secretome profiles of cytokines and chemokines PloS One 9 2014 e92325
    • (2014) PloS One , vol.9
    • Choi, S.S.1    Lee, H.J.2    Lim, I.3    Satoh, J.4    Kim, S.U.5
  • 27
    • 0034092681 scopus 로고    scopus 로고
    • Interleukin-6 inhibits neurotransmitter release and the spread of excitation in the rat cerebral cortex
    • G. D'Arcangelo, V. Tancredi, F. Onofri, M. D'Antuono, S. Giovedi, and F. Benfenati Interleukin-6 inhibits neurotransmitter release and the spread of excitation in the rat cerebral cortex Eur. J. Neurosci. 12 2000 1241 1252
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 1241-1252
    • D'Arcangelo, G.1    Tancredi, V.2    Onofri, F.3    D'antuono, M.4    Giovedi, S.5    Benfenati, F.6
  • 28
    • 0033996866 scopus 로고    scopus 로고
    • The distribution of receptors for the pro-inflammatory cytokines interleukin (IL)-6 and IL-8 in the developing human fetus
    • J.B. Dame, and S.E. Juul The distribution of receptors for the pro-inflammatory cytokines interleukin (IL)-6 and IL-8 in the developing human fetus Early Hum. Dev. 58 2000 25 39
    • (2000) Early Hum. Dev. , vol.58 , pp. 25-39
    • Dame, J.B.1    Juul, S.E.2
  • 29
    • 84883822247 scopus 로고    scopus 로고
    • A cytokine network involving brain-borne IL-1beta, IL-1ra, IL-18, IL-6, and TNFalpha operates during long-term potentiation and learning
    • A. del Rey, D. Balschun, W. Wetzel, A. Randolf, and H.O. Besedovsky A cytokine network involving brain-borne IL-1beta, IL-1ra, IL-18, IL-6, and TNFalpha operates during long-term potentiation and learning Brain, Behav. Immun. 33 2013 15 23
    • (2013) Brain, Behav. Immun. , vol.33 , pp. 15-23
    • Del Rey, A.1    Balschun, D.2    Wetzel, W.3    Randolf, A.4    Besedovsky, H.O.5
  • 31
    • 80052838069 scopus 로고    scopus 로고
    • Cognitive and emotional alterations are related to hippocampal inflammation in a mouse model of metabolic syndrome
    • A.L. Dinel, C. Andre, A. Aubert, G. Ferreira, S. Laye, and N. Castanon Cognitive and emotional alterations are related to hippocampal inflammation in a mouse model of metabolic syndrome PloS One 6 2011 e24325
    • (2011) PloS One , vol.6
    • Dinel, A.L.1    Andre, C.2    Aubert, A.3    Ferreira, G.4    Laye, S.5    Castanon, N.6
  • 32
    • 84892410541 scopus 로고    scopus 로고
    • A novel role for brain interleukin-6: facilitation of cognitive flexibility in rat orbitofrontal cortex
    • J.J. Donegan, M. Girotti, M.S. Weinberg, and D.A. Morilak A novel role for brain interleukin-6: facilitation of cognitive flexibility in rat orbitofrontal cortex J. Neurosci. 34 2014 953 962
    • (2014) J. Neurosci. , vol.34 , pp. 953-962
    • Donegan, J.J.1    Girotti, M.2    Weinberg, M.S.3    Morilak, D.A.4
  • 33
    • 0035153212 scopus 로고    scopus 로고
    • Immune function of astrocytes
    • Y. Dong, and E.N. Benveniste Immune function of astrocytes Glia 36 2001 180 190
    • (2001) Glia , vol.36 , pp. 180-190
    • Dong, Y.1    Benveniste, E.N.2
  • 34
    • 0035864132 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase/extracellular signal-regulated kinase activation in somatodendritic compartments: roles of action potentials, frequency, and mode of calcium entry
    • S.M. Dudek, and R.D. Fields Mitogen-activated protein kinase/extracellular signal-regulated kinase activation in somatodendritic compartments: roles of action potentials, frequency, and mode of calcium entry J. Neurosci. 21 2001 Rc122
    • (2001) J. Neurosci. , vol.21 , pp. Rc122
    • Dudek, S.M.1    Fields, R.D.2
  • 35
    • 19944382538 scopus 로고    scopus 로고
    • Cytokines as mediators of depression: what can we learn from animal studies?
    • A.J. Dunn, A.H. Swiergiel, and R. de Beaurepaire Cytokines as mediators of depression: what can we learn from animal studies? Neurosci. Biobehav. Rev. 29 2005 891 909
    • (2005) Neurosci. Biobehav. Rev. , vol.29 , pp. 891-909
    • Dunn, A.J.1    Swiergiel, A.H.2    De Beaurepaire, R.3
  • 37
    • 5344232095 scopus 로고    scopus 로고
    • Hippocampus: cognitive processes and neural representations that underlie declarative memory
    • H. Eichenbaum Hippocampus: cognitive processes and neural representations that underlie declarative memory Neuron 44 2004 109 120
    • (2004) Neuron , vol.44 , pp. 109-120
    • Eichenbaum, H.1
  • 38
    • 84865775534 scopus 로고    scopus 로고
    • Interleukin-6 and memory functions of encoding and recall in healthy and depressed elderly adults
    • V. Elderkin-Thompson, M.R. Irwin, G. Hellemann, and A. Kumar Interleukin-6 and memory functions of encoding and recall in healthy and depressed elderly adults Am. J. Geriatr. Psychiatry 20 2012 753 763
    • (2012) Am. J. Geriatr. Psychiatry , vol.20 , pp. 753-763
    • Elderkin-Thompson, V.1    Irwin, M.R.2    Hellemann, G.3    Kumar, A.4
  • 39
    • 84856034604 scopus 로고    scopus 로고
    • Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier
    • M.A. Erickson, K. Dohi, and W.A. Banks Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier Neuroimmunomodulation 19 2012 121 130
    • (2012) Neuroimmunomodulation , vol.19 , pp. 121-130
    • Erickson, M.A.1    Dohi, K.2    Banks, W.A.3
  • 40
    • 33847099936 scopus 로고    scopus 로고
    • Astrocytes are active players in cerebral innate immunity
    • C. Farina, F. Aloisi, and E. Meinl Astrocytes are active players in cerebral innate immunity Trends Immunol. 28 2007 138 145
    • (2007) Trends Immunol. , vol.28 , pp. 138-145
    • Farina, C.1    Aloisi, F.2    Meinl, E.3
  • 41
    • 0028829231 scopus 로고
    • IL-6 expression in neurons of transgenic mice causes reactive astrocytosis and increase in ramified microglial cells but no neuronal damage
    • E. Fattori, D. Lazzaro, P. Musiani, A. Modesti, T. Alonzi, and G. Ciliberto IL-6 expression in neurons of transgenic mice causes reactive astrocytosis and increase in ramified microglial cells but no neuronal damage Eur. J. Neurosci. 7 1995 2441 2449
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 2441-2449
    • Fattori, E.1    Lazzaro, D.2    Musiani, P.3    Modesti, A.4    Alonzi, T.5    Ciliberto, G.6
  • 42
    • 0027184141 scopus 로고
    • p42 mitogen-activated protein kinase in brain: prominent localization in neuronal cell bodies and dendrites
    • R.S. Fiore, V.E. Bayer, S.L. Pelech, J. Posada, J.A. Cooper, and J.M. Baraban p42 mitogen-activated protein kinase in brain: prominent localization in neuronal cell bodies and dendrites Neuroscience 55 1993 463 472
    • (1993) Neuroscience , vol.55 , pp. 463-472
    • Fiore, R.S.1    Bayer, V.E.2    Pelech, S.L.3    Posada, J.4    Cooper, J.A.5    Baraban, J.M.6
  • 44
    • 0028069262 scopus 로고
    • Expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat brain during postnatal development
    • R.A. Gadient, and U. Otten Expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat brain during postnatal development Brain Res. 637 1994 10 14
    • (1994) Brain Res. , vol.637 , pp. 10-14
    • Gadient, R.A.1    Otten, U.2
  • 45
    • 0030964023 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6)-a molecule with both beneficial and destructive potentials
    • R.A. Gadient, and U.H. Otten Interleukin-6 (IL-6)-a molecule with both beneficial and destructive potentials Prog. Neurobiol. 52 1997 379 390
    • (1997) Prog. Neurobiol. , vol.52 , pp. 379-390
    • Gadient, R.A.1    Otten, U.H.2
  • 46
    • 84912113143 scopus 로고    scopus 로고
    • Complex deregulation and expression of cytokines and mediators of the immune response in Parkinson's disease brain is region dependent
    • P. Garcia-Esparcia, F. Llorens, M. Carmona, and I. Ferrer Complex deregulation and expression of cytokines and mediators of the immune response in Parkinson's disease brain is region dependent Brain Pathol. 2014
    • (2014) Brain Pathol.
