메뉴 건너뛰기




Volumn 40, Issue 6, 2015, Pages 1095-1101

Capillarisin Suppresses Lipopolysaccharide-Induced Inflammatory Mediators in BV2 Microglial Cells by Suppressing TLR4-Mediated NF-κB and MAPKs Signaling Pathway

Author keywords

Capillarisin; LPS; Microglia; NF B

Indexed keywords

ANTIINFLAMMATORY AGENT; CAPILLARISIN; I KAPPA B ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; NITRITE; PROSTAGLANDIN E2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTACOID; CHROMONE DERIVATIVE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT;

EID: 84930868899     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-015-1567-4     Document Type: Article
Times cited : (30)

References (30)
  • 1
    • 84924191380 scopus 로고    scopus 로고
    • Neuroinflammation, microglia and mast cells in the Pathophysiology of neurocognitive disorders: a review
    • PID: 25470401
    • Skaper SD, Facci L, Giusti P (2014) Neuroinflammation, microglia and mast cells in the Pathophysiology of neurocognitive disorders: a review. CNS Neurol Disord Drug Targets 13:1654–1666
    • (2014) CNS Neurol Disord Drug Targets , vol.13 , pp. 1654-1666
    • Skaper, S.D.1    Facci, L.2    Giusti, P.3
  • 2
    • 10644230076 scopus 로고    scopus 로고
    • (-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury
    • COI: 1:CAS:528:DC%2BD2cXhtVGlurrL, PID: 15478178
    • Li R, Huang YG, Fang D, Le WD (2004) (-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury. J Neurosci Res 78:723–731
    • (2004) J Neurosci Res , vol.78 , pp. 723-731
    • Li, R.1    Huang, Y.G.2    Fang, D.3    Le, W.D.4
  • 3
    • 84924862476 scopus 로고    scopus 로고
    • Targeting microglia for the treatment of Alzheimer’s disease
    • PID: 25435348
    • McGeer PL, McGeer EG (2014) Targeting microglia for the treatment of Alzheimer’s disease. Expert Opin Ther Targets 19:497–506
    • (2014) Expert Opin Ther Targets , vol.19 , pp. 497-506
    • McGeer, P.L.1    McGeer, E.G.2
  • 4
    • 84884906968 scopus 로고    scopus 로고
    • Morphine mediates a proinflammatory phenotype via mu-opioid receptor-PKCvarepsilon-Akt-ERK1/2 signaling pathway in activated microglial cells
    • COI: 1:CAS:528:DC%2BC3sXhtVOrtLzM, PID: 23796752
    • Merighi S, Gessi S, Varani K, Fazzi D, Stefanelli A, Borea PA (2013) Morphine mediates a proinflammatory phenotype via mu-opioid receptor-PKCvarepsilon-Akt-ERK1/2 signaling pathway in activated microglial cells. Biochem Pharmacol 86:487–496
    • (2013) Biochem Pharmacol , vol.86 , pp. 487-496
    • Merighi, S.1    Gessi, S.2    Varani, K.3    Fazzi, D.4    Stefanelli, A.5    Borea, P.A.6
  • 5
    • 69549139978 scopus 로고    scopus 로고
    • Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation
    • COI: 1:CAS:528:DC%2BD1MXhtFGqsLrM, PID: 19576187
    • Dello Russo C, Lisi L, Tringali G, Navarra P (2009) Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation. Biochem Pharmacol 78:1242–1251
    • (2009) Biochem Pharmacol , vol.78 , pp. 1242-1251
    • Dello Russo, C.1    Lisi, L.2    Tringali, G.3    Navarra, P.4
  • 6
    • 76849090223 scopus 로고    scopus 로고
    • Inhibition of nitric oxide production by quercetin in endotoxin/cytokine-stimulated microglia
    • COI: 1:CAS:528:DC%2BC3cXit1Onsbs%3D, PID: 20060843
