The stress response neuropeptide CRF increases amyloid-β production by regulating γ-secretase activity

EMBO Journal

Volumn 34, Issue 12, 2015, Pages 1674-1686

  Park, Hyo Jin ^a,b   Ran, Yong ^a   Jung, Joo In ^a   Holmes, Oliver ^c   Price, Ashleigh R ^a   Smithson, Lisa ^a   Ceballos Diaz, Carolina ^a   Han, Chul ^a   Wolfe, Michael S ^c   Daaka, Yehia ^a   Ryabinin, Andrey E ^d   Kim, Seong Hun ^b   Hauger, Richard L ^e   Golde, Todd E ^a   Felsenstein, Kevin M ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amyloid ; Corticotrophin releasing factor; Stress; arrestin; secretase

Indexed keywords

AMYLOID BETA PROTEIN; BETA ARRESTIN; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; GAMMA SECRETASE; CORTICOTROPIN RELEASING FACTOR RECEPTOR; CYCLIC AMP; SECRETASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; IMMOBILIZATION STRESS; IN VITRO STUDY; INTERNALIZATION; LIPID RAFT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MOTIF; RISK FACTOR; ANALYSIS OF VARIANCE; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; C57BL MOUSE; CELL MEMBRANE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; HEK293 CELL LINE; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNOPRECIPITATION; METABOLISM; PHYSIOLOGICAL STRESS; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CORTICOTROPIN-RELEASING HORMONE; CYCLIC AMP; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEK293 CELLS; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; IMMUNOPRECIPITATION; MEMBRANE MICRODOMAINS; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; PITUITARY-ADRENAL SYSTEM; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRESS, PHYSIOLOGICAL;

EID: 84930871482     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201488795     Document Type: Article

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