MicroRNA landscape in Alzheimer’s disease

CNS and Neurological Disorders - Drug Targets

Volumn 14, Issue 2, 2015, Pages 168-175

  Cogoni, Carlo ^a   Ruberti, Francesca ^b   Barbato, Christian ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CNR   (Italy)

Author keywords

Alzheimer s disease; APP; MicroRNAs; Tau

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; BIOLOGICAL MARKER; BRAIN DERIVED NEUROTROPHIC FACTOR; COFILIN; MICRORNA; SIRTUIN 1; TAU PROTEIN;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; BIPOLAR DISORDER; CENTRAL NERVOUS SYSTEM FUNCTION; DEPRESSION; GENE EXPRESSION REGULATION; HUMAN; MOLECULAR DYNAMICS; MULTIPLE SCLEROSIS; NONHUMAN; PARKINSON DISEASE; PROTEIN EXPRESSION; RNA TRANSLATION; SCHIZOPHRENIA; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; BRAIN; GENETICS; METABOLISM; PATHOLOGY;

ALZHEIMER DISEASE; BRAIN; HUMANS; MICRORNAS;

EID: 84930920475     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/1871527314666150116123305     Document Type: Article

References (68)

1. World Health Organization. Dementia: a Public Health Priority. World Health Organization, Geneva, 2012.
2. Krstic D, Knuesel I. Deciphering the mechanism underlying lateonset Alzheimer disease. Nat Rev Neurol 2013; 9: 25-34.
3. Dubois B, Feldman HH, Jacova C, et al. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. Lancet Neurol 2014; 13: 614-29.
4. Haass C, Selkoe D J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β- peptide. Nat Rev Mol Cell Biol 2007; 8: 101-12.
5. Tan L, Yu JT, Hu N, Tan L. Non-coding RNAs in Alzheimer's disease. Mol Neurobiol 2013 47: 382-93.
6. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136: 215-33.
7. Sun K, Lai EC. Adult-specific functions of animal microRNAs. Nat Rev Genet 2013; 14: 535-48.
8. Nowak JS, Michlewski G. miRNAs in development and pathogenesis of the nervous system. Biochem Soc Trans 2013; 41: 815-20.
9. Hartl M, Grunwald KIC. New roles for "old" microRNAs in nervous system function and disease. Front Mol Neurosci 2013; 24(6): 51.
10. Higa GS, de Sousa E, Walter LT, Kinjo ER, Resende RR, Kihara AH. MicroRNAs in neuronal communication. Mol Neurobiol 2014; 49: 1309-26.
11. Vo NK, Cambronne XA, Goodman RH. MicroRNA pathways in neural development and plasticity. Curr Opin Neurobiol 2010; 20: 457-65.
12. Follert P, Cremer H, Béclin C. MicroRNAs in brain development and function: a matter of flexibility and stability. Front Mol Neurosci 2014; 7: 5.
13. Cogswell, JP, Ward J, Taylor IA, et al. Identification of miRNA changes in Alzheimer's diseasebrain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis 2008; 14: 27-41.
14. Hébert SS, Horré K, Nicolaï L, et al. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci USA 2008; 105: 6415-20.
15. Nunez-Iglesias J, Liu CC, Morgan TE, Finch CE, Zhou XJ. Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation. PLos One 2010; 5: e8898.
16. Hébert SS, Wang WX, Zhu Q, Nelson PT. A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with Lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls. J Alzheimers Dis 2013; 35: 335-48.
17. Lau P, Bossers K, Janky R, et al. Alteration of the microRNA network during the progression of Alzheimer's disease. EMBO Mol Med 2013; 5: 1613-34.
18. Wong HK, Veremeyko T, Patel N, et al. De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease. Hum Mol Genet 2013; 22: 3077-92.
19. Wang WX, Rajeev BW, Stromberg AJ, et al. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci 2008; 28: 1213-23.
20. Boissonneault V, Plante I, Rivest S, Provost P. MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J Biol Chem 2009; 284: 1971-81.
