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Volumn 34, Issue 3, 2014, Pages 953-962

A novel role for brain interleukin-6: Facilitation of cognitive flexibility in rat orbitofrontal cortex

Author keywords

Cognitive flexibility; Depression; Interleukin 6; JAK STAT; Orbitofrontal cortex; Reversal learning

Indexed keywords

INTERLEUKIN 6; JANUS KINASE; STAT PROTEIN;

EID: 84892410541     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3968-13.2014     Document Type: Article
Times cited : (71)

References (53)
  • 1
    • 62649131576 scopus 로고    scopus 로고
    • Impaired hippocampus-dependent and-independent learning in IL-6 deficient mice
    • CrossRef Medline
    • Baier PC, May U, Scheller J, Rose-John S, Schiffelholz T (2009) Impaired hippocampus-dependent and-independent learning in IL-6 deficient mice. Behav Brain Res 200:192-196. CrossRef Medline
    • (2009) Behav Brain Res , vol.200 , pp. 192-196
    • Baier, P.C.1    May, U.2    Scheller, J.3    Rose-John, S.4    Schiffelholz, T.5
  • 4
    • 4344566457 scopus 로고    scopus 로고
    • Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system
    • CrossRef Medline
    • Burger C, Gorbatyuk OS, Velardo MJ, Peden CS, Williams P, Zolotukhin S, Reier PJ, Mandel RJ, Muzyczka N (2004) Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. Mol Ther 10:302-317. CrossRef Medline
    • (2004) Mol Ther , vol.10 , pp. 302-317
    • Burger, C.1    Gorbatyuk, O.S.2    Velardo, M.J.3    Peden, C.S.4    Williams, P.5    Zolotukhin, S.6    Reier, P.J.7    Mandel, R.J.8    Muzyczka, N.9
  • 6
    • 58549096688 scopus 로고    scopus 로고
    • Amyloid-β causes memory impairment by disturbing the JAK2/ STAT3 axis in hippocampal neurons
    • CrossRef Medline
    • Chiba T, Yamada M, Sasabe J, Terashita K, Shimoda M, Matsuoka M, Aiso S (2009) Amyloid-β causes memory impairment by disturbing the JAK2/ STAT3 axis in hippocampal neurons. Mol Psychiatry 14:206-222. CrossRef Medline
    • (2009) Mol Psychiatry , vol.14 , pp. 206-222
    • Chiba, T.1    Yamada, M.2    Sasabe, J.3    Terashita, K.4    Shimoda, M.5    Matsuoka, M.6    Aiso, S.7
  • 7
    • 2442503749 scopus 로고    scopus 로고
    • Cognitive inflexibility after prefrontal serotonin depletion
    • CrossRef Medline
    • Clarke HF, Dalley JW, Crofts HS, Robbins TW, Roberts AC (2004) Cognitive inflexibility after prefrontal serotonin depletion. Science 304:878-880. CrossRef Medline
    • (2004) Science , vol.304 , pp. 878-880
    • Clarke, H.F.1    Dalley, J.W.2    Crofts, H.S.3    Robbins, T.W.4    Roberts, A.C.5
  • 8
    • 58149154858 scopus 로고    scopus 로고
    • Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex
    • CrossRef Medline
    • Clarke HF, Robbins TW, Roberts AC (2008) Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex. J Neurosci 28:10972-10982. CrossRef Medline
    • (2008) J Neurosci , vol.28 , pp. 10972-10982
    • Clarke, H.F.1    Robbins, T.W.2    Roberts, A.C.3
  • 9
    • 77957242004 scopus 로고    scopus 로고
    • A cognitive deficit induced in rats by chronic intermittent cold stress is reversed by chronic antidepressant treatment
    • CrossRef Medline
    • Danet M, Lapiz-Bluhm S, Morilak DA (2010) A cognitive deficit induced in rats by chronic intermittent cold stress is reversed by chronic antidepressant treatment. Int J Neuropsychopharmacol 13:997-1009. CrossRef Medline
    • (2010) Int J Neuropsychopharmacol , vol.13 , pp. 997-1009
    • Danet, M.1    Lapiz-Bluhm, S.2    Morilak, D.A.3
  • 10
    • 37249094173 scopus 로고    scopus 로고
    • From inflammation to sickness and depression: When the immune system subjugates the brain
    • CrossRef Medline
    • Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9:46-56. CrossRef Medline
    • (2008) Nat Rev Neurosci , vol.9 , pp. 46-56
    • Dantzer, R.1    O'Connor, J.C.2    Freund, G.G.3    Johnson, R.W.4    Kelley, K.W.5