    • Garcia-Esparcia, P.1    Llorens, F.2    Carmona, M.3    Ferrer, I.4
  • 49
    • 0031301027 scopus 로고    scopus 로고
    • Physiological and pathological roles of interleukin-6 in the central nervous system
    • D.L. Gruol, and T.E. Nelson Physiological and pathological roles of interleukin-6 in the central nervous system Mol. Neurobiol. 15 1997 307 339
    • (1997) Mol. Neurobiol. , vol.15 , pp. 307-339
    • Gruol, D.L.1    Nelson, T.E.2
  • 50
    • 0342918625 scopus 로고    scopus 로고
    • Localization of gp130 in the developing and adult mouse cerebellum
    • B.K. Ha, and J.S. King Localization of gp130 in the developing and adult mouse cerebellum J. Chem. Neuroanat. 19 2000 129 141
    • (2000) J. Chem. Neuroanat. , vol.19 , pp. 129-141
    • Ha, B.K.1    King, J.S.2
  • 51
    • 33846621575 scopus 로고    scopus 로고
    • The tripartite synapse: roles for gliotransmission in health and disease
    • M.M. Halassa, T. Fellin, and P.G. Haydon The tripartite synapse: roles for gliotransmission in health and disease Trends Mol. Med. 13 2007 54 63
    • (2007) Trends Mol. Med. , vol.13 , pp. 54-63
    • Halassa, M.M.1    Fellin, T.2    Haydon, P.G.3
  • 55
    • 0031028141 scopus 로고    scopus 로고
    • Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain
    • C.J. Heyser, E. Masliah, A. Samimi, I.L. Campbell, and L.H. Gold Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain Proc. Natl. Acad. Sci. U. S. A. 94 1997 1500 1505
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 1500-1505
    • Heyser, C.J.1    Masliah, E.2    Samimi, A.3    Campbell, I.L.4    Gold, L.H.5
  • 56
    • 84865628852 scopus 로고    scopus 로고
    • A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: exploring the causes of heterogeneity
    • S.A. Hiles, A.L. Baker, T. de Malmanche, and J. Attia A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: exploring the causes of heterogeneity Brain, Behav. Immun. 26 2012 1180 1188
    • (2012) Brain, Behav. Immun. , vol.26 , pp. 1180-1188
    • Hiles, S.A.1    Baker, A.L.2    De Malmanche, T.3    Attia, J.4
  • 57
    • 20044385570 scopus 로고    scopus 로고
    • A microdialysis technique for routine measurement of macromolecules in the injured human brain
    • (discussion 1268-1270)
    • J. Hillman, O. Aneman, C. Anderson, F. Sjogren, C. Saberg, and P. Mellergard A microdialysis technique for routine measurement of macromolecules in the injured human brain Neurosurgery 56 2005 1264 1268 (discussion 1268-1270)
    • (2005) Neurosurgery , vol.56 , pp. 1264-1268
    • Hillman, J.1    Aneman, O.2    Anderson, C.3    Sjogren, F.4    Saberg, C.5    Mellergard, P.6
  • 59
    • 0025285835 scopus 로고
    • Elevated levels of interleukin-6 in cerebrospinal fluid from patients with systemic lupus erythematosus and central nervous system involvement
    • S. Hirohata, and T. Miyamoto Elevated levels of interleukin-6 in cerebrospinal fluid from patients with systemic lupus erythematosus and central nervous system involvement Arthritis Rheum. 33 1990 644 649
    • (1990) Arthritis Rheum. , vol.33 , pp. 644-649
    • Hirohata, S.1    Miyamoto, T.2
  • 60
  • 61
    • 0029051259 scopus 로고
    • Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients
    • M. Huell, S. Strauss, B. Volk, M. Berger, and J. Bauer Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients Acta Neuropathol. 89 1995 544 551
    • (1995) Acta Neuropathol. , vol.89 , pp. 544-551
    • Huell, M.1    Strauss, S.2    Volk, B.3    Berger, M.4    Bauer, J.5
  • 62
    • 70350140349 scopus 로고    scopus 로고
    • Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection
    • T. Ichiyama, Y. Ito, M. Kubota, T. Yamazaki, K. Nakamura, and S. Furukawa Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection Brain Dev. 31 2009 731 738
    • (2009) Brain Dev. , vol.31 , pp. 731-738
    • Ichiyama, T.1    Ito, Y.2    Kubota, M.3    Yamazaki, T.4    Nakamura, K.5    Furukawa, S.6
  • 63
    • 16344382456 scopus 로고    scopus 로고
    • Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains
    • K. Imamura, N. Hishikawa, K. Ono, H. Suzuki, M. Sawada, T. Nagatsu, M. Yoshida, and Y. Hashizume Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains Acta Neuropathol. 109 2005 141 150
    • (2005) Acta Neuropathol. , vol.109 , pp. 141-150
    • Imamura, K.1    Hishikawa, N.2    Ono, K.3    Suzuki, H.4    Sawada, M.5    Nagatsu, T.6    Yoshida, M.7    Hashizume, Y.8
  • 64
    • 2442444813 scopus 로고    scopus 로고
    • Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholics
    • M. Irwin, G. Rinetti, L. Redwine, S. Motivala, J. Dang, and C. Ehlers Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholics Brain, Behav. Immun. 18 2004 349 360
    • (2004) Brain, Behav. Immun. , vol.18 , pp. 349-360
    • Irwin, M.1    Rinetti, G.2    Redwine, L.3    Motivala, S.4    Dang, J.5    Ehlers, C.6
  • 65
  • 66
    • 0034534059 scopus 로고    scopus 로고
    • Cytokine responses to LTP induction in the rat hippocampus: a comparison of in vitro and in vivo techniques
    • J.L. Jankowsky, B.E. Derrick, and P.H. Patterson Cytokine responses to LTP induction in the rat hippocampus: a comparison of in vitro and in vivo techniques Learn. Mem. 7 2000 400 412
    • (2000) Learn. Mem. , vol.7 , pp. 400-412
    • Jankowsky, J.L.1    Derrick, B.E.2    Patterson, P.H.3
  • 67
    • 84873279865 scopus 로고    scopus 로고
    • The role of the innate immune system in psychiatric disorders
    • K.A. Jones, and C. Thomsen The role of the innate immune system in psychiatric disorders Mol. Cell. Neurosci. 53 2013 52 62
    • (2013) Mol. Cell. Neurosci. , vol.53 , pp. 52-62
    • Jones, K.A.1    Thomsen, C.2
  • 68
