Age-related declines in general cognitive abilities of Balb/C mice are associated with disparities in working memory, body weight, and general activity

Learning and Memory

Volumn 15, Issue 10, 2008, Pages 733-746

  Matzel, Louis D ^a   Grossman, Henya ^a   Light, Kenneth ^a   Townsend, David ^a   Kolata, Stefan ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; COGNITIVE DEFECT; CONDITIONING; CONTROLLED STUDY; FEAR; FEMALE; MALE; MAZE TEST; MOUSE; NONHUMAN; OLFACTORY DISCRIMINATION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REINFORCEMENT; TASK PERFORMANCE; WORKING MEMORY;

AGING; ANIMALS; BODY WEIGHT; COGNITION; FEMALE; LEARNING; MALE; MEMORY; MICE; MICE, INBRED BALB C; MOTOR ACTIVITY;

EID: 53549099114     PISSN: 10720502     EISSN: 15495485     Source Type: Journal    
DOI: 10.1101/lm.954808     Document Type: Article

References (38)

1. Bach, M.E., Barad, M., Son, H., Zhuo, M., Lu, Y.F., Shih, R., Mansuy, I., Hawkins, R.D., and Kandel, E.R. 1999. Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway. Proc. Natl. Acad. Sci. 96: 5280-5285.
2. Bagger, Y.Z., Tanko, L.B., Alexandersen, P., Qin, G., and Christiansen, C. 2004. The implications of body fat mass and fat distribution for cognitive function in elderly women. Obes. Res. 9: 1519-1526.
3. Barnes, C.A. 1979. Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat. J. Comp. Physiol. Psychol. 93: 74-104.
4. Barnes, C.A. and McNaughton, B.L. 1985. An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses. Behav. Neurosci. 99: 1040-1048.
5. Bimonte, H.A., Nelson, M.E., and Granholm, A.E. 2003. Age-related deficits as working memory load increases: Relationships with growth factors. Neurobiol. Aging 24: 37-48.
6. Conway, A.R. and Engle, R.W. 1996. Individual differences in working memory capacity: More evidence for a general capacity theory. Memory 4: 577-590.
7. Crawley, N.J. 2000. The laboratory mouse. Academic Press, New York.
8. Engle, R.W., Tuholski, S.W., Laughlin, J.E., and Conway, A.R. 1999. Working memory, short-term memory, and general fluid intelligence: A latent-variable approach. J. Exp. Psychol. Gen. 128: 309-331.
9. Feiro, O. and Gould, T.H. 2005. The interactive effects of nicotinic and muscarinic cholinergic receptor inhibition on fear conditioning in young and aged C57BL/6 mice. Pharmacol. Biochem. Behav. 80: 251-262.
10. Gage, F.H., Dunnett, S.B., and Björklund, A. 1984. Spatial learning and motor deficits in aged rats. Neurobiol. Aging 5: 43-48.
11. Gallagher, M. and Rapp, P.R. 1997. The use of animal models to study the effects of aging on cognition. Annu. Rev. Psychol. 48: 339-370.
12. Gould, T.H. and Feiro, O. 2005. Age-related deficits in the retention of memories for cued fear conditioning are reversed by galantamine treatment. Behav. Brain Res. 165: 160-171.
13. Grossman, H.C., Hale, G., Light, K., Kolata, S., Townsend, D.A., Goldfarb, Y., Kusnecov, A., and Matzel, L.D. 2007. Pharmacological modulation of stress reactivity dissociates general learning ability from the propensity for exploration. Behav. Neurosci. 121: 949 -964.
14. Hendrickx, H., McEwen, B.S., and Ouderaa, F. 2005. Metabolism, mood and cognition in aging: The importance of life style and dietary intervention. Neurobiol. Aging 26: 1-5.
15. Kolata, S., Light, K., Townsend, D.A., Hale, G., Grossman, H., and Matzel, L.D. 2005. Variations in working memory capacity predict individual differences in general learning abilities among genetically diverse mice. Neurobiol. Learn. Mem. 84: 242-246.
16. Kolata, S., Light, K., and Matzel, L.D. 2007. Selective attention is the primary determinant of the relationship between working memory and general learning abilities. Learn. Mem. 14: 22-28
17. Kolata, S., Light, K., and Matzel, L.D. 2008. Domain-specific and domain-general learning factors are expressed in genetically heterogeneous CD-1 mice. Intelligence (in press). doi: 10.1016/j.intell.2007.12.001.