  • 11
    • 67349232005 scopus 로고    scopus 로고
    • A role for dopamine D2 receptors in reversal learning
    • CrossRef Medline
    • de Steno DA, Schmauss C (2009) A role for dopamine D2 receptors in reversal learning. Neuroscience 162:118-127. CrossRef Medline
    • (2009) Neuroscience , vol.162 , pp. 118-127
    • de Steno, D.A.1    Schmauss, C.2
  • 12
    • 37049029415 scopus 로고    scopus 로고
    • Orbitofrontal cortex function and structure in depression
    • CrossRef Medline
    • Drevets WC (2007) Orbitofrontal cortex function and structure in depression. Ann N Y Acad Sci 1121:499-527. CrossRef Medline
    • (2007) Ann N Y Acad Sci , vol.1121 , pp. 499-527
    • Drevets, W.C.1
  • 13
    • 65849122513 scopus 로고    scopus 로고
    • IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH Oxidase
    • CrossRef Medline
    • Dugan LL, Ali SS, Shekhtman G, Roberts AJ, Lucero J, Quick KL, Behrens MM (2009) IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH Oxidase. PLos One 4:e5518. CrossRef Medline
    • (2009) PLos One , vol.4
    • Dugan, L.L.1    Ali, S.S.2    Shekhtman, G.3    Roberts, A.J.4    Lucero, J.5    Quick, K.L.6    Behrens, M.M.7
  • 14
    • 84871509729 scopus 로고    scopus 로고
    • 5-HT2A receptors in the orbitofrontal cortex facilitate reversal learning and contribute to the beneficial cognitive effects of chronic citalopram treatment in rats
    • CrossRef Medline
    • Furr A, Lapiz-Bluhm MD, Morilak DA (2012) 5-HT2A receptors in the orbitofrontal cortex facilitate reversal learning and contribute to the beneficial cognitive effects of chronic citalopram treatment in rats. Int J Neuropsychopharmacol 15:1295-1305. CrossRef Medline
    • (2012) Int J Neuropsychopharmacol , vol.15 , pp. 1295-1305
    • Furr, A.1    Lapiz-Bluhm, M.D.2    Morilak, D.A.3
  • 17
    • 80052982705 scopus 로고    scopus 로고
    • Optimizing promoters for recombinant adeno-associated virus-mediated gene expression in the peripheral and central nervous system using self-complementary vectors
    • CrossRef Medline
    • Gray SJ, Foti SB, Schwartz JW, Bachaboina L, Taylor-Blake B, Coleman J, Ehlers MD, Zylka MJ, McCown TJ, Samulski RJ (2011) Optimizing promoters for recombinant adeno-associated virus-mediated gene expression in the peripheral and central nervous system using self-complementary vectors. Hum Gene Ther 22:1143-1153. CrossRef Medline
    • (2011) Hum Gene Ther , vol.22 , pp. 1143-1153
    • Gray, S.J.1    Foti, S.B.2    Schwartz, J.W.3    Bachaboina, L.4    Taylor-Blake, B.5    Coleman, J.6    Ehlers, M.D.7    Zylka, M.J.8    McCown, T.J.9    Samulski, R.J.10
  • 18
    • 34347252689 scopus 로고    scopus 로고
    • Production and characterization of adeno-associated viral vectors
    • CrossRef Medline
    • Grieger JC, Choi VW, Samulski RJ (2006) Production and characterization of adeno-associated viral vectors. Nat Protoc 1:1412-1428. CrossRef Medline
    • (2006) Nat Protoc , vol.1 , pp. 1412-1428
    • Grieger, J.C.1    Choi, V.W.2    Samulski, R.J.3
  • 19
    • 0030902977 scopus 로고    scopus 로고
    • Identification and localization of a skeletal muscle secrotonin 5-HT2A receptor coupled to the Jak/STAT pathway
    • CrossRef Medline
    • Guillet-Deniau I, Burnol AF, Girard J (1997) Identification and localization of a skeletal muscle secrotonin 5-HT2A receptor coupled to the Jak/STAT pathway. J Biol Chem 272:14825-14829. CrossRef Medline
    • (1997) J Biol Chem , vol.272 , pp. 14825-14829
    • Guillet-Deniau, I.1    Burnol, A.F.2    Girard, J.3
  • 20
    • 53949089392 scopus 로고    scopus 로고
    • Acute, regional inflammatory response after traumatic brain injury: Implications for cellular therapy
    • CrossRef Medline
    • Harting MT, Jimenez F, Adams SD, Mercer DW, Cox CS Jr (2008) Acute, regional inflammatory response after traumatic brain injury: implications for cellular therapy. Surgery 144:803-813. CrossRef Medline