    • 0036113566 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6): a possible neuromodulator induced by neuronal activity
    • E. Juttler, V. Tarabin, and M. Schwaninger Interleukin-6 (IL-6): a possible neuromodulator induced by neuronal activity Neuroscientist 8 2002 268 275
    • (2002) Neuroscientist , vol.8 , pp. 268-275
    • Juttler, E.1    Tarabin, V.2    Schwaninger, M.3
  • 69
    • 3042853067 scopus 로고    scopus 로고
    • Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats
    • A.V. Kalueff, K.A. Lehtimaki, A. Ylinen, J. Honkaniemi, and J. Peltola Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats Neurosci. Lett. 365 2004 106 110
    • (2004) Neurosci. Lett. , vol.365 , pp. 106-110
    • Kalueff, A.V.1    Lehtimaki, K.A.2    Ylinen, A.3    Honkaniemi, J.4    Peltola, J.5
  • 70
    • 0037088956 scopus 로고    scopus 로고
    • Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months
    • D.L. King, and G.W. Arendash Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months Physiol. Behav. 75 2002 627 642
    • (2002) Physiol. Behav. , vol.75 , pp. 627-642
    • King, D.L.1    Arendash, G.W.2
  • 71
    • 33748117796 scopus 로고    scopus 로고
    • Interleukin-6: discovery of a pleiotropic cytokine
    • T. Kishimoto Interleukin-6: discovery of a pleiotropic cytokine Arthritis Res. Ther. 8 Suppl. 2 2006 S2
    • (2006) Arthritis Res. Ther. , vol.8 , pp. S2
    • Kishimoto, T.1
  • 72
    • 84900393306 scopus 로고    scopus 로고
    • Spatial learning in the Morris water maze in mice genetically different in the predisposition to catalepsy: the effect of intraventricular treatment with brain-derived neurotrophic factor
    • A.V. Kulikov, D.V. Fursenko, N.V. Khotskin, D.V. Bazovkina, V.A. Kulikov, V.S. Naumenko, E.Y. Bazhenova, and N.K. Popova Spatial learning in the Morris water maze in mice genetically different in the predisposition to catalepsy: the effect of intraventricular treatment with brain-derived neurotrophic factor Pharmacol. Biochem. Behav. 122 2014 266 272
    • (2014) Pharmacol. Biochem. Behav. , vol.122 , pp. 266-272
    • Kulikov, A.V.1    Fursenko, D.V.2    Khotskin, N.V.3    Bazovkina, D.V.4    Kulikov, V.A.5    Naumenko, V.S.6    Bazhenova, E.Y.7    Popova, N.K.8
  • 74
  • 76
    • 0031049044 scopus 로고    scopus 로고
    • Interleukin-6 inhibits long-term potentiation in rat hippocampal slices
    • A.J. Li, T. Katafuchi, S. Oda, T. Hori, and Y. Oomura Interleukin-6 inhibits long-term potentiation in rat hippocampal slices Brain Res. 748 1997 30 38
    • (1997) Brain Res. , vol.748 , pp. 30-38
    • Li, A.J.1    Katafuchi, T.2    Oda, S.3    Hori, T.4    Oomura, Y.5
  • 79
    • 84883771075 scopus 로고    scopus 로고
    • Cerebrospinal fluid inflammatory markers in Parkinson's disease - associations with depression, fatigue, and cognitive impairment
    • D. Lindqvist, S. Hall, Y. Surova, H.M. Nielsen, S. Janelidze, L. Brundin, and O. Hansson Cerebrospinal fluid inflammatory markers in Parkinson's disease - associations with depression, fatigue, and cognitive impairment Brain, Behav. Immun. 33 2013 183 189
    • (2013) Brain, Behav. Immun. , vol.33 , pp. 183-189
    • Lindqvist, D.1    Hall, S.2    Surova, Y.3    Nielsen, H.M.4    Janelidze, S.5    Brundin, L.6    Hansson, O.7
  • 82
    • 0026828552 scopus 로고
    • Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor
    • J.A. Lust, K.A. Donovan, M.P. Kline, P.R. Greipp, R.A. Kyle, and N.J. Maihle Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor Cytokine 4 1992 96 100
    • (1992) Cytokine , vol.4 , pp. 96-100
    • Lust, J.A.1    Donovan, K.A.2    Kline, M.P.3    Greipp, P.R.4    Kyle, R.A.5    Maihle, N.J.6
  • 84
    • 0346728801 scopus 로고    scopus 로고
    • Long-term potentiation and memory
    • M.A. Lynch Long-term potentiation and memory Physiol. Rev. 84 2004 87 136
    • (2004) Physiol. Rev. , vol.84 , pp. 87-136
    • Lynch, M.A.1
  • 85
    • 0030936608 scopus 로고    scopus 로고
    • Intrahippocampal infusion of interleukin-6 impairs avoidance learning in rats
    • T.C. Ma, and X.Z. Zhu Intrahippocampal infusion of interleukin-6 impairs avoidance learning in rats Zhongguo Yao Li Xue Bao. Acta Pharmacol. Sin. 18 1997 121 123
    • (1997) Zhongguo Yao Li Xue Bao. Acta Pharmacol. Sin. , vol.18 , pp. 121-123
    • Ma, T.C.1    Zhu, X.Z.2
  • 86
    • 22244441777 scopus 로고    scopus 로고
    • Physiological levels of pro- and anti-inflammatory mediators in cerebrospinal fluid and plasma: a normative study
    • B. Maier, H.L. Laurer, S. Rose, W.A. Buurman, and I. Marzi Physiological levels of pro- and anti-inflammatory mediators in cerebrospinal fluid and plasma: a normative study J. Neurotrauma 22 2005 822 835
    • (2005) J. Neurotrauma , vol.22 , pp. 822-835
    • Maier, B.1    Laurer, H.L.2    Rose, S.3    Buurman, W.A.4    Marzi, I.5
  • 87
    • 84883740752 scopus 로고    scopus 로고
    • Interictal interleukin-17A levels are elevated and correlate with seizure severity of epilepsy patients
    • L.Y. Mao, J. Ding, W.F. Peng, Y. Ma, Y.H. Zhang, W. Fan, and X. Wang Interictal interleukin-17A levels are elevated and correlate with seizure severity of epilepsy patients Epilepsia 54 2013 e142 145
    • (2013) Epilepsia , vol.54 , pp. e142-145
    • Mao, L.Y.1    Ding, J.2    Peng, W.F.3    Ma, Y.4    Zhang, Y.H.5    Fan, W.6    Wang, X.7
  • 90
    • 33947611555 scopus 로고    scopus 로고
    • Long-term depression: multiple forms and implications for brain function
    • P.V. Massey, and Z.I. Bashir Long-term depression: multiple forms and implications for brain function Trends Neurosci. 30 2007 176 184
    • (2007) Trends Neurosci. , vol.30 , pp. 176-184