21. Long JM, Ray B, Lahiri DK. MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects. Biol Chem 2014; 289: 5184-98.
22. Patel N, Hoang D, Miller N, et al. MicroRNAs can regulate human APP levels. Mol Neurodegener 2008; 6; 3: 10.
23. Hébert S, Horré K, Nicolai L, et al. MicroRNA regulation of Alzheimer's amyloid precursor protein expression. Neurobiol Dis 2009; 33: 422-428.
24. Vilardo E, Barbato C, Ciotti MT, Cogoni C, Ruberti F. MicroRNA- 101 regulates amyloid precursor protein expression in hippocampal neurons. J Biol Chem 2010; 285: 18344-51.
25. Long JM, Lahiri DK. MicroRNA-101 downregulates Alzheimer's amyloid-β precursor protein levels in human cell cultures and is differentially expressed. Biochem Biophys Res Commun 2011; 404: 889-95.
26. Liu W, Liu C, Zhu J, et al. MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice. Neurobiol Aging 2012; 33: 522-34.
27. Long JM, Ray B, Lahiri DK. MicroRNA-153 physiologically inhibits expression of amyloid-β precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients. J Biol Chem 2012; 287: 31298-310.
28. Liang C, Zhu H, Xu Y, et al. MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursorlike protein 2. Brain Res 2012; 1455: 103-13.
29. Smith P, Al Hashimi A, Girard J, Delay C, Hébert SS. In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs. J Neurochem 2011; 116: 240-7.
30. Che H, Sun LH, Guo F, et al. Expression of Amyloid-Associated miRNAs in Both the Forebrain Cortex and Hippocampus of Middle-Aged Rat. J Cell Physiol Biochem 2014; 33: 11-22.
31. Geekiyanage H, Chan C. MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer's disease. J Neurosci 2011; 31: 14820-30.
32. Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 2008; 9: 139- 50.
33. He X, Huang Y, Li B, Gong CX, Schuchman EH. Deregulation of sphingolipid metabolism in Alzheimer's disease. Neurobiol Aging 2010; 31: 398-408.
34. Puglielli L, Ellis BC, Saunders AJ, Kovacs DM. Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis. J Biol Chem 2003; 278: 19777-83.
35. Patil S, Melrose J, Chan C. Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons Eur J Neurosci 2007; 26: 2131-41.
36. Schonrock N, Ke YD, Humphreys D, et al. Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta. PLoS One 2010; 5: e11070.
37. Li JJ, Dolios G, Wang R, Liao FF. Soluble beta-amyloid peptides, but not insoluble fibrils, have specific effect on neuronal microRNA expression. PLoS One 2014; 9: e90770.
38. Hébert S, Papadopoulou AS, Smith P, et al. Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. Hum Mol Genet 2010; 19: 3959-69.
39. Andorfer C, Acker CM, Kress Y, Hof PR, Duff K, Davies P. Cellcycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. J Neurosci 2005; 25: 5446-54.
40. Jaworski T, Dewachter I, Lechat B, et al. GSK-3α/β kinases and amyloid production in vivo. Nature 2011; 480: E4-5.
41. Busser J, Geldmacher DS, Herrup K. Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain. J Neurosci 1998; 18: 2801-7.
42. Keeney JT, Swomley AM, Harris JL, et al. Cell cycle proteins in brain in mild cognitive impairment: insights into progression to Alzheimer disease. Neurotox Res 2012; 22: 220-30.
43. Seward ME, Swanson E, Norambuena A, et al. Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease. J Cell Sci 2013; 126: 1278-86.
44. Absalon S, Kochanek DM, Raghavan V, Krichevsky AM. MiR- 26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. J Neurosci 2013; 33: 14645-59.
45. Wong HK, Veremeyko T, Patel N, et al. De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease. Hum Mol Genet 2013; 22: 3077-92.