    • (2008) Surgery , vol.144 , pp. 803-813
    • Harting, M.T.1    Jimenez, F.2    Adams, S.D.3    Mercer, D.W.4    Cox Jr., C.S.5
  • 24
    • 77956627896 scopus 로고    scopus 로고
    • Mutagenesis of adeno-associated virus type 2 capsid protein VP1 uncovers new roles for basic amino acids in trafficking and cell-specific transduction
    • CrossRef Medline
    • Johnson JS, Li C, DiPrimio N, Weinberg MS, McCown TJ, Samulski RJ (2010) Mutagenesis of adeno-associated virus type 2 capsid protein VP1 uncovers new roles for basic amino acids in trafficking and cell-specific transduction. J Virol 84:8888-8902. CrossRef Medline
    • (2010) J Virol , vol.84 , pp. 8888-8902
    • Johnson, J.S.1    Li, C.2    DiPrimio, N.3    Weinberg, M.S.4    McCown, T.J.5    Samulski, R.J.6
  • 25
    • 0030659512 scopus 로고    scopus 로고
    • Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases
    • CrossRef Medline
    • Kumar A, Commane M, Flickinger TW, Horvath CM, Stark GR (1997) Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases. Science 278:1630-1632. CrossRef Medline
    • (1997) Science , vol.278 , pp. 1630-1632
    • Kumar, A.1    Commane, M.2    Flickinger, T.W.3    Horvath, C.M.4    Stark, G.R.5
  • 26
    • 59449092179 scopus 로고    scopus 로고
    • Chronic intermittent cold stress and serotonin depletion induce deficits of reversal learning in an attentional set-shifting test in rats
    • CrossRef Medline
    • Lapiz-Bluhm MD, Soto-Piña AE, Hensler JG, Morilak DA (2009) Chronic intermittent cold stress and serotonin depletion induce deficits of reversal learning in an attentional set-shifting test in rats. Psychopharmacology 202:329-341. CrossRef Medline
    • (2009) Psychopharmacology , vol.202 , pp. 329-341
    • Lapiz-Bluhm, M.D.1    Soto-Piña, A.E.2    Hensler, J.G.3    Morilak, D.A.4
  • 27
    • 34548695696 scopus 로고    scopus 로고
    • Dopamine D2//D3 receptors play a specific role in the reversal of a learned visual discrimination in monkeys
    • CrossRef Medline
    • Lee B, Groman S, London ED, Jentsch JD (2007) Dopamine D2//D3 receptors play a specific role in the reversal of a learned visual discrimination in monkeys. Neuropsychopharmacology 32:2125-2134. CrossRef Medline
    • (2007) Neuropsychopharmacology , vol.32 , pp. 2125-2134
    • Lee, B.1    Groman, S.2    London, E.D.3    Jentsch, J.D.4
  • 28
    • 68949184845 scopus 로고    scopus 로고
    • Discrimination learning, reversal, and set-shifting in firstepisode schizophrenia: Stability over six years and specific associations with medication type and disorganization syndrome
    • CrossRef Medline
    • Leeson VC, Robbins TW, Matheson E, Hutton SB, Ron MA, Barnes TR, Joyce EM (2009) Discrimination learning, reversal, and set-shifting in firstepisode schizophrenia: stability over six years and specific associations with medication type and disorganization syndrome. Biol Psychiatry 66: 586-593. CrossRef Medline
    • (2009) Biol Psychiatry , vol.66 , pp. 586-593
    • Leeson, V.C.1    Robbins, T.W.2    Matheson, E.3    Hutton, S.B.4    Ron, M.A.5    Barnes, T.R.6    Joyce, E.M.7
  • 29
    • 33747070540 scopus 로고    scopus 로고
    • Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting
    • CrossRef Medline
    • Liston C, Miller MM, Goldwater DS, Radley JJ, Rocher AB, Hof PR, Morrison JH, McEwen BS (2006) Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting. J Neurosci 26:7870-7874. CrossRef Medline
    • (2006) J Neurosci , vol.26 , pp. 7870-7874
    • Liston, C.1    Miller, M.M.2    Goldwater, D.S.3    Radley, J.J.4    Rocher, A.B.5    Hof, P.R.6    Morrison, J.H.7    McEwen, B.S.8
  • 31
    • 0030020083 scopus 로고    scopus 로고
    • Interleukin-6 prevents ischemia-induced learning disability and neuronal and synaptic loss in gerbils