    • Massey, P.V.1    Bashir, Z.I.2
  • 91
    • 53549099114 scopus 로고    scopus 로고
    • Age-related declines in general cognitive abilities of Balb/C mice are associated with disparities in working memory, body weight, and general activity
    • L.D. Matzel, H. Grossman, K. Light, D. Townsend, and S. Kolata Age-related declines in general cognitive abilities of Balb/C mice are associated with disparities in working memory, body weight, and general activity Learn. Mem. 15 2008 733 746
    • (2008) Learn. Mem. , vol.15 , pp. 733-746
    • Matzel, L.D.1    Grossman, H.2    Light, K.3    Townsend, D.4    Kolata, S.5
  • 92
    • 79959639352 scopus 로고    scopus 로고
    • Constant darkness induces IL-6-dependent depression-like behavior through the NF-kappaB signaling pathway
    • F.J. Monje, M. Cabatic, I. Divisch, E.J. Kim, K.R. Herkner, B.R. Binder, and D.D. Pollak Constant darkness induces IL-6-dependent depression-like behavior through the NF-kappaB signaling pathway J. Neurosci. 31 2011 9075 9083
    • (2011) J. Neurosci. , vol.31 , pp. 9075-9083
    • Monje, F.J.1    Cabatic, M.2    Divisch, I.3    Kim, E.J.4    Herkner, K.R.5    Binder, B.R.6    Pollak, D.D.7
  • 93
    • 0034638417 scopus 로고    scopus 로고
    • Expression of interleukin-6 receptor, leukemia inhibitory factor receptor and glycoprotein 130 in the murine cerebellum and neuropathological effect of leukemia inhibitory factor on cerebellar Purkinje cells
    • Y. Morikawa, K. Tohya, S. Tamura, M. Ichihara, A. Miyajima, and E. Senba Expression of interleukin-6 receptor, leukemia inhibitory factor receptor and glycoprotein 130 in the murine cerebellum and neuropathological effect of leukemia inhibitory factor on cerebellar Purkinje cells Neuroscience 100 2000 841 848
    • (2000) Neuroscience , vol.100 , pp. 841-848
    • Morikawa, Y.1    Tohya, K.2    Tamura, S.3    Ichihara, M.4    Miyajima, A.5    Senba, E.6
  • 95
    • 84894080596 scopus 로고    scopus 로고
    • Neuronal activity-dependent STAT3 localization to nucleus is dependent on Tyr-705 and Ser-727 phosphorylation in rat hippocampal neurons
    • S. Murase, and R.D. McKay Neuronal activity-dependent STAT3 localization to nucleus is dependent on Tyr-705 and Ser-727 phosphorylation in rat hippocampal neurons Eur. J. Neurosci. 39 2014 557 565
    • (2014) Eur. J. Neurosci. , vol.39 , pp. 557-565
    • Murase, S.1    Mckay, R.D.2
  • 96
    • 0034738046 scopus 로고    scopus 로고
    • Occurrence of a transcription factor, signal transducer and activators of transcription 3 (Stat3), in the postsynaptic density of the rat brain
    • S. Murata, N. Usuda, A. Okano, S. Kobayashi, and T. Suzuki Occurrence of a transcription factor, signal transducer and activators of transcription 3 (Stat3), in the postsynaptic density of the rat brain Brain Res. Mol. Brain Res. 78 2000 80 90
    • (2000) Brain Res. Mol. Brain Res. , vol.78 , pp. 80-90
    • Murata, S.1    Usuda, N.2    Okano, A.3    Kobayashi, S.4    Suzuki, T.5
  • 97
    • 0022413163 scopus 로고
    • Physicochemical and functional properties of murine B cell-derived B cell growth factor II (WEHI-231-BCGF-II)
    • K. Nakajima, T. Hirano, F. Takatsuki, N. Sakaguchi, N. Yoshida, and T. Kishimoto Physicochemical and functional properties of murine B cell-derived B cell growth factor II (WEHI-231-BCGF-II) J. Immunol. 135 1985 1207 1212
    • (1985) J. Immunol. , vol.135 , pp. 1207-1212
    • Nakajima, K.1    Hirano, T.2    Takatsuki, F.3    Sakaguchi, N.4    Yoshida, N.5    Kishimoto, T.6
  • 99
    • 0033105025 scopus 로고    scopus 로고
    • Altered physiology of Purkinje neurons in cerebellar slices from transgenic mice with chronic central nervous system expression of interleukin-6
    • T.E. Nelson, I.L. Campbell, and D.L. Gruol Altered physiology of Purkinje neurons in cerebellar slices from transgenic mice with chronic central nervous system expression of interleukin-6 Neuroscience 89 1999 127 136
    • (1999) Neuroscience , vol.89 , pp. 127-136
    • Nelson, T.E.1    Campbell, I.L.2    Gruol, D.L.3
  • 100
    • 8144219661 scopus 로고    scopus 로고
    • Chronic interleukin-6 exposure alters metabotropic glutamate receptor-activated calcium signalling in cerebellar Purkinje neurons
    • T.E. Nelson, J.G. Netzeband, and D.L. Gruol Chronic interleukin-6 exposure alters metabotropic glutamate receptor-activated calcium signalling in cerebellar Purkinje neurons Eur. J. Neurosci. 20 2004 2387 2400
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 2387-2400
    • Nelson, T.E.1    Netzeband, J.G.2    Gruol, D.L.3
  • 102
    • 0036314843 scopus 로고    scopus 로고
    • Chronic interleukin-6 exposure alters electrophysiological properties and calcium signaling in developing cerebellar Purkinje neurons in culture
    • T.E. Nelson, C.L. Ur, and D.L. Gruol Chronic interleukin-6 exposure alters electrophysiological properties and calcium signaling in developing cerebellar Purkinje neurons in culture J. Neurophysiol. 88 2002 475 486
    • (2002) J. Neurophysiol. , vol.88 , pp. 475-486
    • Nelson, T.E.1    Ur, C.L.2    Gruol, D.L.3
  • 104
    • 0028293559 scopus 로고
    • Signal transduction pathways mediating astrocyte IL-6 induction by IL-1 beta and tumor necrosis factor-alpha
    • J.G. Norris, L.P. Tang, S.M. Sparacio, and E.N. Benveniste Signal transduction pathways mediating astrocyte IL-6 induction by IL-1 beta and tumor necrosis factor-alpha J. Immunol. 152 1994 841 850
    • (1994) J. Immunol. , vol.152 , pp. 841-850
    • Norris, J.G.1    Tang, L.P.2    Sparacio, S.M.3    Benveniste, E.N.4
  • 106
    • 84879696907 scopus 로고    scopus 로고
    • Emerging role for astroglial networks in information processing: from synapse to behavior