    • Kao TK, Ou YC, Raung SL, Lai CY, Liao SL, Chen CJ (2010) Inhibition of nitric oxide production by quercetin in endotoxin/cytokine-stimulated microglia. Life Sci 86:315–321
    • (2010) Life Sci , vol.86 , pp. 315-321
    • Kao, T.K.1    Ou, Y.C.2    Raung, S.L.3    Lai, C.Y.4    Liao, S.L.5    Chen, C.J.6
  • 8
    • 71549121038 scopus 로고    scopus 로고
    • A novel anti-neuroinflammatory pyridylimidazole compound KR-31360
    • COI: 1:CAS:528:DC%2BD1MXhsFGgtL3N, PID: 19800321
    • Ock J, Kim S, Yi KY, Kim NJ, Han HS, Cho JY, Suk K (2010) A novel anti-neuroinflammatory pyridylimidazole compound KR-31360. Biochem Pharmacol 79:596–609
    • (2010) Biochem Pharmacol , vol.79 , pp. 596-609
    • Ock, J.1    Kim, S.2    Yi, K.Y.3    Kim, N.J.4    Han, H.S.5    Cho, J.Y.6    Suk, K.7
  • 9
    • 46649088909 scopus 로고    scopus 로고
    • Neuroprotective role of tripchlorolide on inflammatory neurotoxicity induced by lipopolysaccharide-activated microglia
    • COI: 1:CAS:528:DC%2BD1cXosVOms70%3D, PID: 18602088
    • Pan XD, Chen XC, Zhu YG, Zhang J, Huang TW, Chen LM, Ye QY, Huang HP (2008) Neuroprotective role of tripchlorolide on inflammatory neurotoxicity induced by lipopolysaccharide-activated microglia. Biochem Pharmacol 76:362–372
    • (2008) Biochem Pharmacol , vol.76 , pp. 362-372
    • Pan, X.D.1    Chen, X.C.2    Zhu, Y.G.3    Zhang, J.4    Huang, T.W.5    Chen, L.M.6    Ye, Q.Y.7    Huang, H.P.8
  • 10
    • 84925535783 scopus 로고    scopus 로고
    • Activation of BV2 microglia by lipopolysaccharide triggers an inflammatory reaction in PC12 cell apoptosis through a toll-like receptor 4-dependent pathway
    • COI: 1:CAS:528:DC%2BC2cXhvFSmt77N, PID: 25387796
    • Dai XJ, Li N, Yu L, Chen ZY, Hua R, Qin X, Zhang YM (2015) Activation of BV2 microglia by lipopolysaccharide triggers an inflammatory reaction in PC12 cell apoptosis through a toll-like receptor 4-dependent pathway. Cell Stress Chaperones 20:321–331
    • (2015) Cell Stress Chaperones , vol.20 , pp. 321-331
    • Dai, X.J.1    Li, N.2    Yu, L.3    Chen, Z.Y.4    Hua, R.5    Qin, X.6    Zhang, Y.M.7
  • 11
    • 78149355932 scopus 로고    scopus 로고
    • Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol
    • COI: 1:CAS:528:DC%2BC3cXhsVWgt7rO, PID: 20650929
    • Zhu X, Owen JS, Wilson MD, Li H, Griffiths GL, Thomas MJ, Hiltbold EM, Fessler MB, Parks JS (2010) Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol. J Lipid Res 51:3196–3206
    • (2010) J Lipid Res , vol.51 , pp. 3196-3206
    • Zhu, X.1    Owen, J.S.2    Wilson, M.D.3    Li, H.4    Griffiths, G.L.5    Thomas, M.J.6    Hiltbold, E.M.7    Fessler, M.B.8    Parks, J.S.9
  • 12
    • 77953503631 scopus 로고    scopus 로고
    • Apolipoprotein CI enhances the biological response to LPS via the CD14/TLR4 pathway by LPS-binding elements in both its N- and C-terminal helix
    • COI: 1:CAS:528:DC%2BC3cXotFGrur8%3D, PID: 20335569
    • Berbee JF, Coomans CP, Westerterp M, Romijn JA, Havekes LM, Rensen PC (2010) Apolipoprotein CI enhances the biological response to LPS via the CD14/TLR4 pathway by LPS-binding elements in both its N- and C-terminal helix. J Lipid Res 51:1943–1952
    • (2010) J Lipid Res , vol.51 , pp. 1943-1952