    • CrossRef Medline
    • Matsuda S, Wen TC, Morita F, Otsuka H, Igase K, Yoshimura H, SakanakaM (1996) Interleukin-6 prevents ischemia-induced learning disability and neuronal and synaptic loss in gerbils. Neurosci Lett 204:109-112. CrossRef Medline
    • (1996) Neurosci Lett , vol.204 , pp. 109-112
    • Matsuda, S.1    Wen, T.C.2    Morita, F.3    Otsuka, H.4    Igase, K.5    Yoshimura, H.6    Sakanaka, M.7
  • 32
    • 31844441871 scopus 로고    scopus 로고
    • Sensitivity to reward and punishment and the prefrontal cortex in major depression
    • CrossRef Medline
    • Must A, SzabóZ, Bódi N, Szász A, Janka Z, Kéri S (2006) Sensitivity to reward and punishment and the prefrontal cortex in major depression. J Affect Disord 90:209-215. CrossRef Medline
    • (2006) J Affect Disord , vol.90 , pp. 209-215
    • Must, A.1    Szabó, Z.2    Bódi, N.3    Szász, A.4    Janka, Z.5    Kéri, S.6
  • 33
    • 30944435466 scopus 로고    scopus 로고
    • Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin
    • CrossRef Medline
    • Ng DC, Lin BH, Lim CP, Huang G, Zhang T, Poli V, Cao X (2006) Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin. J Cell Biol 172:245-257. CrossRef Medline
    • (2006) J Cell Biol , vol.172 , pp. 245-257
    • Ng, D.C.1    Lin, B.H.2    Lim, C.P.3    Huang, G.4    Zhang, T.5    Poli, V.6    Cao, X.7
  • 35
    • 0027310841 scopus 로고
    • Interleukin-1β, but not interleukin-6, impairs spatial navigation learning
    • CrossRef Medline
    • Oitzl MS, van Oers H, Schöbitz B, de Kloet ER (1993) Interleukin-1β, but not interleukin-6, impairs spatial navigation learning. Brain Res 613:160-163. CrossRef Medline
    • (1993) Brain Res , vol.613 , pp. 160-163
    • Oitzl, M.S.1    van Oers, H.2    Schöbitz, B.3    de Kloet, E.R.4
  • 40
    • 0018956701 scopus 로고
    • The biological half-lives of four rats immunoglobulin isotypes
    • Medline
    • Peppard JV, Orlans E (1980) The biological half-lives of four rats immunoglobulin isotypes. Immunology 40:683-686. Medline
    • (1980) Immunology , vol.40 , pp. 683-686
    • Peppard, J.V.1    Orlans, E.2
  • 41
    • 1542407681 scopus 로고    scopus 로고
    • Prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slices
    • CrossRef Medline
    • Pizzi M, Sarnico I, Boroni F, Benarese M, Dreano M, Garotta G, Valerio A, Spano P (2004) Prevention of neuron and oligodendrocyte degeneration by interleukin-6 (IL-6) and IL-6 receptor/IL-6 fusion protein in organotypic hippocampal slices. Mol Cell Neurosci 25:301-311. CrossRef Medline
    • (2004) Mol Cell Neurosci , vol.25 , pp. 301-311
    • Pizzi, M.1    Sarnico, I.2    Boroni, F.3    Benarese, M.4    Dreano, M.5    Garotta, G.6    Valerio, A.7    Spano, P.8
  • 43
    • 2442754920 scopus 로고    scopus 로고
    • The IL-6/sIL-6R fusion protein hyper-IL-6 promotes neurite outgrowth and neuron survival in cultured enteric neurons
    • CrossRef Medline
    • Schäfer KH, Mestres P, März P, Rose-John S (1999) The IL-6/sIL-6R fusion protein hyper-IL-6 promotes neurite outgrowth and neuron survival in cultured enteric neurons. J Interferon Cytokine Res 19:527-532. CrossRef Medline
    • (1999) J Interferon Cytokine Res , vol.19 , pp. 527-532
    • Schäfer, K.H.1    Mestres, P.2    März, P.3    Rose-John, S.4
  • 44
    • 33750936288 scopus 로고    scopus 로고
    • Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers
    • CrossRef Medline
    • Sparkman NL, Buchanan JB, Heyen JR, Chen J, Beverly JL, Johnson RW (2006) Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers. J Neurosci 26:10709-10716. CrossRef Medline
    • (2006) J Neurosci , vol.26 , pp. 10709-10716
    • Sparkman, N.L.1    Buchanan, J.B.2    Heyen, J.R.3    Chen, J.4    Beverly, J.L.5    Johnson, R.W.6
  • 45
    • 34548049265 scopus 로고    scopus 로고
    • The effects of acute psychological stress on circulating inflammatory factors in humans: A review and metaanalysis