    • U. Pannasch, and N. Rouach Emerging role for astroglial networks in information processing: from synapse to behavior Trends Neurosci. 36 2013 405 417
    • (2013) Trends Neurosci. , vol.36 , pp. 405-417
    • Pannasch, U.1    Rouach, N.2
  • 107
    • 0031830922 scopus 로고    scopus 로고
    • Elevated levels of interleukin-6 may occur in cerebrospinal fluid from patients with recent epileptic seizures
    • J. Peltola, M. Hurme, A. Miettinen, and T. Keranen Elevated levels of interleukin-6 may occur in cerebrospinal fluid from patients with recent epileptic seizures Epilepsy Res. 31 1998 129 133
    • (1998) Epilepsy Res. , vol.31 , pp. 129-133
    • Peltola, J.1    Hurme, M.2    Miettinen, A.3    Keranen, T.4
  • 108
    • 0034308079 scopus 로고    scopus 로고
    • Interleukin-6 and interleukin-1 receptor antagonist in cerebrospinal fluid from patients with recent tonic-clonic seizures
    • J. Peltola, J. Palmio, L. Korhonen, J. Suhonen, A. Miettinen, M. Hurme, D. Lindholm, and T. Keranen Interleukin-6 and interleukin-1 receptor antagonist in cerebrospinal fluid from patients with recent tonic-clonic seizures Epilepsy Res. 41 2000 205 211
    • (2000) Epilepsy Res. , vol.41 , pp. 205-211
    • Peltola, J.1    Palmio, J.2    Korhonen, L.3    Suhonen, J.4    Miettinen, A.5    Hurme, M.6    Lindholm, D.7    Keranen, T.8
  • 109
    • 0029874694 scopus 로고    scopus 로고
    • The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations
    • R.S. Petralia, Y.X. Wang, A.S. Niedzielski, and R.J. Wenthold The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations Neuroscience 71 1996 949 976
    • (1996) Neuroscience , vol.71 , pp. 949-976
    • Petralia, R.S.1    Wang, Y.X.2    Niedzielski, A.S.3    Wenthold, R.J.4
  • 110
    • 77954521819 scopus 로고    scopus 로고
    • Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms
    • E. Pineda, D. Shin, R. Sankar, and A.M. Mazarati Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms Epilepsia 51 Suppl. 3 2010 110 114
    • (2010) Epilepsia , vol.51 , pp. 110-114
    • Pineda, E.1    Shin, D.2    Sankar, R.3    Mazarati, A.M.4
  • 111
    • 0028812570 scopus 로고
    • Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons
    • Z. Qiu, K.L. Parsons, and D.L. Gruol Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons J. Neurosci. 15 1995 6688 6699
    • (1995) J. Neurosci. , vol.15 , pp. 6688-6699
    • Qiu, Z.1    Parsons, K.L.2    Gruol, D.L.3
  • 112
    • 0032535026 scopus 로고    scopus 로고
    • Chronic interleukin-6 alters NMDA receptor-mediated membrane responses and enhances neurotoxicity in developing CNS neurons
    • Z. Qiu, D.D. Sweeney, J.G. Netzeband, and D.L. Gruol Chronic interleukin-6 alters NMDA receptor-mediated membrane responses and enhances neurotoxicity in developing CNS neurons J. Neurosci. 18 1998 10445 10456
    • (1998) J. Neurosci. , vol.18 , pp. 10445-10456
    • Qiu, Z.1    Sweeney, D.D.2    Netzeband, J.G.3    Gruol, D.L.4
  • 113
    • 0032946772 scopus 로고    scopus 로고
    • The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes
    • Rheumatology, T. A. C. o The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes Arthritis Rheum. 42 1999 599 608
    • (1999) Arthritis Rheum. , vol.42 , pp. 599-608
    • Rheumatology T.A.C. O1
  • 114
    • 0029560472 scopus 로고
    • Interleukin-6 mRNA expression by cortical neurons in culture: evidence for neuronal sources of interleukin-6 production in the brain
    • G.E. Ringheim, K.L. Burgher, and J.A. Heroux Interleukin-6 mRNA expression by cortical neurons in culture: evidence for neuronal sources of interleukin-6 production in the brain J. Neuroimmunol. 63 1995 113 123
    • (1995) J. Neuroimmunol. , vol.63 , pp. 113-123
    • Ringheim, G.E.1    Burgher, K.L.2    Heroux, J.A.3
  • 116
    • 33748848714 scopus 로고    scopus 로고
    • Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer
    • S. Rose-John, J. Scheller, G. Elson, and S.A. Jones Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer J. Leukoc. Biol. 80 2006 227 236
    • (2006) J. Leukoc. Biol. , vol.80 , pp. 227-236
    • Rose-John, S.1    Scheller, J.2    Elson, G.3    Jones, S.A.4
  • 118
    • 79451474477 scopus 로고    scopus 로고
    • Selective review of cognitive aging
    • T.A. Salthouse Selective review of cognitive aging J. Int. Neuropsychol. Soc. 16 2010 754 760
    • (2010) J. Int. Neuropsychol. Soc. , vol.16 , pp. 754-760
    • Salthouse, T.A.1
  • 119
    • 0037829339 scopus 로고    scopus 로고
    • Profound increase in sensitivity to glutamatergic- but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6
    • H. Samland, S. Huitron-Resendiz, E. Masliah, J. Criado, S.J. Henriksen, and I.L. Campbell Profound increase in sensitivity to glutamatergic- but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6 J. Neurosci. Res. 73 2003 176 187
    • (2003) J. Neurosci. Res. , vol.73 , pp. 176-187
    • Samland, H.1    Huitron-Resendiz, S.2    Masliah, E.3    Criado, J.4    Henriksen, S.J.5    Campbell, I.L.6
  • 121
    • 0027423232 scopus 로고
    • Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain
    • B. Schobitz, E.R. de Kloet, W. Sutanto, and F. Holsboer Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain Eur. J. Neurosci. 5 1993 1426 1435
    • (1993) Eur. J. Neurosci. , vol.5 , pp. 1426-1435
    • Schobitz, B.1    De Kloet, E.R.2    Sutanto, W.3    Holsboer, F.4
  • 122
    • 0034971368 scopus 로고    scopus 로고
    • Plasticity, hippocampal place cells, and cognitive maps
    • M. Shapiro Plasticity, hippocampal place cells, and cognitive maps Arch. Neurol. 58 2001 874 881
    • (2001) Arch. Neurol. , vol.58 , pp. 874-881