    • Berbee, J.F.1    Coomans, C.P.2    Westerterp, M.3    Romijn, J.A.4    Havekes, L.M.5    Rensen, P.C.6
  • 13
    • 77549084879 scopus 로고    scopus 로고
    • Surfactant lipids regulate LPS-induced interleukin-8 production in A549 lung epithelial cells by inhibiting translocation of TLR4 into lipid raft domains
    • COI: 1:CAS:528:DC%2BC3cXptVWnsw%3D%3D, PID: 19648651
    • Abate W, Alghaithy AA, Parton J, Jones KP, Jackson SK (2010) Surfactant lipids regulate LPS-induced interleukin-8 production in A549 lung epithelial cells by inhibiting translocation of TLR4 into lipid raft domains. J Lipid Res 51:334–344
    • (2010) J Lipid Res , vol.51 , pp. 334-344
    • Abate, W.1    Alghaithy, A.A.2    Parton, J.3    Jones, K.P.4    Jackson, S.K.5
  • 14
    • 84900362505 scopus 로고    scopus 로고
    • Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model
    • COI: 1:CAS:528:DC%2BC2cXis1Cqt78%3D, PID: 24495472
    • Khan S, Shehzad O, Chun J, Choi RJ, Park S, Islam MN, Choi JS, Kim YS (2014) Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model. J Ethnopharmacol 152:478–486
    • (2014) J Ethnopharmacol , vol.152 , pp. 478-486
    • Khan, S.1    Shehzad, O.2    Chun, J.3    Choi, R.J.4    Park, S.5    Islam, M.N.6    Choi, J.S.7    Kim, Y.S.8
  • 15
    • 84893776889 scopus 로고    scopus 로고
    • Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases
    • COI: 1:CAS:528:DC%2BC3sXhvFOht7fK, PID: 24333736
    • Lee JH, Chiang SY, Nam D, Chung WS, Lee J, Na YS, Sethi G, Ahn KS (2014) Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases. Cancer Lett 345:140–148
    • (2014) Cancer Lett , vol.345 , pp. 140-148
    • Lee, J.H.1    Chiang, S.Y.2    Nam, D.3    Chung, W.S.4    Lee, J.5    Na, Y.S.6    Sethi, G.7    Ahn, K.S.8
  • 16
    • 84869171007 scopus 로고    scopus 로고
    • Capillarisin inhibits iNOS, COX-2 expression, and proinflammatory cytokines in LPS-induced RAW 264.7 macrophages via the suppression of ERK, JNK, and NF-kappaB activation
    • COI: 1:CAS:528:DC%2BC38Xhs1Glsb7N, PID: 23131135
    • Han S, Lee JH, Kim C, Nam D, Chung WS, Lee SG, Ahn KS, Cho SK, Cho M, Ahn KS (2013) Capillarisin inhibits iNOS, COX-2 expression, and proinflammatory cytokines in LPS-induced RAW 264.7 macrophages via the suppression of ERK, JNK, and NF-kappaB activation. Immunopharmacol Immunotoxicol 35:34–42
    • (2013) Immunopharmacol Immunotoxicol , vol.35 , pp. 34-42
    • Han, S.1    Lee, J.H.2    Kim, C.3    Nam, D.4    Chung, W.S.5    Lee, S.G.6    Ahn, K.S.7    Cho, S.K.8    Cho, M.9    Ahn, K.S.10
  • 17
    • 84872146374 scopus 로고    scopus 로고
    • Molecular mechanism of capillarisin-mediated inhibition of MyD88/TIRAP inflammatory signaling in in vitro and in vivo experimental models
    • COI: 1:CAS:528:DC%2BC38XhvFWhu7%2FJ, PID: 23237934
    • Khan S, Choi RJ, Shehzad O, Kim HP, Islam MN, Choi JS, Kim YS (2013) Molecular mechanism of capillarisin-mediated inhibition of MyD88/TIRAP inflammatory signaling in in vitro and in vivo experimental models. J Ethnopharmacol 145:626–637
    • (2013) J Ethnopharmacol , vol.145 , pp. 626-637
    • Khan, S.1    Choi, R.J.2    Shehzad, O.3    Kim, H.P.4    Islam, M.N.5    Choi, J.S.6    Kim, Y.S.7
  • 18
    • 84874941047 scopus 로고    scopus 로고