    • CrossRef Medline
    • Steptoe A, Hamer M, Chida Y (2007) The effects of acute psychological stress on circulating inflammatory factors in humans: a review and metaanalysis. Brain Behav Immun 21:901-912. CrossRef Medline
    • (2007) Brain Behav Immun , vol.21 , pp. 901-912
    • Steptoe, A.1    Hamer, M.2    Chida, Y.3
  • 46
    • 18844370367 scopus 로고    scopus 로고
    • Cucurbitacin Q: A selective STAT3 activation inhibitor with potent antitumor activity
    • CrossRef Medline
    • Sun J, Blaskovich MA, Jove R, Livingston SK, Coppola D, Sebti SM (2005) Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene 24:3236-3245. CrossRef Medline
    • (2005) Oncogene , vol.24 , pp. 3236-3245
    • Sun, J.1    Blaskovich, M.A.2    Jove, R.3    Livingston, S.K.4    Coppola, D.5    Sebti, S.M.6
  • 47
    • 58149330111 scopus 로고    scopus 로고
    • Neuroprotection of interleukin-6 against NMDA attack and its signal transduction by JAK and MAPK
    • CrossRef Medline
    • Wang XQ, Peng YP, Lu JH, Cao BB, Qiu YH (2009) Neuroprotection of interleukin-6 against NMDA attack and its signal transduction by JAK and MAPK. Neurosci Lett 450:122-126. CrossRef Medline
    • (2009) Neurosci Lett , vol.450 , pp. 122-126
    • Wang, X.Q.1    Peng, Y.P.2    Lu, J.H.3    Cao, B.B.4    Qiu, Y.H.5
  • 48
    • 79959343388 scopus 로고    scopus 로고
    • Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans
    • CrossRef Medline
    • Warner-Schmidt JL, Vanover KE, Chen EY, Marshall JJ, Greengard P (2011) Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans. Proc Natl Acad Sci U S A 108:9262-9267. CrossRef Medline
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 9262-9267
    • Warner-Schmidt, J.L.1    Vanover, K.E.2    Chen, E.Y.3    Marshall, J.J.4    Greengard, P.5
  • 49
    • 0037072285 scopus 로고    scopus 로고
    • Interleukin-6 and risk of cognitive decline: MacArthur Studies of Successful Aging
    • CrossRef Medline
    • Weaver JD, Huang MH, Albert M, Harris T, Rowe JW, Seeman TE (2002) Interleukin-6 and risk of cognitive decline: MacArthur Studies of Successful Aging. Neurology 59:371-378. CrossRef Medline
    • (2002) Neurology , vol.59 , pp. 371-378
    • Weaver, J.D.1    Huang, M.H.2    Albert, M.3    Harris, T.4    Rowe, J.W.5    Seeman, T.E.6
  • 50
    • 84858963873 scopus 로고    scopus 로고
    • Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors
    • CrossRef Medline
    • Wei H, Chadman KK, McCloskey DP, Sheikh AM, Malik M, Brown WT, Li X (2012) Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors. Biochim Biophys Acta 1822:831-842. CrossRef Medline
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 831-842
    • Wei, H.1    Chadman, K.K.2    McCloskey, D.P.3    Sheikh, A.M.4    Malik, M.5    Brown, W.T.6    Li, X.7
  • 51
    • 0034595401 scopus 로고    scopus 로고
    • A systematic review of newer pharmacotherapies for depression in adults: Evidence report summary: Clinical guideline, part 2
    • CrossRef Medline
    • Williams JW Jr, Mulrow CD, Chiquette E, Noël PH, Aguilar C, Cornell J (2000) A systematic review of newer pharmacotherapies for depression in adults: evidence report summary: clinical guideline, part 2. Ann Intern Med 132:743-756. CrossRef Medline
    • (2000) Ann Intern Med , vol.132 , pp. 743-756
    • Williams Jr., J.W.1    Mulrow, C.D.2    Chiquette, E.3    Noël, P.H.4    Aguilar, C.5    Cornell, J.6
  • 53
    • 78651412528 scopus 로고    scopus 로고
    • Immune modulation of learning, memory, neural plasticity and neurogenesis
    • CrossRef Medline
    • Yirmiya R, Goshen I (2011) Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain Behav Immun 25:181-213. CrossRef Medline
    • (2011) Brain Behav Immun , vol.25 , pp. 181-213
    • Yirmiya, R.1    Goshen, I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.