    • Shapiro, M.1
  • 123
    • 0030858013 scopus 로고    scopus 로고
    • Differential modulation of short and long latency sensory responses in the SI cortex by IL-6
    • H.C. Shin, S. Oh, S.C. Jung, J. Park, and C.K. Won Differential modulation of short and long latency sensory responses in the SI cortex by IL-6 Neuroreport 8 1997 2841 2844
    • (1997) Neuroreport , vol.8 , pp. 2841-2844
    • Shin, H.C.1    Oh, S.2    Jung, S.C.3    Park, J.4    Won, C.K.5
  • 124
    • 68249112361 scopus 로고    scopus 로고
    • Distinct neuroinflammatory profile in post-mortem human Huntington's disease
    • A. Silvestroni, R.L. Faull, A.D. Strand, and T. Moller Distinct neuroinflammatory profile in post-mortem human Huntington's disease Neuroreport 20 2009 1098 1103
    • (2009) Neuroreport , vol.20 , pp. 1098-1103
    • Silvestroni, A.1    Faull, R.L.2    Strand, A.D.3    Moller, T.4
  • 125
    • 27744497918 scopus 로고    scopus 로고
    • Declarative memory, awareness, and transitive inference
    • C. Smith, and L.R. Squire Declarative memory, awareness, and transitive inference J. Neurosci. 25 2005 10138 10146
    • (2005) J. Neurosci. , vol.25 , pp. 10138-10146
    • Smith, C.1    Squire, L.R.2
  • 126
    • 57149094857 scopus 로고    scopus 로고
    • Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress
    • N.L. Sparkman, and R.W. Johnson Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress Neuroimmunomodulation 15 2008 323 330
    • (2008) Neuroimmunomodulation , vol.15 , pp. 323-330
    • Sparkman, N.L.1    Johnson, R.W.2
  • 127
    • 77955576631 scopus 로고    scopus 로고
    • Pathways for cytokine secretion
    • A.C. Stanley, and P. Lacy Pathways for cytokine secretion Physiol. Bethesda 25 2010 218 229
    • (2010) Physiol. Bethesda , vol.25 , pp. 218-229
    • Stanley, A.C.1    Lacy, P.2
  • 128
    • 0028298627 scopus 로고
    • Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice
    • S.C. Steffensen, I.L. Campbell, and S.J. Henriksen Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice Brain Res. 652 1994 149 153
    • (1994) Brain Res. , vol.652 , pp. 149-153
    • Steffensen, S.C.1    Campbell, I.L.2    Henriksen, S.J.3
  • 129
    • 0026553710 scopus 로고
    • Detection of interleukin-6 and alpha 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients
    • S. Strauss, J. Bauer, U. Ganter, U. Jonas, M. Berger, and B. Volk Detection of interleukin-6 and alpha 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients Lab. Investig. 66 1992 223 230
    • (1992) Lab. Investig. , vol.66 , pp. 223-230
    • Strauss, S.1    Bauer, J.2    Ganter, U.3    Jonas, U.4    Berger, M.5    Volk, B.6
  • 132
    • 0035166616 scopus 로고    scopus 로고
    • The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory
    • J.D. Sweatt The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory J. Neurochem. 76 2001 1 10
    • (2001) J. Neurochem. , vol.76 , pp. 1-10
    • Sweatt, J.D.1
  • 133
    • 84902265558 scopus 로고    scopus 로고
    • Usefulness of interleukin 6 levels in the cerebrospinal fluid for the diagnosis of bacterial meningitis
    • W. Takahashi, T.A. Nakada, R. Abe, K. Tanaka, Y. Matsumura, and S. Oda Usefulness of interleukin 6 levels in the cerebrospinal fluid for the diagnosis of bacterial meningitis J. Crit. Care 29 2014 693.e691 693.e696
    • (2014) J. Crit. Care , vol.29 , pp. 693e691-693e696
    • Takahashi, W.1    Nakada, T.A.2    Abe, R.3    Tanaka, K.4    Matsumura, Y.5    Oda, S.6
  • 134
    • 0033943842 scopus 로고    scopus 로고
    • The inhibitory effects of interleukin-6 on synaptic plasticity in the rat hippocampus are associated with an inhibition of mitogen-activated protein kinase ERK
    • V. Tancredi, M. D'Antuono, C. Cafe, S. Giovedi, M.C. Bue, G. D'Arcangelo, F. Onofri, and F. Benfenati The inhibitory effects of interleukin-6 on synaptic plasticity in the rat hippocampus are associated with an inhibition of mitogen-activated protein kinase ERK J. Neurochem. 75 2000 634 643
    • (2000) J. Neurochem. , vol.75 , pp. 634-643
    • Tancredi, V.1    D'Antuono, M.2    Cafe, C.3    Giovedi, S.4    Bue, M.C.5    D'arcangelo, G.6    Onofri, F.7    Benfenati, F.8
  • 135
    • 34548049497 scopus 로고    scopus 로고
    • Cognitive dysfunction associated with metabolic syndrome
    • V.H. Taylor, and G.M. MacQueen Cognitive dysfunction associated with metabolic syndrome Obes. Rev. 8 2007 409 418
    • (2007) Obes. Rev. , vol.8 , pp. 409-418
    • Taylor, V.H.1    Macqueen, G.M.2
  • 136
    • 0035937650 scopus 로고    scopus 로고
    • Early induction of interleukin-6 mRNA in the hippocampus and cortex of APPsw transgenic mice Tg2576
    • R. Tehranian, H. Hasanvan, K. Iverfeldt, C. Post, and M. Schultzberg Early induction of interleukin-6 mRNA in the hippocampus and cortex of APPsw transgenic mice Tg2576 Neurosci. Lett. 301 2001 54 58
    • (2001) Neurosci. Lett. , vol.301 , pp. 54-58
    • Tehranian, R.1    Hasanvan, H.2    Iverfeldt, K.3    Post, C.4    Schultzberg, M.5
  • 137
    • 0031688582 scopus 로고    scopus 로고
    • Role of the brain in interleukin-6 modulation
    • L. Terreni, and M.G. De Simoni Role of the brain in interleukin-6 modulation Neuroimmunomodulation 5 1998 214 219
    • (1998) Neuroimmunomodulation , vol.5 , pp. 214-219
    • Terreni, L.1    De Simoni, M.G.2
  • 139
    • 0035917870 scopus 로고    scopus 로고
    • Aberrant cytokine gene expression in the hippocampus in murine systemic lupus erythematosus
    • M. Tomita, B.J. Holman, and T.J. Santoro Aberrant cytokine gene expression in the hippocampus in murine systemic lupus erythematosus Neurosci. Lett. 302 2001 129 132
    • (2001) Neurosci. Lett. , vol.302 , pp. 129-132