18. Kuningas, M., de Rijk, R.H., Westendorp, R.G.J., Jolles, J., Slagboom, P.E., and van Heemst, D. 2007. Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors. Neuropsychopharmacology 32: 1295-1301.
19. Markowska, A.L. and Breckler, S.J. 1999. Behavioral biomarkers of aging: Illustration of a multi-variate approach for detecting age-related cognitive changes. J. Gerontol. 54: B549-B566.
20. Markowska, A.L. and Savonenko, A.V. 2002a. Protective effect of practice on cognition during aging: Implications for predictive characteristics of performance and efficacy of practice. Neurobiol. Learn. Mem. 78: 294-320.
21. Markowska, A.L. and Savonenko, A. 2002b. Retardation of cognitive aging by life-long diet restriction: Implications for genetic variance. Neurobiol. Aging 23: 75-86.
22. Markowska, A.L., Koliatsos, V.E., Breckler, S.J., Price, D.L., and Olton, D.S. 1994. Human nerve growth factor improves spatial memory in aged but not in young rats. J. Neurosci. 14: 4815-4824.
23. Matzel, L.D., Han, Y.R., Grossman, H., Karnik, M.S., Patel, D., Scott, N., Specht, S.M., and Gandhi, C.C. 2003. Individual differences in the expression of a "general" learning ability in mice. J. Neurosci. 23: 6423-6433.
24. Matzel, L.D., Townsend, D.A., Grossman, H., Han, Y.R., Hale, G., Zappulla, M., Light, K., and Kolata, S. 2006. Exploration in outbred mice covaries with general learning abilities irrespective of stress reactivity, emotionality, and physical attributes. Neurobiol. Learn. Mem. 86: 228-240.
25. Meliska, C.J., Burke, P.A., Bartke, A., and Jensen, R.A. 1997. Inhibitory avoidance and appetitive learning in aged normal mice: Comparison with transgenic mice having elevated plasma growth hormone levels. Neurobiol. Learn. Mem. 68: 1-12.
26. Morris, R.G.M. 1981. Spatial localization does not require the presence of local cues. Learn. Motiv. 12: 239-261.
27. Nalbantoglu, J., Tirado-Santiago, G., Lahsaini, A., Poirier, J., Goncalves, O., Verge, G., Momoli, F., Welner, S.A., Massicotte, G., Julien, J.P., et al. 1997. Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature 387: 500-505.
28. Newman, M.C. and Kaszniak, A.W. 2000. Spatial memory and aging: Performance on a human analog of the Morris Water Maze. Aging Neuropsychol. Cogn. 7: 86-93.
29. Plomin, R. 1999. Genetics and general cognitive ability. Nature (Suppl.) 402: C25-C29.
30. Plomin, R. and Spinath, F.M. 2002. Genetics and general cognitive ability (g). Trends Cogn. Sci. 6: 169-176.
31. Rosenzweig, E.S. and Barnes, C.A. 2003. Impact of aging on hippocampal function: Plasticity, network dynamics, and cognition. Prog. Neurobiol. 69: 143-179.
32. Salthouse, T.A., Atkinson, T.M., and Berish, D.E. 2003. Executive function as a potential mediator of age-related cognitive decline in normal adults. J. Exp. Psychol. Gen. 132: 566-594.
33. Sara, S.J., Roullet, P., and Przybyslawski, J. 1999. Consolidation of memory for odor-reward association: β-Adrenergic receptor involvement in the late phase. Learn. Mem. 6: 88-96.
34. Sternberg, R.J. 1997. Intelligence and life-long learning. Am. Psychol. 52: 1134-1139.
35. Sternberg, R.J. and Kaufman, J.C. 1998. Human abilities. Annu. Rev. Psychol. 49: 479-502.
36. Vogel, R.W., Ewers, M., Ross, C., Gould, T.J., and Woodruf-Pak, D.S. 2002. Age-related impairment in the 250-millisecond delay eyeblink classical conditioning procedure in C57BL/6 mice. Learn. Mem. 9: 321-336.
37. Winocur, G. and Hasher, L. 2004. Age and time of day effects on learning and memory in a non-matching-to-sample test. Neurobiol. Aging 25: 1107-1115.
38. Yanai, S., Okaichi, Y., and Okaichi, H. 2004. Long-term dietary restriction causes negative effects on cognitive functions in rats. Neurobiol. Aging 25: 325-332.