46. Lau P, Bossers K, Janky R, et al. Alteration of the microRNA network during the progression of Alzheimer's disease. EMBO Mol Med 2013; 5: 1613-34.
47. Zovoilis A, Agbemenyah HY, Agis-Balboa RC, et al. microRNA- 34c is a novel target to treat dementias. EMBO J 2011; 30: 4299- 308.
48. Lee ST, Chu K, Jung KH, et al. miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model. Ann Neurol 2012; 72: 269-77.
49. Tesseur I, Zou K, Esposito L, et al. Deficiency in neuronal TGFbeta signaling promotes neurodegeneration and Alzheimer's pathology. J Clin Invest 2006; 116: 3060-9.
50. Caraci F, Battaglia G, Busceti C, et al. TGF-beta 1 protects against Abeta-neurotoxicity via the phosphatidylinositol-3-kinase pathway. Neurobiol Dis 2008; 30: 234-42.
51. Wang H, Liu J, Zong Y, et al. miR-106b aberrantly expressed in a double transgenic mouse model for Alzheimer's disease targets TGF-β type II receptor. Brain Res 2010; 1357: 166-74.
52. Barak B, Shvarts-Serebro I, Modai S, et al. Opposing actions of environmental enrichment and Alzheimer's disease on the expression of hippocampal microRNAs in mouse models. Transl Psychiatry 2013; 3: e304.
53. Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee, JJ, Lotvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007; 9: 654-9.
54. Arroyo JD, Chevillet JR, Kroh EM, et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci USA 2011; 108: 5003-8
55. Xu L, Yang BF, Ai J. MicroRNA transport: a new way in cell communication. J Cell Physiol 2013; 228: 1713-9.
56. Kosaka N, Yoshioka Y, Hagiwara K, Tominaga N, Katsuda T, Ochiya T. Trash or Treasure: extracellular microRNAs and cell-tocell communication. Front Genet 2013; 4: 173.
57. Sala Frigerio C, Lau P, Salta E, et al. Reduced expressionof hsamiR- 27a-3p in CSF of patients with Alzheimer disease. Neurology 2013; 81: 2103-6.
58. Muller M, Kuiperij HB, Claassen JA, Kusters B, Verbeek MM. MicroRNAs in Alzheimer's disease: differential expression in hippocampus and cell-free cerebrospinal fluid. Neurobiol Aging 2014; 35: 152-8.
59. Lehmann SM, Kruger C, Park B, et al. An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci 2012; 15: 827-35.
60. Kiko T, Nakagawa K, Tsuduki T, Furukawa K, Arai H, Miyazawa T. MicroRNAs in plasma and cerebrospinal fluid as potential markers for Alzheimer's disease. J Alzheimers Dis 2014; 39: 253-9.
61. Galasko D, Golde TE. Biomarkers for Alzheimer's disease in plasma, serum and blood - conceptual and practical problems. Alzheimers Res Ther 2013; 5: 10
62. Sheinerman KS, Tsivinsky VG, Crawford, F, Mullan MJ, Abdullah L, Umansky SR. Plasma microRNA biomarkers for detection of mild cognitive impairment. Aging 2012; 4: 590-605.
63. Kumar P, Dezso Z, MacKenzie C, et al. Circulating miRNA biomarkersfor Alzheimer's disease. PLoS One 8 2013; e69807.
64. Tylee DS, Kawaguchi DM, Glatt SJ. On the outside, looking in: a review and evaluation of the comparability of blood and brain "-omes". Am J Med Genet B Neuropsychiatr Genet 2013; 162B: 595-603.
65. Schipper HM, Maes OC, Chertkow HM, Wang E. MicroRNA expression in Alzheimer blood mononuclear cells. Gene Regul Syst Biol 2007; 1: 263-74.
66. Leidinger P, Backes C, Deutscher S, et al. A blood based 12- miRNA signature of Alzheimer disease patients. Genome Biol 2013; 14: R78.
67. Nelson PT, Wang WX. MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study. J Alzheimers Dis 2010; 21: 75-9.
68. Yao J, Hennessey T, Flynt A, Lai E, Beal MF, Lin MT. MicroRNA-related cofilin abnormality in Alzheimer's disease. PLoS One 2010; 5(12): e15546.