    • Tomita, M.1    Holman, B.J.2    Santoro, T.J.3
  • 140
    • 0035311631 scopus 로고    scopus 로고
    • Cerebellar dysfunction is associated with overexpression of proinflammatory cytokine genes in lupus
    • M. Tomita, B.J. Holman, L.S. Williams, K.C. Pang, and T.J. Santoro Cerebellar dysfunction is associated with overexpression of proinflammatory cytokine genes in lupus J. Neurosci. Res. 64 2001 26 33
    • (2001) J. Neurosci. Res. , vol.64 , pp. 26-33
    • Tomita, M.1    Holman, B.J.2    Williams, L.S.3    Pang, K.C.4    Santoro, T.J.5
  • 141
  • 142
    • 0033823044 scopus 로고    scopus 로고
    • Intrathecal cytokines in systemic lupus erythematosus with central nervous system involvement
    • E. Trysberg, H. Carlsten, and A. Tarkowski Intrathecal cytokines in systemic lupus erythematosus with central nervous system involvement Lupus 9 2000 498 503
    • (2000) Lupus , vol.9 , pp. 498-503
    • Trysberg, E.1    Carlsten, H.2    Tarkowski, A.3
  • 143
    • 44649187461 scopus 로고    scopus 로고
    • Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones
    • N. Tsakiri, I. Kimber, N.J. Rothwell, and E. Pinteaux Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones Mol. Cell. Neurosci. 38 2008 259 265
    • (2008) Mol. Cell. Neurosci. , vol.38 , pp. 259-265
    • Tsakiri, N.1    Kimber, I.2    Rothwell, N.J.3    Pinteaux, E.4
  • 144
    • 37349123154 scopus 로고    scopus 로고
    • Mechanisms of interleukin-6 synthesis and release induced by interleukin-1 and cell depolarisation in neurones
    • N. Tsakiri, I. Kimber, N.J. Rothwell, and E. Pinteaux Mechanisms of interleukin-6 synthesis and release induced by interleukin-1 and cell depolarisation in neurones Mol. Cell. Neurosci. 37 2008 110 118
    • (2008) Mol. Cell. Neurosci. , vol.37 , pp. 110-118
    • Tsakiri, N.1    Kimber, I.2    Rothwell, N.J.3    Pinteaux, E.4
  • 145
    • 0033168292 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) production by astrocytes: autocrine regulation by IL-6 and the soluble IL-6 receptor
    • N.J. Van Wagoner, J.W. Oh, P. Repovic, and E.N. Benveniste Interleukin-6 (IL-6) production by astrocytes: autocrine regulation by IL-6 and the soluble IL-6 receptor J. Neurosci. 19 1999 5236 5244
    • (1999) J. Neurosci. , vol.19 , pp. 5236-5244
    • Van Wagoner, N.J.1    Oh, J.W.2    Repovic, P.3    Benveniste, E.N.4
  • 146
    • 11144230769 scopus 로고    scopus 로고
    • Neuroglial activation and neuroinflammation in the brain of patients with autism
    • D.L. Vargas, C. Nascimbene, C. Krishnan, A.W. Zimmerman, and C.A. Pardo Neuroglial activation and neuroinflammation in the brain of patients with autism Ann. Neurol. 57 2005 67 81
    • (2005) Ann. Neurol. , vol.57 , pp. 67-81
    • Vargas, D.L.1    Nascimbene, C.2    Krishnan, C.3    Zimmerman, A.W.4    Pardo, C.A.5
  • 147
    • 42449147571 scopus 로고    scopus 로고
    • Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study
    • J.F. Vazquez, H.W. Clement, O. Sommer, E. Schulz, and D. van Calker Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study J. Neurochem. 105 2008 904 909
    • (2008) J. Neurochem. , vol.105 , pp. 904-909
    • Vazquez, J.F.1    Clement, H.W.2    Sommer, O.3    Schulz, E.4    Van Calker, D.5
  • 148
    • 34347383586 scopus 로고    scopus 로고
    • Chronic interleukin-6 alters the level of synaptic proteins in hippocampus in culture and in vivo
    • E.J. Vereyken, H. Bajova, S. Chow, P.N. de Graan, and D.L. Gruol Chronic interleukin-6 alters the level of synaptic proteins in hippocampus in culture and in vivo Eur. J. Neurosci. 25 2007 3605 3616
    • (2007) Eur. J. Neurosci. , vol.25 , pp. 3605-3616
    • Vereyken, E.J.1    Bajova, H.2    Chow, S.3    De Graan, P.N.4    Gruol, D.L.5
  • 149
    • 46049103354 scopus 로고    scopus 로고
    • The role of cytokines in the pathophysiology of epilepsy
    • A. Vezzani, S. Balosso, and T. Ravizza The role of cytokines in the pathophysiology of epilepsy Brain, Behav. Immun. 22 2008 797 803
    • (2008) Brain, Behav. Immun. , vol.22 , pp. 797-803
    • Vezzani, A.1    Balosso, S.2    Ravizza, T.3
  • 150
    • 0037464388 scopus 로고    scopus 로고
    • Interleukin-6 receptor expression and localization after transient global ischemia in gerbil hippocampus
    • F. Vollenweider, M. Herrmann, U. Otten, and C. Nitsch Interleukin-6 receptor expression and localization after transient global ischemia in gerbil hippocampus Neurosci. Lett. 341 2003 49 52
    • (2003) Neurosci. Lett. , vol.341 , pp. 49-52
    • Vollenweider, F.1    Herrmann, M.2    Otten, U.3    Nitsch, C.4
  • 151
    • 3843121075 scopus 로고    scopus 로고
    • Elevated interleukin-6 levels in cerebrospinal fluid of vascular dementia patients
    • K. Wada-Isoe, Y. Wakutani, K. Urakami, and K. Nakashima Elevated interleukin-6 levels in cerebrospinal fluid of vascular dementia patients Acta Neurol. Scand. 110 2004 124 127
    • (2004) Acta Neurol. Scand. , vol.110 , pp. 124-127
    • Wada-Isoe, K.1    Wakutani, Y.2    Urakami, K.3    Nakashima, K.4
  • 152
    • 0029757719 scopus 로고    scopus 로고
    • Characteristic localization of gp130 (the signal-transducing receptor component used in common for IL-6/IL-11/CNTF/LIF/OSM) in the rat brain
    • D. Watanabe, R. Yoshimura, M. Khalil, K. Yoshida, T. Kishimoto, T. Taga, and H. Kiyama Characteristic localization of gp130 (the signal-transducing receptor component used in common for IL-6/IL-11/CNTF/LIF/OSM) in the rat brain Eur. J. Neurosci. 8 1996 1630 1640
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 1630-1640
    • Watanabe, D.1    Yoshimura, R.2    Khalil, M.3    Yoshida, K.4    Kishimoto, T.5    Taga, T.6    Kiyama, H.7
  • 153