    • Resveratrol protects cortical neurons against microglia-mediated neuroinflammation
    • COI: 1:CAS:528:DC%2BC3sXjslSqsL4%3D, PID: 22585561
    • Zhang F, Wang H, Wu Q, Lu Y, Nie J, Xie X, Shi J (2013) Resveratrol protects cortical neurons against microglia-mediated neuroinflammation. Phytotherapy research: PTR 27:344–349
    • (2013) Phytotherapy research : PTR , vol.27 , pp. 344-349
    • Zhang, F.1    Wang, H.2    Wu, Q.3    Lu, Y.4    Nie, J.5    Xie, X.6    Shi, J.7
  • 19
    • 84919492287 scopus 로고    scopus 로고
    • Isobutyrylshikonin inhibits lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in BV2 microglial cells by suppressing the PI3 K/Akt-mediated nuclear transcription factor-kappaB pathway
    • COI: 1:CAS:528:DC%2BC2cXhslOqtbjN, PID: 25454762
    • Jayasooriya RG, Lee KT, Kang CH, Dilshara MG, Lee HJ, Choi YH, Choi IW, Kim GY (2014) Isobutyrylshikonin inhibits lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in BV2 microglial cells by suppressing the PI3 K/Akt-mediated nuclear transcription factor-kappaB pathway. Nutr Res 34:1111–1119
    • (2014) Nutr Res , vol.34 , pp. 1111-1119
    • Jayasooriya, R.G.1    Lee, K.T.2    Kang, C.H.3    Dilshara, M.G.4    Lee, H.J.5    Choi, Y.H.6    Choi, I.W.7    Kim, G.Y.8
  • 20
    • 84928400339 scopus 로고    scopus 로고
    • lipopolysaccharide-stimulated transglutaminase 2 expression enhances endocytosis activity in the mouse microglial cell line BV-2
    • PID: 25301694
    • Kawabe K, Takano K, Moriyama M, Nakamura Y (2014) lipopolysaccharide-stimulated transglutaminase 2 expression enhances endocytosis activity in the mouse microglial cell line BV-2. Neuroimmunomodulation. doi:10.1159/000365484
    • (2014) Neuroimmunomodulation
    • Kawabe, K.1    Takano, K.2    Moriyama, M.3    Nakamura, Y.4
  • 21
    • 84906491827 scopus 로고    scopus 로고
    • Effect of the semen extract of Cuscuta chinensis on inflammatory responses in LPS-stimulated BV-2 microglia
    • PID: 25156282
    • Kang SY, Jung HW, Lee MY, Lee HW, Chae SW, Park YK (2014) Effect of the semen extract of Cuscuta chinensis on inflammatory responses in LPS-stimulated BV-2 microglia. Chin J Nat Med 12:573–581
    • (2014) Chin J Nat Med , vol.12 , pp. 573-581
    • Kang, S.Y.1    Jung, H.W.2    Lee, M.Y.3    Lee, H.W.4    Chae, S.W.5    Park, Y.K.6
  • 23
    • 84907096973 scopus 로고    scopus 로고
    • Tiliroside, a dietary glycosidic flavonoid, inhibits TRAF-6/NF-kappaB/p38-mediated neuroinflammation in activated BV2 microglia
    • COI: 1:CAS:528:DC%2BC2cXhsVOhsrnP, PID: 25152356
    • Velagapudi R, Aderogba M, Olajide OA (2014) Tiliroside, a dietary glycosidic flavonoid, inhibits TRAF-6/NF-kappaB/p38-mediated neuroinflammation in activated BV2 microglia. Biochim Biophys Acta 1840:3311–3319
    • (2014) Biochim Biophys Acta , vol.1840 , pp. 3311-3319
    • Velagapudi, R.1    Aderogba, M.2    Olajide, O.A.3
  • 24
    • 84901586086 scopus 로고    scopus 로고
    • Potential biomarkers relating pathological proteins, neuroinflammatory factors and free radicals in PD patients with cognitive impairment: a cross-sectional study
    • PID: 24884485