    • 84884369430 scopus 로고    scopus 로고
    • Brain IL-6 and autism
    • H. Wei, I. Alberts, and X. Li Brain IL-6 and autism Neuroscience 252 2013 320 325
    • (2013) Neuroscience , vol.252 , pp. 320-325
    • Wei, H.1    Alberts, I.2    Li, X.3
  • 155
    • 79956040296 scopus 로고    scopus 로고
    • IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation
    • H. Wei, H. Zou, A.M. Sheikh, M. Malik, C. Dobkin, W.T. Brown, and X. Li IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation J. Neuroinflammation 8 2011 52
    • (2011) J. Neuroinflammation , vol.8 , pp. 52
    • Wei, H.1    Zou, H.2    Sheikh, A.M.3    Malik, M.4    Dobkin, C.5    Brown, W.T.6    Li, X.7
  • 156
    • 0027453380 scopus 로고
    • Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1 beta or IL-1RA but increases in the associated acute phase proteins IL-6, alpha 2-macroglobulin and C-reactive protein
    • J.A. Wood, P.L. Wood, R. Ryan, N.R. Graff-Radford, C. Pilapil, Y. Robitaille, and R. Quirion Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1 beta or IL-1RA but increases in the associated acute phase proteins IL-6, alpha 2-macroglobulin and C-reactive protein Brain Res. 629 1993 245 252
    • (1993) Brain Res. , vol.629 , pp. 245-252
    • Wood, J.A.1    Wood, P.L.2    Ryan, R.3    Graff-Radford, N.R.4    Pilapil, C.5    Robitaille, Y.6    Quirion, R.7
  • 157
    • 0025820808 scopus 로고
    • Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production
    • M.N. Woodroofe, G.S. Sarna, M. Wadhwa, G.M. Hayes, A.J. Loughlin, A. Tinker, and M.L. Cuzner Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production J. Neuroimmunol. 33 1991 227 236
    • (1991) J. Neuroimmunol. , vol.33 , pp. 227-236
    • Woodroofe, M.N.1    Sarna, G.S.2    Wadhwa, M.3    Hayes, G.M.4    Loughlin, A.J.5    Tinker, A.6    Cuzner, M.L.7
  • 158
    • 84928649092 scopus 로고    scopus 로고
    • A systematic review of two outcomes in autism spectrum disorder - epilepsy and mortality
    • S. Woolfenden, V. Sarkozy, G. Ridley, M. Coory, and K. Williams A systematic review of two outcomes in autism spectrum disorder - epilepsy and mortality Dev. Med. Child Neurol. 54 2012 306 312
    • (2012) Dev. Med. Child Neurol. , vol.54 , pp. 306-312
    • Woolfenden, S.1    Sarkozy, V.2    Ridley, G.3    Coory, M.4    Williams, K.5
  • 160
    • 48749106396 scopus 로고    scopus 로고
    • IL-6 mediated alterations on immobile behavior of rats in the forced swim test via ERK1/2 activation in specific brain regions
    • T.H. Wu, and C.H. Lin IL-6 mediated alterations on immobile behavior of rats in the forced swim test via ERK1/2 activation in specific brain regions Behav. Brain Res. 193 2008 183 191
    • (2008) Behav. Brain Res. , vol.193 , pp. 183-191
    • Wu, T.H.1    Lin, C.H.2
  • 162
    • 34848870004 scopus 로고    scopus 로고
    • Changes in behavior and amino acid neurotransmitters in the brain of rats with seizure induced by IL-1beta or IL-6
    • Z. Xiaoqin, L. Zhengli, Z. Changgeng, W. Xiaojing, and L. Li Changes in behavior and amino acid neurotransmitters in the brain of rats with seizure induced by IL-1beta or IL-6 J. Huazhong Univ. Sci. Technol. Med. Sci. 25 2005 236 239
    • (2005) J. Huazhong Univ. Sci. Technol. Med. Sci. , vol.25 , pp. 236-239
    • Xiaoqin, Z.1    Zhengli, L.2    Changgeng, Z.3    Xiaojing, W.4    Li, L.5
  • 167
    • 0032916578 scopus 로고    scopus 로고
    • Increased interleukin-6 expression by microglia from brain of aged mice
    • S.M. Ye, and R.W. Johnson Increased interleukin-6 expression by microglia from brain of aged mice J. Neuroimmunol. 93 1999 139 148
    • (1999) J. Neuroimmunol. , vol.93 , pp. 139-148
    • Ye, S.M.1    Johnson, R.W.2
  • 168
    • 0035796896 scopus 로고    scopus 로고
    • Regulation of interleukin-6 gene expression in brain of aged mice by nuclear factor kappaB
    • S.M. Ye, and R.W. Johnson Regulation of interleukin-6 gene expression in brain of aged mice by nuclear factor kappaB J. Neuroimmunol. 117 2001 87 96
    • (2001) J. Neuroimmunol. , vol.117 , pp. 87-96
    • Ye, S.M.1    Johnson, R.W.2
  • 169
    • 84862785339 scopus 로고    scopus 로고
    • A meta-analysis of pro-inflammatory cytokines in the plasma of epileptic patients with recent seizure
    • N. Yu, Q. Di, Y. Hu, Y.F. Zhang, L.Y. Su, X.H. Liu, and L.C. Li A meta-analysis of pro-inflammatory cytokines in the plasma of epileptic patients with recent seizure Neurosci. Lett. 514 2012 110 115
    • (2012) Neurosci. Lett. , vol.514 , pp. 110-115
    • Yu, N.1    Di, Q.2    Hu, Y.3    Zhang, Y.F.4    Su, L.Y.5    Liu, X.H.6    Li, L.C.7
  • 170
    • 0032053686 scopus 로고    scopus 로고
    • Involvement of cytokines in normal CNS development and neurological diseases: recent progress and perspectives
    • B. Zhao, and J.P. Schwartz Involvement of cytokines in normal CNS development and neurological diseases: recent progress and perspectives J. Neurosci. Res. 52 1998 7 16
    • (1998) J. Neurosci. Res. , vol.52 , pp. 7-16
    • Zhao, B.1    Schwartz, J.P.2
  • 172
    • 34249320472 scopus 로고    scopus 로고
    • Early discrimination reversal learning impairment and preserved spatial learning in a longitudinal study of Tg2576 APPsw mice
    • J.M. Zhuo, S.L. Prescott, M.E. Murray, H.Y. Zhang, M.G. Baxter, and M.M. Nicolle Early discrimination reversal learning impairment and preserved spatial learning in a longitudinal study of Tg2576 APPsw mice Neurobiol. Aging 28 2007 1248 1257
    • (2007) Neurobiol. Aging , vol.28 , pp. 1248-1257
    • Zhuo, J.M.1    Prescott, S.L.2    Murray, M.E.3    Zhang, H.Y.4    Baxter, M.G.5    Nicolle, M.M.6


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