    • Yu SY, Zuo LJ, Wang F, Chen ZJ, Hu Y, Wang YJ, Wang XM, Zhang W (2014) Potential biomarkers relating pathological proteins, neuroinflammatory factors and free radicals in PD patients with cognitive impairment: a cross-sectional study. BMC Neurol 14:113
    • (2014) BMC Neurol , vol.14 , pp. 113
    • Yu, S.Y.1    Zuo, L.J.2    Wang, F.3    Chen, Z.J.4    Hu, Y.5    Wang, Y.J.6    Wang, X.M.7    Zhang, W.8
  • 25
    • 84908084191 scopus 로고    scopus 로고
    • Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-gamma agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson’s disease
    • COI: 1:CAS:528:DC%2BC2cXhsVSqt73F, PID: 25134730
    • Pisanu A, Lecca D, Mulas G, Wardas J, Simbula G, Spiga S, Carta AR (2014) Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-gamma agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson’s disease. Neurobiol Dis 71:280–291
    • (2014) Neurobiol Dis , vol.71 , pp. 280-291
    • Pisanu, A.1    Lecca, D.2    Mulas, G.3    Wardas, J.4    Simbula, G.5    Spiga, S.6    Carta, A.R.7
  • 26
    • 84871250985 scopus 로고    scopus 로고
    • Fenretinide inhibited de novo ceramide synthesis and proinflammatory cytokines induced by Aggregatibacter actinomycetemcomitans
    • COI: 1:CAS:528:DC%2BC3sXhtF2gsrg%3D, PID: 23139430
    • Yu H, Valerio M, Bielawski J (2013) Fenretinide inhibited de novo ceramide synthesis and proinflammatory cytokines induced by Aggregatibacter actinomycetemcomitans. J Lipid Res 54:189–201
    • (2013) J Lipid Res , vol.54 , pp. 189-201
    • Yu, H.1    Valerio, M.2    Bielawski, J.3
  • 27
    • 84863799417 scopus 로고    scopus 로고
    • Macrophage SR-BI regulates LPS-induced pro-inflammatory signaling in mice and isolated macrophages
    • COI: 1:CAS:528:DC%2BC38XhtFSqtL3M, PID: 22589557
    • Cai L, Wang Z, Meyer JM, Ji A, van der Westhuyzen DR (2012) Macrophage SR-BI regulates LPS-induced pro-inflammatory signaling in mice and isolated macrophages. J Lipid Res 53:1472–1481
    • (2012) J Lipid Res , vol.53 , pp. 1472-1481
    • Cai, L.1    Wang, Z.2    Meyer, J.M.3    Ji, A.4    van der Westhuyzen, D.R.5
  • 29
    • 84899445444 scopus 로고    scopus 로고
    • H-RN, a novel antiangiogenic peptide derived from hepatocyte growth factor inhibits inflammation in vitro and in vivo through PI3 K/AKT/IKK/NF-kappaB signal pathway
    • COI: 1:CAS:528:DC%2BC2cXkslGntLs%3D, PID: 24630926
    • Wang L, Xu Y, Yu Q, Sun Q, Xu Y, Gu Q, Xu X (2014) H-RN, a novel antiangiogenic peptide derived from hepatocyte growth factor inhibits inflammation in vitro and in vivo through PI3 K/AKT/IKK/NF-kappaB signal pathway. Biochem Pharmacol 89:255–265
    • (2014) Biochem Pharmacol , vol.89 , pp. 255-265
    • Wang, L.1    Xu, Y.2    Yu, Q.3    Sun, Q.4    Xu, Y.5    Gu, Q.6    Xu, X.7
  • 30
    • 84884149694 scopus 로고    scopus 로고
    • Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling
    • COI: 1:CAS:528:DC%2BC3sXhsVCltLnE, PID: 23924694
    • Danai LV, Guilherme A, Guntur KV, Straubhaar J, Nicoloro SM, Czech MP (2013) Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling. J Lipid Res 54:2697–2707
    • (2013) J Lipid Res , vol.54 , pp. 2697-2707
    • Danai, L.V.1    Guilherme, A.2    Guntur, K.V.3    Straubhaar, J.4    Nicoloro, S.M.5    Czech, M.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.